Abstract:
BACKGROUND:Most medical liver biopsies in the UK are now taken in radiology departments using 18 g biopsy needles. Subjectively, the resulting biopsies are narrow and fragile. AIM:To compare the quality of liver biopsy tissue sections obtained from 16 and 18 g biopsy needles. METHOD:Fifty consecutive routine medical liver biopsies obtained with 16 and 18 g needles, processed identically in the same laboratory, were measured using digital pathology software. We recorded their fragmentation, length, width, area and number of portal tracts. RESULTS:Biopsies obtained with 16 g needles more often resulted in an intact core in tissue sections than those with 18 g needles (71% vs 24%, p<0.001) and were significantly wider (average width of tissue 0.88 vs 0.53 mm, p<0.001). The average total area of tissue per pass was 11.38 mm(2) compared with 8.34 mm(2) (p<0.001). The number of complete portal tracts per length of biopsy was very variable, but double for 16 vs 18 g biopsies. Routinely taking two passes with the 18 g needle compensated for the reduced area, but the resulting liver in tissue sections was fragmented and distorted. CONCLUSIONS:Our results support the routine use of 16 g rather than 18 g biopsy needles for routine ultrasound-guided medical liver biopsies. A second pass should be considered if the first biopsy core is short, especially for investigation of disease stage.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Palmer T,Georgiades I,Treanor D,Wright A,Shah M,Khosla R,Wyatt JIdoi
10.1136/jclinpath-2013-201954subject
Has Abstractpub_date
2014-05-01 00:00:00pages
415-9issue
5eissn
0021-9746issn
1472-4146pii
jclinpath-2013-201954journal_volume
67pub_type
杂志文章,多中心研究abstract:BACKGROUND:Parathyroid hormone (PTH) is important in the evaluation of patients with calcium metabolism disorders and/or chronic renal disease. AIMS:To assess the differences between serum and plasma PTH measurements using the Advia Centaur. METHODS:Twenty six paired serum and edetate samples from patients with chron...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.022186
更新日期:2005-09-01 00:00:00
abstract::The mean areas of lymphoid follicles have been determined in 20 specimens of malignant follicular (centrocytic-centroblastic) lymphoma, 15 specimens of reactive follicular hyperplasia and 10 palatine tonsils. In all of the benign specimens and whenever possible for those showing malignancy, the areas of both the whole...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.9.1055
更新日期:1983-09-01 00:00:00
abstract::A rapid and simple enzyme linked immunosorbent assay (ELISA) for the detection of specific IgG against Toxoplasma gondii was compared with the dye test on 533 serum samples. In general, results were comparable but not with sera that contained high concentrations of toxoplasma specific IgM or that had been heated at 56...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.7.802
更新日期:1988-07-01 00:00:00
abstract::Three cases of islet cell necrosis in neonates are reported. The association of this rare condition with antepartum haemorrhage, anoxia, shock and intravascular coagulation are discussed. The clinical and morphological appearances were compared with previous descriptions of this condition and an association with neona...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.40.10.1206
更新日期:1987-10-01 00:00:00
abstract:AIMS:Children in a United Kingdom national trial for relapsed non-B lymphoblastic leukaemia (ALL) had their diagnostic and relapse marrow cytomorphology compared to see what changes occur during the evolution of the disease. METHODS:Each relapse slide was assessed blindly for French American British (FAB) type and oth...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.11.1051
更新日期:1995-11-01 00:00:00
abstract::Electron microscopical and cytochemical studies of intestinal biopsies from a patient with typical features of the Cronkhite-Canada syndrome show that the primary process affects the crypts. This results in cystic dilatation associated with expansion and focal degeneration of the crypt compartment of the intestinal ep...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.3.271
更新日期:1985-03-01 00:00:00
abstract::The results of measurement of gamma globulin in the cerebrospinal fluid by electrophoresis and by an immunological technique are compared. In some fluids marked discrepancies were found. Such discrepancies, when substantiated and better understood, may have diagnostic significance. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.16.4.370
更新日期:1963-07-01 00:00:00
