Update on eighth edition American Joint Committee on Cancer classification for cutaneous melanoma and overview of potential pitfalls in histological examination of staging parameters.


:Cutaneous melanoma causes most of the skin cancer deaths in the USA. Melanoma is the fifth most common cancer among men and the sixth most common cancer among women. The incidence of melanoma has risen sharply over the past three decades. In this review, which is informed by our extensive experience at a large cancer centre, we outline the key differences between the tumour, node and metastases staging criteria for cutaneous melanoma in the seventh and eighth editions of the AJCC Cancer Staging Manual We also offer advice on how to assess the histophenotypic parameters that are relevant for staging, with a special focus on avoiding potential pitfalls, and how to report all the prognostically and therapeutically relevant histophenotypic parameters. Correct assessment and reporting of these clinically relevant histophenotypic parameters is of outmost importance for practising pathologists because these parameters help treating clinicians select the most appropriate personalised treatment for patients in this era of promising targeted and immunotherapies.


J Clin Pathol


Trinidad CM,Torres-Cabala CA,Curry JL,Prieto VG,Aung PP




Has Abstract


2019-04-01 00:00:00














  • Nasal polyposis in Peutz-Jeghers syndrome: a distinct histopathological and molecular genetic entity.

    abstract:BACKGROUND:Peutz-Jeghers syndrome (PJS) is an autosomal dominant hamartomatous polyposis syndrome of the gastrointestinal tract, caused by a germline STK11/LKB1 mutation. Nasal polyposis was described in the original report by Peutz. Recently, a molecular-genetic association between nasal polyposis and PJS has been rep...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: de Leng WW,Westerman AM,Weterman MA,Jansen M,van Dekken H,Giardiello FM,de Rooij FW,Paul Wilson JH,Offerhaus GJ,Keller JJ

    更新日期:2007-04-01 00:00:00


    abstract::A study has been made by clinical methods and by bio-assay of the effectiveness of a régime for prophylaxis against tetanus. The two principal objects of the method were to ensure that active immunization was offered to all patients who had received antitoxin and to measure the effect of the combined administration of...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章



    更新日期:1965-01-01 00:00:00

  • Thorotrast associated nodular regenerative hyperplasia of the liver.

    abstract::A case of nodular regenerative hyperplasia (NRH) of the liver is described in association with exposure to the radiographic contrast medium Thorotrast. This is the first case in which the pathological findings have been fully documented. It is suggested that NRH may have developed through Thorotrast induced damage to ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审


    authors: Beer TW,Carr NJ,Buxton PJ

    更新日期:1998-12-01 00:00:00

  • PD-L1 expression on routine samples of non-small cell lung cancer: results and critical issues from a 1-year experience of a centralised laboratory.

    abstract:AIMS:Our laboratory is a centralised centre receiving routine non-small cell lung cancer (NSCLC) samples for programmed death ligand-1 (PD-L1) immunohistochemical (IHC) evaluation. Since literature data are not concordant here we review our clinical records to assess the rate of PD-L1 positive and negative NSCLC cases ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Vigliar E,Malapelle U,Iaccarino A,Acanfora G,Pisapia P,Clery E,De Luca C,Bellevicine C,Troncone G

    更新日期:2019-06-01 00:00:00

  • Ewing family of tumours involving the vulva and vagina: report of a series of four cases.

    abstract:BACKGROUND:Ewing's sarcoma and peripheral primitive neuroectodermal tumour (pPNET) are now regarded as two morphological ends of a spectrum of neoplasms, characterised by a t(11;22) or other related chromosomal translocation involving the EWS gene on chromosome 22 and referred to as Ewing family of tumours (EFTs). EFTs...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审


    authors: McCluggage WG,Sumathi VP,Nucci MR,Hirsch M,Dal Cin P,Wells M,Flanagan AM,Fisher C

    更新日期:2007-06-01 00:00:00

  • Validity of whole genomes sequencing results in neoplasms in precision medicine.

    abstract:OBJECTIVE:To compare the whole genomes sequencing (WGS) results in the 100K Genomes project with the results of routine molecular diagnostics in precision medicine. MATERIALS AND METHODS:We analysed 374 cancers including a high tumour mutational burden (TMB-high) subgroup, defined as >10 non-synonymous single nucleoti...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Echejoh G,Liu Y,Chung-Faye G,Charlton J,Moorhead J,Clark B,Davidson P,Sarker D,Ross P,Ooft ML

