Liver disease in infancy: histological features and relationship to alpha-antitrypsin phenotype.

abstract：:Monoclonal antibodies to factor VIII antigen (VIII:Ag) and von Willebrand factor (vWf:Ag) were immobilised on Sephacryl S-1000 and tested for their ability to deplete normal human citrated plasma of factor VIII. A combination of two antibodies to VIII:Ag and one antibody to vWf:Ag was required to produce plasma contai...

journal_title：Journal of clinical pathology

authors： Hornsey VS,Waterston YG,Prowse CV

更新日期：1988-05-01 00:00:00

abstract：AIMS:Pim-1 is a serine/threonine kinase that has been shown to play an integral role in the development of a number of human cancers, such as haematolymphoid malignancies. Recently, evidence has shown Pim-1 to be important in prostatic carcinogenesis. In order to further our understanding of its role in prostate cancer...

journal_title：Journal of clinical pathology

authors： Cibull TL,Jones TD,Li L,Eble JN,Ann Baldridge L,Malott SR,Luo Y,Cheng L

更新日期：2006-03-01 00:00:00

abstract：:Two diabetic patients with symptomatic urinary tract infection by Torulopsis glabrata were successfully treated with two-week courses of 5-fluorocytosine. ...

journal_title：Journal of clinical pathology

authors： Speller DC

更新日期：1974-01-01 00:00:00

abstract：:The biochemical assay for the oestrogen receptor has shown the clinical value of knowing the concentration of the receptor within tissue. The immunohistochemical assay is rapidly taking over from the biochemical assay. Therefore, it is vital to have an equivalent scoring system that will have the same predictive value...

journal_title：Journal of clinical pathology

authors： Leake R,Barnes D,Pinder S,Ellis I,Anderson L,Anderson T,Adamson R,Rhodes T,Miller K,Walker R

更新日期：2000-08-01 00:00:00

abstract：:The congenital dyserythropoietic anaemias (CDAs) are a group of rare hereditary disorders characterised by ineffective erythropoiesis and morphological abnormalities in the erythroblasts. Patients may present with jaundice or with symptoms of anaemia, gall stones or iron overload. The diagnosis can be challenging and ...

journal_title：Journal of clinical pathology

authors： Dukka S,King MJ,Hill QA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:In primary aldosteronism (PA) the main source of aldosterone hypersecretion is an aldosterone-producing adenoma (APA) or a bilateral hyperplasia. Histopathology of the adrenal gland from patients with PA has been difficult, as there are no morphological criteria to ascertain which are the cells that produce ...

journal_title：Journal of clinical pathology

authors： Volpe C,Höög A,Ogishima T,Mukai K,Lu M,Thorén M,Hamberger B

更新日期：2013-04-01 00:00:00

abstract：AIMS:To compare intratumorous microvessel density (MVD) and clinicopathological features in two different groups of hepatocellular carcinoma (HCC), namely: hepatitis B virus (HBV) related HCC (B-HCC) and HCV related HCC (C-HCC). METHODS:Fifty consecutive cases each of B-HCC and of C-HCC were studied. Microvessel numbe...

journal_title：Journal of clinical pathology

authors： Messerini L,Novelli L,Comin CE

更新日期：2004-08-01 00:00:00

abstract：:It was postulated that the short chain fatty acids (SCFA) produced by anaerobic bacteria might serve as microbial markers in purulent material. Eighteen pus specimens from various sources were analysed by gas-liquid chromatography (GLC), and the SCFA detected were compared with the microorganisms isolated by conventio...

journal_title：Journal of clinical pathology

authors： Ladas S,Arapakis G,Malamou-Ladas H,Palikaris G,Arseni A

更新日期：1979-11-01 00:00:00

abstract：:Three hundred specimens of oesophagus obtained at necropsy from infants and children aged from 0 to 14 years, dying from a variety of causes, were examined prospectively for evidence of gastric heterotopia. Gastric heterotopia was observed in 63 (21%) of the whole series, representing a much higher incidence than repo...

journal_title：Journal of clinical pathology

authors： Variend S,Howat AJ

更新日期：1988-07-01 00:00:00

abstract：:Patients with congenital lung cysts are at increased risk of developing carcinoma, but the mechanisms concerned are not clear. The case of a young adult who developed a bronchioloalveolar carcinoma associated with a cystic congenital adenomatoid malformation is reported. The adjacent lung showed an unusual intra-alveo...

journal_title：Journal of clinical pathology

authors： Sheffield EA,Addis BJ,Corrin B,McCabe MM

更新日期：1987-06-01 00:00:00

abstract：:Gastrointestinal (GI) symptoms including abdominal pain, bloating and diarrhoea are a relatively common reason for consulting a physician. They may be due to inflammatory bowel disease (inflammatory bowel disease; Crohn's disease, ulcerative colitis and indeterminate colitis), malignancy (colorectal cancer), infectiou...

