Abstract:
BACKGROUND:Squamous differentiation/squamous metaplasia is often associated with endometrial adenocarcinoma and benign lesions, such as endometrial hyperplasia and chronic endometritis. Morules have distinct histological characteristics, and are referred to as squamous metaplasia or squamoid metaplasia. AIM:To focus on the histological characteristics of morules and clarify the difference between morules and squamous differentiation. MATERIALS/METHODS:Twenty endometrioid carcinomas with morules or squamous differentiation, five adenosquamous carcinomas, and eight non-carcinomatous endometrial lesions with morules were investigated. Numerous antibodies for epithelial membrane antigen (EMA), involucrin, cytokeratins, neuropeptides, and oncofetal antigens were used for immunohistochemistry. In situ hybridisation and polymerase chain reaction were used to detect human papillomavirus (HPV). RESULTS:The morules observed were uniform cell clusters, with no squamous differentiation. They were immunonegative for epithelial antigens including involucrin, EMA, and cytokeratins, but were positive for neurone specific enolase. A few morules were immunopositive for acetylcholine esterase, and one case was positive for somatostatin; neither oncofetal nor proliferative cell markers, including blood group A, B, and AB, or other neuropeptides were demonstrated in the morules. HPV DNA was not found in either the morules in the carcinomas or in the benign lesions. However, true squamous differentiation tissue in four endometrioid carcinomas and two adenosquamous carcinomas was HPV positive using in situ hybridisation. CONCLUSION:Morules are histologically distinct from squamous metaplasia/squamous differentiation tissue. Morules are thought to be neuroectodermal-like cell clusters, and are not infected with HPV. In contrast, some of the true squamous differentiation tissue was associated with HPV infection.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Chinen K,Kamiyama K,Kinjo T,Arasaki A,Ihama Y,Hamada T,Iwamasa Tdoi
10.1136/jcp.2004.017996keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
918-26issue
9eissn
0021-9746issn
1472-4146pii
57/9/918journal_volume
57pub_type
杂志文章abstract::In two families with severe sex-linked muscular dystrophy, high levels of alpha-hydroxybutyrate dehydrogenase (HBD), lactate dehydrogenase (LD), aspartate transaminase (AspT), aldolase, and creatine phosphokinase (CPK) were found in the sera of three young affected males. In both families the mother had a raised level...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.19.3.250
更新日期:1966-05-01 00:00:00
abstract::In this necropsy review of 37 cases of acute pancreatitis, evidence is presented that there are at least two different initiating mechanisms in acute necrotising pancreatitis in man. Firstly, there is primary duct inflammation, with subsequent inflammation and necrosis of the pancreatic parenchyma surrounding the excr...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.33.12.1125
更新日期:1980-12-01 00:00:00
abstract::The necropsy findings in an elderly woman, who had been treated with methyldopa and who had died during treatment for accidental hypothermia, showed acute periductal inflammation of obviously similar duration in an entopic pancreas in the wall of the jejunum and in the ectopic pancreas. This supports the hypothesis th...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.4.430
更新日期:1988-04-01 00:00:00
abstract::Distinctly increased levels of antibodies to measles virus envelope antigens haemolysin and haemagglutinin were found in the sera of patients with chronic active hepatitis compared with a normal control group, using immunofluorescence and functional tests. Similarly, a higher incidence of smooth muscle antibody of bot...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.11.1281
更新日期:1985-11-01 00:00:00
abstract::Sodium-alpha-naphthylamine-4-sulphonate (Naphthionin) appears to shorten the bleeding time in normal subjects and to be of value in the management of the bleeding defect in patients with thrombocytopenia when given by intravenous or intramuscular injection. A good response was achieved in three patients suffering from...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.17.6.680
更新日期:1964-11-01 00:00:00
abstract::Formalin fixation followed by routine paraffin embedding allows the demonstration of intracellular immunoglobulin by a sandwich technique using either peroxidase or fluorescein isothyocyanate labelled antibody conjugates. The results compared favourably with those obtained using either the fresh frozen or the Sainte-M...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.27.7.548
更新日期:1974-07-01 00:00:00
abstract::Three hundred and ninety eight serum samples from 270 human immunodeficiency virus (HIV) antibody positive asymptomatic homosexual men were tested in the Abbott and Dupont HIV antigen ELISA tests. In the Abbott test 62 (16%) of the sera were positive, according to the manufacturer's instructions, compared with 55 (14%...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.43.5.420
