Abstract:
:In order to detect the heat labile toxin of Escherichia coli human embryo lung fibroblast cells were seeded with whole cell lysate preparations of the organism to be tested. Positive results consisted of growth inhibition and cytopathic change which were easily seen. Heat-labile toxin was produced by strains belonging to the conventional epidemic serotypes of E. coli (EEC) and by non-EEC strains. Toxin-producing organisms were detected in 20% of healthy children examined. The method is suitable for use in the diagnostic laboratory and is easily adapted to a microtitre plate system suitable for screening purposes.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Holzel Hdoi
10.1136/jcp.32.12.1216subject
Has Abstractpub_date
1979-12-01 00:00:00pages
1216-21issue
12eissn
0021-9746issn
1472-4146journal_volume
32pub_type
杂志文章abstract::A patient with megaloblastic anaemia due to nutritional folate deficiency is described. Partial villous atrophy and malabsorption of xylose showed progressive improvement to normal with folic acid therapy. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.24.2.131
更新日期:1971-03-01 00:00:00
abstract:BACKGROUND:Peutz-Jeghers syndrome (PJS) is an autosomal dominant hamartomatous polyposis syndrome of the gastrointestinal tract, caused by a germline STK11/LKB1 mutation. Nasal polyposis was described in the original report by Peutz. Recently, a molecular-genetic association between nasal polyposis and PJS has been rep...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2005.036418
更新日期:2007-04-01 00:00:00
abstract::This is a retrospective study of the results of 4,642 blood cultures taken from 2,190 patients from 1960 to 1967 in one London hospital. The results suggested that an increased incidence of bacteraemias at this particular hospital was mainly due to the increase in the number of patients having blood cultures. Some of ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.23.2.166
更新日期:1970-03-01 00:00:00
abstract::A comparison is made of tests for thyroglobulin antibody, using gel diffusion, electroprecipitin, bentonite flocculation, tanned red cell agglutination, and latex slide agglutination techniques on sera from cases of Hashimoto's disease and other thyroid disorders. Any increase in gamma globulin was also noted from the...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.15.2.153
更新日期:1962-03-01 00:00:00
abstract:AIMS:Apoptosis in prostate cancer was evaluated after three months of combined endocrine therapy to investigate the association with tumour grade, tumour stage, and the immunohistochemical detection of p53 and bcl-2 in tumour cells before and after therapy. METHODS:Twenty six formalin fixed, paraffin wax embedded core...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.5.384
更新日期:1997-05-01 00:00:00
abstract:AIMS:To determine the sensitivity and specificity of a multiplex PCR assay for the contemporary identification of major species involved in oral candidiasis, without extraction and purification of DNA from the samples under investigation; and evaluation of this method in comparison with routine phenotypic culture ident...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2006.040782
更新日期:2007-09-01 00:00:00
abstract:AIMS:The aim of this study was to assess the prevalence and drug resistance of Ureaplasma species and Mycoplasma hominis in outpatients with genital manifestation from 2005 to 2013 in Hangzhou, China. METHODS:A total of 2689 female and 2336 male patients with various genital symptoms were included in this study. Speci...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2014-202248
更新日期:2014-09-01 00:00:00
abstract:AIMS:Cryptogenic organising pneumonia (COP) and acute fibrinous and organising pneumonia (AFOP) are recognised patterns of organising pneumonia (OP), a condition that resembles pneumonia but is not caused by infection. We have recognised granulomatous organising pneumonia (GOP) to be a similar histopathological entity ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2014-202626
更新日期:2015-06-01 00:00:00
abstract::The cell volumes of mononuclear cells, T lymphocytes, B lymphocytes, and monocytes from the peripheral blood of 20 normal individuals were compared to neoplastic lymphoid cells from 14 patients with chronic lymphocytic leukaemia (CLL), 20 individuals with acute lymphocytic leukaemia (ALL), and 18 cases of non-Hodgkin'...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.10.1083
更新日期:1981-10-01 00:00:00
abstract::Platelet adhesiveness has been assessed on whole blood from a series of 34 diabetics and 50 control subjects using adenosine diphosphate (A.D.P.) and by adherence to glass microspherules (ballotini). Using both techniques it was possible to demonstrate a significant increase in platelet adhesiveness in the diabetic pa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.20.6.845
更新日期:1967-11-01 00:00:00
abstract:AIMS:The signalling system of phosphoinositides (PIs) is involved in a number of cell and tissue functions including membrane trafficking, ion channel activity, cell cycle, apoptosis, differentiation and cell and tissue polarity. Recently, a role in cell migration was hypothesised for PI and related molecules including...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2011-200096
更新日期:2011-10-01 00:00:00
abstract::Aztreonam blood agar, a new selective medium for Gram positive aerobic bacteria, was evaluated in comparison with conventional media for skin swabs. Aztreonam agar increased the number of isolates of Staphylococcus aureus by 17%. By producing purer growths on primary isolation, it significantly speeded up the identifi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.8.769
更新日期:1993-08-01 00:00:00
abstract::Lymphocyte-depleted classical Hodgkin lymphoma (LDCHL) is the rarest entity among the classical Hodgkin lymphoma (CHL) subtypes, accounting for <1% of CHL cases in Western countries. Similarly, primary splenic Hodgkin lymphoma is a rare diagnosis among all cases of lymphomatous involvement of spleen. Representing a co...
