Lipoprotein composition and serum Lp(a) lipoprotein in hypobetalipoproteinaemia.

Abstract:

:A family with hypobetalipoproteinaemia was studied to examine the Lp(a) lipoprotein, lipoprotein cholesterol, and triglyceride composition of the serum lipids. Lp(a) lipoprotein was measured by immunoassay. Serum lipoproteins were separated by ultracentrifugation. Cholesterol and triglycerides were measured using standard enzymatic assays. Serum apolipoprotein B was low and Lp(a) undetectable in the index patient and in her father and son. Separation of the lipoproteins by ultracentrifugation showed a low cholesterol content of serum low density lipoprotein in the affected family members and also a low triglyceride content of high density lipoprotein particles in two affected members. It is concluded that serum lipoprotein cholesterol is altered in hypobetalipoproteinaemia, and family members of index cases have undetectable serum Lp(a) lipoprotein concentrations.

journal_name

J Clin Pathol

authors

Crook M,Swaminathan R

doi

10.1136/jcp.48.6.587

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

587-9

issue

6

eissn

0021-9746

issn

1472-4146

journal_volume

48

pub_type

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