Biochemical assessment of acute myocardial ischaemia.

Abstract:

AIMS:To evaluate the efficacy of biochemical parameters in different fluids in the diagnosis of myocardial infarction of different causes, analysed after death. METHODS:The myoglobin concentration and total creatine kinase (CK) and creatine kinase MB isoenzyme (CK-MB) activities were measured in serum, pericardial fluid, and vitreous humour from seven diagnostic groups of cadavers classified according to the severity of myocardial ischaemia and cause of death. Lactate dehydrogenase (LDH) and myosin were measured only in serum and pericardial fluid, and cathepsin D only in pericardial fluid. Routine haematoxylin and eosin and acridine orange staining were used for microscopy studies of heart tissue. RESULTS:In pericardial fluid there were substantial differences between the different groups with respect to CK, CK-MB, and LDH activities and myosin concentrations. The highest values were found in cases with morphological evidence of myocardial ischaemia. CONCLUSIONS:Biochemical parameters, which reach the pericardial fluid via passive diffusion and ultrafiltration due to a pressure gradient, were thus detectable in this fluid earlier than in serum in cases with myocardial ischaemia. These biochemical parameters may be of use for ruling out myocardial ischaemia in those controversial cases in which reliable morphological findings are lacking.

journal_name

J Clin Pathol

authors

Perez-Cárceles MD,Osuna E,Vieira DN,Martínez A,Luna A

doi

10.1136/jcp.48.2.124

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

124-8

issue

2

eissn

0021-9746

issn

1472-4146

journal_volume

48

pub_type

杂志文章
  • Detection of cytomegalovirus by in situ hybridisation and immunohistochemistry using new monoclonal antibody CCH2: a comparison of methods.

    abstract::In situ hybridisation, immunohistochemistry, and morphological analysis for the detection of cytomegalovirus (CMV) were compared in routinely processed tissue sections from a patient with acquired immune deficiency syndrome (AIDS) and widespread CMV infection. Both in situ hybridisation and immunohistochemistry with t...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.41.9.1005

    authors: Niedobitek G,Finn T,Herbst H,Gerdes J,Grillner L,Landqvist M,Wirgart BZ,Stein H

    更新日期:1988-09-01 00:00:00

  • Helicobacter pylori infection in patients with Barrett's oesophagus: a prospective immunohistochemical study.

    abstract::The prevalence of Helicobacter pylori infection in patients with Barrett's oesophagus was studied prospectively. A sensitive immunohistochemical staining of H pylori was performed in oesophageal and gastric biopsies of 73 patients from a surveillance group with this condition. H pylori was detected in 11 cases of Barr...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.49.2.176

    authors: Ricaurte O,Fléjou JF,Vissuzaine C,Goldfain D,Rotenberg A,Cadiot G,Potet F

    更新日期:1996-02-01 00:00:00

  • Serum alanine aminotransferase (ALT) and gamma-glutamyltransferase (gamma-GT) activities in north London blood donors.

    abstract::Serum alanine aminotransferase (ALT) and gamma-glutamyltransferase (gamma-GT) activities were measured in over 2000 north London blood donors. The results were compared with those from the United States. The percentage of the total donor population with ALT activities above 40 IU/l in 1986 was greater than that found ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.40.11.1340

    authors: Mijovic V,Contreras M,Barbara J

    更新日期:1987-11-01 00:00:00

  • Excretion of faecal viruses during the first year of life.

    abstract::Four hundred faecal samples, collected at approximately weekly intervals during the first year of life from nine babies, were examined for the presence of viruses. Only nine (2.3%) samples contained a virus detectable by electron microscopy, and on all but one occasion only one type of virus was present and that in sm...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.33.8.774

    authors: Harbour J,Shipp AP,Waller DK,Higgins PG

    更新日期:1980-08-01 00:00:00

  • Meningitis due to Gemella haemolysans after radiofrequency trigeminal rhizotomy.

    abstract::Meningitis due to Gemella haemolysans developed in a 73 year old woman after thermolysis of the Gasserian ganglion for trigeminal neuralgia. The taxonomy of this organism is discussed, and previous cases of infection are reviewed. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.38.5.558

    authors: Mitchell RG,Teddy PJ

    更新日期:1985-05-01 00:00:00

  • MicroRNA as potential biomarker in HCV-associated diffuse large B-cell lymphoma.

