Immunoglobulin subtyping and quantification in direct antiglobulin test: positive haemolysis in an HIV-prevalent setting.

abstract：AIM:To evaluate the clinical usefulness of three commercially available assays for Her-2/neu oncogene and protein measurements. The Her-2/neu protein is overexpressed, mostly as a result of gene amplification, in 20-30% of human breast cancers, and has been shown to have prognostic and predictive value for treatment wi...

journal_title：Journal of clinical pathology

authors： Wang S,Saboorian MH,Frenkel E,Hynan L,Gokaslan ST,Ashfaq R

更新日期：2000-05-01 00:00:00

abstract：:The amyloid deposits in 21 renal biopsy specimens were subjected to a detailed immunohistochemical analysis using a panel of antibodies against recognised constituents of tissue amyloid. This was a retrospective study of material originally submitted during the investigation of various renal abnormalities and studied ...

journal_title：Journal of clinical pathology

authors： Fitzmaurice RJ,Bartley C,McClure J,Ackrill P

更新日期：1991-03-01 00:00:00

abstract：AIMS:N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been shown to be useful for ruling out heart failure in primary care. In this study, we examined the accuracy of the Cobas h232 point-of-care (POC) instrument in primary care compared with an in-hospital measurement. Furthermore, we investigated the user-fr...

journal_title：Journal of clinical pathology

authors： Hex C,Smeets M,Penders J,Van Hoof V,Verbakel J,Buntinx F,Vaes B

更新日期：2018-06-01 00:00:00

abstract：:Strokes are one of the most common causes of mortality and long term severe disability. There is evidence that lipoprotein (a) (Lp(a)) is a predictor of many forms of vascular disease, including premature coronary artery disease. Several studies have also evaluated the association between Lp(a) and ischaemic (thrombot...

journal_title：Journal of clinical pathology

authors： Milionis HJ,Winder AF,Mikhailidis DP

更新日期：2000-07-01 00:00:00

abstract：:Two cases of interstitial pneumonia are described. They were characterized by mononuclear cell infiltration of the alveolar walls and protein-rich exudate into the alveolar cavities, with localized hyaline membrane formation. Coxsackie B5 virus was isolated from the lungs of both patients at necropsy. ...

journal_title：Journal of clinical pathology

authors： Flewett TH

更新日期：1965-11-01 00:00:00

abstract：BACKGROUND:An increased level of serum C-reactive protein (CRP) is a known prognostic factor for acute coronary events and sudden cardiac death, and it is associated with coronary calcification. CRP is expressed in coronary arteries, but its role in the development of coronary plaques is unclear. AIM:To investigate CR...

journal_title：Journal of clinical pathology

authors： Norja S,Nuutila L,Karhunen PJ,Goebeler S

更新日期：2007-05-01 00:00:00

abstract：AIMS:Periductal angiogenesis in ductal carcinoma in situ is associated with an increased risk of subsequently developing a recurrence. This study aimed to (1) identify the relation between periductal and stromal vascularity and recurrence and (2) determine whether thymidine phosphorylase (TP) is associated with angioge...

journal_title：Journal of clinical pathology

authors： Teo NB,Shoker BS,Jarvis C,Sloane JP,Holcombe C

更新日期：2003-12-01 00:00:00

abstract：:Small cell neuroendocrine carcinoma of the breast is a rare tumour with less than 30 cases reported in the literature. The clinicopathological findings of three cases of primary neuroendocrine carcinoma of the breast and a review of the pertinent literature are presented. The morphological and immunohistochemical patt...

journal_title：Journal of clinical pathology

authors： Adegbola T,Connolly CE,Mortimer G

更新日期：2005-07-01 00:00:00

abstract：AIM:To determine the size of a cervical biopsy specimen with human papillomavirus (HPV) infection required to enable in situ hybridisation to be carried out with a guarantee of a reliable result. METHODS:In situ hybridisation was carried out in 142 cervical uterine biopsy specimens classified histologically as low gra...

journal_title：Journal of clinical pathology

authors： Gómez F,Corcuera MT,Muñoz E,Roldan M,Alonso MJ,Abad M,Paz JI,López-Bravo A

更新日期：1995-01-01 00:00:00

abstract：:Tumour tissue from 29 patients with primary brain lymphoma was reviewed to determine if there was an aetiological association between Epstein-Barr virus and polyclonal and monoclonal lymphoproliferations. The morphology and immunophenotype in 24 patients for whom paraffin wax embedded tissue was available were studied...

journal_title：Journal of clinical pathology

authors： Murphy JK,Young LS,Bevan IS,Lewis FA,Dockey D,Ironside JW,O'Brien CJ,Wells M

