Morphological and functional disturbances of platelets induced by cryopreservation.

abstract：:Care in the preparation and preservation of reagents, together with certain modifications in apparatus and technique, have eliminated the difficulties from plasma ammonia analysis. Ammonia contamination from the laboratory atmosphere has not proved an especial hazard, and no major setback has been encountered in the a...

journal_title：Journal of clinical pathology

authors： Fenton JC,Williams AH

更新日期：1968-01-01 00:00:00

abstract：:If native or heparinized blood is passed slowly through a column of glass beads at room temperature, the number of platelets removed from the initial drop emerging from the column is less than that removed from the final drop. At 4 degrees C. this difference disappears. If the blood is passed rapidly through such colu...

journal_title：Journal of clinical pathology

authors： O'Brien JR,Heywood JB

更新日期：1967-01-01 00:00:00

abstract：:A case is reported of a patient with plasmacytoma which assumed different clinicopathological features over seven years. The tumour first presented as a subcutaneous mass which was misdiagnosed as anaplastic carcinoma. Complete response to radiotherapy ensued but recurrence took the form of an intracerebral tumour. Fu...

journal_title：Journal of clinical pathology

authors： Kwong YL,Ng WK

更新日期：1994-10-01 00:00:00

abstract：AIM:Thalassaemia is a good candidate disease for control by preventive genetic programmes in developing countries. Accurate population frequency data are needed for planning the control of thalassaemia in the high risk Guangdong Province of southern China. METHODS:In total, 13397 consecutive samples from five geograph...

journal_title：Journal of clinical pathology

authors： Xu XM,Zhou YQ,Luo GX,Liao C,Zhou M,Chen PY,Lu JP,Jia SQ,Xiao GF,Shen X,Li J,Chen HP,Xia YY,Wen YX,Mo QH,Li WD,Li YY,Zhuo LW,Wang ZQ,Chen YJ,Qin CH,Zhong M

更新日期：2004-05-01 00:00:00

abstract：AIM:We examined the genetic alterations in a mother and son with multiple eosinophilic chromophobe renal cell carcinomas (chRCCs) showing no other features. METHODS:Germline DNA and bilateral renal cell carcinoma DNA were genetically analysed by whole-exome sequencing. Candidate gene alterations in the first patient's...

journal_title：Journal of clinical pathology

authors： Sakamoto H,Yamasaki T,Sumiyoshi T,Utsunomiya N,Takeda M,Kamba T,Nakamura E,Ogawa O

更新日期：2018-10-01 00:00:00

abstract：:Fluorescence in situ hybridisation (FISH) analysis is now widely employed in the diagnosis and risk stratification of a wide range of malignant diseases. While this technique is used successfully with formalin-fixed paraffin-embedded (FFPE) sections from numerous tissue types, FISH analysis of FFPE tissue sections fro...

journal_title：Journal of clinical pathology

authors： Neat MJ,Moonim MT,Dunn RG,Geoghegan H,Foot NJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is an important diagnosis. New criteria have been defined for impaired glucose metabolism and, accordingly, there is a need for precise and accurate glucose analysis for the correct classification of patients. However, neither the World Health Organisation nor the National Service Framework...

journal_title：Journal of clinical pathology

authors： Twomey PJ

更新日期：2004-07-01 00:00:00

abstract：AIMS:To evaluate the effect of microwave irradiation on the staining quality of a range of commonly used primary antibodies in archival, formalin fixed, paraffin wax embedded material, with emphasis on antibodies that have previously worked successfully only on frozen tissue. METHODS:Immunocytochemistry (streptavidin-...

journal_title：Journal of clinical pathology

authors： Cuevas EC,Bateman AC,Wilkins BS,Johnson PA,Williams JH,Lee AH,Jones DB,Wright DH

更新日期：1994-05-01 00:00:00

abstract：:The ability of erythrocytes to synthesize porphyrins from delta-aminolaevulic acid was compared in healthy people, patients with true iron-deficiency anaemia, and anaemic patients with rheumatoid arthritis. Porphyrin synthesis was found to be impaired in true iron deficiency but not in rheumatoid arthritis cases showi...

journal_title：Journal of clinical pathology

authors： Gutniak O,Kopéc M,Nieczaj J

更新日期：1971-05-01 00:00:00

abstract：:A unique case of a metastatic non-desmoplastic sarcomatoid malignant melanoma in an axillary lymph node showing smooth muscle differentiation in a 54 year old woman is described. The tumour cells exhibited alpha-smooth muscle actin, HHF-35 and desmin positivity but were negative for S100 protein and HMB-45. Ultrastruc...