    abstract:AIMS:To identify molecular characteristics to hepatitis C virus (HCV)-associated diffuse large B-cell lymphoma (DLBCL) through a comprehensive miRNAs expression profiling. METHODS:In this study, miRNA profiles were obtained from 37 patients with DLBCLs and 60 patients with reactive lymph nodes, equally distributed acc...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2014-202352

    authors: Augello C,Gianelli U,Savi F,Moro A,Bonoldi E,Gambacorta M,Vaira V,Baldini L,Bosari S

    更新日期:2014-08-01 00:00:00

  • Postoperative changes in platelet adhesiveness.

    abstract::Platelet adhesiveness was measured in patients undergoing operation. With the rotating bulb technique adhesiveness increased steadily to the sixth and ninth days following surgery. The glass bead filter technique demonstrated a marked increase in platelet adhesiveness on the day following operation. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.20.5.708

    authors: Bennett PN

    更新日期:1967-09-01 00:00:00

  • Increased gastric epithelial cell proliferation in Helicobacter pylori associated follicular gastritis.

    abstract:AIMS:An increase in the proliferative state of the gastric epithelium has been attributed to infection with Helicobacter pylori. In order to obtain a more precise estimate of the magnitude of this change, the proliferative state of 17 cases of florid H pylori associated follicular gastritis was examined using the antib...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.49.1.68

    authors: Havard TJ,Sarsfield P,Wotherspoon AC,Steer HW

    更新日期:1996-01-01 00:00:00

  • Fatal pulmonary fibrosis: a post-COVID-19 autopsy case.

    abstract::There is growing evidence of histopathological changes in autopsied individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, data on histopathological changes in autopsied patients with eradicated COVID-19 are limited. We performed an autopsy on a Caucasian female in her 80s, wh...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2020-206879

    authors: Schwensen HF,Borreschmidt LK,Storgaard M,Redsted S,Christensen S,Madsen LB

    更新日期:2020-07-28 00:00:00

  • Mucosal argyrophil endocrine cells in pernicious anaemia and upper gastrointestinal carcinoid tumours.

    abstract::The number and density of argyrophil endocrine cells were morphometrically calculated in gastric fundal mucosal biopsy specimens taken from 64 patients with pernicious anaemia (five with gastric carcinoids, 15 with nodular argyrophil cell hyperplasia, 44 with diffuse argyrophil cell hyperplasia) and from 14 healthy co...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.42.4.371

    authors: Sjöblom SM,Sipponen P,Karonen SL,Järvinen HJ

    更新日期:1989-04-01 00:00:00

  • My approach to pathology of the pituitary gland.

    abstract::The sellar region is the site of a large number of pathological entities arising from the pituitary and adjacent anatomical structures, including brain, blood vessels, nerves and meninges. The surgical pathology of this area requires the accurate identification of neoplastic lesions, including pituitary adenoma and ca...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.2005.031187

    authors: Al-Brahim NY,Asa SL

    更新日期:2006-12-01 00:00:00

  • THE THYMUS IN HEPATIC CIRRHOSIS.

    abstract::A post-mortem examination, in the case of a 34-year-old man dying suddenly from head injuries sustained in a road accident, showed early cirrhosis of the liver and associated splenomegaly 17 years after an attack of infective hepatitis. The histology of the thymus showed abnormal changes in the medulla, consisting of ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.16.5.445

    authors: CORRIDAN M

    更新日期:1963-09-01 00:00:00

  • Histological analysis of parotid and submandibular glands in chronic alcohol abuse: a necropsy study.

    abstract::A quantitative histological analysis of the major salivary glands was carried out at necropsy in 28 alcoholics and in a series of age and sex matched controls. The findings were related to the different types of histologically diagnosed liver disease present. Significant quantitative changes of salivary gland structur...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.41.8.837

    authors: Scott J,Burns J,Flower EA

    更新日期:1988-08-01 00:00:00

  • Ascorbate status and fibrinogen concentrations after cerebrovascular accident.

    abstract::Leucocyte ascorbate (LA) and serum ascorbate (SA) were measured in patients who had sustained an acute cerebrovascular accident. There was a significant fall in LA and Sa within 24 hours of the incident and this persisted for several weeks. The "stress" of the event resulted in a rise in serum cortisol concentration a...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.35.2.195

    authors: Hume R,Vallance BD,Muir MM

    更新日期:1982-02-01 00:00:00

  • Detection of the C protein gene among group B streptococci using PCR.

