EBV-related primary splenic lymphocyte-depleted classical Hodgkin lymphoma.

Abstract:

:Lymphocyte-depleted classical Hodgkin lymphoma (LDCHL) is the rarest entity among the classical Hodgkin lymphoma (CHL) subtypes, accounting for <1% of CHL cases in Western countries. Similarly, primary splenic Hodgkin lymphoma is a rare diagnosis among all cases of lymphomatous involvement of spleen. Representing a combination of these two rare entities is the primary splenic LDCHL, with only one case reported in the literature. Here, we report second case of primary splenic LDCHL with a unique presentation. The patient was a 60-year-old Caucasian HIV-negative woman with a history of extranodal pleuropulmonary marginal zone lymphoma (MZL) treated with rituximab who presented with new-onset splenomegaly. Splenectomy revealed large number of Hodgkin/Reed-Sternberg cells (CD15+, CD30+, PAX5+ and EBER+) with the background consisting of histiocytes and smaller number of lymphocytes and eosinophils. There was no evidence of nodal or other extranodal site involvement. Thus, in addition to being a very rare entity, this case also provides an additional point of interest: the disease arose in the backdrop of previous diagnosis of extranodal pleuropulmonary MZL successfully treated with rituximab. We discuss the potential implications.

journal_name

J Clin Pathol

authors

Parekh V,Peker D

doi

10.1136/jclinpath-2015-203145

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

947-50

issue

11

eissn

0021-9746

issn

1472-4146

pii

jclinpath-2015-203145

journal_volume

68

pub_type

信件
  • Antifibrinolytic activity in normal pregnancy.

    abstract::It is found that serum antifibrinolytic activity is inhibitory both to the spontaneous fibrinolytic activity and to the activity of streptokinase-activated plasminogen. The titres of serum antiplasmin activity during gestation, labour, and the puerperium are all of the same order and do not differ from those in non-pr...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.13.3.220

    authors: BIEZENSKI JJ

    更新日期:1960-05-01 00:00:00

  • Differential expression of ribosomal proteins in myelodysplastic syndromes.

    abstract::Aberrations of ribosomal biogenesis have been implicated in several congenital bone marrow failure syndromes, such as Diamond-Blackfan anaemia, Shwachman-Diamond syndrome and Dyskeratosis Congenita. Recent studies have identified haploinsufficiency of RPS14 in the acquired bone marrow disease isolated 5q minus syndrom...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2015-203093

    authors: Rinker EB,Dueber JC,Qualtieri J,Tedesco J,Erdogan B,Bosompem A,Kim AS

    更新日期:2016-02-01 00:00:00

  • Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelial.

    abstract::A new monoclonal antibody, Ber-EP4, directed against a partially formol resistant epitope on the protein moiety of two 34 kilodalton and 39 kilodalton glycopolypeptides on human epithelial cells is described. Immunostaining of a wide range of normal and neoplastic human tissues and cell lines showed that all carcinoma...

    journal_title:Journal of clinical pathology

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    authors: Latza U,Niedobitek G,Schwarting R,Nekarda H,Stein H

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    journal_title:Journal of clinical pathology

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  • Cancer-associated proteins in effusion fluids.

    abstract::Two cancer-associated proteins, carcinoembryonic antigen (CEA) and pregnancy-associated alpha2 glycoprotein (PAG), together with 13 normal serum proteins were measured in the serum and effusion fluid of patients with ascites and pleural effusions. The results indicate that CEA measurement in effusion fluid is more eff...

    journal_title:Journal of clinical pathology

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    authors: Booth SN,Lakin G,Dykes PW,Burnett D,Bradwell AR

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  • A simplified economic approach to thyroid FNA cytology and surgical intervention in thyroid nodules.

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    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2012-201339

    authors: Poller DN,Kandaswamy P

    更新日期:2013-07-01 00:00:00

  • Routine operation of an Elliott 903 computer in a clinical chemistry laboratory.

    abstract::Experience gained in the last four years concerning the capabilities and limitations of an 8K Elliott 903 (18-bit word) computer with magnetic tape backing store in the routine operation of a clinical chemistry laboratory is described. Designed as a total system, routine operation has latterly had to be confined to da...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.26.7.480

    authors: Whitby LG,Simpson D

    更新日期:1973-07-01 00:00:00

  • Malignant histiocytosis (histiocytic medullary reticulosis) with spindle cell differentiation and tumour formation.

