Recurrent thrombotic occlusions of arteries and veins caused by intravascular metastatic adenocarcinoma.

abstract：AIM:We examined the genetic alterations in a mother and son with multiple eosinophilic chromophobe renal cell carcinomas (chRCCs) showing no other features. METHODS:Germline DNA and bilateral renal cell carcinoma DNA were genetically analysed by whole-exome sequencing. Candidate gene alterations in the first patient's...

journal_title：Journal of clinical pathology

authors： Sakamoto H,Yamasaki T,Sumiyoshi T,Utsunomiya N,Takeda M,Kamba T,Nakamura E,Ogawa O

更新日期：2018-10-01 00:00:00

abstract：AIMS:To investigate a potential diagnostic use of alpha fetoprotein (alpha FP) isoform analysis by lectin affinity electrophoresis to distinguish between endodermal sinus tumours arising in the vagina in infants from those at other sites. METHODS:alpha FP in the serum of a patient with a vaginal endodermal sinus tumou...

journal_title：Journal of clinical pathology

authors： Yamamoto R,Taketa K,Ebina Y,Cho Y,Hareyama H,Sakuragi N,Makinoda S,Kobayashi K,Nishi S,Fujimoto S

更新日期：1997-10-01 00:00:00

abstract：:Liver copper concentrations in percutaneous biopsy specimens were measured by neutron activation analysis and compared with histological staining for copper by rubeanic acid and rhodanine, and with copper-associated protein stained by orcein. Liver copper concentrations were elevated in 31 of 35 biopsies from patients...

journal_title：Journal of clinical pathology

authors： Jain S,Scheuer PJ,Archer B,Newman SP,Sherlock S

更新日期：1978-08-01 00:00:00

abstract：:The prevalence of Helicobacter pylori infection in patients with Barrett's oesophagus was studied prospectively. A sensitive immunohistochemical staining of H pylori was performed in oesophageal and gastric biopsies of 73 patients from a surveillance group with this condition. H pylori was detected in 11 cases of Barr...

journal_title：Journal of clinical pathology

authors： Ricaurte O,Fléjou JF,Vissuzaine C,Goldfain D,Rotenberg A,Cadiot G,Potet F

更新日期：1996-02-01 00:00:00

abstract：AIM:To investigate the natural history of patients with non-alcoholic steatohepatitis by means of a prospective histological study. METHODS:One thousand five hundred and seventy one patients underwent liver biopsy at the Western Infirmary in Glasgow during the 10 year period 1985 to 1994. All biopsies were reported by...

journal_title：Journal of clinical pathology

authors： Evans CD,Oien KA,MacSween RN,Mills PR

更新日期：2002-09-01 00:00:00

abstract：:A 5 month old girl had typical clinical features of acute myocarditis just after the febrile period of exanthem subitum and died immediately. She had been healthy, with normal development, and there was no family history of particular note. Myocardial postmortem findings were compatible with acute myocarditis. Althoug...

journal_title：Journal of clinical pathology

authors： Yoshikawa T,Ihira M,Suzuki K,Suga S,Kito H,Iwasaki T,Kurata T,Tanaka T,Saito Y,Asano Y

更新日期：2001-10-01 00:00:00

abstract：:Here, we report the pathological findings of nine complete autopsies of individuals who died in community settings in the UK, three of which were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), three tested negative for SARS-CoV-2 but are likely false negatives, and three died of other respi...

journal_title：Journal of clinical pathology

authors： Youd E,Moore L

更新日期：2020-12-01 00:00:00

abstract：:Distinctly increased levels of antibodies to measles virus envelope antigens haemolysin and haemagglutinin were found in the sera of patients with chronic active hepatitis compared with a normal control group, using immunofluorescence and functional tests. Similarly, a higher incidence of smooth muscle antibody of bot...

journal_title：Journal of clinical pathology

authors： Shirodaria PV,McMillan SA,Callender ME,Haire M,Fleming E,Merrett JD,Fulton TT

更新日期：1985-11-01 00:00:00

abstract：:A case of chronic neutrophilic leukaemia (CNL) is reported. The diagnosis was based on leucocytosis with mature neutrophils, a raised leucocyte alkaline phosphatase score, negative Philadelphia chromosome, and extensive infiltration of neutrophils in various differentiation stages into the bone marrow. When viewed by ...

journal_title：Journal of clinical pathology

authors： Takemori N,Hirai K,Onodera R,Saito N,Namiki M

更新日期：1994-04-01 00:00:00

abstract：:Melanocytes in melanocytic naevi and melanomas can display great variation. The presence of nuclear pseudoinclusions (NPI) is said to be useful in the histological and cytological differential diagnosis of malignant melanoma. The prevalence and characteristics of NPI in a series of 493 naevi and 50 melanomas are descr...

