Abstract：
BACKGROUND:Nitric oxide synthase (NOS), particularly endothelial and inducible forms (e/i-NOS), are expressed in various cancers, including breast cancer. In mammary fibroepithelial lesions, NOS expression in stromal cells has been reported to be lower in fibroadenomas than in phyllodes tumours. AIMS:To investigate NOS expression in phyllodes tumours of varying degrees of malignancy. METHODS:One hundred and sixty seven mammary phyllodes tumours (97 benign, 47 borderline malignant, and 23 frankly malignant) were evaluated for e-NOS and i-NOS expression by immunohistochemistry. Correlations with previously reported expression of stromal vascular growth factor (VEGF) and microvessel density were also performed. RESULTS:Stromal expression of e-NOS was absent, weak, moderate, and strong in 43%, 31%, 13%, and 13% of benign tumours; 17%, 26%, 13%, and 44% of borderline malignant tumours; and 17%, 35%, 13%, and 35% of frankly malignant tumours, respectively. Stromal expression of i-NOS was 77%, 18%, 4%, and 1% in benign tumours; 42%, 28%, 19%, and 11% in borderline malignant tumours; and 43%, 13%, 26%, and 18% in frankly malignant tumours, respectively. Stromal expression of both i-NOS and e-NOS was significantly different between the benign and malignant (borderline and frank) groups of phyllodes tumours (p < 0.0001). Furthermore, the expression of i-NOS correlated with stromal VEGF expression and microvessel density. The expression of NOS in the epithelial cells was strong, and showed no differences between the different groups of tumours. CONCLUSIONS:Higher stromal expression of NOS in phyllodes tumours is associated with malignancy, suggesting a possible role in malignant progression, particularly metastasising potential.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Tse GM,Wong FC,Tsang AK,Lee CS,Lui PC,Lo AW,Law BK,Scolyer RA,Karim RZ,Putti TCdoi
10.1136/jcp.2004.023028keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
600-4issue
6eissn
0021-9746issn
1472-4146pii
58/6/600journal_volume
58pub_type
杂志文章,多中心研究abstract：:Several diseases of the small intestine, including gluten-sensitivity, present with malabsorption and a "flat" mucosa. Determination of the mitotic index of epithelial lymphocytes provides a simple, objective method of assessing, and thus of predicting, whether a flat mucosa is due to gluten-sensitivity (index greater...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.36.2.149
更新日期：1983-02-01 00:00:00
abstract：:There is currently much speculation over the precise nature of lobular carcinoma in-situ of the breast and its significance. Histochemical study shows that it is rich in sialomucin. This has a characteristic intracellular distribution which distinghishes lobular carcinoma in-situ from cancerization of lobules. The sam...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.28.9.711
更新日期：1975-09-01 00:00:00
abstract：:The applicability of a recently developed non-radioactive DNA labelling and detection method, which uses the digoxigenin (DIG) enzyme linked immunosorbent assay (ELISA) system, for the detection of viral infections in pathology specimens by in situ hybridisation, was examined. Its efficacy was compared with that of bi...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.43.10.806
更新日期：1990-10-01 00:00:00
abstract：:The results of using a product of serum thyroxine and triiodothyronine binding coefficient, estimated by simple methods, to give a ;free thyroxine index' in normal women, in pregnant women, and in patients taking oral contraceptives is described. The method is believed to provide a reliable means of assessing thyroid ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.21.6.767
更新日期：1968-11-01 00:00:00
abstract：AIMS:To compare the expression of immunohistochemical variables between benign and malignant components of malignant peripheral nerve sheath tumour (MPNST) arising within neurofibroma. METHODS:Eight cases of MPNST arising within a neurofibroma, associated with neurofibromatosis type 1 (NF1), were studied. The areas of...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.54.8.631
更新日期：2001-08-01 00:00:00
abstract：:A case of combined squamous and intestinal metaplasia of the renal pelvis, associated with hydronephrosis, chronic pyelonephritis, and lithiasis, is reported. The changes are considered to be due primarily to mechanical irritation of the pelvic epithelium. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.22.2.187
更新日期：1969-03-01 00:00:00
abstract：OBJECTIVE:Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy, most frequently affecting the head and neck. Treatment often requires surgery and can have significant functional morbidity. Research into disease pathogenesis and second line medical management of cSCC is limited. We assess geneti...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2019-206038