    abstract:AIM:To develop a polymerase chain reaction (PCR) for the specific detection of the C protein gene in strains of group B Streptococcus. METHODS:A single primer pair derived from the nucleotide sequence of the IgA binding beta antigen of the C protein complex permitted the specific amplification of a 592 base pair DNA f...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.46.7.633

    authors: Mawn JA,Simpson AJ,Heard SR

    更新日期:1993-07-01 00:00:00

  • The value of a study of the mucosubstances in rectal biopsies from patients with carcinoma of the rectum and lower sigmoid in the diagnosis of premalignant mucosa.

    abstract::One hundred and twenty-one rectal biopsies from 99 patients with carcinoma of the rectum or lower sigmoid colon were investigated using a high iron-diamine-Alcian blue technique for sulphated and non-sulphated acid mucins. It was found that in normal rectal mucosa sulphomucins are the main carbohydrate component of th...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.25.2.123

    authors: Filipe MI

    更新日期:1972-02-01 00:00:00

  • Sea blue histiocytosis: a common abnormality of the bone marrow in myelodysplastic syndromes.

    abstract:AIMS:To determine whether myelodysplastic syndromes (MDS) are associated with sea blue histiocytosis in the bone marrow. METHODS:A retrospective review of bone marrow aspirates from 35 patients presenting consecutively with MDS and from 20 patients with each of the following: normal marrow appearance (routine staging ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.46.11.1030

    authors: Howard MR,Kesteven PJ

    更新日期:1993-11-01 00:00:00

  • Is breast specimen shrinkage really a problem in breast-conserving surgery?

    abstract:BACKGROUND:Breast-conserving surgery currently focuses on improving margin clearance and excision volume, the main pathology report parameters for oncological and cosmetic outcomes. AIM:To quantitatively evaluate discrepancies in surgical and pathological estimates of breast specimen sizes, including the influence of ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1136/jclinpath-2011-200392

    authors: Krekel NM,van Slooten HJ,Barbé E,de Lange de Klerk ES,Meijer S,van den Tol MP

    更新日期:2012-03-01 00:00:00

  • Abnormal spiral artery remodelling in the decidual segment during pregnancy: from histology to clinical correlation.

    abstract:INTRODUCTION:Modification of the spiral arteries with loss of the muscular vascular wall, invaded by the trophoblasts, represents the goal of the physiological vascular adaptation during human implantation. When physiological vascular changes do not occur, an unfavourable evolution of gestation may develop as suggested...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2011-200092

    authors: Avagliano L,Bulfamante GP,Morabito A,Marconi AM

    更新日期:2011-12-01 00:00:00

  • Growth of crypt cell nodules in duodenal mucosa in man during organ culture in vitro.

    abstract::Culture of peroral biopsy specimens from duodenal mucosa in vitro for 22 hours using a basic culture medium resulted in the formation of crypt cell nodules. The addition of collagen and serotonin to the culture medium increased the occurrence of the nodules and, invariably, their size. The nodules were situated on the...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.38.12.1388

    authors: Challacombe DN,Wheeler EE

    更新日期:1985-12-01 00:00:00

  • Blind comparison of Abbott and Dupont HIV antigen ELISA tests for detecting antigenaemia in asymptomatic human immunodeficiency virus antibody positive homosexual men.

    abstract::Three hundred and ninety eight serum samples from 270 human immunodeficiency virus (HIV) antibody positive asymptomatic homosexual men were tested in the Abbott and Dupont HIV antigen ELISA tests. In the Abbott test 62 (16%) of the sera were positive, according to the manufacturer's instructions, compared with 55 (14%...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.43.5.420

    authors: Shanson DC,Brown KE,Goonesekera S,Gazzard B,Coates AR

    更新日期:1990-05-01 00:00:00

  • Post-test probability that men in the community with raised plasma ferritin concentrations are hazardous drinkers.

    abstract:BACKGROUND:Raised plasma ferritin concentrations occur unexpectedly during iron studies done by primary care physicians. Plasma ferritin concentration has been positively associated with alcohol use among men. AIM:To determine the post-test probability that men in the community with raised plasma ferritin concentratio...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.52.11.853

    authors: Peach HG,Bath NE

    更新日期:1999-11-01 00:00:00

  • Immunochemical faecal occult blood tests have superior stability and analytical performance characteristics over guaiac-based tests in a controlled in vitro study.

