A literary portrait of a case of Hodgkin lymphoma by Wilkie Collins?

abstract：:Fluorigenic substrates prepared from 4-methylumbelliferone provide a simple, convenient method for detecting and assaying group-specific hydrolase activity in small quantities of whole mycobacteria. Physico-chemical properties of the enzymes such as pH dependence and heat stability may also be studied. A technique is ...

journal_title：Journal of clinical pathology

authors： Grange JM

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:Autoreactive humoral and cellular immune responses may be involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC). Certain human leucocyte antigens (HLA) could also be linked to the development of IDC. AIM:To determine whether various markers of autoimmunity are present in the final phase of...

journal_title：Journal of clinical pathology

authors： de Leeuw N,Melchers WJ,Ruiter DJ,Caforio AL,Balk AH,de Jonge N,Galama JM

更新日期：1999-10-01 00:00:00

abstract：:Three cases of islet cell necrosis in neonates are reported. The association of this rare condition with antepartum haemorrhage, anoxia, shock and intravascular coagulation are discussed. The clinical and morphological appearances were compared with previous descriptions of this condition and an association with neona...

journal_title：Journal of clinical pathology

authors： Roberts PF

更新日期：1987-10-01 00:00:00

abstract：AIMS:To determine the sensitivity and specificity of a multiplex PCR assay for the contemporary identification of major species involved in oral candidiasis, without extraction and purification of DNA from the samples under investigation; and evaluation of this method in comparison with routine phenotypic culture ident...

journal_title：Journal of clinical pathology

authors： Liguori G,Lucariello A,Colella G,De Luca A,Marinelli P

更新日期：2007-09-01 00:00:00

abstract：:A method utilizing a general dehydrogenase reaction has been used to demonstrate early gross myocardial infarctions. The procedure takes advantage of substrate and enzyme loss from the damaged myocardium. In the viable muscle, where endogenous substrates, coenzymes, and dehydrogenases are present, reduction of Nitro-B...

journal_title：Journal of clinical pathology

authors： Ramkissoon RA

更新日期：1966-09-01 00:00:00

abstract：:A case of bilateral gonadoblastoma/dysgerminoma in a 46 XY phenotypical female is presented. Increased circulating beta human chorionic gonadotropin (beta-HCG) and testosterone together with a decreased concentration of follicle stimulating hormone (FSH) reflected the activities of these tumours. The patient is alive ...

journal_title：Journal of clinical pathology

authors： Fisher RA,Salm R,Spencer RW

更新日期：1982-04-01 00:00:00

abstract：:Formalin fixation followed by routine paraffin embedding allows the demonstration of intracellular immunoglobulin by a sandwich technique using either peroxidase or fluorescein isothyocyanate labelled antibody conjugates. The results compared favourably with those obtained using either the fresh frozen or the Sainte-M...

journal_title：Journal of clinical pathology

authors： Burns J,Hambridge M,Taylor CR

更新日期：1974-07-01 00:00:00

abstract：:Three hundred specimens of oesophagus obtained at necropsy from infants and children aged from 0 to 14 years, dying from a variety of causes, were examined prospectively for evidence of gastric heterotopia. Gastric heterotopia was observed in 63 (21%) of the whole series, representing a much higher incidence than repo...

journal_title：Journal of clinical pathology

authors： Variend S,Howat AJ

更新日期：1988-07-01 00:00:00

abstract：AIMS:To assess the consistency and reproducibility of assessment of c-erbB-2 immunostaining, and to examine some of the problems relating to inter- and intraobserver variability in the documentation of positive staining; to profile the spectrum of cytoplasmic and membranous staining in a wide range of tumour types. ME...

journal_title：Journal of clinical pathology

authors： Kay EW,Walsh CJ,Cassidy M,Curran B,Leader M

更新日期：1994-09-01 00:00:00

abstract：:Several studies have recently documented the presence of persistently abnormal liver function tests in asymptomatic haemophiliacs. While the aetiology is unknown it is possible that repeated exposure to agents transmitted in blood products may be important. This study has attempted to determine the prevalence of viral...

journal_title：Journal of clinical pathology

authors： McVerry BA,Ross MG,Knowles WA,Voke J

更新日期：1979-04-01 00:00:00

abstract：:The serotype of 320 strains of Proteus mirabilis from clinical material was determined. Using 20 O antisera and four H antisera 61% of strains could be fully identified and 90% partially identified. A large number of serotypes were recognized but no difference was found between the serotype of organisms infecting the ...

