Porphyrin biosynthesis in the erythrocytes of patients with sideropenic anaemias.

abstract：AIMS:To study the homozygous deletion and methylation status of the 5' CpG island of the p16 and p15 genes (9p21) in a set of primary advanced head and neck squamous cell carcinomas (SCC) and to test whether inactivation of these genes by these mechanisms contributes to head and neck SCC development. METHODS:DNA was e...

journal_title：Journal of clinical pathology

authors： González MV,Pello MF,López-Larrea C,Suárez C,Menéndez MJ,Coto E

更新日期：1997-06-01 00:00:00

abstract：:A radioimmunoassay for human growth hormone using activated charcoal is described and its precision, accuracy, and sensitivity are defined. Results are presented for growth hormone measurements in plasma obtained during hypoglycaemia induced with insulin in patients of short stature and during glucose tolerance tests ...

journal_title：Journal of clinical pathology

authors： Thomas FJ,Lloyd HM,Thomas MJ

更新日期：1972-09-01 00:00:00

abstract：:Urines from patients with symptoms of urinary tract infection yielded mixed growths of different colony types of Escherichia coli. The different colony types were found to be variants of single infecting strains caused by mutation or by phase action. It is suggested that care should be exercised in the interpretation ...

journal_title：Journal of clinical pathology

authors： Nichols GL

更新日期：1975-09-01 00:00:00

abstract：AIM:To assess the reliability of local international normalised ratios (INR) using a set of three international reference preparation (IRP) certified freeze dried plasmas. METHODS:55 centres in the United Kingdom and the Republic of Ireland participated; 36 centres employed coagulometers and 19 a manual prothrombin ti...

journal_title：Journal of clinical pathology

authors： Poller L

更新日期：1998-05-01 00:00:00

abstract：AIM:IgG4 disease is rare. However, IgG4 tubulointerstitial nephritis (TIN) is the most common renal manifestation. IgG4 disease is usually associated with elevated serum IgG4 levels and other organ involvement, low-density renal lesions on enhanced CT imaging and immune activation. The incidence of IgG4-TIN may be unde...

journal_title：Journal of clinical pathology

authors： Mac K,Wu XJ,Mai J,Howlin K,Suranyi M,Yong J,Makris A

更新日期：2017-06-01 00:00:00

abstract：AIMS:Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive non-Hodgkin's lymphoma that represents a heterogeneous group of disease that is differentially characterised by clinical, molecular and cytogenetic features. MYC, BCL2 and BCL6 gene rearrangements have been identified as prognostic factors...

journal_title：Journal of clinical pathology

authors： Tourneret A,Alame M,Rigau V,Bauchet L,Fabbro M,De Oliveira L,Cacheux V,Costes V,Lacheretz-Szablewski V

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:RCAS1 (receptor binding cancer antigen expressed on SiSo cells) is a tumour associated antigen. It is involved in immune evasion by tumour cells, by binding to receptors on cells involved in the immune response, such as T cells and natural killer cells, and inducing apoptosis. High expression of RCAS1 has be...

journal_title：Journal of clinical pathology

authors： Leelawat K,Watanabe T,Nakajima M,Tujinda S,Suthipintawong C,Leardkamolkarn V

更新日期：2003-10-01 00:00:00

abstract：:Serum lysozyme levels were determined by a turbidometric method using egg white lysozyme as standard in 100 patients with Crohn's disease, 86 with ulcerative colitis, 31 with coeliac disease, and in 38 normal control subjects. Though the levels in Crohn's disease were significantly higher than those in ulcerative coli...

journal_title：Journal of clinical pathology

authors： Mallas E,Terry JM,Asquith P,Cooke WT

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:Some uterine endometrioid adenocarcinomas exhibit a distinctive morphological phenotype characterised by the formation of microcystic, elongated and fragmented (MELF) glands. Immunohistochemical studies have suggested that MELF-type changes represent an epithelial-mesenchymal transition which has been associ...

journal_title：Journal of clinical pathology

authors： Stewart CJ,Amanuel B,Grieu F,Carrello A,Iacopetta B

更新日期：2010-07-01 00:00:00

abstract：:The congenital dyserythropoietic anaemias (CDAs) are a group of rare hereditary disorders characterised by ineffective erythropoiesis and morphological abnormalities in the erythroblasts. Patients may present with jaundice or with symptoms of anaemia, gall stones or iron overload. The diagnosis can be challenging and ...