更新日期：1990-03-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) encompasses a histological spectrum of liver disease, from simple steatosis through to cirrhosis. As the worldwide rates of obesity have increased, NAFLD has become the commonest cause of liver disease in many developed countries, affecting up to a third of the population. The...

journal_title：Journal of clinical pathology

authors： Dyson JK,McPherson S,Anstee QM

更新日期：2013-12-01 00:00:00

abstract：:Incomplete expression of human haemoglobin beta-chains at birth may lead to difficulty in the early demonstration of an inherited beta-chain variant. In this case, the rare unstable variant, Hb Tacoma beta30 (B12) arg leads to ser, although not present in cord blood in sufficient amounts to be easily detected by routi...

journal_title：Journal of clinical pathology

authors： Deacon-Smith RA,Lee-Potter JP

更新日期：1978-09-01 00:00:00

abstract：:In decalcified (5% nitric acid) and undecalcified (glycol-methacrylate or resin embedded) routinely processed bone specimens osteoclasts against resorbing surfaces were identified with monoclonal antibodies directed against leucocyte common antigen (LCA) (PD7/26, 2B11), CD68 (KP1), and gpIIIa (Y2/51) but not against H...

journal_title：Journal of clinical pathology

authors： Athanasou NA,Puddle B,Quinn J,Woods CG

更新日期：1991-08-01 00:00:00

abstract：AIMS:The purpose of this study was to compare the DNA-methylation signature in classic chronic Philadelphia negative myeloproliferative neoplasms (MPN), polycythaemia vera (PV) and essential thrombocythaemia (ET), in order to obtain a global insight into DNA-methylation changes associated with these malignancies. METH...

journal_title：Journal of clinical pathology

authors： Barrio S,Gallardo M,Albizua E,Jimenez A,Rapado I,Ayala R,Gilsanz F,Martin-Subero JI,Martinez-Lopez J

更新日期：2011-11-01 00:00:00

abstract：AIMS:To study whether differences in eradication rates of antibiotics may be explained by differences in secretion of antibiotics in gastric juice. METHODS:A single intravenous dose of either ampicillin 500 mg, erythromycin 500 mg, or metronidazole 500 mg was administered to four healthy Helicobacter pylori negative v...

journal_title：Journal of clinical pathology

authors： van Zanten SJ,Goldie J,Hollingsworth J,Silletti C,Richardson H,Hunt RH

更新日期：1992-03-01 00:00:00

abstract：AIMS:Neoadjuvant chemoradiation therapy (CRT) is an increasingly used therapeutic strategy for rectal cancer. Clinically, it remains a major challenge to predict therapeutic response and patient outcome after CRT. Rsf-1 (HBXAP), a novel nuclear protein with histone chaperon function, mediates ATPase-dependent chromatin...

journal_title：Journal of clinical pathology

authors： Lin CY,Tian YF,Wu LC,Chen LT,Lin LC,Hsing CH,Lee SW,Sheu MJ,Lee HH,Wang YH,Shiue YL,Wu WR,Huang HY,Hsu HP,Li CF,Chen SH

更新日期：2012-08-01 00:00:00

abstract：:The Scottish Meningococcus and Pneumococcus Reference Laboratory provides a national service for the laboratory confirmation of meningococcal and pneumococcal disease in Scotland. The main tests used for the laboratory confirmation of meningococcal disease are culture, the polymerase chain reaction (PCR), antibody tes...

journal_title：Journal of clinical pathology

authors： Clarke SC,Diggle MA,Reid JA,Thom L,Edwards GF

更新日期：2001-07-01 00:00:00

abstract：:Although the UK National Institute for Health and Care Excellence guidelines recommend that in patients with biopsy-proven invasive lobular carcinoma (ILC), preoperative MRI scan is considered, the accuracy of diagnosis of ILC in core biopsy of the breast has not been previously investigated. Eleven pathology laborato...

journal_title：Journal of clinical pathology

authors： Naidoo K,Beardsley B,Carder PJ,Deb R,Fish D,Girling A,Hales S,Howe M,Wastall LM,Lane S,Lee AH,Philippidou M,Quinn C,Stephenson T,Pinder SE

更新日期：2016-12-01 00:00:00

abstract：:Sixty-nine specimens of liver tissue from 53 infants with neonatal hepatitis or its sequelae were examined without knowledge of the alpha1-antitrypsin phenotype. Distinctive, diastase-resistant, PAS-positive, pure magenta-coloured, sharply defined globules, 2-20 microns in diameter were found in periportal and parasep...