    更新日期:2020-10-29 00:00:00

  • MUC1 and MUC2 in pancreatic neoplasia.

    abstract::MUCs are glycoproteins with various roles in homeostasis and carcinogenesis. Among other actions, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. In contrast, MUC2 is normally found only in goblet cells, where it contributes to the prote...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审


    authors: Levi E,Klimstra DS,Andea A,Basturk O,Adsay NV

    更新日期:2004-05-01 00:00:00

  • Iatrogenic lesions and artefacts in gynaecological pathology.

    abstract::Increasingly in the field of medicine, new therapeutic modalities, both surgical and non-surgical, are being introduced. Some of these may significantly alter the pathological appearance of normal and neoplastic tissue and result in problems for the pathologist. In this review, iatrogenic pathology within the female g...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审


    authors: Clarke B,McCluggage WG

    更新日期:2009-02-01 00:00:00

  • Evaluation and comparison of neutrophil bipolar shape formation with a migration assay.

    abstract::The neutrophil shape change response to a chemotactic formylpeptide was assessed. Neutrophil bipolar shape formation (BSF) was also simultaneously assessed with a Boyden chamber-based neutrophil migration assay. Both assays were precise and relatively reproducible; the average coefficient of variation for the BSF assa...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Lord RA,Roath S

    更新日期:1990-04-01 00:00:00

  • Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries.

    abstract:BACKGROUND:Currently, no specific immunohistochemical markers are available to differentiate primary mucinous epithelial ovarian cancer (MOC) from adenocarcinomas originating at other sites that have metastasised to the ovary, which may have an impact on patient management and prognosis. AIM:To investigate the express...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,多中心研究


    authors: Heinzelmann-Schwarz VA,Scolyer RA,Scurry JP,Smith AN,Gardiner-Garden M,Biankin AV,Baron-Hay S,Scott C,Ward RL,Fink D,Hacker NF,Sutherland RL,O'Brien PM

    更新日期:2007-06-01 00:00:00


    abstract::Pathological findings are described in four cases of a new aminoaciduria in which homocystine is excreted in the urine. All the patients were mentally retarded children. Three of them presented diagnostic features of Marfan's syndrome. Necropsy on one case and biopsy findings in the others are described. Fatty change ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章



    更新日期:1964-07-01 00:00:00

  • The value of autopsies in the era of high-tech medicine: discrepant findings persist.

    abstract:AIMS:Although the autopsy is still the gold standard for quality assessment of clinical diagnoses, autopsy rates have been declining over the last decades to <10%. The aim of this study was to investigate the value of autopsies in the high-tech medicine era by determining the frequency of discrepancies between clinical...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Kuijpers CC,Fronczek J,van de Goot FR,Niessen HW,van Diest PJ,Jiwa M

    更新日期:2014-06-01 00:00:00

  • Cell block processing is optimal for assessing endoscopic ultrasound fine needle aspiration specimens of pancreatic mucinous cysts.

    abstract:AIMS:The cell block technique for assessing endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) specimens from pancreatic mucinous cystic lesions (MCLs) was systematically evaluated for the first time, including comparisons with three traditional methods of assessing such specimens. METHODS:The prospective a...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Wong NACS,Gwiti P,Murigu T,Melegh Z,Beavers S,Gordon F,Alexandridis E,Norton S

    更新日期:2020-02-01 00:00:00

  • BCL2 and BCL6 atypical/unbalanced gene rearrangements in diffuse large B-cell lymphoma are indicators of an aggressive clinical course.

    abstract:AIMS:Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive non-Hodgkin's lymphoma that represents a heterogeneous group of disease that is differentially characterised by clinical, molecular and cytogenetic features. MYC, BCL2 and BCL6 gene rearrangements have been identified as prognostic factors...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Tourneret A,Alame M,Rigau V,Bauchet L,Fabbro M,De Oliveira L,Cacheux V,Costes V,Lacheretz-Szablewski V

    更新日期:2020-09-10 00:00:00

  • Modified detergent Ziehl-Neelsen technique for the staining of Cyclospora cayetanensis.