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    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

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    authors: Macgillivray JB,Duthie JS

    更新日期:1977-02-01 00:00:00

  • Dose response relationships and interference of simultaneous skin tests in delayed hypersensitivity.

    abstract::The relationship between the intensity of the delayed hypersensitivity reaction and the dose of antigen used for its elicitation change with time after sensitization. At three weeks the reactions to 100 mug of egg albumen were little different from those to 1 mug but at 14 weeks 100 mug gave much stronger reactions. T...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

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    authors: Jokipii AM,Jokipii L

    更新日期:1973-09-01 00:00:00

  • Increased stool sampling during a waterborne outbreak of cryptosporidiosis does not increase the detection of other faecal pathogens.

    abstract:AIMS:To ascertain the effect of enhanced surveillance following an outbreak of waterborne cryptosporidiosis on the number of faecal specimens submitted to the local microbiology laboratory and the number positive for common enteric pathogens. The outbreak provided an opportunity to estimate the extent of routine under ...

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  • Immunohistochemical localisation of tissue plasminogen activator and urokinase in the vessel wall.

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    更新日期:1985-02-01 00:00:00

  • Association of metabolic syndrome and IgA nephropathy.

    abstract:BACKGROUND:The disorders associated with metabolic syndrome (MS) can lead to renal disease. IgA nephropathy is the most common form of glomerulonephritis, and many patients with this disorder progress to renal failure. AIMS:To identify the effect of MS on IgA nephropathy by retrospectively comparing patients who had I...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2009.074278

    authors: Wang L,Zhang Y,Chen S,Chen J,Zhuang Y,Chen J

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  • Lysosomal localisation of parallel tubular arrays in chronic lymphocytic leukaemia of T cell origin: an ultrastructural cytochemical study.

    abstract::An ultrastructural cytochemical study of lysosomal acid phosphatase was performed on leukemic cells in a case of chronic lymphocytic leukaemia of T cell origin (T-CLL). The cells showed inclusion bodies known as parallel tubular arrays, which often lay within acid phosphatase-positive, membrane-bound spaces. This sugg...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.35.2.167

    authors: Capron F,PErrot JY,Boucheix C,Reynes M,Tricottet V,Bernadou A,Diebold J

    更新日期:1982-02-01 00:00:00

  • First family case of haemoglobinopathy Titusville in France and literature overview.

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    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jclinpath-2018-205616

    authors: Ruetsch C,Raffort J,Panaia-Ferrari P,Deconde C,Caruba-Bafghi C,Naimi M,Kavafyan J,Suissa L,Chinetti G

    更新日期:2019-07-01 00:00:00

  • Severe hypoglycaemia caused by raised insulin-like growth factor II in disseminated breast cancer.

    abstract::A 60 year old woman with disseminated ductal carcinoma of the breast developed non-islet cell tumour induced hypoglycaemia (NICTH). The concentrations of the two insulin-like growth factors, IGF-I and IGF-II, were < 2 nmol/l and 94.1 nmol/l, respectively. The IGF-II to IGF-I ratio was > 47 (normal < 10). Insulin (< 3 ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.52.10.780

    authors: Bessell EM,Selby C,Ellis IO

    更新日期:1999-10-01 00:00:00

  • Strong expression of the neuronal transcription factor FOXP2 is linked to an increased risk of early PSA recurrence in ERG fusion-negative cancers.

    abstract:BACKGROUND AND AIMS:Transcription factors of the forkhead box P (FOXP1-4) family have been implicated in various human cancer types before. The relevance and role of neuronal transcription factor FOXP2 in prostate cancer is unknown. METHODS:A tissue microarray containing samples from more than 11 000 prostate cancers ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2012-201335

    authors: Stumm L,Burkhardt L,Steurer S,Simon R,Adam M,Becker A,Sauter G,Minner S,Schlomm T,Sirma H,Michl U

    更新日期:2013-07-01 00:00:00

  • Aplastic anaemia associated with organochlorine pesticide: case reports and review of evidence.

    abstract::Three patients with aplastic anaemia had a history of substantial previous exposure to organochlorine pesticides. The temporal association between chemical exposure and the onset of first symptoms of anaemia was strongly supportive. Organochlorines have the property of lipid affinity and accumulation in adipose tissue...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

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    authors: Rugman FP,Cosstick R

    更新日期:1990-02-01 00:00:00

  • Toxoplasmosis in heart and heart and lung transplant recipients.

    abstract::Of the first 250 heart and 35 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 217 heart and 33 heart and lung patients were investigated serologically for evidence of Toxoplasma gondii infection. Six patients acquired primary T gondii in...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

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  • False penicillin resistance in Neisseria meningitidis following direct susceptibility tests from blood cultures.

    abstract::Blood cultures drawn from a patient with clinically diagnosed invasive meningococcal disease, who had been previously administered benzylpenicillin, had beta-lactamases added to increase the probability of recovery of the causative organism. The blood cultures subsequently yielded Neisseria meningitidis but direct sus...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.54.11.893

    authors: Weightman NC

    更新日期:2001-11-01 00:00:00

  • Incidence of toxoplasmosis in women at a London hospital.