journal_title：Journal of clinical pathology

authors： Banerjee SS,Bishop PW,Nicholson CM,Eyden BP

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:The Sysmex XN haematology instrument performs automatic reflex testing, depending on sample results. A nucleated red blood cell (NRBC) count is provided on all samples. The instrument has a smaller footprint (34%) than previous Sysmex XE analysers. METHODS:An evaluation comparing all results to the Sysmex X...

journal_title：Journal of clinical pathology

authors： Briggs C,Longair I,Kumar P,Singh D,Machin SJ

更新日期：2012-11-01 00:00:00

abstract：:An enzyme linked immunosorbent assay (ELISA) based on the antibody class capture method for the detection of specific IgM against Toxoplasma gondii, using the microtitre plate format, was developed. Antigen binding was detected using a monoclonal antibody, CIE3, conjugated to horseradish peroxidase. Prior mixing of th...

journal_title：Journal of clinical pathology

authors： Payne RA,Joynson DH,Balfour AH,Harford JP,Fleck DG,Mythen M,Saunders RJ

更新日期：1987-03-01 00:00:00

abstract：AIM:To determine whether sampling the anterior and posterior cervical lips in hysterectomy specimens provides the best opportunity for detecting unsuspected cervical intraepithelial neoplasia (CIN). METHODS:The frequency with which CIN was identified at a range of positions on the anterior and posterior lips and left ...

journal_title：Journal of clinical pathology

authors： Heatley M

更新日期：1995-04-01 00:00:00

abstract：:Three hundred and ninety eight serum samples from 270 human immunodeficiency virus (HIV) antibody positive asymptomatic homosexual men were tested in the Abbott and Dupont HIV antigen ELISA tests. In the Abbott test 62 (16%) of the sera were positive, according to the manufacturer's instructions, compared with 55 (14%...

journal_title：Journal of clinical pathology

authors： Shanson DC,Brown KE,Goonesekera S,Gazzard B,Coates AR

更新日期：1990-05-01 00:00:00

abstract：:To assess the pattern and severity of liver disease in patients who had undergone jejuno-ileal bypass for the treatment of morbid obesity, 23 patients were biopsied, all of whom had had intact bypasses for more than 10 years. These were examined by light and electron microscopy. Previous biopsy specimens from each pat...

journal_title：Journal of clinical pathology

authors： Boon AP,Thompson H,Baddeley RM

更新日期：1988-12-01 00:00:00

abstract：:Autoinfective strongyloidiasis is often fatal in immunosuppressed patients or in immunocomprised hosts. An interesting case of Strongyloides stercolaris hyperinfection was seen in an immunocompetent patient. This report describes a case of fatal strogyloidiasis in a 79 year old man, who had suffered gastrointestinal d...

journal_title：Journal of clinical pathology

authors： Mayayo E,Gomez-Aracil V,Azua-Blanco J,Azua-Romeo J,Capilla J,Mayayo R

更新日期：2005-04-01 00:00:00

abstract：:A 43-year-old man, admitted with a swollen right thigh, was diagnosed with a deep vein thrombosis. On day 6 he became septic. A CT scan demonstrated a right-sided hydronephrosis and a large retroperitoneal collection. Blood cultures and perinephric pus grew Escherichia coli resistant to amoxicillin only. On day 12 a v...

journal_title：Journal of clinical pathology

authors： Alleyne SA,Bukhari SS,Fraser M,Spiers P

更新日期：2010-04-01 00:00:00

abstract：:The number of granulocyte/macrophage colonies grown in vitro from bone marrow cells obtained from 90 rib segments and 30 ;normal' bone marrow aspirates was found to be highly variable. Considerable variation was also noted in the relationship between colony number and the number of cells cultured in both groups. The a...

journal_title：Journal of clinical pathology

authors： Morris TC,McNeill TA,Bridges JM

更新日期：1974-10-01 00:00:00

abstract：AIMS:Use of the polymerase chain reaction for the detection of Mycobacterium tuberculosis (TB PCR) as a basis for making clinical decisions on the initiation of antituberculosis treatment was studied. METHODS:A retrospective study involving a cohort of 155 patients being investigated for tuberculosis in an infectious ...

journal_title：Journal of clinical pathology

authors： Cheng VC,Yam WC,Hung IF,Woo PC,Lau SK,Tang BS,Yuen KY

更新日期：2004-03-01 00:00:00

abstract：AIMS:To assess the association between Helicobacter pylori-associated gastritis and HLA-DR antigen (class II antigen) expression. METHODS:Fifty endoscopic gastric biopsy specimens were studied for the presence of H pylori, degree and type of inflammation, and for HLA-DR antigen expression in the epithelium. The cases ...