    abstract::Cyclospora cayetanensis is a cause of prolonged diarrhoea, mainly in travellers. Laboratory diagnosis may be achieved by a number of methods such as the staining of faecal smears by the modified Ziehl-Neelsen (ZN) technique. Safer methods using this technique have been described for the staining of acid fast bacilli a...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Clarke SC,McIntyre M

    更新日期:1996-06-01 00:00:00

  • Hepatitis B antigen (HBAg) and its antibody (HBAb) in hospital patients.

    abstract::Sera from 5171 inpatients have been tested for HBAg and HBAb during the 18-month period ending in December 1972. The incidence of HBAg (0.116%) was similar to that in blood donors (0.119%) in the same area, being tested for the first time by the same technique. By contrast the incidence of HBAb in patients (0.271%) wa...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Payne RW,Barr A,Wallace J

    更新日期:1974-02-01 00:00:00

  • Atypical aspirates of the breast: a dilemma in current cytology practice.

    abstract:AIMS:The probabilistic approach is widely adopted for breast fine needle aspiration cytology. However, a definite cytological diagnosis is not always possible for C3 (atypia) cases, which poses a management dilemma as this represents a mixed category of benign and malignant cases. It would be beneficial to be able to p...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,多中心研究


    authors: Yu SN,Li J,Wong SI,Tsang JYS,Ni YB,Chen J,Tse GM

    更新日期:2017-12-01 00:00:00

  • Foveolar hyperplasia at the gastric cardia: prevalence and associations.

    abstract:AIMS:In the gastric antrum and body, foveolar hyperplasia is a feature of reactive gastritis resulting from--for example, duodenogastric bile reflux and the use of non-steroidal anti-inflammatory drugs (NSAIDs). The aim of this study was to examine the occurrence and clinical relevance of gastric cardiac foveolar hyper...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Voutilainen M,Juhola M,Färkkilä M,Sipponen P

    更新日期:2002-05-01 00:00:00

  • Hodgkin's lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments.

    abstract:BACKGROUND:Hodgkin's lymphoma (HL) is characterised by an ineffective immune response that is predominantly mediated by CD4+ T-cells. AIMS:To analyse the expression of the key regulatory T-cell transcription factors (TFs) in the T-cells of HL involved tissues in order to assess the nature of the T(H) immune response i...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Atayar C,van den Berg A,Blokzijl T,Boot M,Gascoyne RD,Visser L,Poppema S

    更新日期:2007-10-01 00:00:00

  • Connexin 43 expression predicts poor progression-free survival in patients with non-muscle invasive urothelial bladder cancer.

    abstract:OBJECTIVES:To evaluate the protein expression of connexin 43 (Cx43) in primary urothelial bladder cancer and test its association with the histopathological characteristics and clinical outcome. METHODS:A tissue microarray containing 348 tissue samples from 174 patients with primary urothelial carcinomas of the bladde...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Poyet C,Buser L,Roudnicky F,Detmar M,Hermanns T,Mannhard D,Höhn A,Rüschoff J,Zhong Q,Sulser T,Moch H,Wild PJ

    更新日期:2015-10-01 00:00:00

  • Detection of apoptosis by the TUNEL technique in clinically localised prostatic cancer before and after combined endocrine therapy.

    abstract:AIMS:Apoptosis in prostate cancer was evaluated after three months of combined endocrine therapy to investigate the association with tumour grade, tumour stage, and the immunohistochemical detection of p53 and bcl-2 in tumour cells before and after therapy. METHODS:Twenty six formalin fixed, paraffin wax embedded core...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Colecchia M,Frigo B,Del Boca C,Guardamagna A,Zucchi A,Colloi D,Leopardi O

    更新日期:1997-05-01 00:00:00

  • Artificial factor VIII deficient plasma: preparation using monoclonal antibodies and its use in one stage coagulation assays.

    abstract::Monoclonal antibodies to factor VIII antigen (VIII:Ag) and von Willebrand factor (vWf:Ag) were immobilised on Sephacryl S-1000 and tested for their ability to deplete normal human citrated plasma of factor VIII. A combination of two antibodies to VIII:Ag and one antibody to vWf:Ag was required to produce plasma contai...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Hornsey VS,Waterston YG,Prowse CV