    abstract:AIMS:The aims of this study were (1) to determine the measurement accuracy of a widely used guaiac faecal occult blood test (gFOBT) compared with an immunochemical faecal occult blood test (iFOBT) during in vitro studies, including their analytical stability over time at ambient temperature and at 4°C; and (2) to compa...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2010.085399

    authors: Lee CS,O'Gorman P,Walsh P,Qasim A,McNamara D,O'Morain CA,Boran GP

    更新日期:2011-06-01 00:00:00

  • Accuracy, user-friendliness and usefulness of the Cobas h232 point-of-care test for NT-proBNP in primary care.

    abstract:AIMS:N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been shown to be useful for ruling out heart failure in primary care. In this study, we examined the accuracy of the Cobas h232 point-of-care (POC) instrument in primary care compared with an in-hospital measurement. Furthermore, we investigated the user-fr...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1136/jclinpath-2017-204746

    authors: Hex C,Smeets M,Penders J,Van Hoof V,Verbakel J,Buntinx F,Vaes B

    更新日期:2018-06-01 00:00:00

  • Acquired immunodeficiency syndrome in a patient with no known risk factors: a pathological study.

    abstract::We present the pathological findings in a case of acquired immunodeficiency syndrome (AIDS) in a patient with no known risk factor. Postmortem examination showed klebsiella lung abscess, generalised cytomegalovirus infection, cerebral toxoplasmosis, and a primary cerebral lymphoma. An additional feature was the presen...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.37.4.471

    authors: Burt AD,Scott G,Shiach CR,Isles CG

    更新日期:1984-04-01 00:00:00

  • Intraduct papillary mucinous neoplasm of the pancreas: a tumour linked with IgG4-related disease?

    abstract:OBJECTIVES:Intraduct papillary mucinous neoplasm (IPMN) is a pancreatic tumour that is often associated with chronic pancreatitis (CP) in the surrounding pancreas. Type 1 autoimmune pancreatitis (AIP) is a fibro-inflammatory condition with characteristic histological features and prominent IgG4+ plasma cells and is par...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2013-201516

    authors: Bateman AC,Culver EL,Sommerlad M,Chetty R

    更新日期:2013-08-01 00:00:00

  • Histometry of lymphoid infiltrate in the thyroid of primary thyrotoxicosis patients. Relation of extent of thyroiditis to preoperative drug treatment and postoperative hypothyroidism.

    abstract::The thyroids of primary thyrotoxicosis patients prepared for partial thyroidectomy with propranolol contained much more lymphoid infiltrate than those prepared with carbimazole. No relation was found between the extent of lymphoid infiltrate in the thyroid and the development of postoperative hypothyroidism either bet...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.29.5.398

    authors: Young RJ,Sherwood MB,Simpson JG,Nicol AG,Michie W,Beck JS

    更新日期:1976-05-01 00:00:00

  • Serotyping and the Dienes reaction on Proteus mirabilis from hospital infections.

    abstract::The serotype of 320 strains of Proteus mirabilis from clinical material was determined. Using 20 O antisera and four H antisera 61% of strains could be fully identified and 90% partially identified. A large number of serotypes were recognized but no difference was found between the serotype of organisms infecting the ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.22.3.263

    authors: De Louvois J

    更新日期:1969-05-01 00:00:00

  • Clinicopathological significance of HER2/neu genetic heterogeneity in HER2/neu non-amplified invasive breast carcinomas and its concurrent axillary metastasis.

    abstract:BACKGROUND:HER2/neu (HER2) is a significant prognostic marker for breast carcinomas. Recently, new guidelines defining HER2 genetic heterogeneity (GH) were published by the College of American Pathologists. AIMS:To determine the prevalence of HER2 GH as defined in primary invasive breast carcinoma, to determine its re...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2012-201403

    authors: Shafi H,Astvatsaturyan K,Chung F,Mirocha J,Schmidt M,Bose S

    更新日期:2013-08-01 00:00:00

  • A histochemical comparison of the O-acylated sialic acids of the epithelial mucins in ulcerative colitis, Crohn's disease, and normal controls.

    abstract::Two histochemical techniques, the PAT/KOH/PAS and the PBT/KOH/PAS, were used to investigate the side chain O-acyl substitution patterns of the sialic acids of the colonic epithelial mucins in cases of ulcerative colitis and Crohn's disease. In both diseases there was, as compared to normal, a reduction in the proporti...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.32.12.1272

    authors: Culling CF,Reid PE,Dunn WL

    更新日期:1979-12-01 00:00:00