Abstract:
AIMS:The macroH2A histone variants are epigenetic marks for inactivated chromatin. In this study, we examined the expression of macroH2A2 in anal neoplasm from anal intraepithelial neoplasia (AIN) to anal squamous cell carcinoma (SCC). METHODS:AIN and anal SCC samples were analysed for macroH2A2 expression, HIV and human papilloma virus (HPV). The association of macroH2A2 expression with clinical grade, disease recurrence, overall survival and viral involvement was determined. RESULTS:macroH2A2 was expressed in normal squamous tissue and lower grade AIN (I and II). Expression was lost in 38% of high-grade AIN (III) and 71% of anal SCC (p=0.002). Patients with AIN with macroH2A2-negative lesions showed earlier recurrence than those with macroH2A2-positive neoplasm (p=0.017). With anal SCC, macroH2A2 loss was more prevalent in the HPV-negative tumours. CONCLUSIONS:Loss of histone variant macroH2A2 expression is associated with the progression of anal neoplasm and can be used as a prognostic biomarker for high-grade AIN and SCC.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Hu WH,Miyai K,Sporn JC,Luo L,Wang JY,Cosman B,Ramamoorthy Sdoi
10.1136/jclinpath-2015-203367subject
Has Abstractpub_date
2016-07-01 00:00:00pages
627-31issue
7eissn
0021-9746issn
1472-4146pii
jclinpath-2015-203367journal_volume
69pub_type
杂志文章abstract::Plasma fibronectin concentrations up to 85 mg/100 ml were found in hyperthyroid patients. There was a significant correlation between free thyroxine index and plasma fibronectin values. Hypothyroid patients had low to normal fibronectin concentrations. Parallel decreases of thyroid hormones and plasma fibronectin conc...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.1.64
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.11.1032
更新日期:1992-11-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.024182
更新日期:2005-07-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:2011-11-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
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更新日期:1983-02-01 00:00:00
abstract::During 1971 and 1972, 71 cultures of neisseriae that attacked lactose were received by this laboratory. All strains except one from an eye swab were from the nasopharynx of healthy subjects. Nineteen similar strains from the nasopharynx were isolated in this laboratory. The characteristics of these strains were compar...
journal_title:Journal of clinical pathology
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更新日期:1973-06-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.4.414
更新日期:1981-04-01 00:00:00