journal_title：Journal of clinical pathology

authors： Sherwood RA

更新日期：2012-11-01 00:00:00

abstract：:The potencies of six commercially manufactured heparins have been measured by the British Pharmacopoeial (BP) assay and activated partial thromboplastin time (APTT), protamine sulphate, and anti-Xa assays. The APTT/BP potency ratios were found to vary with the preparation but this was not dependent on the tissue sourc...

journal_title：Journal of clinical pathology

authors： Shah GA,Dhall TZ,Ferguson I,Davis MR,Graham DT,Pomeroy AR,Dhall DP

更新日期：1980-06-01 00:00:00

abstract：:A questionnaire was circulated to clinical biochemistry laboratories in the North West Thames region of the United Kingdom requesting information on extralaboratory equipment. Data on the types and numbers of instruments in use, their relationship with the laboratory, and quality assurance procedures were obtained. La...

journal_title：Journal of clinical pathology

authors： Burrin JM,Fyffe JA

更新日期：1988-09-01 00:00:00

abstract：:Synovial sarcoma is a distinctive soft tissue neoplasm with monophasic and biphasic forms. It is typically a deep-seated soft tissue tumour of the extremities of young adults and occasional cases have been described in large peripheral nerves. A rare example has a predominance of the glandular component and may mimic ...

journal_title：Journal of clinical pathology

authors： Weinreb I,Perez-Ordoñez B,Guha A,Kiehl TR

更新日期：2008-05-01 00:00:00

abstract：:A case of squamous cell carcinoma of the terminal ileum with no underlying duplication or inflammatory disorder is described. The neoplasm seemed to have originated from the surface epithelium, invading the wall and metastasising to the regional lymph nodes. The 65 year old patient was free of disease three years afte...

journal_title：Journal of clinical pathology

authors： Platt CC,Haboubi NY,Schofield PF

更新日期：1991-03-01 00:00:00

abstract：AIM:Recent events surrounding postmortem practices have necessitated several changes in the way necropsies are conducted both within the medicolegal and hospital settings. These changes have resulted in a striking reduction in the frequency of brain retention for neuropathological examination. Aberdeen Royal Infirmary,...

journal_title：Journal of clinical pathology

authors： Sharma M,Grieve JH

更新日期：2006-04-01 00:00:00

abstract：AIMS:To investigate the association of cagA positivity and non-opsonic neutrophil activation capacity in wild-type Helicobacter pylori strains with peptic ulcer disease or chronic gastritis only. METHODS:Helicobacter pylori were isolated from antral biopsies of 53 consecutive patients with chronic antral gastritis, of...

journal_title：Journal of clinical pathology

authors： Danielsson D,Farmery SM,Blomberg B,Perry S,Rautelin H,Crabtree JE

更新日期：2000-04-01 00:00:00

abstract：:A 65-year-old woman with a history of a left heminephrectomy for renal carcinoma developed hypercalcaemia 11 years after the operation. The same kidney was found to contain a recurrent renal carcinoma. After the radical nephrectomy of the left kidney, hypercalcaemia remitted but reappeared 11 months later. The right k...

journal_title：Journal of clinical pathology

authors： Szwed JJ,Gott LJ,Lempke RE,Seo IS

更新日期：1979-03-01 00:00:00

abstract：:A method of typing Pseudomonas pyocyanea is described which makes use of the property of bacteriocine production. The method was applied in an epidemiological study of Ps. pyocyanea infection in a general hospital. It was found that the majority of strains believed on epidemiological grounds to be of common origin wer...

journal_title：Journal of clinical pathology

authors： DARRELL JH,WAHBA AH

更新日期：1964-05-01 00:00:00

abstract：AIMS:Myospherulosis is a rare condition characterised by sac-like structures containing spheroid bodies in cysts or cystic spaces in the tissue. This condition has not previously been reported in the liver. The association with previous portal vein embolisation using a mixture of butyl 2-cyanoacrylate and ethiodised oi...

journal_title：Journal of clinical pathology

authors： Lui PC,Luk IS,Lee CK,Lui YH,Leung CY,Choi CH

更新日期：2004-02-01 00:00:00

abstract：AIMS:Multiple myeloma (MM) is a heterogeneous disease characterised by genetically complex abnormalities. The classical mutational spectrum includes recurrent chromosomal aberrations and gene-level mutations. Recurrent translocations involving the IGH gene such as t(11;14), t(4;14) and t(14;16) are well known. However,...