更新日期:1990-05-01 00:00:00
abstract::Current techniques for lymphocyte transformation are evaluated and criticised. A simple technique, designed to meet these criticisms, is described in detail, with particular reference to lymphocyte separation and scoring methods. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.21.2.175
更新日期:1968-03-01 00:00:00
abstract::The effect of radiotherapy on normal buccal mucosa was investigated using the quantitative techniques of cytomorphology (measurement of nuclear and cytoplasmic area) and DNA cytophotometry. These techniques were applied to smears obtained before, during, and after irradiation. Nuclear area and cytoplasmic area increas...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.9.940
更新日期:1989-09-01 00:00:00
abstract::The results of the measurement of vitamin B(12) absorption by counting the radioactivity of 5 ml. serum obtained eight to 10 hours after the ingestion of an oral dose of 0.5 mug. vitamin B(12) labelled with 0.5 muc. (57)Co are compared with those obtained with the urinary excretion (Schilling) test. Inadequate urine c...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.19.6.606
更新日期:1966-11-01 00:00:00
abstract::A male patient with a 17 year history of intractable ulcerative colitis of the entire type was treated by total proctocolectomy. Colonoscopy before surgery did not identify dysplasia. Histological examination of the resected colorectum revealed that, in addition to chronic inflammatory infiltrates, there were 21 areas...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.56.12.963
更新日期:2003-12-01 00:00:00
abstract::Platelet transfusions have the highest incidence of post-transfusion sepsis compared with any other blood products. Recent reports suggest that platelet-related bacteraemia occurs at a frequency of approximately 50 times greater than that for red blood cells. The source is usually skin contaminants from the donor and ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2007.050492
更新日期:2010-03-01 00:00:00
abstract:AIMS:To investigate whether increasing the daily baseline of gut calcium can cause a gradual downregulation of the active intestinal transport of calcium via reduced parathyroid hormone (PTH) mediated activation of vitamin D, and to discuss why such a mechanism might prevent calcium oxalate rich stones. To demonstrate ...
journal_title:Journal of clinical pathology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/jcp.54.1.54
更新日期:2001-01-01 00:00:00
abstract:AIMS:To use the polymerase chain reaction to detect monoclonality at the immunoglobulin heavy chain gene locus in cells derived from lymph node aspirates. METHODS:A nested two-stage polymerase chain reaction (PCR) for the VDJ region of the immunoglobulin heavy chain gene was used to detect monoclonality. The total num...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.5.420
更新日期:1992-05-01 00:00:00
abstract::During the last decade, a dramatic rise in the development and application of artificial intelligence (AI) tools for use in pathology services has occurred. This trend is often expected to continue and reshape the field of pathology in the coming years. The deployment of computational pathology and applications of AI ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jclinpath-2020-206908
更新日期:2020-08-06 00:00:00
abstract::The immunofluorescent examination of nasopharyngeal secretions has been compared with conventional cell culture for the diagnosis of respiratory syncytial (RS) virus infection in children under the age of 2 years in Newcastle upon Tyne and Manchester. Two hundred and sixty-eight identifications of RS virus were made b...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.24.4.308
更新日期:1971-05-01 00:00:00
abstract:AIMS:To determine the effect of pregnancy on C4d concentrations and to assess whether C4d remains a useful disease activity marker in the management of connective tissue diseases during pregnancy. METHODS:Plasma C3, C4, and C4d concentrations were measured in 83 women at various stages of normal pregnancy and compared...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.1.66
更新日期:1992-01-01 00:00:00
abstract:AIM:To investigate serum placental-type alkaline phosphatase (PLAP-type) activities in women with squamous and glandular malignancies of the reproductive tract using an immunoradiometric assay. METHODS:PLAP-type immunoreactivity was measured in 180 women with non-ovarian malignancies of the reproductive tract and the ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.11.1035
更新日期:1994-11-01 00:00:00
abstract:AIMS:To compare the efficacy of and tolerance to oral fluconazole and intraconazole in preventing fungal infection in neutropenic patients with haematological malignancies. PATIENTS:213 consecutive, afebrile adult patients treated with or without autologous stem cell transplantation for haematological malignancies. M...