    更新日期:1988-05-01 00:00:00

  • MAGE-A family expression is correlated with poor survival of patients with lung adenocarcinoma: a retrospective clinical study based on tissue microarray.

    abstract:OBJECTIVES:As the best characterised cancer/testis antigen family members, melanoma-associated antigens (MAGE) have been reported to be expressed in various malignant tumours. However, the expression pattern of MAGE-A family in lung adenocarcinoma (LAC) specimens and their prognostic and therapeutic significance for pa...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Sang M,Gu L,Yin D,Liu F,Lian Y,Zhang X,Liu S,Huang W,Wu Y,Shan B

    更新日期:2017-06-01 00:00:00

  • Laboratory assessment of the status of Her-2/neu protein and oncogene in breast cancer specimens: comparison of immunohistochemistry assay with fluorescence in situ hybridisation assays.

    abstract:AIM:To evaluate the clinical usefulness of three commercially available assays for Her-2/neu oncogene and protein measurements. The Her-2/neu protein is overexpressed, mostly as a result of gene amplification, in 20-30% of human breast cancers, and has been shown to have prognostic and predictive value for treatment wi...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Wang S,Saboorian MH,Frenkel E,Hynan L,Gokaslan ST,Ashfaq R

    更新日期:2000-05-01 00:00:00

  • Histology of chronic gastritis with and without duodenitis in patients with Helicobacter pylori infection.

    abstract:AIM:To compare the histological characteristics of Helicobacter pylori positive chronic gastritis in patients with and without associated duodenitis. METHODS:Gastric mucosal biopsy specimens were obtained from patients undergoing endoscopy for dyspepsia. Severity of gastritis and density of H pylori infection were gra...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Phull PS,Price AB,Stephens J,Rathbone BJ,Jacyna MR

    更新日期:1996-05-01 00:00:00

  • Cytomegalovirus colitis in immunocompetent individual.

    abstract::A woman with peripheral vascular disease developed cytomegalovirus colitis following repair of abdominal aortic aneurysm. Cytomegalovirus colitis developing in an immunocompetent individual may be caused by a breach in the integrity of the mucosal lining of the colon from various causes and should alert the clinician ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: al Mahdy H

    更新日期:1998-06-01 00:00:00

  • Bilateral gonadoblastoma/dysgerminoma in a 46 XY individual: case report with hormonal studies.

    abstract::A case of bilateral gonadoblastoma/dysgerminoma in a 46 XY phenotypical female is presented. Increased circulating beta human chorionic gonadotropin (beta-HCG) and testosterone together with a decreased concentration of follicle stimulating hormone (FSH) reflected the activities of these tumours. The patient is alive ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Fisher RA,Salm R,Spencer RW

    更新日期:1982-04-01 00:00:00

  • Ischaemic lesions of the alimentary tract.

    abstract::The clinical and pathological findings in 23 patients with ischaemic lesions of the alimentary tract (ischaemic enterocolitis) are described. These are compared with findings in 13 patients with occlusive thrombosis of the superior mesenteric artery. The pathological features distinguishing the two conditions are disc...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: McDonald GS,Hourihane DO

    更新日期:1972-02-01 00:00:00

  • Validation of whole slide imaging in the primary diagnosis of gynaecological pathology in a University Hospital.

    abstract:AIMS:Experience in the use of whole slide imaging (WSI) for primary diagnosis in pathology is very limited. We aimed to determine the accuracy of interpretation of WSI compared with conventional light microscopy (CLM) in the diagnosis of routine gynaecological biopsies. METHODS:All gynaecological specimens (n=452) rec...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Ordi J,Castillo P,Saco A,Del Pino M,Ordi O,Rodríguez-Carunchio L,Ramírez J

    更新日期:2015-01-01 00:00:00

  • Analysis of T cell receptor beta chain CDR3 size using RNA extracted from formalin fixed paraffin wax embedded tissue.

    abstract:AIMS:To isolate RNA and DNA simultaneously from formalin fixed paraffin wax embedded tissue to assess the clonality of enteropathy associated T cell lymphomas and to analyse it in detail by a non-radioactive method of T cell receptor complementarity determining region 3 (CDR3) spectratyping. METHODS:DNA and RNA were i...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: O'Shea U,Wyatt JI,Howdle PD

    更新日期:1997-10-01 00:00:00