journal_title：Journal of clinical pathology

authors： Lin M,Lee PL,Chiu L,Chua C,Ban KHK,Lin AHF,Chan ZL,Chung TH,Yan B,Chng WJ

更新日期：2018-08-01 00:00:00

abstract：:This report describes the case of a 76 year old man who suffered from febrile ulceronecrotic Mucha-Habermann disease (FUMHD). Despite this patient's typical clinical and histological findings, the fulminating course led to death. Polymerase chain reaction (PCR) analysis of the skin lesions showed that the infiltrating...

journal_title：Journal of clinical pathology

authors： Miyamoto T,Takayama N,Kitada S,Hagari Y,Mihara M

更新日期：2003-10-01 00:00:00

abstract：AIMS:Children in a United Kingdom national trial for relapsed non-B lymphoblastic leukaemia (ALL) had their diagnostic and relapse marrow cytomorphology compared to see what changes occur during the evolution of the disease. METHODS:Each relapse slide was assessed blindly for French American British (FAB) type and oth...

journal_title：Journal of clinical pathology

authors： Lilleyman JS,Stevens RF,Hann IM,Gibson BE,Britton JA,Darbyshire PJ,Oakhill A

更新日期：1995-11-01 00:00:00

abstract：:In vitro morphological and functional studies were carried out on platelets which had been cryopreserved in the presence of 5% dimethyl sulphoxide (DMSO). Overall loss of platelets was around 50%. Those which survived freezing and reconstitution showed marked morphological deterioration, increase of procoagulant activ...

journal_title：Journal of clinical pathology

authors： Baythoon H,Tuddenham EG,Hutton RA

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There has been a steady decline in the overt teaching of many basic and pathology sciences in the medical curriculum worldwide. As interns are the doctors most likely to request and act on tests, an assessment of their confidence in dealing with laboratory investigations was undertaken. METHOD...

journal_title：Journal of clinical pathology

authors： Stanfliet JC,Macauley J,Pillay TS

更新日期：2009-07-01 00:00:00

abstract：AIM:Thalassaemia is a good candidate disease for control by preventive genetic programmes in developing countries. Accurate population frequency data are needed for planning the control of thalassaemia in the high risk Guangdong Province of southern China. METHODS:In total, 13397 consecutive samples from five geograph...

journal_title：Journal of clinical pathology

authors： Xu XM,Zhou YQ,Luo GX,Liao C,Zhou M,Chen PY,Lu JP,Jia SQ,Xiao GF,Shen X,Li J,Chen HP,Xia YY,Wen YX,Mo QH,Li WD,Li YY,Zhuo LW,Wang ZQ,Chen YJ,Qin CH,Zhong M

更新日期：2004-05-01 00:00:00

abstract：AIMS:To validate a method of assessment of low hepatic iron concentration based on a biochemical colorimetric assay plus histological scoring. METHODS:The within-day and day to day precision of the iron colorimetric assay was determined on frozen rat liver. The coefficient of variation (CV) of iron measurement in two ...

journal_title：Journal of clinical pathology

authors： Imbert-Bismut F,Charlotte F,Turlin B,Khalil L,Piton A,Brissot P,Le Charpentier Y,Delattre J,Opolon P,Deugnier Y,Poynard T

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Recent studies have shown that minichromosome maintenance (MCM) proteins (Mcm2-7) may be useful proliferation markers in dysplasia and cancer in various tissues. AIMS:To investigate the use of Mcm7 as a proliferation marker in 79 lymph node negative prostate cancers and compare it with Ki-67, a commonly use...

journal_title：Journal of clinical pathology

authors： Padmanabhan V,Callas P,Philips G,Trainer TD,Beatty BG

更新日期：2004-10-01 00:00:00

abstract：AIMS:To evaluate an indirect immunofluorescence flow cytometry technique in a series of patients with large fetomaternal haemorrhage (FMH). METHODS:Patient samples identified by Kleihauer testing in local laboratories as having FMH > 4 ml were sent for flow cytometric analysis. In a proportion of cases the mothers rec...

journal_title：Journal of clinical pathology

authors： Johnson PR,Tait RC,Austin EB,Shwe KH,Lee D

更新日期：1995-11-01 00:00:00

abstract：:Three cases of plasmacytoma of the thyroid are described and their clinical and histological features recorded. Two were considered to be true extramedullary plasmacytomas, the third the initial manifestation of a disseminated myelomatous process. Plasmacytomas of the thyroid are shown to have many features in common ...

journal_title：Journal of clinical pathology

authors： More JR,Dawson DW,Ralston AJ,Craig I

更新日期：1968-09-01 00:00:00