Abstract:
:Cutaneous melanoma causes most of the skin cancer deaths in the USA. Melanoma is the fifth most common cancer among men and the sixth most common cancer among women. The incidence of melanoma has risen sharply over the past three decades. In this review, which is informed by our extensive experience at a large cancer centre, we outline the key differences between the tumour, node and metastases staging criteria for cutaneous melanoma in the seventh and eighth editions of the AJCC Cancer Staging Manual We also offer advice on how to assess the histophenotypic parameters that are relevant for staging, with a special focus on avoiding potential pitfalls, and how to report all the prognostically and therapeutically relevant histophenotypic parameters. Correct assessment and reporting of these clinically relevant histophenotypic parameters is of outmost importance for practising pathologists because these parameters help treating clinicians select the most appropriate personalised treatment for patients in this era of promising targeted and immunotherapies.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Trinidad CM,Torres-Cabala CA,Curry JL,Prieto VG,Aung PPdoi
10.1136/jclinpath-2018-205417subject
Has Abstractpub_date
2019-04-01 00:00:00pages
265-270issue
4eissn
0021-9746issn
1472-4146pii
jclinpath-2018-205417journal_volume
72pub_type
杂志文章,评审abstract::A 72 year old woman presented with a suspected myocardial infarction. An echocardiograph showed no acute changes but her plasma creatine kinase (CK) activity was increased at 343 U/l (< 175 normal range). The apparent creatine kinase-MB activity by a CK-M subunit immunoinhibition assay was 350 U/l. In view of the disc...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.6.552
更新日期:1994-06-01 00:00:00
abstract::We determined the relative strengths of association between 23 most commonly ordered laboratory tests and the adverse outcome as indicators of relative criticalness. The lowest and highest results for 23 most commonly ordered laboratory tests, 24 hours prior to death during critical care unit (CCU) stay or discharge f...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2018-205549
更新日期:2019-04-01 00:00:00
abstract::Meningitis due to Gemella haemolysans developed in a 73 year old woman after thermolysis of the Gasserian ganglion for trigeminal neuralgia. The taxonomy of this organism is discussed, and previous cases of infection are reviewed. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.5.558
更新日期:1985-05-01 00:00:00
abstract:AIMS:Because sentinel lymph node (SLN) biopsy for breast cancer has become well established, one of the challenges now is to determine which patients require a completion axillary dissection following a positive SLN biopsy. METHODS:A prospective database of patients who underwent SLN biopsy for invasive breast cancer ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.57.1.73
更新日期:2004-01-01 00:00:00
abstract::As part of a wider survey of infections and defence mechanisms, concentrations of serum immunoglobulins IgG, IgA, and IgM were measured regularly by single radial immunodiffusion in a group of children receiving treatment for acute lymphoblastic leukaemia while in their first remission. IgM concentrations were often m...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.5.479
更新日期:1981-05-01 00:00:00
abstract::The Kallestad Corporation recently suggested that their new buffer system for the nephelometric detection of rheumatoid factor conferred advantages over existing systems. Two rate nephelometric procedures, the Kallestad QM-300 and the Beckman ICS-II (RF), were therefore compared. Sera (n = 157) were selected on the ba...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.43.3.243
更新日期:1990-03-01 00:00:00
abstract:AIM:The evaluation of allelic losses at the FHIT and the BRCA1 genes and at three other loci at the 17q region in a series of 34 sporadic breast cancer cases from Southern Brazil. METHODS:The samples were evaluated for loss of heterozygosity (LOH) at the FHIT and the BRCA1 genes and at three other microsatellite marke...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2003.013490
更新日期:2004-04-01 00:00:00
abstract::Aztreonam blood agar, a new selective medium for Gram positive aerobic bacteria, was evaluated in comparison with conventional media for skin swabs. Aztreonam agar increased the number of isolates of Staphylococcus aureus by 17%. By producing purer growths on primary isolation, it significantly speeded up the identifi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.8.769
更新日期:1993-08-01 00:00:00
abstract::The biochemical classification of the Klebsiella proposed by Cowan, Steel, Shaw, and Duguid (1960) has been applied to 50 strains isolated as the pure or predominant growth from sputum, and Klebsiella species have been correlated with the severity of the chest infection in the patient. A modification in nomenclature i...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.15.5.478
更新日期:1962-09-01 00:00:00
abstract::Twenty five specimens of branchial cyst from the same number of patients have been examined. On staining with haematoxylin and eosin a consistent finding was that the mural lymphoid follicles were always aligned with their mantle zones towards the luminal epithelium. With conventional staining lymphatic sinuses were n...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.7.784
更新日期:1985-07-01 00:00:00
abstract::A 51 year old woman presented with rectal bleeding from a mass lying just above the dentate line. Multiple biopsies were taken before the diagnosis of a benign lymphoid polyp was made. This is a rare condition that more commonly presents in children and poses a diagnostic challenge. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.12.1034
更新日期:1997-12-01 00:00:00
abstract::The aim of this article is to provide knowledge of the origin of catecholamines and metabolites so that there can be an informed approach to the methods for biochemical screening for a possible phaeochromocytoma; The article includes a review of catecholamine and metadrenaline metabolism, with methods used in biochemi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2009.071647
更新日期:2010-08-01 00:00:00
abstract::The cell volumes of mononuclear cells, T lymphocytes, B lymphocytes, and monocytes from the peripheral blood of 20 normal individuals were compared to neoplastic lymphoid cells from 14 patients with chronic lymphocytic leukaemia (CLL), 20 individuals with acute lymphocytic leukaemia (ALL), and 18 cases of non-Hodgkin'...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.10.1083
更新日期:1981-10-01 00:00:00
abstract::Tubercle bacilli, which survived heat fixation, were detected with a slide culture technique which allowed the entire smear to be examined. Both conventional flame fixation and the use of a controlled hot-plate failed to render tuberculous sputum smears safe for further handling. Smears which were stained with the ph...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.7.719