journal_title：Journal of clinical pathology

authors： Rose DS

更新日期：1995-07-01 00:00:00

abstract：:A method for identifying Helicobacter pylori using a non-isotopic in situ hybridisation technique is described. A probe generated by polymerase chain reaction (PCR) with primers directed against parts of the Helicobacter pylori 16SrRNA sequence was used. Paraffin wax embedded gastric biopsy specimens from patients wit...

journal_title：Journal of clinical pathology

authors： Bashir MS,Lewis FA,Quirke P,Lee A,Dixon MF

更新日期：1994-09-01 00:00:00

abstract：:Tissue microarray (TMA) is an established and valuable tool, particularly in translational research and clinical trials, allowing resource-efficient use, and high-throughput profiling, of large numbers of tumours. Despite this, there is little evidence, or guidance, on the optimum manufacture, use and assessment of TM...

journal_title：Journal of clinical pathology

authors： Pinder SE,Brown JP,Gillett C,Purdie CA,Speirs V,Thompson AM,Shaaban AM,Translational Subgroup of the NCRI Breast Clinical Studies Group.

更新日期：2013-03-01 00:00:00

abstract：:A rapid and reproducible electrophoretic method for the separation and quantitation of haemoglobins on cellulose acetate is described. The accuracy of the method and its possible sources of error are discussed. The normal range for haemoglobin A(2) by this method is 1% to 3% of the total haemoglobin concentration. Blo...

journal_title：Journal of clinical pathology

authors： Marengo-Rowe AJ

更新日期：1965-11-01 00:00:00

abstract：:Sera from 20 cases of toxoplasmic lymphadenopathy were examined by an enzyme linked immunosorbent assay toxoplasma IgG avidity (ELISA) at two laboratories. The results obtained were largely in agreement and showed that sera from patients with acute infection had low avidity IgG (30% or less), whereas sera from patient...

journal_title：Journal of clinical pathology

authors： Joynson DH,Payne RA,Rawal BK

更新日期：1990-12-01 00:00:00

abstract：:The possible use of sodium hypochlorite solution buffered to pH 7.6 and containing 100 ppm available chlorine (avCl) for disinfecting fibrescopes was investigated. A flexible fibrescope experimentally contaminated with Pseudomonas putida, Mycobacterium fortuitum, or Bacillus subtilis spores was effectively disinfected...

journal_title：Journal of clinical pathology

authors： Coates D,Death JE

更新日期：1982-03-01 00:00:00

abstract：:An antibody was raised against a protein isolated from the cytoplasm of mesothelioma cells. It was subsequently used in an immunoperoxidase procedure on formalin fixed, paraffin embedded tissue sections. A representative sample of benign and malignant tumours from all the systems of the human body was examined. All th...

journal_title：Journal of clinical pathology

authors： Donna A,Betta PG,Bellingeri D,Marchesini A

更新日期：1986-09-01 00:00:00

abstract：:The interference of IgM-class rheumatoid factor (RF) in the solid-phase radioimmunoassay (RIA) of rubella virus IgM antibodies was studied. Acute rubella infections did not significantly activate RF. False-positive rubella antibody results were obtained, however, when patients with raised RF levels were tested. If a l...

journal_title：Journal of clinical pathology

authors： Meurman OH,Ziola BR

更新日期：1978-05-01 00:00:00

abstract：AIMS:To develop a strategy for neonatal screening of sickle cell disease (SCD) and effective enrollment of affected neonates in a comprehensive follow-up programme adapted to the socioeconomic conditions, health structures and cultural background of an African setting. METHODS:The strategy implemented at the two large...

journal_title：Journal of clinical pathology

authors： Rahimy MC,Gangbo A,Ahouignan G,Alihonou E

更新日期：2009-01-01 00:00:00

abstract：:As patients with multiple myeloma (MM) have a variable clinical course, predictive markers would help determine the appropriate treatment strategy. Clinical staging is commonly used to predict outcome, but tumour marker expression and the underlying genetic changes are increasingly used to assess the biological aggres...

journal_title：Journal of clinical pathology

authors： Yeung J,Chang H

更新日期：2008-07-01 00:00:00

abstract：:Polymorphous low-grade adenocarcinoma (PLGA) is a rare tumour that mostly affects oral minor salivary glands. Our review of the literature found that there are only two reported cases of PLGA originating in the nasopharynx. Another nasopharyngeal PLGA in a 14-year-old boy is reported, focusing on the histopathological...

