Is clinical practice variability the major reason for differences in pathology requesting patterns in general practice?

abstract：:A sensitive gas chromatography-mass spectrometric method was used to measure the generation in whole blood of leukotriene B4 (LTB4), a potent stimulator of neutrophil chemotaxis, in eight patients with chronic granulocytic leukaemia (CGL) and 12 healthy controls. LTB4 was detectable in unstimulated samples from all th...

journal_title：Journal of clinical pathology

authors： Reilly IA,Knapp HR,Fitzgerald GA

更新日期：1988-11-01 00:00:00

abstract：:Serum alanine aminotransferase (ALT) and gamma-glutamyltransferase (gamma-GT) activities were measured in over 2000 north London blood donors. The results were compared with those from the United States. The percentage of the total donor population with ALT activities above 40 IU/l in 1986 was greater than that found ...

journal_title：Journal of clinical pathology

authors： Mijovic V,Contreras M,Barbara J

更新日期：1987-11-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) was infused intravenously to eight women for the termination of pregnancy and tests of platelet function: coagulation and fibrinolysis were studied before and during the infusion.Platelet adhesiveness, as measured by a cellophane membrane test-cell system, was significantly diminished by PG...

journal_title：Journal of clinical pathology

authors： Howie PW,Calder AA,Forbes CD,Prentice CR

更新日期：1973-05-01 00:00:00

abstract：:A latex enzyme immunoassay (LEIA) for detecting IgG class antibody to rubella virus was compared with the latex agglutination test (LA) and a haemagglutination inhibition assay (HI). Of 243 sera tested, four discrepant results were observed among all three techniques, corresponding to borderline values. Except for one...

journal_title：Journal of clinical pathology

authors： Duverlie G,Roussel C,Driencourt M,Orfila J

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:In primary cutaneous melanoma, the sentinel node (SN) biopsy is an accurate method for the staging of the lymph nodes. Positron emission tomography (PET) has been suggested as a useful alternative. However, the sensitivity of PET may be too low to detect SN metastases, which are often small. AIM:To predict ...

journal_title：Journal of clinical pathology

authors： Mijnhout GS,Hoekstra OS,van Lingen A,van Diest PJ,Adèr HJ,Lammertsma AA,Pijpers R,Meijer S,Teule GJ

更新日期：2003-04-01 00:00:00

abstract：:Rocket-line immunoelectrophoresis (R-LIE) with antigen containing intermediate gel, and co-agglutination utilising protein A-containing staphylococci coated with specific antibodies, were adapted for serotyping the prototypes of group B meningococci. Both were found to have the same specificity as agar gel double diff...

journal_title：Journal of clinical pathology

authors： Danielsson D,Olcén P

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:A previous survey has highlighted the fact that most individuals in chemical pathology identifiable from specialist society membership failed to publish material in Medline cited journals during a five year period. It could be considered that published research that is not cited in other work is not useful u...

journal_title：Journal of clinical pathology

authors： Reynolds TM,Wierzbicki AS

更新日期：2004-04-01 00:00:00

abstract：:The applicability of a recently developed non-radioactive DNA labelling and detection method, which uses the digoxigenin (DIG) enzyme linked immunosorbent assay (ELISA) system, for the detection of viral infections in pathology specimens by in situ hybridisation, was examined. Its efficacy was compared with that of bi...

journal_title：Journal of clinical pathology

authors： Furuta Y,Shinohara T,Sano K,Meguro M,Nagashima K

更新日期：1990-10-01 00:00:00

abstract：:A comparison of Skirrow's, Butzler's, Blaser's, Campy-BAP and Preston media for Campylobacter spp was made using human, animal and environmental specimens. Butzler's medium gave the lowest isolation rate and Preston medium, which was the most selective, the highest isolation rate. Enrichment culture using Preston enri...

journal_title：Journal of clinical pathology

authors： Bolton FJ,Coates D,Hinchliffe PM,Robertson L

更新日期：1983-01-01 00:00:00

abstract：:Guinea-pigs, rats, dogs, rabbits, monkeys, sheep, and goats were screened for G-6PD activity in erythrocytes by the methaemoglobin reduction test, the brilliant cresyl blue decolorization test, and the spectrophotometric determination of the NADPH generation rate. Guinea-pigs, rats, dogs, rabbits, and monkeys were fou...

