Abstract：
AIMS:To investigate the histopathological changes in the livers of patients undergoing cholecystectomy and to relate these changes to the underlying biliary tract pathology. METHODS:Liver changes in 67 patients undergoing cholecystectomy were investigated. Sixty three had gall stones, one cholesterolosis only, and there were three cases of acute acalculous cholecystitis. RESULTS:Only 34% of the patients had completely normal liver biopsy specimens. The most clinically important pathology was found in 11 of the 14 patients with choledocholithiasis: three of these had cholangitis and eight had features of large bile duct obstruction (four also had chronic cholestasis and portal-portal linking fibrosis). Non-specific reactive hepatitis was the most common abnormality in the remaining 53 patients with cholecystitis alone, and was found in 18. A further four patients had chronic cholestasis without fibrosis and early primary biliary cirrhosis was a coincidental finding in another. Clinical symptoms were poorly correlated with gall bladder and liver pathology apart from an association between jaundice and choledocholithiasis. Liver function tests of obstructive pattern were noted in 23 of 58 patients, most of whom had choledocholithiasis or non-specific reactive hepatitis. Bile cultures were positive in 10 of 42 patients, predominantly in cases of cholangitis and acute cholecystitis. CONCLUSIONS:Cholangitis and extensive fibrosis associated with large bile duct obstruction are common findings in patients with choledocholithiasis. The liver disease may progress to secondary biliary cirrhosis if the obstruction is not relieved, emphasising the need for early surgery. A peroperative liver biopsy may be useful to exclude cirrhosis in these patients, but is unlikely to be informative in those with cholecystitis alone.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Geraghty JM,Goldin RDdoi
10.1136/jcp.47.5.457subject
Has Abstractpub_date
1994-05-01 00:00:00pages
457-60issue
5eissn
0021-9746issn
1472-4146journal_volume
47pub_type
杂志文章abstract：AIMS:To develop a rapid, sensitive, and specific non-isotopic in situ hybridisation (NISH) procedure for the detection of Epstein-Barr virus in formalin fixed, paraffin wax embedded tissues. METHODS:Two low molecular weight RNAs, designated EBER-1 and EBER-2 (Epstein-Barr encoded RNA), were used: cells latently infect...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.45.7.616
更新日期：1992-07-01 00:00:00
abstract：:The effect of acute hypoglycaemia on platelet function was examined in patients undergoing an insulin stress test. Enhanced platelet aggregation was observed in all cases but platelet count, platelet adenine nucleotides, and the plasma level of von Willebrand factor were unchanged overall. The onset of the hypoglycaem...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.32.5.434
更新日期：1979-05-01 00:00:00
abstract：:Two newborn babies with an intact atrial septum are described. In one, the two components of the atrial septum appeared to have become fused after relatively normal initial development; the left side of this heart was hypoplastic. In the other baby the formation of the atrial septum appeared to have been completely an...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.19.6.549
更新日期：1966-11-01 00:00:00
abstract：AIMS:To validate the Singapore nomogram for outcome prediction in breast phyllodes tumours in a large cohort of Singaporean patients, as previous validation studies were conducted on small numbers of patients. We also investigate the association of fibroadenomas and phyllodes tumours within a subset of our cohort. MET...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2017-204568
更新日期：2018-02-01 00:00:00
abstract：:Aberrations of ribosomal biogenesis have been implicated in several congenital bone marrow failure syndromes, such as Diamond-Blackfan anaemia, Shwachman-Diamond syndrome and Dyskeratosis Congenita. Recent studies have identified haploinsufficiency of RPS14 in the acquired bone marrow disease isolated 5q minus syndrom...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2015-203093
更新日期：2016-02-01 00:00:00
abstract：:Rates of urinary excretion concomitant with the molecular size distribution of filtered polymer fragments were determined in five normovolaemic men dosed with 30 g/m2 BSA of a species of HES (HES 350/0.60) possessing a M-W of 350 000 combined with an MS of 0.60. Approximately 13% of the total injected dose of HES 350/...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.34.4.361
更新日期：1981-04-01 00:00:00
abstract：:A study has been made by clinical methods and by bio-assay of the effectiveness of a régime for prophylaxis against tetanus. The two principal objects of the method were to ensure that active immunization was offered to all patients who had received antitoxin and to measure the effect of the combined administration of...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.18.1.23