journal_title：Journal of clinical pathology

authors： Wee A,Teh M,Kang JY

更新日期：1992-01-01 00:00:00

abstract：:DNA typing was requested to investigate a presumptive cancer diagnosis error by confirming whether benign and cancerous prostatic tissue in the same presurgical haematoxylin and eosin stained slide belonged to the same person. After independent histological re-examination of the slide by a pathologist, manual slide di...

journal_title：Journal of clinical pathology

authors： Alonso A,Alves C,Suárez-Mier MP,Albarrán C,Pereira L,Fernández de Simón L,Martín P,García O,Gusmão L,Sancho M,Amorim A

更新日期：2005-01-01 00:00:00

abstract：AIMS:To compare prognostic information obtained by image analysis cytometry of paraffin wax embedded soft tissue sarcomas with conventional assessment. METHODS:A CAS 200 image analyser was used to determine DNA content of Feulgen stained cytology preparations and tissue sections and to quantify immunostaining by Ki67 ...

journal_title：Journal of clinical pathology

authors： Michie BA,Black C,Reid RP,Barrett A,Hamblen DL

更新日期：1994-05-01 00:00:00

abstract：AIMS:To investigate whether cholesterol and lactate dehydrogenase (LDH) measurements in fluids are more sensitive and specific markers for differentiating between exudates and transudates, as confirmed clinically, than the measurement of fluid total protein concentrations alone. PATIENTS/METHODS:Serum, pleural fluid, ...

journal_title：Journal of clinical pathology

authors： Paramothayan NS,Barron J

更新日期：2002-01-01 00:00:00

abstract：AIMS:To determine whether the monoclonal antibody (MoAb) 83D4, previously shown to be highly specific for carcinoma cells, can be used as an immunocytological marker to discriminate between benign and malignant cells in serous effusions; and to test for a correlation between expression of the antigen reacting with MoAb...

journal_title：Journal of clinical pathology

authors： Beuzelin-Yvraut M,Bourguignat A,Phillips E,Roseto A,Osinaga E

更新日期：1995-05-01 00:00:00

abstract：:Staphylococcus aureus isolated between 1967 and 1975 from the nose and skin lesions of patients in dermatology wards and from the burns of patients in a burns unit in Birmingham showed a high incidence of multiple antibiotic-resistant strains in both environments. Over 20% of the strains isolated from patients on admi...

journal_title：Journal of clinical pathology

authors： Ayliffe GA,Green W,Livingston R,Lowbury EJ

更新日期：1977-01-01 00:00:00

abstract：:The necropsy findings in an elderly woman, who had been treated with methyldopa and who had died during treatment for accidental hypothermia, showed acute periductal inflammation of obviously similar duration in an entopic pancreas in the wall of the jejunum and in the ectopic pancreas. This supports the hypothesis th...

journal_title：Journal of clinical pathology

authors： Benbow EW

更新日期：1988-04-01 00:00:00

abstract：AIM:To investigate whether there is loss of the p27Kip1 protein in developing cervical cancer and whether p27Kip1 immunoreactivity has any relation to the proliferative indicator Ki-67. METHODS:The expression of p27Kip1 and Ki-67 was assessed by immunohistochemistry in serial sections from normal epithelium (13), low ...

journal_title：Journal of clinical pathology

authors： Troncone G,Vetrani A,de Rosa G,Gerbasio D,Palombini L

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Hodgkin's lymphoma (HL) is characterised by an ineffective immune response that is predominantly mediated by CD4+ T-cells. AIMS:To analyse the expression of the key regulatory T-cell transcription factors (TFs) in the T-cells of HL involved tissues in order to assess the nature of the T(H) immune response i...

journal_title：Journal of clinical pathology

authors： Atayar C,van den Berg A,Blokzijl T,Boot M,Gascoyne RD,Visser L,Poppema S

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Inflammatory cells contribute to the growth and spread of human malignancies by producing molecules that enhance tumour invasiveness. AIMS:To characterise the inflammatory infiltrate in pancreatic ductal adenocarcinoma and to analyse its contribution to angiogenesis and its prognostic relevance. METHODS:Im...

journal_title：Journal of clinical pathology

authors： Esposito I,Menicagli M,Funel N,Bergmann F,Boggi U,Mosca F,Bevilacqua G,Campani D

更新日期：2004-06-01 00:00:00

abstract：AIMS:To assess the presence of carcinoma in situ (CIS) in patients with nasopharyngeal carcinoma (NPC) and to see if the number of biopsy sites facilitates detection of CIS. METHODS:Formalin fixed, paraffin wax embedded biopsy specimens (n = 285) from 187 patients with NPC in 1987 were studied for the presence of CIS ...

journal_title：Journal of clinical pathology

authors： Chan CW,Nicholls JM,Sham JS,Dickens P,Choy D

更新日期：1992-10-01 00:00:00