journal_title:Journal of clinical pathology
pub_type: 信件
doi:10.1136/jclinpath-2015-203145
更新日期:2015-11-01 00:00:00
abstract:AIMS:To evaluate the IRIS flow microscope for the examination of urine specimens and to compare its performance with that of manual methods; in addition, to assess its usefulness as a screening system for the detection of significant bacteriuria in a routine clinical laboratory. METHODS:The IRIS system was compared wi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.56.11.844
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Recent studies have shown that minichromosome maintenance (MCM) proteins (Mcm2-7) may be useful proliferation markers in dysplasia and cancer in various tissues. AIMS:To investigate the use of Mcm7 as a proliferation marker in 79 lymph node negative prostate cancers and compare it with Ki-67, a commonly use...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.016436
更新日期:2004-10-01 00:00:00
abstract::Tumour associated antigens recognised by cellular or humoral effectors of the immune system are potential targets for antigen specific cancer immunotherapy. Different categories of cancer antigens have been identified that induce cytotoxic T lymphocyte (CTL) responses in vitro and in vivo, namely: (1) "cancer testis" ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.54.9.669
更新日期:2001-09-01 00:00:00
abstract::Visceral botryomycosis is rare, and documented sites are lung, brain, kidney, liver and prostate. This report describes a rare autopsy case of disseminated visceral botryomycosis, with bulky, grape-like botryomycotic vegetations in the heart, and similar abscesses in the lungs and bone marrow. This is the first such r...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2008.057588
更新日期:2008-08-01 00:00:00
abstract::A "Centrifichem" centrifugal analyser was found using a double fluorescence/bacterial tracer method to be a source of airborne and surface contamination in the laboratory. The airborne contamination was controlled by a modification incorporating a filter. Ubiquitous surface contamination generally accompanied the proc...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.11.1229
更新日期:1988-11-01 00:00:00
abstract::The applicability of a hapten-antihapten sandwich technique incorporating a monoclonal antihapten bridge antibody to localisation of tissue antigen is described. The results show that the method is both versatile and selective and has the potential of being even more sensitive than currently used immunoperoxidase meth...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.9.1000
更新日期:1981-09-01 00:00:00
abstract::A new sensitive nitrite test, the SRN test, was evaluated for its suitability as a reliable screening technique for the detection of bacteriuria. The SRN test was compared to a currently available nitrite test, the Microstix nitrite test, and the results obtained with both nitrite tests were assessed in comparison wit...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.7.723
更新日期:1981-07-01 00:00:00
abstract:AIMS:To determine prognostic significance of immunohistochemical markers and investigate possible germinal centre (GC) derivation in primary lymphoma of bone (PLB). METHODS:Immunohistochemical expression of BCL-6, CD10, BCL-2, p53, CD30, CD44 and MUM-1 was studied in 36 patients with PLB. All cases were clinically sta...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2008.063156
更新日期:2009-09-01 00:00:00
abstract::An alternative method for detecting the production of slime by coagulase negative staphylococci was compared with the routinely used Christensen method on 124 isolates of coagulase negative staphylococci from carriage sites, blood cultures, and infected peritoneal dialysis fluids. The alternative method requires the u...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.8.872
更新日期:1989-08-01 00:00:00
abstract::The laboratory findings in seven cases of endocarditis caused by coagulase-negative staphylococci are presented. The usefulness of biochemical characterization of the strains in diagnosis and the selection of antibiotics for prophylaxis and treatment are discussed. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.26.7.517
更新日期:1973-07-01 00:00:00
abstract::Colonising Campylobacter pyloridis were identified histologically in gastric biopsy specimens from 89% of 83 patients with non-ulcer dyspepsia and chronic gastritis, but not in 58 dyspeptic patients with normal mucosa. The presence and population density of organisms was associated with the presence of intraepithelial...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.39.8.863
更新日期:1986-08-01 00:00:00
abstract::Human and chicken blood were snap-frozen as droplets in liquid ntirogen. Storage in the vapour phase liquid nitrogen container for nine months followed by rapid thawing resulted in approximately 10% haemolysis of the red cells. The ability of the thawed red cells to haemagglutinate viruses was unimpaired by the manipu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.33.1.8
更新日期:1980-01-01 00:00:00
abstract::In October 1859, 'The Queen of Hearts' was published by Wilkie Collins. This book is a collection of 10 short stories written by the protagonists (three retired brothers), in order to keep their niece (aka the queen of hearts) entertained, until the arrival of her fiancé-to-be. The second story of the book, titled 'Br...
journal_title:Journal of clinical pathology
pub_type: 历史文章,杂志文章
doi:10.1136/jcp.2010.085571
更新日期:2011-02-01 00:00:00
abstract::Clonality analysis of the immunoglobulin heavy chain (IgH) gene is helpful in identifying malignant B cell infiltrates in the bone marrow and is usually carried out on separate aspirates or on the same formalin-fixed decalcified bone marrow specimen. To determine whether the removal of the decalcification step would i...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2005.030379
更新日期:2006-10-01 00:00:00
abstract::Laribacter hongkongensis is a Gram-negative, facultative anaerobic, motile, S-shaped, urease-positive bacillus associated with invasive infections in liver cirrhosis patients and community-acquired gastroenteritis. Most cases of L hongkongensis infections occur in eastern countries. Information is lacking on the usefu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2013-201651
更新日期:2013-12-01 00:00:00
abstract::A 57 year old woman presented complaining of increasing abdominal swelling of six months duration. A mixed solid cystic left ovarian tumour measuring 24 cm in diameter was excised. Histology showed numerous cysts lined by benign mucinous epithelium blending imperceptibly into borderline clear cell and mucinous areas t...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.53.12.938
更新日期:2000-12-01 00:00:00
abstract:AIMS:Marked thrombocytosis is uncommon in chronic myelogenous leukaemia (CML) but may be associated with mutation of JAK2 V617F, calreticulin (CALR) and/or phospho-STAT5 (p-STAT5) activation in other myeloproliferative neoplasms (MPNs), particularly essential thrombocythaemia (ET). We investigated the JAK2 V617F, CALR ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2015-203498
更新日期:2016-08-01 00:00:00