    abstract::Toxoplasmosis is an infection, congenital or acquired, caused by Toxoplasma gondii. A pilot study using toxoplasmin skin antigen was undertaken to establish the incidence of the infection in the London area as a preliminary to a larger study of the effects of the infection upon pregnancy, the foetus, and the newborn i...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.22.6.649

    authors: Ruoss CF,Bourne GL

    更新日期:1969-11-01 00:00:00

  • Haemodialysis related osteomalacia: a staining method to demonstrate aluminium.

    abstract::A slight modification in tissue processing and staining technique enables a previously described method for staining aluminium to be used to demonstrate aluminium in osteomalacia associated with haemodialysis. The stain appears to be accurate in diagnosing this condition and may assist in establishing the diagnosis be...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.34.12.1352

    authors: Buchanan MR,Ihle BU,Dunn CM

    更新日期:1981-12-01 00:00:00

  • Co-expression in Helicobacter pylori of cagA and non-opsonic neutrophil activation enhances the association with peptic ulcer disease.

    abstract:AIMS:To investigate the association of cagA positivity and non-opsonic neutrophil activation capacity in wild-type Helicobacter pylori strains with peptic ulcer disease or chronic gastritis only. METHODS:Helicobacter pylori were isolated from antral biopsies of 53 consecutive patients with chronic antral gastritis, of...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

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    authors: Danielsson D,Farmery SM,Blomberg B,Perry S,Rautelin H,Crabtree JE

    更新日期:2000-04-01 00:00:00

  • Anaerobic infections of the urinary tract: are they being missed?

    abstract::Routine anaerobic culture of urine identified the urinary tract as the primary focus of sepsis in a postoperative patient with Bacteroides fragilis septicaemia. Specimens of urine from six other symptomatic patients grew > 10(8) cfu/litre of a Bacteroides species in pure growth. The significance of these isolates is d...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.51.9.709

    authors: Bannon J,Hatem MH,Noone M

    更新日期:1998-09-01 00:00:00

  • Lysosomal enzyme cytochemistry in acute leukaemia.

    abstract::A cytochemical study of the lysosomal enzyme beta-glucuronidase in 60 cases of acute leukaemia has shown a qualitative difference in the cytoplasmic distribution of the enzyme between blast cells of the lymphoid and myeloid cell series. This difference provides a useful additional method for cytochemical classificatio...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.24.9.831

    authors: Mann JR,Simpson JS,Munkley RM,Stuart J

    更新日期:1971-12-01 00:00:00

  • CYTOENZYMATICAL DIFFERENTIATION OF NORMAL AND NEOPLASTIC PLASMA CELLS.

    abstract::A histochemical method is described of differentiating between normal and neoplastic cells in plasma using the activity of various enzymes characteristic of plasma cells. It was found that in both types of cell increased or diminished activity of cytoenzymes is a useful means of distinguishing between normal and abnor...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.18.3.345

    authors: SZMIGIELSKI S,LITWIN J,ZUPANSKA B

    更新日期:1965-05-01 00:00:00

  • Corticosteroids as adjunctive treatment in Austrian's syndrome (pneumococcal endocarditis, meningitis, and pneumonia): report of two cases and review of the literature.

    abstract::This report describes two cases of Osler's triad of pneumonia, meningitis, and endocarditis, as a result of Streptococcus pneumoniae infection, also called Austrian's syndrome. In the first patient, a 51 year old non-alcoholic man, the aortic valve was affected and needed to be replaced in an emergency operation. The ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.56.11.879

    authors: du Cheyron D,Lesage A,Le Page O,Flais F,Leclercq R,Charbonneau P

    更新日期:2003-11-01 00:00:00

  • Evaluation of an enhanced pathological examination protocol for sentinel lymph nodes from patients with breast carcinoma.

    abstract::Clinical trials have shown that many patients with breast cancer with limited sentinel lymph node (SLN) metastatic disease can safely avoid axillary lymph node dissection. Ultra-staging of initially negative SLNs may not confer additional clinical benefit. Despite this, protocols of 'enhanced pathological examination'...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2020-206629

    authors: Murray C,Al Shehhi A,Ó'Riain C,Dunne B,Maguire A

    更新日期:2020-10-22 00:00:00

  • Serotyping and the Dienes reaction on Proteus mirabilis from hospital infections.

    abstract::The serotype of 320 strains of Proteus mirabilis from clinical material was determined. Using 20 O antisera and four H antisera 61% of strains could be fully identified and 90% partially identified. A large number of serotypes were recognized but no difference was found between the serotype of organisms infecting the ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.22.3.263

    authors: De Louvois J

    更新日期:1969-05-01 00:00:00

  • Evaluation of the Microring YT system for identifying clinical yeast isolates.

    abstract::The Microring YT is a commercial system for identifying clinical yeast isolates. The system uses a series of discs impregnated with inhibitory agents mounted on a ring. The pattern of growth and inhibition produced provides a six digit code which can be compared with a table provided by the manufacturer. The performan...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.44.9.775

    authors: Ridgway EJ,Allen KD

    更新日期:1991-09-01 00:00:00