journal_title：Journal of clinical pathology

authors： Dukka S,King MJ,Hill QA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:HER2/neu (HER2) is a significant prognostic marker for breast carcinomas. Recently, new guidelines defining HER2 genetic heterogeneity (GH) were published by the College of American Pathologists. AIMS:To determine the prevalence of HER2 GH as defined in primary invasive breast carcinoma, to determine its re...

journal_title：Journal of clinical pathology

authors： Shafi H,Astvatsaturyan K,Chung F,Mirocha J,Schmidt M,Bose S

更新日期：2013-08-01 00:00:00

abstract：:Fluorescence in situ hybridisation (FISH) analysis is now widely employed in the diagnosis and risk stratification of a wide range of malignant diseases. While this technique is used successfully with formalin-fixed paraffin-embedded (FFPE) sections from numerous tissue types, FISH analysis of FFPE tissue sections fro...

journal_title：Journal of clinical pathology

authors： Neat MJ,Moonim MT,Dunn RG,Geoghegan H,Foot NJ

更新日期：2013-01-01 00:00:00

abstract：:Recent evidence shows that chronic liver disease induced by hepatitis delta virus is closely associated with production of autoantibodies. To verify this sera from patients with hepatitis delta virus and from those with hepatitis B virus mediated chronic liver disease were tested for a panel of autoantibodies. Althoug...

journal_title：Journal of clinical pathology

authors： Zauli D,Crespi C,Bianchi FB,Craxi A,Pisi E

更新日期：1986-08-01 00:00:00

abstract：:The discovery of ETS gene fusions as common events in prostate cancer represents a paradigmatic shift in the significance attributed to chromosomal translocations as a key mechanistic player in carcinogenesis. However, these chromosomal fusion events are poorly understood, as their functional significance and therapeu...

journal_title：Journal of clinical pathology

authors： Attard G,Ang JE,Olmos D,de Bono JS

更新日期：2008-08-01 00:00:00

abstract：AIMS:To investigate whether cholesterol and lactate dehydrogenase (LDH) measurements in fluids are more sensitive and specific markers for differentiating between exudates and transudates, as confirmed clinically, than the measurement of fluid total protein concentrations alone. PATIENTS/METHODS:Serum, pleural fluid, ...

journal_title：Journal of clinical pathology

authors： Paramothayan NS,Barron J

更新日期：2002-01-01 00:00:00

abstract：:A small epidemic of gastroenteritis in a children's hospital is described, and also the biochemical characteristics of the causative organism. Stress is laid on the fact that failure to recognize that epidemic strains of Escherichia coli may be late lactose fermentors can lead to errors or delay in diagnosis. ...

journal_title：Journal of clinical pathology

authors： SHEDDEN WI,POTTER CW,DUBOWITZ V,WOOD M

更新日期：1962-09-01 00:00:00

abstract：:A case of signet-ring cell lymphoma affecting bone marrow is reported. The tumour presented as multiple lytic lesions in the lumbosacral spine. A bone biopsy specimen showed the typical appearances of signet-ring cell lymphoma, and the cells stained positively with antiserum to CD20, though neither immunoglobulin ligh...

journal_title：Journal of clinical pathology

authors： Talbot DC,Davies JH,Maclennan KA,Smith IE

更新日期：1994-02-01 00:00:00

abstract：:The epithelium of the human fallopian tube (oviduct) and cervix were studied by histological, immunohistological, and ultrastructural methods with a view to establishing the nature of the so called "basal" and "reserve" cells. The results indicated that the "basal" cells of the oviductal epithelia were T lymphocytes, ...

journal_title：Journal of clinical pathology

authors： Peters WM

更新日期：1986-03-01 00:00:00

abstract：:This report describes a left adrenal tumour in a 16 year old Chinese girl who presented with fever of unknown origin. The histological and ultrastructural features of the adrenal tumour were those of a primitive small round cell tumour with neuroendocrine differentiation. Cytogenetic analysis of cultured tumour cells ...

journal_title：Journal of clinical pathology

authors： Lam KY,Lo CY,Shek TW,Ma ES,Au WY,Chan GC

更新日期：2001-12-01 00:00:00

abstract：:Gastrointestinal (GI) symptoms including abdominal pain, bloating and diarrhoea are a relatively common reason for consulting a physician. They may be due to inflammatory bowel disease (inflammatory bowel disease; Crohn's disease, ulcerative colitis and indeterminate colitis), malignancy (colorectal cancer), infectiou...