abstract::A case of IgD myeloma accompanied by diffuse osteosclerosis is reported. A trephine biopsy specimen showed only reticulin fibrosis, but histomorphometric analysis of a full thickness transiliac bone biopsy specimen showed increased trabecular bone mass, with no local deposit of tumour. An excess of bone surfaces were ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.5.486
更新日期:1988-05-01 00:00:00
abstract::A patient with a 10 year history of monoclonal gammopathy of undetermined significance and Bence Jones proteinuria, and a 44 year history of ankylosing spondylitis, developed a nephrotic syndrome secondary to renal amyloidosis. Clinically the amyloidosis was ascribed to Bence Jones proteinuria rather than to the burnt...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.10.934
更新日期:1992-10-01 00:00:00
abstract::A young woman presented with bilateral ovarian tumours. Multiple sections of each tumour were shown to many pathologists for consultation; some considered the tumours to be borderline, whereas others thought that one or both of them was malignant. Morphometry showed that the numerical classification probabilities for ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.10.1110
更新日期:1984-10-01 00:00:00
abstract:OBJECTIVE:We explore factors such as the blood sampling site (capillary vs venous), the equipment (HemoCue vs automated haematology analyser) and the model of the HemoCue device (201+ vs 301) that may impact haemoglobin measurements in capillary and venous blood. METHODS:Eleven studies were identified, and bias, conco...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-206717
更新日期:2020-10-06 00:00:00
abstract:OBJECTIVES:To evaluate the protein expression of connexin 43 (Cx43) in primary urothelial bladder cancer and test its association with the histopathological characteristics and clinical outcome. METHODS:A tissue microarray containing 348 tissue samples from 174 patients with primary urothelial carcinomas of the bladde...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2015-202898
更新日期:2015-10-01 00:00:00
abstract:AIMS:Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive non-Hodgkin's lymphoma that represents a heterogeneous group of disease that is differentially characterised by clinical, molecular and cytogenetic features. MYC, BCL2 and BCL6 gene rearrangements have been identified as prognostic factors...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-206767
更新日期:2020-09-10 00:00:00
abstract:BACKGROUND:An increased level of serum C-reactive protein (CRP) is a known prognostic factor for acute coronary events and sudden cardiac death, and it is associated with coronary calcification. CRP is expressed in coronary arteries, but its role in the development of coronary plaques is unclear. AIM:To investigate CR...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2006.038729
更新日期:2007-05-01 00:00:00
abstract:AIMS:To compare the sensitivity and specificity of new rabbit monoclonal antibody SP3 with those of mouse monoclonal and rabbit polyclonal antibodies using HER2 amplification defined by chromogenic in situ hybridisation (CISH) as the gold standard. METHODS:Serial sections from tissue microarrays (TMAs) containing 84 b...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2007.053892
更新日期:2008-08-01 00:00:00
abstract:AIMS:To develop a quantitative reverse transcriptase polymerase chain reaction (Q-RT-PCR) for severe acute respiratory syndrome coronavirus (SARS-CoV) detection and explore the potential of using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA as an internal control to exclude false negative results. METHODS:SAR...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.016592
更新日期:2005-03-01 00:00:00
abstract::The separation of mesothelial hyperplasia from early malignant mesothelioma remains one of the most difficult problems in histopathology. Inconclusive cases are termed "atypical mesothelial hyperplasia" and treated expectantly. A 49 year old male pipeline engineer was diagnosed as having atypical mesothelial hyperplas...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.52.7.535
更新日期:1999-07-01 00:00:00
abstract::A new sensitive nitrite test, the SRN test, was evaluated for its suitability as a reliable screening technique for the detection of bacteriuria. The SRN test was compared to a currently available nitrite test, the Microstix nitrite test, and the results obtained with both nitrite tests were assessed in comparison wit...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.7.723
更新日期:1981-07-01 00:00:00
abstract::The results of a histological study of normal osteoid tissue in man, the monkey, the dog, and the rat, using thin microtome sections of plastic-embedded undecalcified bone, are described. Osteoid tissue covers the entire bone surface, except for areas of active resorption, although the thickness of the layer of osteoi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.25.3.229