更新日期：2020-01-01 00:00:00
abstract：:The Human Leukocyte Antigen (HLA) system plays a critical role in regulating the immune response. As a consequence of its role in immune regulation and exquisite polymorphism, the HLA system also constitutes an immunological barrier which must be avoided or otherwise overcome in clinical transplantation. This introduc...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.2009.072371
更新日期：2010-05-01 00:00:00
abstract：:Renal endocrine tumours are extremely rare, and carcinoid tumoral elements in renal cell carcinoma have never been reported. This is the first report of a composite renal cell carcinoma containing a clear cell renal cell carcinoma associated with carcinoid tumoral elements, in a patient with synchronous metastatic dis...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2009.070292
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Breast cancer is increasing in Indonesia and other developing countries. Germline mutations in the BRCA1/2 genes are most strongly associated with a high risk for breast cancer development. There have been no reports on BRCA1/2 gene mutations in the Indonesian population. Genetic research yielding insight in...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2004.020388
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND:Squamous differentiation/squamous metaplasia is often associated with endometrial adenocarcinoma and benign lesions, such as endometrial hyperplasia and chronic endometritis. Morules have distinct histological characteristics, and are referred to as squamous metaplasia or squamoid metaplasia. AIM:To focus o...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2004.017996
更新日期：2004-09-01 00:00:00
abstract：:A 19 year old man presented with unilateral testicular swelling and pain. An initial diagnosis of epididymo-orchitis was modified to a presumed testicular neoplasm following ultrasonography. The final diagnosis of isolated testicular vasculitis was established following histological examination of the orchidectomy spe...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.12.1121
更新日期：1994-12-01 00:00:00
abstract：:A case of B-CLL which was complicated by chronic renal failure due to leukaemic infiltration of the kidney is reported. Treatment with chlorambucil, prednisolone, and renal bed irradiation resulted in a substantial improvement in renal function which persisted until the the patient's death from marrow failure some eig...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.46.12.1131
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Diabetes mellitus is an important diagnosis. New criteria have been defined for impaired glucose metabolism and, accordingly, there is a need for precise and accurate glucose analysis for the correct classification of patients. However, neither the World Health Organisation nor the National Service Framework...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2003.013417
更新日期：2004-07-01 00:00:00
abstract：:Rates of urinary excretion concomitant with the molecular size distribution of filtered polymer fragments were determined in five normovolaemic men dosed with 30 g/m2 BSA of a species of HES (HES 350/0.60) possessing a M-W of 350 000 combined with an MS of 0.60. Approximately 13% of the total injected dose of HES 350/...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.34.4.361
更新日期：1981-04-01 00:00:00
abstract：:Platelet adhesiveness has been measured in citrated whole blood and in platelet-rich plasma obtained from normal subjects, splenectomized patients, and from patients in whom the diagnosis of recurrent venous thrombosis had been made. The duration of centrifugation used in the preparation of platelet-rich plasma was fo...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.21.3.397
更新日期：1968-05-01 00:00:00
abstract：:Primary low grade marginal zone B cell lymphoma (MZL) of the breast and localised mammary amyloidosis are exceedingly rare entities. This report describes the case of a woman with long standing Sjögren's syndrome presenting with asymptomatic MZL of the breast showing plasmacytic differentiation, associated with local ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.56.1.74
更新日期：2003-01-01 00:00:00
abstract：:In two out of three cases of idiopathic fibrosis of the mediastinum there was also retroperitoneal fibrosis, and in one of them extensive fibrosis of the lungs. One of these, a fit middle-aged man, died suddenly with severe coronary artery stenosis due to fibrosis. The third case was that of a young man with a solitar...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.31.1.78
更新日期：1978-01-01 00:00:00