更新日期：1965-01-01 00:00:00
abstract：AIMS:Strong thyroglobulin immunoreactivity within sinus histiocytes in a lymph node draining a papillary thyroid carcinoma was observed in a recent case. This prompted the investigation of whether thyroglobulin immunoreactivity is common in regional lymph nodes in cases of thyroid malignancy. METHODS:Eighty seven lymp...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.54.4.314
更新日期：2001-04-01 00:00:00
abstract：:Reticulin antibodies have been classified by immunofluorescence into five types reacting with distinct antigens of intra- and extracellular components in mesenchyme. Two types of fibrillar antigens can be distinguished on the basis of the staining patterns, anatomical distribution, and species specificity. A third ant...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.26.11.841
更新日期：1973-11-01 00:00:00
abstract：:Sera from 5171 inpatients have been tested for HBAg and HBAb during the 18-month period ending in December 1972. The incidence of HBAg (0.116%) was similar to that in blood donors (0.119%) in the same area, being tested for the first time by the same technique. By contrast the incidence of HBAb in patients (0.271%) wa...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.27.2.125
更新日期：1974-02-01 00:00:00
abstract：:Early epidemiological studies of cervical neoplasia suggested a causal relation with sexual activity and human papillomaviruses (HPVs) have emerged as prime suspects as venerally transmitted carcinogens. HPVs fall into two broad camps: low risk types, associated with cervical condylomas and CIN 1; and high risk types ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.51.2.96
更新日期：1998-02-01 00:00:00
abstract：AIM:To evaluate the accuracy of the approximate linear formula of International Normalised Ratio (INR) imprecision by formal mathematical analysis. METHODS:Using probability theory, an exact formula for the coefficient of variation (CV) of the INR was derived. The CV from the approximate formula was compared with the ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.7.635
更新日期：1994-07-01 00:00:00
abstract：:In an era when immunohistochemistry (IHC) is increasingly depended on for histological subtyping, and IHC-determined biomarker informing rapid treatment choices is on the horizon; reproducible, quantifiable techniques are required. This study aimed to compare automated IHC scoring to quantify 6 DNA damage response pro...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2020-207081
更新日期：2020-11-19 00:00:00
abstract：:The ability of erythrocytes to synthesize porphyrins from delta-aminolaevulic acid was compared in healthy people, patients with true iron-deficiency anaemia, and anaemic patients with rheumatoid arthritis. Porphyrin synthesis was found to be impaired in true iron deficiency but not in rheumatoid arthritis cases showi...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.4.336
更新日期：1971-05-01 00:00:00
abstract：BACKGROUND:Nitric oxide synthase (NOS), particularly endothelial and inducible forms (e/i-NOS), are expressed in various cancers, including breast cancer. In mammary fibroepithelial lesions, NOS expression in stromal cells has been reported to be lower in fibroadenomas than in phyllodes tumours. AIMS:To investigate NO...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,多中心研究
doi：10.1136/jcp.2004.023028
更新日期：2005-06-01 00:00:00
abstract：AIMS:Computational pathology platforms incorporate digital microscopy with sophisticated image analysis to permit rapid, continuous measurement of protein expression. We compared two computational pathology platforms on their measurement of breast tumour oestrogen receptor (ER) and progesterone receptor (PR) expression...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2016-204107
更新日期：2017-05-01 00:00:00
abstract：AIMS:To examine whether variations in pathology test requesting between different general practices can be accounted for by sociodemographic or other descriptive indicators of the practice. METHOD:This was a comparative analysis of requesting patterns across a range of pathology tests representing 95% of those request...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,多中心研究
doi：10.1136/jcp.55.4.312
更新日期：2002-04-01 00:00:00
abstract：:A cytochemical study of the lysosomal enzyme beta-glucuronidase in 60 cases of acute leukaemia has shown a qualitative difference in the cytoplasmic distribution of the enzyme between blast cells of the lymphoid and myeloid cell series. This difference provides a useful additional method for cytochemical classificatio...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.9.831
更新日期：1971-12-01 00:00:00