journal_title：Journal of clinical pathology

authors： Sherwood RA

更新日期：2012-11-01 00:00:00

abstract：:The haematological features of 118 cases of primary myelodysplastic syndromes (PMDS) were reviewed to see how these could be related and classified according to the recent FAB proposals. A majority of the cases were elderly who presented with a macrocytic or normocytic anaemia and reticulocytopenia. Cases of acquired ...

journal_title：Journal of clinical pathology

authors： Juneja SK,Imbert M,Jouault H,Scoazec JY,Sigaux F,Sultan C

更新日期：1983-10-01 00:00:00

abstract：AIM:To examine lymphocyte subsets in patients with myelodysplastic syndromes (MDS); and to correlate immunohistological variables with prognosis. METHODS:Bone marrow trephine biopsy specimens from 65 patients with MDS were immunophenotyped using a panel of antibodies. A minimum of 1000 cells from representative areas ...

journal_title：Journal of clinical pathology

authors： Hilbe W,Eisterer W,Schmid C,Starz I,Silly H,Duba C,Ludescher C,Thaler J

更新日期：1994-06-01 00:00:00

abstract：AIMS/BACKGROUND:Telomerase is an enzyme that is expressed in most human neoplasms and is associated with tumour immortality. Determination of the point in neoplastic transformation at which telomerase is expressed may aid the understanding of tumour pathogenesis and progression. Despite numerous reports on telomerase, ...

journal_title：Journal of clinical pathology

authors： Kleinschmidt-DeMasters BK,Hashizumi TL,Sze CI,Lillehei KO,Shroyer AL,Shroyer KR

更新日期：1998-04-01 00:00:00

abstract：:In order to classify the underlying disorder in four patients with biopsy-proven amyloidosis without overt monoclonal gammopathy, the cytoplasmic immunoglobulin (Ig) distribution of bone marrow plasma cells was evaluated using direct immunofluorescence microscopy. This procedure revealed the presence of a monoclonal p...

journal_title：Journal of clinical pathology

authors： Thielemans C,Aelbrecht W,Verbeelen D,Somers G,De Waele M,Van Camp B

更新日期：1982-03-01 00:00:00

abstract：:Three strains of Past. septica were isolated in Hong Kong. The clinical histories and the detailed bacteriological and serological studies are presented. ...

journal_title：Journal of clinical pathology

authors： WONG PC,CHAN-TEOH CH

更新日期：1964-03-01 00:00:00

abstract：:A technique is described for obtaining samples of bladder epithelium using soluble swabs. Changes indicating neoplasia were seen in a large proportion of patients with bladder carcinoma. These changes were absent in the non-neoplastic control cases. The method provided tissue similar to that obtained by biopsy and sur...

journal_title：Journal of clinical pathology

authors： Trott PA,Williams G,Attridge PW

更新日期：1969-11-01 00:00:00

abstract：AIMS:To investigate whether increasing the daily baseline of gut calcium can cause a gradual downregulation of the active intestinal transport of calcium via reduced parathyroid hormone (PTH) mediated activation of vitamin D, and to discuss why such a mechanism might prevent calcium oxalate rich stones. To demonstrate ...

journal_title：Journal of clinical pathology

authors： Williams CP,Child DF,Hudson PR,Davies GK,Davies MG,John R,Anandaram PS,De Bolla AR

更新日期：2001-01-01 00:00:00

abstract：:Platelet adhesiveness was measured in patients undergoing operation. With the rotating bulb technique adhesiveness increased steadily to the sixth and ninth days following surgery. The glass bead filter technique demonstrated a marked increase in platelet adhesiveness on the day following operation. ...

journal_title：Journal of clinical pathology

authors： Bennett PN

更新日期：1967-09-01 00:00:00

abstract：AIMS:Inflammatory bowel disease (IBD)-associated precancerous lesions may be adenomatous or non-adenomatous with various histomorphologies. We aim to validate the newly proposed classification, to explore the neoplastic nature of the non-adenomatous lesions and to elucidate the molecular mechanisms underlying the diffe...

journal_title：Journal of clinical pathology

authors： Gui X,Köbel M,Ferraz JG,Iacucci M,Ghosh S,Liu S,Ou Y,Perizzolo M,Winkfein RJ,Rambau P,Demetrick DJ

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Microscopic examination of scalp hair can provide important diagnostic information in a range of paediatric conditions. It is a non-invasive and cost effective investigation, which is not widely performed. AIMS:To examine retrospectively the value of hair examination by light microscopy, including polarisin...

journal_title：Journal of clinical pathology

authors： Smith VV,Anderson G,Malone M,Sebire NJ

更新日期：2005-12-01 00:00:00