COVID-19 autopsy in people who died in community settings: the first series.

Abstract:

:Here, we report the pathological findings of nine complete autopsies of individuals who died in community settings in the UK, three of which were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), three tested negative for SARS-CoV-2 but are likely false negatives, and three died of other respiratory infections. Autopsy revealed firm, consolidated lungs or lobar pneumonia. Histology of the lungs showed changes of diffuse alveolar damage with fibrin membrane formation, thickened alveolar walls and interstitium with lymphocytic infiltrate, and type 2 pneumocyte hyperplasia with shedding into the alveolar space. This series is the first in the world to describe autopsy findings in individuals dying suddenly in the community, not previously known to have COVID-19 infection, and the first autopsy series in the UK. During a time when testing in the UK is currently primarily offered to patients in hospital or symptomatic key workers, with limited testing available in community settings, it highlights the importance of testing for COVID-19 at autopsy. Two deaths occurred in care homes where a diagnosis of COVID-19 allowed the health protection team to provide support in that 'closed setting' to reduce the risks of onward transmission. This work highlights the need for frequent COVID-19 testing in the management of patients in community settings. Comprehensive virology and microbiology assessment is pivotal to correctly identify the cause of death, including those due to COVID-19 infection, and to derive accurate death statistics.

journal_name

J Clin Pathol

authors

Youd E,Moore L

doi

10.1136/jclinpath-2020-206710

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

840-844

issue

12

eissn

0021-9746

issn

1472-4146

pii

jclinpath-2020-206710

journal_volume

73

pub_type

杂志文章
  • Evaluation of five commercial kits to detect dsDNA antibodies.

    abstract::Experiments were performed to evaluate five commercial kit assays used for the detection of antibodies to dsDNA. The kits were compared using a performance index score as recommended by the guidelines of the European Committee for Clinical Laboratory Standards. The highest performance score was obtained using the radi...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.41.11.1223

    authors: McMillan SA,Fay AC

    更新日期:1988-11-01 00:00:00

  • Fatal head injury in children.

    abstract::A comprehensive neuropathological study was undertaken on 87 children aged between 2 and 15 years with fatal head injuries to identify those features which occurred at the time of head injury (fractured skull, contusions, intracranial haematoma and diffuse axonal injury) and those which were subsequently produced by c...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.42.1.18

    authors: Graham DI,Ford I,Adams JH,Doyle D,Lawrence AE,McLellan DR,Ng HK

    更新日期:1989-01-01 00:00:00

  • Best practice in primary care pathology: review 14.

    abstract::This 14th best practice review is the second of a pair that examines tumour marker requesting primary care situations. This review considers carbohydrate antigen 125, α-fetoprotein and human chorionic gonadotropin. It is presented in question-answer format, referenced for each question. The recommendations represent a...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jclinpath-2011-200293

    authors: Cabrera-Abreu JC,Smellie WS,Bowley R,Shaw N

    更新日期:2012-02-01 00:00:00

  • Bacteriocine typing of Proteus.

    abstract::A method of typing isolates of Proteus mirabilis and Proteus vulgaris is described based on the sensitivity of the organisms to bacteriocine. Twelve standard proteocine producing strains were selected from a large number of isolates tested, and from these liquid proteocine preparations were prepared. The sensitivities...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.28.10.784

    authors: Al-Jumaili IJ

    更新日期:1975-10-01 00:00:00

  • Thymidine phosphorylase expression in progression of cervical cancer: correlation with microvessel count, proliferating cell nuclear antigen, and apoptosis.

    abstract:AIMS:To determine how epithelial and stromal thymidine phosphorylase expression affects angiogenesis, rapid tumour growth, and decreased apoptotic activity in cervical cancer at varying stages of progression. METHODS:Epithelial and stromal thymidine phosphorylase expression, the microvessel count (reflected by factor ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.52.8.598

    authors: Fujiwaki R,Hata K,Iida K,Maede Y,Koike M,Miyazaki K

    更新日期:1999-08-01 00:00:00

  • The pathology of placenta accreta, a worldwide epidemic.

    abstract::The incidence of placenta accreta, defined as the abnormal adherence of the placenta to the uterine wall, has been increasing alarmingly in the developed as well as the developing world. There is considerable maternal morbidity and mortality related to the condition. The pathophysiology focuses on the balance between ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.2008.055202

    authors: Khong TY

    更新日期:2008-12-01 00:00:00

  • Diagnosis of metastases from testicular germ cell tumours using fine needle aspiration cytology.

    abstract::The cytological features of testicular germ cell tumours were established in smears from 15 freshly resected tumours. These features were applied to the fine needle aspiration cytology diagnosis of metastases in 27 patients referred for chemotherapy. There were 16 positive reports in 32 aspirates of which 13 were take...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.40.11.1324

    authors: Highman WJ,Oliver RT

    更新日期:1987-11-01 00:00:00

  • Dose response relationships and interference of simultaneous skin tests in delayed hypersensitivity.

