Abstract:
:A 5 month old girl had typical clinical features of acute myocarditis just after the febrile period of exanthem subitum and died immediately. She had been healthy, with normal development, and there was no family history of particular note. Myocardial postmortem findings were compatible with acute myocarditis. Although the isolation of human herpesvirus 6 (HHV-6) was not attempted, positive IgM antibody to HHV-6 was detected in the patient's serum. Moreover, HHV-6 variant B DNA was detected in several tissues, including myocardium, by the polymerase chain reaction (PCR). In contrast, antibody responses to human herpesvirus 7, another causal agent of exanthem subitum, were not found, and enteroviral RNA was not detected in myocardial tissues by reverse transcription PCR. Apoptotic changes were seen in infiltrating cells within the myocardial tissues by means of the TUNEL method. HHV-6 antigen was not detected in several tissues (including myocardium) by immunohistochemical analysis. In conclusion, HHV-6 may have been the causative agent of fatal acute myocarditis in this infant.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Yoshikawa T,Ihira M,Suzuki K,Suga S,Kito H,Iwasaki T,Kurata T,Tanaka T,Saito Y,Asano Ydoi
10.1136/jcp.54.10.792keywords:
subject
Has Abstractpub_date
2001-10-01 00:00:00pages
792-5issue
10eissn
0021-9746issn
1472-4146journal_volume
54pub_type
杂志文章,评审abstract::A sensitive gas chromatography-mass spectrometric method was used to measure the generation in whole blood of leukotriene B4 (LTB4), a potent stimulator of neutrophil chemotaxis, in eight patients with chronic granulocytic leukaemia (CGL) and 12 healthy controls. LTB4 was detectable in unstimulated samples from all th...
journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:2004-01-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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pub_type: 临床试验,杂志文章
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:1998-06-01 00:00:00
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journal_title:Journal of clinical pathology
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更新日期:2011-05-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:2012-04-01 00:00:00
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更新日期:1986-10-01 00:00:00
abstract:OBJECTIVE:To compare the whole genomes sequencing (WGS) results in the 100K Genomes project with the results of routine molecular diagnostics in precision medicine. MATERIALS AND METHODS:We analysed 374 cancers including a high tumour mutational burden (TMB-high) subgroup, defined as >10 non-synonymous single nucleoti...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-206998
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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journal_title:Journal of clinical pathology
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doi:10.1136/jcp.36.9.1028
更新日期:1983-09-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:1966-07-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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