Abstract:
BACKGROUND AND AIMS:Transcription factors of the forkhead box P (FOXP1-4) family have been implicated in various human cancer types before. The relevance and role of neuronal transcription factor FOXP2 in prostate cancer is unknown. METHODS:A tissue microarray containing samples from more than 11 000 prostate cancers from radical prostatectomy specimens with clinical follow-up data was analysed for FOXP2 expression by immunohistochemistry. FOXP2 data were also compared with pre-existing ERG fusion (by fluorescence in situ hybridisation and immunohistochemistry) and cell proliferation (Ki67 labelling index) data. RESULTS:There was a moderate to strong FOXP2 protein expression in basal and secretory cells of normal prostatic glands. As compared with normal cells, FOXP2 expression was lost or reduced in 25% of cancers. Strong FOXP2 expression was linked to advanced tumour stage, high Gleason score, presence of lymph node metastases and early tumour recurrence (p<0.0001; each) in ERG fusion-negative, but not in ERG fusion-positive cancers. High FOXP2 expression was linked to high Ki67 labelling index (p<0.0001) in all cancers irrespective of ERG fusion status. CONCLUSIONS:These data demonstrate that similar high FOXP2 protein levels as in normal prostate epithelium exert a 'paradoxical' oncogenic role in 'non fusion-type' prostate cancer. It may be speculated that interaction of FOXP2 with members of pathways that are specifically activated in 'non fusion-type' cancers may be responsible for this phenomenon.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Stumm L,Burkhardt L,Steurer S,Simon R,Adam M,Becker A,Sauter G,Minner S,Schlomm T,Sirma H,Michl Udoi
10.1136/jclinpath-2012-201335subject
Has Abstractpub_date
2013-07-01 00:00:00pages
563-8issue
7eissn
0021-9746issn
1472-4146pii
jclinpath-2012-201335journal_volume
66pub_type
杂志文章abstract:AIM:To examine peripheral blood and skeletal muscle from patients with chronic fatigue syndrome for exogenous retrovirus. METHODS:Blood samples from 30 patients and muscle biopsy specimens of 15 patients were examined for retroviral sequences by DNA extraction, polymerase chain reaction (PCR), and Southern blotting hy...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.12.1058
更新日期:1992-12-01 00:00:00
abstract:AIM:To develop a simple but reliable polymerase chain reaction (PCR) method to determine the HIV-1 status of patients on formalin fixed, paraffin wax embedded lymph node tissue. METHODS:Fifty lymph node specimens, 20 from HIV-1 seropositive and 30 from HIV-1 seronegative patients, were analysed. Lymph nodes with a var...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.8.733
更新日期:1995-08-01 00:00:00
abstract::Serum labelled with (59)Fe for ferrokinetic studies should contain only [(59)Fe] transferrin. [(59)Fe] ferric citrate was incubated at 37 degrees C for up to 24 hours with sera having an excess latent iron-binding capacity. The results showed that unbound [(59)Fe] ferric citrate may be present for several hours. An an...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.24.5.472
更新日期:1971-07-01 00:00:00
abstract::The neutrophil shape change response to a chemotactic formylpeptide was assessed. Neutrophil bipolar shape formation (BSF) was also simultaneously assessed with a Boyden chamber-based neutrophil migration assay. Both assays were precise and relatively reproducible; the average coefficient of variation for the BSF assa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.43.4.342
更新日期:1990-04-01 00:00:00
abstract::Hereditary spherocytosis is a relatively common haematological disorder and will be encountered by all haematologists. The abundance of new information, dealing principally with molecular and genetic aspects of pathophysiology, is beginning to have implications for its investigation and management. While these advance...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.44.6.441
更新日期:1991-06-01 00:00:00
abstract:AIMS:To evaluate the role of hepatocyte expression of leucocyte adhesion molecules and major histocompatibility complex (MHC) antigens in the pathogenesis of chronic viral hepatitis. METHODS:The expression of intercellular adhesion molecule 1 (ICAM-1), lymphocyte function associated antigen 3 (LFA-3), and MHC class I ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.11.1004
更新日期:1993-11-01 00:00:00
abstract::Activation of the complement system, the main humoral mediator of inflammation, is restrained by the action of enzyme inhibitors including alpha 1-antitrypsin. Deficiency leads to chronic liver disease in about one in five children with this genetic defect. Complement activation was investigated in 34 children with al...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.10.855