abstract：:The role of active hepatitis B virus (HBV) infection in chronic HBsAg positive hepatitis with and without hepatitis delta virus (HDV) superinfection was analysed in percutaneous liver biopsy specimens from 50 patients. Each specimen was divided into two--one part for histological evaluation and for the detection of HB...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.42.7.689
更新日期：1989-07-01 00:00:00
abstract：:Five cases of malignant histiocytosis of the intestine and one case of true histiocytic lymphoma were studied using immunohistological techniques. In paraffin sections tumour cells in all cases were shown to contain alpha-1-antitrypsin and to express the leucocyte common antigen. Four of the five cases of malignant hi...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.39.1.8
更新日期：1986-01-01 00:00:00
abstract：:Organising pneumonia (otherwise referred to as bronchiolitis obliterans organising pneumonia) is characterised histologically by plugs of granulation tissue, which are present predominantly within small airways, alveolar ducts and peri-bronchiolar alveoli. This pattern is not specific for any disorder or cause, but is...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jclinpath-2012-201342
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Over 90% of Ewing's sarcoma/primitive neuroectodermal tumour (ES/PNET) cases have the t(11;22) chromosomal rearrangement, which is also found in other small round cell tumours, including desmoplastic small round cell tumour (DSRCT) and clear cell sarcoma (CCS). Although this rearrangement can be analysed by ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2004.025502
更新日期：2005-10-01 00:00:00
abstract：AIM:To compare the sensitivity and staining pattern of the new immunohistochemical antibody to tyrosinase (T311) with S-100, HMB45, and the recently evaluated antibody to melan-A (A103) in a range of melanocytic lesions. METHOD:Archival, formalin fixed, paraffin wax embedded sections from 50 benign and malignant melan...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.54.3.196
更新日期：2001-03-01 00:00:00
abstract：AIMS:Traditionally, advanced stage ovarian carcinoma is treated by debulking surgery followed by chemotherapy. However, in some circumstances preoperative chemotherapy may be given before optimal surgical debulking. This study aims to describe the morphological features found in ovarian carcinoma after chemotherapy bec...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.55.1.27
更新日期：2002-01-01 00:00:00
abstract：:A method is described for the estimation of serum free fatty acids based on the ultramicro method of Novák. The difficulty of obtaining an accurate standard graph has been overcome and the interfering effects of phospholipids have been reduced. The method is simple to perform and gives accurate, precise results in 50 ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.21.5.567
更新日期：1968-09-01 00:00:00
abstract：:Three strains of Past. septica were isolated in Hong Kong. The clinical histories and the detailed bacteriological and serological studies are presented. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.17.2.107
更新日期：1964-03-01 00:00:00
abstract：:A simple, standardised procedure was used for processing data from External Quality Assessment Schemes and for producing performance charts. A graphic presentation of cumulative performance is generated for each test, using an integrated software package to display results in a standardised format. This permits interp...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.44.1.17
更新日期：1991-01-01 00:00:00
abstract：:Concentration of factor VIII from fresh plasma by cryoprecipitation remains the basis for preparation of products used to treat haemophilia A. This paper describes the preparation of a factor VIII concentrate from small plasma pools in transfusion centres with drying facilities. The dried concentrate from one litre of...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.34.10.1091
更新日期：1981-10-01 00:00:00
abstract：:Evaluation of histological diagnosis requires an index of agreement (to measure repeatability and validity) together with a method of assessing bias. Cohen's kappa statistic appears to be the most suitable tool for measuring levels of agreement, which if unsatisfactory may be caused by bias. Further study of bias is p...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.36.11.1269
更新日期：1983-11-01 00:00:00
abstract：:Splenic pathology was analysed in 73 patients with immune thrombocytopenic purpura who underwent splenectomy for bleeding that had been resistant to adrenocorticosteroids. The mean splenic weight was 100 g. The only notable macroscopic feature was the prominence of Malpighian corpuscles in 15 cases. Microscopic examin...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.38.9.985
更新日期：1985-09-01 00:00:00
