Abstract:
BACKGROUND:Hodgkin's lymphoma (HL) is characterised by an ineffective immune response that is predominantly mediated by CD4+ T-cells. AIMS:To analyse the expression of the key regulatory T-cell transcription factors (TFs) in the T-cells of HL involved tissues in order to assess the nature of the T(H) immune response in HL. METHODS AND RESULTS:By immunohistochemistry, GATA3 was strongly and T-bet exclusively expressed in a subset of interfollicular lymphocytes in the reactive lymphoid tissues. In classical HL (CHL), which is generally located in the interfollicular zones, a predominance of T-bet+ T-cells and lesser amounts of GATA3+ and c-Maf+ T-cells was found, concordant with the pattern of the normal interfollicular compartment. In reactive lymphoid tissues, c-Maf was observed mostly in T-lymphocytes within the germinal centres (GCs). Nodular lymphocyte predominance type of Hodgkin's lymphoma (NLPHL) and progressively transformed germinal centres cases, showed a majority of c-Maf+ T-cells, consistent with the pattern in normal GCs. NLPHL cases uniformly showed c-Maf+/CD57+ T-cell rosettes around the neoplastic cells; these rosettes were absent in "paragranuloma-type" T-cell/histiocyte rich B-cell lymphoma. CONCLUSIONS:T-cell TF expression profiles of the reactive T-cells in both subtypes of HL are in accordance with the expression profile observed in the distinct lymphoid compartments.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Atayar C,van den Berg A,Blokzijl T,Boot M,Gascoyne RD,Visser L,Poppema Sdoi
10.1136/jcp.2006.044222subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1092-7issue
10eissn
0021-9746issn
1472-4146pii
jcp.2006.044222journal_volume
60pub_type
杂志文章abstract:AIMS:To investigate how clinical microbiology laboratories should report and interpret mixed mould isolates including Aspergillus species from clinical samples and the criteria for susceptibility testing of the isolates. METHODS:Retrospectively collected data from our laboratory information system of moulds isolated b...
journal_title:Journal of clinical pathology
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更新日期:2011-06-01 00:00:00
abstract::The prevalence of Helicobacter pylori infection in patients with Barrett's oesophagus was studied prospectively. A sensitive immunohistochemical staining of H pylori was performed in oesophageal and gastric biopsies of 73 patients from a surveillance group with this condition. H pylori was detected in 11 cases of Barr...
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journal_title:Journal of clinical pathology
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doi:10.1136/jcp.28.1.37
更新日期:1975-01-01 00:00:00
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journal_title:Journal of clinical pathology
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更新日期:2008-01-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.8.705
更新日期:1994-08-01 00:00:00
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journal_title:Journal of clinical pathology
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更新日期:1971-03-01 00:00:00
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journal_title:Journal of clinical pathology
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更新日期:1997-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-09-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.5.577
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:1989-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-02-01 00:00:00
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doi:10.1136/jcp.37.1.70
更新日期:1984-01-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.26.1.52
更新日期:1973-01-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2009.070201
更新日期:2009-12-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
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更新日期:1973-08-01 00:00:00
abstract::In a twenty-year period 19 appendicectomy specimens were diagnosed as primary Crohn's disease. This represents 4.9% of the total number of both resection specimens and mucosal biopsies diagnosed as Crohn's disease during that time. This is a review of the main histopathological features found in these appendices and t...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1983-06-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.7.584
更新日期:1996-07-01 00:00:00