更新日期:1991-10-01 00:00:00
abstract::Two patients are reported in whom initial misdiagnoses of medullary cancer or trabecular hyaline adenoma for papillary carcinoma were made. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.8.776
更新日期:1993-08-01 00:00:00
abstract::Liver diseases are associated with complex haemostasis defects, in which platelets, coagulation, and fibrinolysis may all be affected. The low plasma concentrations of clotting factors often found can be the result of many changes such as impaired synthesis, increased catabolism due to intravascular coagulation, or al...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.5.523
更新日期:1984-05-01 00:00:00
abstract:UNLABELLED:Encapsulated papillary carcinoma (EPC) of the breast is a distinct histological subtype characterised by malignant epithelial proliferation supported by fibrovascular stalks. Although EPC typically lacks myoepithelial cells, it shows indolent clinical course. The classification of EPC as an in situ, or invas...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2012-200710
更新日期:2012-08-01 00:00:00
abstract::A spectrophotometric assay of proteolytic enzyme activity is described in which the optical density obtained by a given enzyme preparation is related (2 alpha less than 0.01) to the serological activity of that preparation in a two stage technique. The assay appears to be of use for the standardisation of enzyme prepa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.3.329
更新日期:1984-03-01 00:00:00
abstract:AIM:To identify and review cases of false negative needle core biopsy (NCB) in the preoperative investigation of radial scar/complex sclerosing lesion (RS/CSL) lesions - that is, benign NCB from RS/CSL which contained malignancy on excision. METHODS AND RESULTS:A total of 11 false negative NCB in RS/CSL lesions from 2...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2006.037069
更新日期:2007-03-01 00:00:00
abstract:AIM:We aimed to assess the one step nucleic acid amplification (OSNA) assay as an intraoperative method in comparison with frozen sections (FS) for detection of metastasis in sentinel lymph nodes (SLNs) of breast cancer. METHOD:100 SLNs from patients with breast carcinoma were enrolled within a 3-month period. Alterna...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2014-202361
更新日期:2014-12-01 00:00:00
abstract:AIMS:Positive direct antiglobulin tests (DATs) are valuable in identifying the aetiology of autoimmune haemolysis and in guiding therapeutic intervention. However, in HIV-positive individuals with background polyclonal gammopathy, a positive DAT in the absence of haemolysis is common. In this setting, IgG quantificatio...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-207113
更新日期:2020-12-16 00:00:00
abstract::The morphological classification and diagnosis of bladder neoplasms is summarised, with specific focus on histological typing, grading and staging. Four diagnostic categories are described on the basis of the pattern of growth of the urothelial lesions and tumours (flat, exophytic or papillary, endophytic, and invasiv...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2007.049312
更新日期:2008-01-01 00:00:00
abstract::A commercial latex slide test (Oxoid DR 620) for the identification of Escherichia coli O157 was compared with a standard tube agglutination method using E coli O157 antiserum (Difco). Thirty isolates previously confirmed as E coli O157 were positive by both methods: 30 isolates of E coli of serogroups other than O157...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.10.1109
更新日期:1989-10-01 00:00:00
abstract::Accurate histopathological assessment of biopsies is important for the diagnosis, subclassification, and management of chronic idiopathic inflammatory bowel disease (IBD). British Society of Gastroenterology (BSG) guidelines for the initial histopathological diagnosis of IBD were published in 1997. Changes since then ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,实务指引
doi:10.1136/jclinpath-2013-201885
更新日期:2013-12-01 00:00:00
abstract::A 67 year old woman with rheumatoid arthritis was admitted to hospital in acute renal failure. Her clinical features included increasing dyspnoea and oedema, and a computed tomogram of the abdomen showed a large mass in the retroperitoneum. Twenty six days later, she died, and a post mortem examination was carried out...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.11.1064
更新日期:1993-11-01 00:00:00