更新日期:1972-03-01 00:00:00
abstract::Metabolic balance studies for iron have been carried out on 24 apparently healthy elderly people (11 men and 13 women) aged 69.7 to 85.5 years living in their own homes and eating self selected diets. Several biochemical and haematological indices of iron state were also measured. The mean daily iron intake was 176 mu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.12.1353
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:RCAS1 (receptor binding cancer antigen expressed on SiSo cells) is a tumour associated antigen. It is involved in immune evasion by tumour cells, by binding to receptors on cells involved in the immune response, such as T cells and natural killer cells, and inducing apoptosis. High expression of RCAS1 has be...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.56.10.764
更新日期:2003-10-01 00:00:00
abstract::A family with hypobetalipoproteinaemia was studied to examine the Lp(a) lipoprotein, lipoprotein cholesterol, and triglyceride composition of the serum lipids. Lp(a) lipoprotein was measured by immunoassay. Serum lipoproteins were separated by ultracentrifugation. Cholesterol and triglycerides were measured using stan...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.6.587
更新日期:1995-06-01 00:00:00
abstract::Accurate histopathological assessment of biopsies is important for the diagnosis, subclassification, and management of chronic idiopathic inflammatory bowel disease (IBD). British Society of Gastroenterology (BSG) guidelines for the initial histopathological diagnosis of IBD were published in 1997. Changes since then ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,实务指引
doi:10.1136/jclinpath-2013-201885
更新日期:2013-12-01 00:00:00
abstract::A case of Legionella pneumophila pneumonia with rhabdomyolysis-induced acute tubulointerstitial nephritis (ATIN) and prolonged renal dysfunction is presented. The patient was a 54-year-old man, admitted with high-grade fever, ataxia and muscle dysfunction; chest roentgenogram showed multilobular infiltrations. L pneum...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2008.057000
更新日期:2008-09-01 00:00:00
abstract::Cyclospora cayetanensis is a cause of prolonged diarrhoea, mainly in travellers. Laboratory diagnosis may be achieved by a number of methods such as the staining of faecal smears by the modified Ziehl-Neelsen (ZN) technique. Safer methods using this technique have been described for the staining of acid fast bacilli a...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.6.511
更新日期:1996-06-01 00:00:00
abstract:AIMS:To establish the current sensitivity of two commercial kits for culture confirmation of Neisseria gonorrhoeae strains circulating in the UK. METHODS:A total of 544 strains were studied (199 gonococci from male patients attending hospitals in the county of Avon, 204 unselected N gonorrhoeae isolates from male pati...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.10.919
更新日期:1995-10-01 00:00:00
abstract:AIMS:Sentinel lymph node (SLN) biopsy is the preferred surgical technique for staging the axilla in clinically node-negative breast cancer. Accurate intraoperative staging allows for the immediate performance of an axillary clearance in node-positive patients. We assessed the Metasin assay for the intraoperative analys...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2016-203728
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Cytokeratin immunohistochemistry (IHC) reveals a higher rate of occult lymph node metastases among lobular carcinomas than among ductal breast cancers. IHC is widely used but is seldom recommended for the evaluation of sentinel lymph nodes in breast cancer patients. OBJECTIVE:To assess the value of cytokera...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jcp.2005.029991
更新日期:2006-05-01 00:00:00
abstract::A case of florid rheumatoid heart disease with complete heart block is described, and the histopathology of the atrioventricular conducting tissue is described in detail. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.23.7.623
更新日期:1970-10-01 00:00:00
abstract::Eight strains of Pseudomonas putrefaciens have been received from among 466 strains of Pseudomonas submitted to the Computer Trials Laboratory for identification over the last eight years. Two of the strains of P. putrefaciens from patients with otitis media and otitis externa respectively appear to have played a path...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.28.2.149
更新日期:1975-02-01 00:00:00