journal_title：Journal of clinical pathology

authors： Talbot IC,Mowat AP

更新日期：1975-07-01 00:00:00

abstract：:During 1971 and 1972, 71 cultures of neisseriae that attacked lactose were received by this laboratory. All strains except one from an eye swab were from the nasopharynx of healthy subjects. Nineteen similar strains from the nasopharynx were isolated in this laboratory. The characteristics of these strains were compar...

journal_title：Journal of clinical pathology

authors： Pykett AH

更新日期：1973-06-01 00:00:00

abstract：:This article reviews recent information concerning the origin of osteoclasts and the local and systemic regulation of their activity. It appears that much of the environmental responsiveness of osteoclasts is mediated by cells of the osteoblastic lineage, which exert a major influence on the localisation, induction, s...

journal_title：Journal of clinical pathology

authors： Chambers TJ

更新日期：1985-03-01 00:00:00

abstract：:A rapidly fatal case of enteritis necroticans in a 24 year old man with diabetes was caused by Clostridium perfringens type C. The role of beta toxin in the disease is discussed. This type has not been previously described as a causative agent in necrotising bowel disease of man outside endemic areas. ...

journal_title：Journal of clinical pathology

authors： Severin WP,de la Fuente AA,Stringer MF

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Peutz-Jeghers syndrome (PJS) is an autosomal dominant hamartomatous polyposis syndrome of the gastrointestinal tract, caused by a germline STK11/LKB1 mutation. Nasal polyposis was described in the original report by Peutz. Recently, a molecular-genetic association between nasal polyposis and PJS has been rep...

journal_title：Journal of clinical pathology

authors： de Leng WW,Westerman AM,Weterman MA,Jansen M,van Dekken H,Giardiello FM,de Rooij FW,Paul Wilson JH,Offerhaus GJ,Keller JJ

更新日期：2007-04-01 00:00:00

abstract：:Laboratory studies on clotrimazole showed that it had marked activity in vitro against all the Candida spp. and Cryptococcus spp. tested, against almost all strains of dermatophytes, and against Aspergillus spp and other fungal genera responsible for systemic mycoses; it had limited activity towards Gram-positive bact...

journal_title：Journal of clinical pathology

authors： Holt RJ,Newman RL

更新日期：1972-12-01 00:00:00

abstract：:The production of antitoxin after Clostridium difficile-induced diarrhoea has not been reported previously. The stool of a patient with prolonged antibiotic-associated diarrhoea contained C. difficile toxin, and the serum neutralised the cytopathic effect of C. difficile toxin in tissue culture. ...

journal_title：Journal of clinical pathology

authors： Lishman AH,Al-Jumaili IJ,Record CO

更新日期：1981-04-01 00:00:00

abstract：:Langerhans' cells were studied in the epidermis of two patients with active Behçet's disease and compared with those in two normal controls. Ultrastructural morphology and the percentage of Langerhans' cells found were similar in patients' (1.88%) and the control epidermis (1.79%). The density of Langerhans' cells in ...

journal_title：Journal of clinical pathology

authors： Kohn S,Haim S,Gilhar A,Friedman-Birnbaum R,Nir I

更新日期：1984-06-01 00:00:00

abstract：AIMS:The incidence of RAS/RAF/PI3KA and TP53 gene mutations in colorectal cancer (CRC) is well established. Less information, however, is available on other components of the CRC genomic landscape, which are potential CRC prognostic/predictive markers. METHODS:Following a previous validation study, ion-semiconductor n...

journal_title：Journal of clinical pathology

authors： Malapelle U,Pisapia P,Sgariglia R,Vigliar E,Biglietto M,Carlomagno C,Giuffrè G,Bellevicine C,Troncone G

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Gastric mucosa associated lymphoid tissue (MALT) lymphoma is a low grade B cell lymphoma histologically characterised by neoplastic B cells surrounding follicles in a marginal zone pattern and selectively infiltrating epithelium to form characteristic lymphoepithelial lesions. AIMS:To identify solitary epit...

journal_title：Journal of clinical pathology

authors： Sutak J,Stoddard C,Smith ME

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Microscopic examination of scalp hair can provide important diagnostic information in a range of paediatric conditions. It is a non-invasive and cost effective investigation, which is not widely performed. AIMS:To examine retrospectively the value of hair examination by light microscopy, including polarisin...

journal_title：Journal of clinical pathology

authors： Smith VV,Anderson G,Malone M,Sebire NJ

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Some uterine endometrioid adenocarcinomas exhibit a distinctive morphological phenotype characterised by the formation of microcystic, elongated and fragmented (MELF) glands. Immunohistochemical studies have suggested that MELF-type changes represent an epithelial-mesenchymal transition which has been associ...

journal_title：Journal of clinical pathology

authors： Stewart CJ,Amanuel B,Grieu F,Carrello A,Iacopetta B

更新日期：2010-07-01 00:00:00