abstract::A 19 year old man presented with unilateral testicular swelling and pain. An initial diagnosis of epididymo-orchitis was modified to a presumed testicular neoplasm following ultrasonography. The final diagnosis of isolated testicular vasculitis was established following histological examination of the orchidectomy spe...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.12.1121
更新日期:1994-12-01 00:00:00
abstract::As part of a study to establish the prevalence of renal calculus disease, alkaline phosphatase activity was measured by the method recommended by the Scandinavian Society for Clinical Chemistry and Clinical Physiology in the plasma of 3823 adults from the Scottish new town of Cumbernauld. The enzyme activity differs i...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.31.12.1202
更新日期:1978-12-01 00:00:00
abstract::Synovium was collected from 15 patients who were undergoing joint surgery. Two groups were defined by clinical diagnosis: patients with primary osteoarthritis (n = 4); and those with rheumatoid arthritis (n = 11). The synovium was studied using histological and morphometric techniques. In agreement with previous studi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.8.847
更新日期:1988-08-01 00:00:00
abstract::A 51 year old woman presented with rectal bleeding from a mass lying just above the dentate line. Multiple biopsies were taken before the diagnosis of a benign lymphoid polyp was made. This is a rare condition that more commonly presents in children and poses a diagnostic challenge. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.12.1034
更新日期:1997-12-01 00:00:00
abstract::A case of combined squamous and intestinal metaplasia of the renal pelvis, associated with hydronephrosis, chronic pyelonephritis, and lithiasis, is reported. The changes are considered to be due primarily to mechanical irritation of the pelvic epithelium. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.22.2.187
更新日期:1969-03-01 00:00:00
abstract::Chromosome studies were attempted on 97% of necropsies carried out in the Department of Histopathology of the Adelaide Children's Hospital over the four-year period ending May 1981. Results were obtained from 89% of necropsies of which 7.5% had major chromosome abnormalities. The chromosome results are analysed accord...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.2.140
更新日期:1983-02-01 00:00:00
abstract:AIMS:To investigate a potential diagnostic use of alpha fetoprotein (alpha FP) isoform analysis by lectin affinity electrophoresis to distinguish between endodermal sinus tumours arising in the vagina in infants from those at other sites. METHODS:alpha FP in the serum of a patient with a vaginal endodermal sinus tumou...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.10.856
更新日期:1997-10-01 00:00:00
abstract::A study has been made by clinical methods and by bio-assay of the effectiveness of a régime for prophylaxis against tetanus. The two principal objects of the method were to ensure that active immunization was offered to all patients who had received antitoxin and to measure the effect of the combined administration of...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.18.1.23
更新日期:1965-01-01 00:00:00
abstract::Two cases of anticonvulsant megaloblastic anaemia are described, showing features of unusual interest. Though both cases were apparently deficient in folic acid, the Figlu tests were negative. One patient had an extremely low serum B(12) concentration apparently associated with defective B(12) absorption due to defici...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.18.5.593
更新日期:1965-09-01 00:00:00
abstract::A patient with multiple myeloma had antigenically related monoclonal Fc-gamma fragments and complete IgG-kappa molecules in the serum. The urine contained only Fc-gamma fragments in the absence of Bence-Jones protein. The two distinct M-components in the serum showed electrophoretic identity but could be separated by ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.33.10.936
更新日期:1980-10-01 00:00:00
abstract::Tests of iron and folate nutrition have been carried out in early pregnancy and at delivery in 63 Bantu females. Accepted normal values for serum iron, and percentage saturation of transferrin, but not for unsaturated iron-binding capacity, for non-pregnant subjects were found to apply equally well in pregnancy. Conco...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.19.2.173
更新日期:1966-03-01 00:00:00
abstract::The mucin and gland content of 26 rectal biopsy specimens--five normal specimens, 10 from patients with ulcerative colitis, and 11 from patients with Crohn's disease--were measured using a Quantimet image analyser. There was significantly less mucin in the groups with ulcerative colitis compared with either those with...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.43.2.143
更新日期:1990-02-01 00:00:00