abstract：:Five hundred and seven strains of bacteria isolated from the urine of patients with significant bacteriuria (more than 10(8) colony-forming units per litre) were tested for sensitivity to co-trimoxazole by the agar diffusion technique. Each organism was tested with a combined disk containing trimethoprim and sulphamet...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.34.2.199
更新日期：1981-02-01 00:00:00
abstract：AIMS:Clot waveform analysis (CWA) has been reported to extend the interpretation of clotting time measurement. The parameters obtained from successive derivatives of the clotting reaction curves reflect the rates of activation of individual coagulation factors, theoretically dissecting the cascade pathway. This study a...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2018-205517
更新日期：2019-03-01 00:00:00
abstract：:A patient with chronic granulomatous disease who was being treated with steroids was diagnosed with a soft tissue Scedosporium apiospermum infection. Despite extensive treatment with antifungals progression to involve solid tissue (bone) occurred. Treatment required an HLA matched bone marrow transplant, which led to ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.55.10.784
更新日期：2002-10-01 00:00:00
abstract：:Sixty-nine specimens of liver tissue from 53 infants with neonatal hepatitis or its sequelae were examined without knowledge of the alpha1-antitrypsin phenotype. Distinctive, diastase-resistant, PAS-positive, pure magenta-coloured, sharply defined globules, 2-20 microns in diameter were found in periportal and parasep...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.28.7.559
更新日期：1975-07-01 00:00:00
abstract：AIM:To assess the reliability of local international normalised ratios (INR) using a set of three international reference preparation (IRP) certified freeze dried plasmas. METHODS:55 centres in the United Kingdom and the Republic of Ireland participated; 36 centres employed coagulometers and 19 a manual prothrombin ti...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,多中心研究
doi：10.1136/jcp.51.5.356
更新日期：1998-05-01 00:00:00
abstract：AIMS:To assess the consistency and reproducibility of assessment of c-erbB-2 immunostaining, and to examine some of the problems relating to inter- and intraobserver variability in the documentation of positive staining; to profile the spectrum of cytoplasmic and membranous staining in a wide range of tumour types. ME...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.9.816
更新日期：1994-09-01 00:00:00
abstract：:One hundred and two bone marrow samples were analysed by histological and immunohistochemical methods for neurone specific enolase (NSE). The biopsies were performed to determine the extent of bone marrow disease in 84 neuroblastomas, nine embryonal rhabdomyosarcomas, five Ewing's sarcomas, two cases of Hodgkin's dise...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.44.4.309
更新日期：1991-04-01 00:00:00
abstract：:Experience after 18 months' work with the SMA-4 system of multiple analysis for routine haematology is described, as well as the modifications to the machine which have been made for smoother operation. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.22.1.19
更新日期：1969-01-01 00:00:00
abstract：BACKGROUND:Over 90% of Ewing's sarcoma/primitive neuroectodermal tumour (ES/PNET) cases have the t(11;22) chromosomal rearrangement, which is also found in other small round cell tumours, including desmoplastic small round cell tumour (DSRCT) and clear cell sarcoma (CCS). Although this rearrangement can be analysed by ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2004.025502
更新日期：2005-10-01 00:00:00
abstract：:Rosetting and non-rosetting lymphocytes collected from normal individuals were stained for the presence of beta-glucuronidase, periodic-acid Schiff activity, gamma glutamyl transpeptidase, acid phosphatase, and alpha-naphthyl butyrate esterase. Lymphocytes which formed rosettes with sheep erythrocytes and non-rosette ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.30.7.653
更新日期：1977-07-01 00:00:00
abstract：:A patient with multiple injuries developed a severe coagulation defect due to a deficiency of vitamin K. None of the usual predisposing factors was present and the patient's diet was very poor. Dietary deficiency of vitamin K and the importance of antibiotic therapy in its production are discussed. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.30.12.1147
更新日期：1977-12-01 00:00:00
abstract：:The relation between the choline containing surfactant phospholipids lecithin and sphingomyelin in amniotic fluid and fetal lung maturity is well established. An enzymatic method that had been automated and optimised for use on a centrifugal analyser was used to measure the total choline containing phospholipids in am...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.38.11.1304
更新日期：1985-11-01 00:00:00