journal_title：Journal of clinical pathology

authors： Cheun LH

更新日期：1966-11-01 00:00:00

abstract：:In this necropsy review of 37 cases of acute pancreatitis, evidence is presented that there are at least two different initiating mechanisms in acute necrotising pancreatitis in man. Firstly, there is primary duct inflammation, with subsequent inflammation and necrosis of the pancreatic parenchyma surrounding the excr...

journal_title：Journal of clinical pathology

authors： Foulis AK

更新日期：1980-12-01 00:00:00

abstract：:Three hundred and sixty samples of blood from 230 hospital patients were examined and compared with the results of simultaneous blood culture to determine the value of buffy-coat microscopy in detecting bacteraemia. One observer found 86 positive smears, 12 of which were from patients with positive blood cultures and ...

journal_title：Journal of clinical pathology

authors： Coppen MJ,Noble CJ,Aubrey C

更新日期：1981-12-01 00:00:00

abstract：:Haematological malignancies are a diverse group of cancers that affect the blood, bone marrow and lymphatic systems. Laboratory diagnosis of haematological malignancies is dependent on combining several technologies, including morphology, immunophenotyping, cytogenetics and molecular genetics correlated clinical detai...

journal_title：Journal of clinical pathology

authors： Snowden JA,O'Connell S,Hawkins J,Dalley C,Jack A,Mannari D,McNamara C,Scott M,Shenton G,Soilleux E,Macbeth F,Guideline Committee.

更新日期：2017-06-01 00:00:00

abstract：:A 57 year old woman presented complaining of increasing abdominal swelling of six months duration. A mixed solid cystic left ovarian tumour measuring 24 cm in diameter was excised. Histology showed numerous cysts lined by benign mucinous epithelium blending imperceptibly into borderline clear cell and mucinous areas t...

journal_title：Journal of clinical pathology

authors： Dutt N,Berney DM

更新日期：2000-12-01 00:00:00

abstract：:A spectrophotometric assay of proteolytic enzyme activity is described in which the optical density obtained by a given enzyme preparation is related (2 alpha less than 0.01) to the serological activity of that preparation in a two stage technique. The assay appears to be of use for the standardisation of enzyme prepa...

journal_title：Journal of clinical pathology

authors： Phillips PK,Prior D,Dawes B

更新日期：1984-03-01 00:00:00

abstract：AIMS:Immunohistochemical stains have greatly improved the diagnostic accuracy of renal cell carcinoma (RCC) for primary and distant tumours. We evaluate a marker that has recently been incorporated in clinical practice, PAX-8, in primary and metastatic RCCs. METHODS:Two distinct tissue microarrays were used, one consi...

journal_title：Journal of clinical pathology

authors： Barr ML,Jilaveanu LB,Camp RL,Adeniran AJ,Kluger HM,Shuch B

更新日期：2015-01-01 00:00:00

abstract：:Evaluation of histological diagnosis requires an index of agreement (to measure repeatability and validity) together with a method of assessing bias. Cohen's kappa statistic appears to be the most suitable tool for measuring levels of agreement, which if unsatisfactory may be caused by bias. Further study of bias is p...

journal_title：Journal of clinical pathology

authors： Silcocks PB

更新日期：1983-11-01 00:00:00

abstract：:It has been suggested that Coxsackie B virus infections may play a part in causing or triggering myocardial infarction. This study was designed to compare the incidence of such infections in Coronary Care Unit patients and normal controls. The choice of a suitable criterion for diagnosis of Coxsackie infection is disc...

journal_title：Journal of clinical pathology

authors： O'Neill D,McArthur JD,Kennedy JA,Clements G

更新日期：1983-06-01 00:00:00

abstract：:In order to detect the heat labile toxin of Escherichia coli human embryo lung fibroblast cells were seeded with whole cell lysate preparations of the organism to be tested. Positive results consisted of growth inhibition and cytopathic change which were easily seen. Heat-labile toxin was produced by strains belonging...

journal_title：Journal of clinical pathology

authors： Holzel H

更新日期：1979-12-01 00:00:00

abstract：:Numerous clinical pathology departments are deploying or planning to deploy digital pathology systems for all or part of their diagnostic output. Digital pathology is an evolving technology, and it is important that departments uphold or improve on current standards. Leeds Teaching Hospitals NHS Trust has been scannin...

