Cytomegalovirus infections in heart and heart and lung transplant recipients.

Abstract:

:Of the first 166 heart and 15 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 162 were investigated for cytomegalovirus (CMV) infection by serological methods. Altogether, 73 (45%) developed CMV infection after transplantation: 30 (18.5%) had acquired primary infection and 43 (26.5%) reactivation or reinfection. Six patients died of primary infection, probably acquired from the donor organ. Recipients negative for CMV antibody who received an organ from an antibody positive donor had the most severe disease. Heart and lung transplant recipients experienced more severe primary CMV infection than those in whom the heart alone was transplanted. The most sensitive and rapid serological method was a mu-capture enzyme linked immunosorbent assay (ELISA) for detecting CMV specific IgM, the amount of which was often of prognostic value and influenced the management of patients.

journal_name

J Clin Pathol

authors

Wreghitt TG,Hakim M,Gray JJ,Kucia S,Wallwork J,English TA

doi

10.1136/jcp.41.6.660

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

660-7

issue

6

eissn

0021-9746

issn

1472-4146

journal_volume

41

pub_type

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