Abstract:
:Using a radioimmunoassay technique serum alpha-fetoprotein could be detected in healthy adults in concentrations of less than 20 microgram/l. Of patients with acute, viral hepatitis 43% exhibited a transient rise of serum alpha-fetoprotein, the peak occurring eight to nine days after the maximum recorded serum aspartate transaminase activity. Patients with hepatic damage due to paracetamol poisoning were also shown to have transiently raised levels, the peak occurring earlier than in subjects with viral hepatitis. Six subjects with fatal fulminant hepatitis were studied; the three with the more protracted illness were noted to have increased levels before death. Twenty of 163 cases of chronic liver disease also had raised serum alpha-fetoprotein concentrations. In four, primary liver cell cancer developed; in two of these the serum alpha-fetoprotein levels rose progressively, and in two it remained raised but at low levels.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Eleftheriou N,Heathcote J,Thomas HC,Sherlock Sdoi
10.1136/jcp.30.8.704subject
Has Abstractpub_date
1977-08-01 00:00:00pages
704-8issue
8eissn
0021-9746issn
1472-4146journal_volume
30pub_type
杂志文章abstract:AIMS:To establish a three dimensional reconstruction of an invasive breast carcinoma using basic laboratory equipment to evaluate and characterise the spatial arrangement of the parenchymal cells of the breast. METHODS:One hundred and twenty eight sequential 4 microm sections (20 microm apart) of the tumour were stain...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.024794
更新日期:2005-09-01 00:00:00
abstract::The activities of three commercial products of papain were compared as supplied and after activation, and when used in the enzyme-serum method for rhesus (D) grouping. Certain dangers in activation became apparent, and accurate determination of the proportions of papain to anti-D appeared more important than indiscrim...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.15.6.503
更新日期:1962-11-01 00:00:00
abstract::A patient with multiple myeloma had antigenically related monoclonal Fc-gamma fragments and complete IgG-kappa molecules in the serum. The urine contained only Fc-gamma fragments in the absence of Bence-Jones protein. The two distinct M-components in the serum showed electrophoretic identity but could be separated by ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.33.10.936
更新日期:1980-10-01 00:00:00
abstract:AIMS:The Royal College of Pathologists recommend that a median of at least 12 lymph nodes should be harvested during pathological staging of colorectal cancer. It is not always easy to harvest the required number, especially in patients with rectal cancer receiving neoadjuvant therapy. Lymph node revealing solutions, f...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2015-203281
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND/AIMS:CD10 (CALLA) has recently been reported to be expressed in spindle cell neoplasia, and has been used to differentiate endometrial stromal sarcoma from leiomyoma and leiomyosarcoma. In the breast, myoepithelial cells express CD10, but there are few studies of the expression of CD10 in mammary fibroepithe...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.020917
更新日期:2005-02-01 00:00:00
abstract::The Kallestad Corporation recently suggested that their new buffer system for the nephelometric detection of rheumatoid factor conferred advantages over existing systems. Two rate nephelometric procedures, the Kallestad QM-300 and the Beckman ICS-II (RF), were therefore compared. Sera (n = 157) were selected on the ba...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.43.3.243
更新日期:1990-03-01 00:00:00
abstract:AIMS:The localisation of the translocation breakpoint of the Ewing sarcoma family of tumours shows significant variability on relatively large regions of fusion partner genes. As a consequence, many alternative forms of EWSR1-ETS translocation exist which make the RNA-based molecular diagnostics of Ewing sarcoma family...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2012-201154
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Mycosis fungoides (MF) is the most common skin lymphoid neoplasm. In initial stages, differential diagnosis of MF from other benign dermal lymphoid infiltrates (BDLI) may be impossible on morphological basis alone. In previous studies, only deletion of CD7 in MF proved to be of diagnostic help, but not the r...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jcp.2007.048553
更新日期:2008-02-01 00:00:00
abstract::Common acute lymphoblastic leukaemia antigen (CALLA) was first characterised in lymphoid leukaemic cells. The antigen is present in different stages of lymphoid cell differentiation as well as in subsets of myeloid cells, and further studies have also shown its presence in non-lymphoid tissues. The recent cloning and ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.43.8.654
更新日期:1990-08-01 00:00:00
abstract::A 35 year old man with a fatal Campylobacter jejuni infection is described. He had HbE/beta zero thalassaemia and had undergone splenectomy nine months previously for hypersplenism; he also had chronic hepatitis C infection. He presented with high grade fever but no gastrointestinal symptoms and rapidly progressed to ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.5.436
更新日期:1997-05-01 00:00:00
abstract::Eight strains of Moraxella phenylpyruvica have been isolated from clinical material in the United Kingdom, the first to be reported from this country. They were characterized, together with three strains of M. phenylpyruvica of the National Collection of Type Cultures (NCTC), and compared with NCTC strains of eight ot...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.25.11.959
更新日期:1972-11-01 00:00:00
abstract::Non-Hodgkin's lymphoma is not commonly a familial condition. This is believed to be the first two cases of primary pancreatic lymphoma within a single family. The two cases, a brother and sister, both presented in their 60s and were diagnosed histologically as having high grade B cell lymphoma affecting the pancreas, ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.51.1.80
更新日期:1998-01-01 00:00:00
abstract:AIMS:To investigate the optimal method for the detection of campylobacters from stool samples by comparing selective culture with membrane filtration and the polymerase chain reaction (PCR). METHODS:Three hundred and forty three stool samples were investigated by each of the three methods mentioned above. Selective cu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.55.10.749
更新日期:2002-10-01 00:00:00
abstract:AIMS:To determine whether Ki-67 immunoexpression in penile squamous cell carcinoma (PSCC) has a prognostic value and correlates with lymph node metastasis, human papillomavirus (HPV) infection and patient survival. METHODS:148 formalin-fixed paraffin-embedded PSCC samples were tissue-microarrayed, including 97 usual-t...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2011-200638