journal_title:Journal of clinical pathology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/jcp.52.5.376
更新日期:1999-05-01 00:00:00
abstract::This best practice review examines four series of common primary care questions in laboratory medicine: (i) "minor" blood platelet count and haemoglobin abnormalities; (ii) diagnosis and monitoring of anaemia caused by iron deficiency; (iii) secondary hyperlipidaemia and hypertriglyceridaemia; and (iv) glycated haemog...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.200X.033944
更新日期:2006-08-01 00:00:00
abstract::Serum total calcium was measured in 1693 patients during a four-month period. We examined the effects of adjustment for albumin concentration on the interpretation of single measurements of serum total calcium and on the variation of series of measurements in individual patients. Markedly abnormal total calcium concen...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.32.1.56
更新日期:1979-01-01 00:00:00
abstract:AIMS:To assess A103 (melan-A) immunoreactivity in a range of ovarian sex cord stromal tumours and to evaluate it for the differential diagnosis of other neoplasms. METHODS:Paraffin embedded tissue sections from 45 sex cord stromal tumours and 44 potential histological mimics were examined immunohistochemically using t...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.53.3.206
更新日期:2000-03-01 00:00:00
abstract::A moderatley sensitive, rapid, and economical test scheme for the detection of infantile gastroenteritis virus (IGV) in stool or antibody in serum has been developed and evaluated. The test scheme with minor modifications was an adaptation of a counter-immunoelectro-osmophoresis system we once used for the detection o...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.29.3.191
更新日期:1976-03-01 00:00:00
abstract::In 12 normal subjects plasma calcium and phosphorus concentrations were estimated during a normal working day. In the individual subjects fluctuations from the fasting values occurred during the period of study, but at no time during that period did the mean values differ significantly from the fasting plasma calcium ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.23.9.772
更新日期:1970-12-01 00:00:00
abstract::Aberrations of ribosomal biogenesis have been implicated in several congenital bone marrow failure syndromes, such as Diamond-Blackfan anaemia, Shwachman-Diamond syndrome and Dyskeratosis Congenita. Recent studies have identified haploinsufficiency of RPS14 in the acquired bone marrow disease isolated 5q minus syndrom...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2015-203093
更新日期:2016-02-01 00:00:00
abstract::A case of cryptococcal meningo-encephalitis is described. Treatment with the fungicidal agent amphotericin B resulted in temporary improvement, but the patient relapsed and died 17 months after diagnosis. The pathology and treatment of the disease are discussed. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.18.3.296
更新日期:1965-05-01 00:00:00
abstract:AIMS:To investigate the expression of the placental cell-specific associated proteins in infantile haemangioma (IH). METHODS:Immunohistochemical staining was used to investigate the expression of human chorionic gonadotrophin (hCG), human placental lactogen (hPL), human leucocyte antigen-G (HLA-G), cytokeratin 7 (CK7)...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2011-200191
更新日期:2011-10-01 00:00:00
abstract::The amyloid deposits in 21 renal biopsy specimens were subjected to a detailed immunohistochemical analysis using a panel of antibodies against recognised constituents of tissue amyloid. This was a retrospective study of material originally submitted during the investigation of various renal abnormalities and studied ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.3.200
更新日期:1991-03-01 00:00:00
abstract::A cytochemical study of the lysosomal enzyme beta-glucuronidase in 60 cases of acute leukaemia has shown a qualitative difference in the cytoplasmic distribution of the enzyme between blast cells of the lymphoid and myeloid cell series. This difference provides a useful additional method for cytochemical classificatio...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.24.9.831
更新日期:1971-12-01 00:00:00
abstract:BACKGROUND:Thymidine phosphorylase (TP) is the key enzyme for capecitabine activation in tumour cells. AIMS:To examine whether TP expression in tumour cells and stroma is predictive of the tumour response to capecitabine plus docetaxel chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS...
journal_title:Journal of clinical pathology
pub_type: 临床试验,杂志文章
doi:10.1136/jcp.2004.022764
更新日期:2005-06-01 00:00:00