更新日期:1981-07-01 00:00:00
abstract::Two cases of peritoneal granulomatous reactions to food starch are described. They followed bowel perforation and clinically mimicked tuberculous and glove-powder starch peritonitis. Their histological differences from corn-starch peritonitis warrant attention in the absence of previous documentation of starch as a co...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.4.435
更新日期:1983-04-01 00:00:00
abstract::Carcinoma-associated fibroblast (CAF) as prominent cell type of the tumour microenvironment has complex interaction with both the cancer cells and other non-neoplastic surrounding cells. The CAF-derived regulators and extracellular matrix proteins can support cancer progression by providing a protective microenvironme...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jclinpath-2014-202561
更新日期:2014-12-01 00:00:00
abstract::Experiments are described with glass fibre filter paper and complete glass filters as fitted to high pre-vacuum autoclaves to determine whether organisms can grow or penetrate through the filters. A filter consisting of four layers of glass fibre paper fitted inside a sterilizer chamber for a year and used for 96 ster...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.16.3.259
更新日期:1963-05-01 00:00:00
abstract:AIMS:To investigate the optimal method for the detection of campylobacters from stool samples by comparing selective culture with membrane filtration and the polymerase chain reaction (PCR). METHODS:Three hundred and forty three stool samples were investigated by each of the three methods mentioned above. Selective cu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.55.10.749
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Fatty liver disease (FLD), of either alcoholic (AFLD) or non-alcoholic (NAFLD) aetiologies, is characterised histologically by features that are lobulocentric that typically affect zone 3, in contrast with portal-based inflammation characteristics of other forms of chronic liver disease. AIM:The authors aim...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2010.079145
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Epstein's syndrome is defined as a subtype of Alport's syndrome, and is distinguished from the other subtypes by accompanying macrothrombocytopenia. Mutations in collagen IV genes are known to be involved in the pathogenesis of typical Alport's syndrome. However, the presence of an underlying genetic defect ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.11.919
更新日期:1997-11-01 00:00:00
abstract::Methods are described for the estimation of plasma and urine alpha-amino nitrogen by the colorimetric ninhydrin reaction; in the method for urine, both ammonia and urea are separated by a rapid ion-exchange resin procedure. Two methods of estimation are given; one has the advantage of great simplicity, but involves th...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.17.2.150
更新日期:1964-03-01 00:00:00
abstract:AIM:To assess the ability of the commercially available monoclonal antibody 1B12 (BioGenex, San Ramon, USA) to identify C albicans in formalin fixed, paraffin wax embedded material (FFPE). METHODS:Broth cultures of 20 strains of seven Candida species were resuspended in 4% agarose blocks, fixed in formalin for 24 hour...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.51.11.857
更新日期:1998-11-01 00:00:00
abstract::A case of Legionella pneumophila pneumonia with rhabdomyolysis-induced acute tubulointerstitial nephritis (ATIN) and prolonged renal dysfunction is presented. The patient was a 54-year-old man, admitted with high-grade fever, ataxia and muscle dysfunction; chest roentgenogram showed multilobular infiltrations. L pneum...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2008.057000
更新日期:2008-09-01 00:00:00
abstract::Autoinfective strongyloidiasis is often fatal in immunosuppressed patients or in immunocomprised hosts. An interesting case of Strongyloides stercolaris hyperinfection was seen in an immunocompetent patient. This report describes a case of fatal strogyloidiasis in a 79 year old man, who had suffered gastrointestinal d...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.017756
更新日期:2005-04-01 00:00:00
abstract::Fifty-three breast carcinomas were examined by an indirect immunoperoxidase technique for the presence of the alpha-subunit of human chorionic gonadotrophin. Positive staining occurred in 12 (22.6%). There was no correlation between alpha-subunit production and specific histological features, but production was relate...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.31.3.245
更新日期:1978-03-01 00:00:00
abstract:AIMS:To establish the current sensitivity of two commercial kits for culture confirmation of Neisseria gonorrhoeae strains circulating in the UK. METHODS:A total of 544 strains were studied (199 gonococci from male patients attending hospitals in the county of Avon, 204 unselected N gonorrhoeae isolates from male pati...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.10.919
更新日期:1995-10-01 00:00:00
abstract::Synovial sarcoma is a distinctive soft tissue neoplasm with monophasic and biphasic forms. It is typically a deep-seated soft tissue tumour of the extremities of young adults and occasional cases have been described in large peripheral nerves. A rare example has a predominance of the glandular component and may mimic ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2007.053124
更新日期:2008-05-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) encompasses a histological spectrum of liver disease, from simple steatosis through to cirrhosis. As the worldwide rates of obesity have increased, NAFLD has become the commonest cause of liver disease in many developed countries, affecting up to a third of the population. The...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jclinpath-2013-201620
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Epidermal growth factor receptor (EGFR) gene mutation at the kinase domain and EGFR gene amplification are reported to be predictors of the response to EGFR tyrosine kinase inhibitors in lung cancer cases. In malignant mesothelioma (MM), the role of EGFR is less clear. METHODS:Thirty-eight MM specimens were...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2011-200631
更新日期:2012-06-01 00:00:00
abstract:AIMS:Common variable immunodeficiency (CVID) is the most common serious primary immunodeficiency. This paper describes the immunological consequences of human immunodeficiency virus (HIV) infection in a patient with familial CVID subsequently treated with highly active antiretroviral therapy (HAART). METHODS:Serial me...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.54.9.713
更新日期:2001-09-01 00:00:00