journal_title：Journal of clinical pathology

authors： De Louvois J

更新日期：1969-05-01 00:00:00

abstract：:Neisseria gonorrhoeae is one of the most important causes of sexually transmitted disease. We do not fully understand the pathogenesis of infection with this organism, although recent improvements in immunological and molecular techniques have brought us closer to an answer. These techniques are now also being used to...

journal_title：Journal of clinical pathology

authors： Easmon CS,Ison CA

更新日期：1987-09-01 00:00:00

abstract：AIMS:To assess the presence of carcinoma in situ (CIS) in patients with nasopharyngeal carcinoma (NPC) and to see if the number of biopsy sites facilitates detection of CIS. METHODS:Formalin fixed, paraffin wax embedded biopsy specimens (n = 285) from 187 patients with NPC in 1987 were studied for the presence of CIS ...

journal_title：Journal of clinical pathology

authors： Chan CW,Nicholls JM,Sham JS,Dickens P,Choy D

更新日期：1992-10-01 00:00:00

abstract：AIMS:Common variable immunodeficiency (CVID) is the most common serious primary immunodeficiency. This paper describes the immunological consequences of human immunodeficiency virus (HIV) infection in a patient with familial CVID subsequently treated with highly active antiretroviral therapy (HAART). METHODS:Serial me...

journal_title：Journal of clinical pathology

authors： Jolles S,Tyrer M,Johnson M,Webster D

更新日期：2001-09-01 00:00:00

abstract：:Serious infection caused by Lancefield group C streptococci is unusual in man. Two unrelated deaths associated with these organisms in a 55 year old woman who died after three days of diarrhoea and vomiting, and in a 65 old man who died after a week of non-specific symptoms, are presented. Post mortem examination show...

journal_title：Journal of clinical pathology

authors： Bateman AC,Ramsay AD,Pallett AP

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Periostin is a secreted adhesion protein, normally expressed in mesenchime-derived cells. Aberrant expression of the periostin gene in epithelial tumours seems to play a role in angiogenesis and metastases. AIMS:To investigate periostin expression in a consecutive series of breast carcinomas and correlate i...

journal_title：Journal of clinical pathology

authors： Puglisi F,Puppin C,Pegolo E,Andreetta C,Pascoletti G,D'Aurizio F,Pandolfi M,Fasola G,Piga A,Damante G,Di Loreto C

更新日期：2008-04-01 00:00:00

abstract：:Thirty-seven percutaneous renal biopsies showing no significant abnormalities on light microscopy were studied electron optically and by immunofluorescence when available. Assessment of the pathological material was followed by analysis of the patients' clinical notes, and a clinicopathological correlation was carried...

journal_title：Journal of clinical pathology

authors： Lawler W,Tarpey P,Williams G,Acheson EJ,Mallick NP

更新日期：1976-05-01 00:00:00

abstract：:A case of Cryptococcus neoformans meningitis is described in an HIV negative patient with undiagnosed systemic sarcoidosis. The patient presented with signs of meningitis together with generalised lymphadenopathy and hepatosplenomegaly. Cryptococcal meningitis was diagnosed on lumbar puncture. She was treated with int...

journal_title：Journal of clinical pathology

authors： Botha RJ,Wessels E

更新日期：1999-12-01 00:00:00

abstract：:Mast cells were identified by electronmicroscopy in the alveolar wall of the lung in 20 subjects (10 normal, 10 abnormal). A quantitative and qualitative study was made of the mast cells. In the normal lung there was an average concentration of 350 mast cells/mm2 of alveolar wall and in the abnormal 523/mm2. Mast cell...

journal_title：Journal of clinical pathology

authors： Fox B,Bull TB,Guz A

更新日期：1981-12-01 00:00:00

abstract：:Cutaneous melanoma causes most of the skin cancer deaths in the USA. Melanoma is the fifth most common cancer among men and the sixth most common cancer among women. The incidence of melanoma has risen sharply over the past three decades. In this review, which is informed by our extensive experience at a large cancer ...

journal_title：Journal of clinical pathology

authors： Trinidad CM,Torres-Cabala CA,Curry JL,Prieto VG,Aung PP

更新日期：2019-04-01 00:00:00

abstract：:Concentration of factor VIII from fresh plasma by cryoprecipitation remains the basis for preparation of products used to treat haemophilia A. This paper describes the preparation of a factor VIII concentrate from small plasma pools in transfusion centres with drying facilities. The dried concentrate from one litre of...