更新日期:2012-06-01 00:00:00
abstract::The thyroids of primary thyrotoxicosis patients prepared for partial thyroidectomy with propranolol contained much more lymphoid infiltrate than those prepared with carbimazole. No relation was found between the extent of lymphoid infiltrate in the thyroid and the development of postoperative hypothyroidism either bet...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.29.5.398
更新日期:1976-05-01 00:00:00
abstract::This review of the histomorphometry of bone outlines methods of biopsy and processing of specimens in the laboratory, the basic principles of morphometry, and the measurements made in order to obtain estimates of the proportional volumes and surfaces occupied by different components of bone. Variability such as that b...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.36.12.1323
更新日期:1983-12-01 00:00:00
abstract::Factor VII levels have been measured in 100 patients with liver disease following parenteral vitamin K1 therapy. There was good agreement between specific factor VII measurements and the one-stage prothrombin time apart from six patients with compensated cirrhosis in whom the prothrombin time was prolonged despite the...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.29.11.971
更新日期:1976-11-01 00:00:00
abstract:AIMS:Diffuse large B-cell lymphoma (DLBCL) is an aggressive and potentially fatal disease. Prediction of risk of relapse is based on clinical markers. There is a need for more accurate biomarkers to select patients for more aggressive first-line treatments. Peroxiredoxins (Prxs) are a family of potent antioxidant prote...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2014-202771
更新日期:2015-07-01 00:00:00
abstract::We present the pathological findings in a case of acquired immunodeficiency syndrome (AIDS) in a patient with no known risk factor. Postmortem examination showed klebsiella lung abscess, generalised cytomegalovirus infection, cerebral toxoplasmosis, and a primary cerebral lymphoma. An additional feature was the presen...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.4.471
更新日期:1984-04-01 00:00:00
abstract::An ultramicro electrophoretic technique for the separation of serum lipoproteins is described using agarose gel on microscope slides.The interaction between the agarose gel and lipoproteins has been reduced and the separation between beta- and pre-beta-lipoproteins has been improved over existing methods. A semiquanti...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.24.1.83
更新日期:1971-02-01 00:00:00
abstract::Two isolates of Proteus mirabilis and four of Esch. coli which would not grow on commonly used commercial sensitivity test media are reported. These organisms appear to be resistant to co-trimoxazole, are exacting towards thymidine, and five of six were isolated from patients who had been treated with co-trimoxazole. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.25.12.1086
更新日期:1972-12-01 00:00:00
abstract:BACKGROUND:The TNM classification for renal cell cancer (RCC) should accurately predict and assign prognostic information for patients. In this study the recent 2010 revision to the TNM classification was compared with the previous 2002 classification with regard to survival outcomes. METHODS:All patients having radic...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2011-200468
更新日期:2012-04-01 00:00:00
abstract:AIMS:The histopathological diagnosis of low-grade dysplasia (LGD) in Barrett's oesophagus (BO) is associated with poor interobserver agreement and guidelines dictate expert review. To facilitate nationwide expert review in the Netherlands, a web-based digital review panel has been set up, which currently consists of ei...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-206511
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Breast-conserving surgery currently focuses on improving margin clearance and excision volume, the main pathology report parameters for oncological and cosmetic outcomes. AIM:To quantitatively evaluate discrepancies in surgical and pathological estimates of breast specimen sizes, including the influence of ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jclinpath-2011-200392
更新日期:2012-03-01 00:00:00
abstract::Accurate histopathological assessment of biopsies is important for the diagnosis, subclassification, and management of chronic idiopathic inflammatory bowel disease (IBD). British Society of Gastroenterology (BSG) guidelines for the initial histopathological diagnosis of IBD were published in 1997. Changes since then ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,实务指引
doi:10.1136/jclinpath-2013-201885
更新日期:2013-12-01 00:00:00
abstract::Primary low grade marginal zone B cell lymphoma (MZL) of the breast and localised mammary amyloidosis are exceedingly rare entities. This report describes the case of a woman with long standing Sjögren's syndrome presenting with asymptomatic MZL of the breast showing plasmacytic differentiation, associated with local ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.56.1.74
更新日期:2003-01-01 00:00:00
abstract::The detection of lymphoid cells by routine examination of the urine after renal allotransplantation has proved to be a useful early indication of rejection. In a study of 36 rejection episodes, 20 (56%) were associated with a significant number of lymphocytes in the urine. The incidence was much higher when rejection ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.23.2.99
更新日期:1970-03-01 00:00:00
abstract:AIMS:Hypomethylating agents (HMAs) exhibit clinical efficacy in patients with myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN). This study was performed to assess residual disease status by flow cytometry immunophenotyping (FCI) methods in patients with MDS or MDS/MPN treated w...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2016-203715
更新日期:2016-04-15 00:00:00
abstract::Immunological methods of pregnancy diagnosis using both tanned red cell and latex particles are compared in a series of women (up to the fourteenth week of gestation) and also in negative controls. The tanned red cell test showed slightly more accurate and sensitive results throughout the trial. In 31 samples also sub...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.16.6.590
更新日期:1963-11-01 00:00:00
abstract::Only four cases of tracheopathia osteoplastica have been reported in Britain in the past 110 years. Ten further cases are now reported; in two the diagnosis was made at bronchoscopy. It is suggested that the reputed rarity of the condition in Britain is not the whole picture. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.20.6.814
更新日期:1967-11-01 00:00:00