journal_title：Journal of clinical pathology

authors： Wei YC,Huang CC,Chien CY,Hwang JC,Chen WJ

更新日期：2008-10-01 00:00:00

abstract：:The T(4)-free thyroxine index was used as the thyroid function test of first choice in a district general hospital for one year. Ninety-two patients were assessed both initially and at follow up by a single physician. The index agreed with clinical assessment in 69 out of 74 patients in whom diagnosis was unequivocal....

journal_title：Journal of clinical pathology

authors： Howorth PJ,Ward RL

更新日期：1972-03-01 00:00:00

abstract：AIMS:It has been suggested that adenocarcinomas of the lower oesophagus and gastric cardia should be reclassified as oesophagogastric junction (OGJ) cancers. This study aimed to define the frequency of OGJ cancers in a geographically defined population of 4.3 million people. METHODS:All cases of oesophageal and gastri...

journal_title：Journal of clinical pathology

authors： Byrne JP,Mathers JM,Parry JM,Attwood SE,Bancewicz J,Woodman CB

更新日期：2002-03-01 00:00:00

abstract：AIMS:To investigate the occurrence of abnormal patterns of HLA-ABC and HLA-DR expression in enteropathy associated T cell lymphoma and to relate such abnormalities to the Epstein Barr virus (EBV) status of the tumours. METHODS:Eleven enteropathy associated T cell lymphomas were immunostained with HC10 (HLA-ABC heavy c...

journal_title：Journal of clinical pathology

authors： Ashton-Key M,Singh N,Pan LX,Smith ME

更新日期：1996-07-01 00:00:00

abstract：:KRAS mutation status predicts response to anti-EGFR therapy in colorectal cancer patients. Here we report an interesting case of discordant KRAS mutation status in a patient with two separate tumour foci. Tumour A in sigmoid colon invaded through muscularis propria into the subserosal fat with metastatic disease in re...

journal_title：Journal of clinical pathology

authors： Li X,Pezeshkpour G,Phan RT

更新日期：2015-01-01 00:00:00

abstract：:In October 1859, 'The Queen of Hearts' was published by Wilkie Collins. This book is a collection of 10 short stories written by the protagonists (three retired brothers), in order to keep their niece (aka the queen of hearts) entertained, until the arrival of her fiancé-to-be. The second story of the book, titled 'Br...

journal_title：Journal of clinical pathology

authors： Fernandez-Flores A

更新日期：2011-02-01 00:00:00

abstract：:A 43-year-old man, admitted with a swollen right thigh, was diagnosed with a deep vein thrombosis. On day 6 he became septic. A CT scan demonstrated a right-sided hydronephrosis and a large retroperitoneal collection. Blood cultures and perinephric pus grew Escherichia coli resistant to amoxicillin only. On day 12 a v...

journal_title：Journal of clinical pathology

authors： Alleyne SA,Bukhari SS,Fraser M,Spiers P

更新日期：2010-04-01 00:00:00

abstract：AIMS:To assess the frequency and cause of incidental (non-metastatic) lymph node pathology discovered before or at radical prostatectomy. METHODS:Eight hundred and fifty four consecutive lymphadenectomies received between 1988 and 2001 were reviewed. All had been processed and stained routinely. Additional techniques,...

journal_title：Journal of clinical pathology

authors： Winstanley AM,Sandison A,Bott SR,Dogan A,Parkinson MC

更新日期：2002-08-01 00:00:00

abstract：:TLE 1 is the human homologue belonging to a family of four genes and is located on chromosome 9q21. It consists of 19 exons. Although it does not bind directly to DNA, it acts as a repressor of several signalling pathways via transcription factors. TLE1 protein has several physiological roles in embryogenesis, haemato...

journal_title：Journal of clinical pathology

authors： Pinto K,Chetty R

更新日期：2021-01-13 00:00:00

abstract：:The mechanism of DNA degradation and its clinical applications were examined. When purified lambda phage and extracted liver DNA were fixed in phosphate buffered formaldehyde, the DNA did not degrade, but there was incomplete digestion with endonuclease. Rat liver tissues were fixed under various conditions and DNA ex...

journal_title：Journal of clinical pathology

authors： Tokuda Y,Nakamura T,Satonaka K,Maeda S,Doi K,Baba S,Sugiyama T

更新日期：1990-09-01 00:00:00

abstract：:Specimens from 95 patients attending a venereal diseases clinic were examined for gonococci by three methods--a conventional culture technique using modified Thayer-Martin medium, microscopy of a Gram-stained direct smear, and the Microcult system. For 56% of the specimens the results by all three methods agreed. Assu...

journal_title：Journal of clinical pathology

authors： Williams RJ,Ratnatunga CS,Hamilton-Miller JM,Brumfitt W

更新日期：1978-03-01 00:00:00