journal_title：Journal of clinical pathology

authors： Williams BJ,Treanor D

更新日期：2020-07-01 00:00:00

abstract：:Fluorigenic substrates prepared from 4-methylumbelliferone provide a simple, convenient method for detecting and assaying group-specific hydrolase activity in small quantities of whole mycobacteria. Physico-chemical properties of the enzymes such as pH dependence and heat stability may also be studied. A technique is ...

journal_title：Journal of clinical pathology

authors： Grange JM

更新日期：1978-04-01 00:00:00

abstract：:In vitro morphological and functional studies were carried out on platelets which had been cryopreserved in the presence of 5% dimethyl sulphoxide (DMSO). Overall loss of platelets was around 50%. Those which survived freezing and reconstitution showed marked morphological deterioration, increase of procoagulant activ...

journal_title：Journal of clinical pathology

authors： Baythoon H,Tuddenham EG,Hutton RA

更新日期：1982-08-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the risk factors for proximal resection margin involvement and its impact on survival outcome in patients with proximal gastric cancer. METHODS:A total of 488 patients who underwent potentially curative resection for proximal gastric cancer were retrospectively reviewed. Clini...

journal_title：Journal of clinical pathology

authors： Zhao B,Lu H,Bao S,Luo R,Mei D,Xu H,Huang B

更新日期：2020-08-01 00:00:00

abstract：:With lymph node enlargement, the possibility of a malignant process such as metastatic carcinoma or lymphoma needs to be excluded. This report describes a 47 year old woman with inguinal lymph node enlargement initially suspicious for lymphoma. Fine needle aspiration findings favoured reactive hyperplasia, but a malig...

journal_title：Journal of clinical pathology

authors： Péoc'h M,Duprez D,Grice G,Fabre-Bocquentin B,Gressin R,Pasquier B

更新日期：2000-07-01 00:00:00

abstract：:Partial myoepithelial differentiation is common in simple epithelial hyperplasia (epitheliosis) of the breast but functional myoepithelial differentiation with basement membrane production is exceedingly rare. A peculiar change of hyaline globules within benign epithelial hyperplasia has been recognised before as "col...

journal_title：Journal of clinical pathology

authors： Wells CA,Wells CW,Yeomans P,Viña M,Jordan S,d'Ardenne AJ

更新日期：1990-11-01 00:00:00

abstract：AIM:To compare the histological characteristics of Helicobacter pylori positive chronic gastritis in patients with and without associated duodenitis. METHODS:Gastric mucosal biopsy specimens were obtained from patients undergoing endoscopy for dyspepsia. Severity of gastritis and density of H pylori infection were gra...

journal_title：Journal of clinical pathology

authors： Phull PS,Price AB,Stephens J,Rathbone BJ,Jacyna MR

更新日期：1996-05-01 00:00:00

abstract：:Eight strains of Moraxella phenylpyruvica have been isolated from clinical material in the United Kingdom, the first to be reported from this country. They were characterized, together with three strains of M. phenylpyruvica of the National Collection of Type Cultures (NCTC), and compared with NCTC strains of eight ot...

journal_title：Journal of clinical pathology

authors： Snell JJ,Hill LR,Lapage SP

更新日期：1972-11-01 00:00:00

abstract：:A new sensitive nitrite test, the SRN test, was evaluated for its suitability as a reliable screening technique for the detection of bacteriuria. The SRN test was compared to a currently available nitrite test, the Microstix nitrite test, and the results obtained with both nitrite tests were assessed in comparison wit...

journal_title：Journal of clinical pathology

authors： Rabi T

更新日期：1981-07-01 00:00:00

abstract：:Monoclonal antibodies to factor VIII antigen (VIII:Ag) and von Willebrand factor (vWf:Ag) were immobilised on Sephacryl S-1000 and tested for their ability to deplete normal human citrated plasma of factor VIII. A combination of two antibodies to VIII:Ag and one antibody to vWf:Ag was required to produce plasma contai...

journal_title：Journal of clinical pathology

authors： Hornsey VS,Waterston YG,Prowse CV

更新日期：1988-05-01 00:00:00

abstract：AIM:To investigate the fate of Streptococcus pneumoniae C-polysaccharide antigen in serum in patients with S pneumoniae bacteraemia. METHOD:In vitro dissociation experiments were performed to demonstrate that C-polysaccharide was masked by ligands in normal and acute phase serum. Serum samples from 22 patients with S ...

journal_title：Journal of clinical pathology

authors： Gillespie SH,Smith MD,Dickens A,Raynes JG,McAdam KP

更新日期：1995-09-01 00:00:00