journal_title：Journal of clinical pathology

authors： Millgan G,Graham R,Hanratty S,Muir W,Mitchell R

更新日期：1981-10-01 00:00:00

abstract：:Hereditary breast cancer accounts for up to 5-10% of all breast carcinomas. Recent studies have demonstrated that mutations in two high-penetrance genes, namely BRCA1 and BRCA2, are responsible for about 16% of the familial risk of breast cancer. Even though subsequent studies have failed to find another high-penetran...

journal_title：Journal of clinical pathology

authors： Tan DS,Marchiò C,Reis-Filho JS

更新日期：2008-10-01 00:00:00

abstract：:The biochemical assay for the oestrogen receptor has shown the clinical value of knowing the concentration of the receptor within tissue. The immunohistochemical assay is rapidly taking over from the biochemical assay. Therefore, it is vital to have an equivalent scoring system that will have the same predictive value...

journal_title：Journal of clinical pathology

authors： Leake R,Barnes D,Pinder S,Ellis I,Anderson L,Anderson T,Adamson R,Rhodes T,Miller K,Walker R

更新日期：2000-08-01 00:00:00

abstract：:In four persons of one family the existence of an enzymatic defect, presumably consisting of a deficiency of glutaminase in the cells of the renal tubules, is postulated, and is implied by a reduced elimination of ammonia in the urine, by a relatively low urinary pH, and by its increased titratable acidity. The most c...

journal_title：Journal of clinical pathology

authors： KRAWCZYNSKI J,SAGAN Z,WALAJTYS E,ILOWIECKA K

更新日期：1965-03-01 00:00:00

abstract：:Phyllodes tumours (PTs) of the breast are true biphasic neoplasms within which interactions between the epithelium and stroma are critical for tumour development and progression. Despite numerous studies reporting the results of ancillary marker investigations in PTs, the current histological grading systems remain un...

journal_title：Journal of clinical pathology

authors： Karim RZ,O'Toole SA,Scolyer RA,Cooper CL,Chan B,Selinger C,Yu B,Carmalt H,Mak C,Tse GM,Tan PH,Putti TC,Lee CS

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Whole slide images (WSI) have been used in many pathology applications such as teleconsultation, teaching and research, but not in primary diagnostics. The aim of this study was to test the feasibility of using WSI in primary diagnostics of paediatric pathology specimens and placental tissue. MATERIALS AN...

journal_title：Journal of clinical pathology

authors： Al-Janabi S,Huisman A,Nikkels PG,ten Kate FJ,van Diest PJ

更新日期：2013-03-01 00:00:00

abstract：AIMS:To develop a strategy for neonatal screening of sickle cell disease (SCD) and effective enrollment of affected neonates in a comprehensive follow-up programme adapted to the socioeconomic conditions, health structures and cultural background of an African setting. METHODS:The strategy implemented at the two large...

journal_title：Journal of clinical pathology

authors： Rahimy MC,Gangbo A,Ahouignan G,Alihonou E

更新日期：2009-01-01 00:00:00

abstract：:Haemoglobin, haematocrit, and plasma iron values were estimated on blood samples collected from 100 male and 113 female National Blood Transfusion Service blood donors, and from 83 male and 66 female age-matched control subjects. No significant differences in any of these values were found to exist between the donors ...

journal_title：Journal of clinical pathology

authors： French EA,Sitlani PK

更新日期：1969-11-01 00:00:00

abstract：:A patient with megaloblastic anaemia due to nutritional folate deficiency is described. Partial villous atrophy and malabsorption of xylose showed progressive improvement to normal with folic acid therapy. ...

journal_title：Journal of clinical pathology

authors： Dawson DW

更新日期：1971-03-01 00:00:00

abstract：:A patient complained of severe diarrhoea for about four years. About 2.5 m of the jejunum was resected and duodenal polyps were also removed at laparotomy. Histologically, they were tubular or tubulovillus adenomas, which closely resembled colonic adenomas. No malignant change was detected in these adenomas. Severe in...

journal_title：Journal of clinical pathology

authors： Nakamura T,Kimura H,Nakano G

更新日期：1986-09-01 00:00:00