    abstract::The relationship between the intensity of the delayed hypersensitivity reaction and the dose of antigen used for its elicitation change with time after sensitization. At three weeks the reactions to 100 mug of egg albumen were little different from those to 1 mug but at 14 weeks 100 mug gave much stronger reactions. T...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.26.9.687

    authors: Jokipii AM,Jokipii L

    更新日期:1973-09-01 00:00:00

  • Reduced expression of alpha-catenin, beta-catenin, and gamma-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer.

    abstract:AIMS:To investigate the expression of catenins (alpha, beta, and gamma) in non-small cell lung carcinoma (NSCLC) and its relation to clinicopathological factors and prognosis. METHODS:The expression of catenins was analysed immunohistochemically in 261 patients with resected NSCLC, diagnosed between 1978 and 1996 in e...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.54.5.391

    authors: Pirinen RT,Hirvikoski P,Johansson RT,Hollmén S,Kosma VM

    更新日期:2001-05-01 00:00:00

  • An automated microbiological method for the measurement of vitamin B12.

    abstract::An automated method for the microbiological assay of vitamin B(12) is described. A chloramphenicol-resistant strain of Lactobacillus leichmannii is used as the test organism and this eliminates the need for sterilization or aseptic addition. Precipitation of the serum protein is avoided by dilution of the serum with a...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.26.7.494

    authors: Davis RE,Moulton J,Kelly A

    更新日期:1973-07-01 00:00:00

  • Production of freeze-dried human antihaemophilic cryoprecipitate.

    abstract::Concentration of factor VIII from fresh plasma by cryoprecipitation remains the basis for preparation of products used to treat haemophilia A. This paper describes the preparation of a factor VIII concentrate from small plasma pools in transfusion centres with drying facilities. The dried concentrate from one litre of...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.34.10.1091

    authors: Millgan G,Graham R,Hanratty S,Muir W,Mitchell R

    更新日期:1981-10-01 00:00:00

  • Tuberous sclerosis: unusual associations in four cases.

    abstract::Tuberous sclerosis is a rare disease with classic primary or secondary changes affecting mainly the cerebrum, skin, kidneys, and heart. Such lesions are generally hamartomatous and thus display malignant features only in rare cases. This paper describes four cases of tuberous sclerosis which were unique in their assoc...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.37.3.272

    authors: Ilgren EB,Westmoreland D

    更新日期:1984-03-01 00:00:00

  • Rate nephelometric determination of rheumatoid factor: comparison between Kallestad QM-300 and Beckman ICS-II (RF) methods.

    abstract::The Kallestad Corporation recently suggested that their new buffer system for the nephelometric detection of rheumatoid factor conferred advantages over existing systems. Two rate nephelometric procedures, the Kallestad QM-300 and the Beckman ICS-II (RF), were therefore compared. Sera (n = 157) were selected on the ba...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.43.3.243

    authors: Collins RJ,Neil JC,Wilson RJ

    更新日期:1990-03-01 00:00:00

  • Lipoprotein composition and serum Lp(a) lipoprotein in hypobetalipoproteinaemia.

    abstract::A family with hypobetalipoproteinaemia was studied to examine the Lp(a) lipoprotein, lipoprotein cholesterol, and triglyceride composition of the serum lipids. Lp(a) lipoprotein was measured by immunoassay. Serum lipoproteins were separated by ultracentrifugation. Cholesterol and triglycerides were measured using stan...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.48.6.587

    authors: Crook M,Swaminathan R

    更新日期:1995-06-01 00:00:00

  • Gene of the month: TMPRSS2 (transmembrane serine protease 2).

    abstract::Transmembrane serine protease 2 is encoded by the TMPRSS2 gene. The gene is widely conserved and has two isoforms, both being autocatalytically activated from the inactive zymogen form. A fusion gene between the TMPRSS2 gene and ERG (erythroblast-specific-related gene), an oncogenic transcription factor, is the most c...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jclinpath-2020-206987

    authors: Thunders M,Delahunt B

    更新日期:2020-12-01 00:00:00

  • Use of morphometry in cytological preparations for diagnosing follicular non-Hodgkin's lymphomas.

    abstract::Morphometric techniques were applied to cytocentrifuge smears from 27 patients with histologically confirmed follicular non-Hodgkin's lymphoma to determine the usefulness of this method in diagnosis. Analysis of quantitative data confirmed that most subtypes were classified correctly on the basis of the proportion of ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.41.4.370

    authors: Stevens MW,Crowley KS,Fazzalari NL,Woods AE

    更新日期:1988-04-01 00:00:00

  • Effect of new plastics and leucocyte contamination on in vitro storage of platelet concentrates.

    abstract::Platelet concentrates were prepared for in vitro storage in either Fenwal PL-732 or Cutter CLX platelet packs. The units were stored at 22 degrees C for seven days with either horizontal or tumbler agitation. Measurement of pH, hypotonic shock response and serotonin uptake indicated in vitro viability was well maintai...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.36.12.1382

    authors: Taylor MA,Tandy NP,Fraser ID

    更新日期:1983-12-01 00:00:00

  • Lectin affinity electrophoresis in a yolk sac tumour in the vagina with yolk sac tumour-type glycoform of alpha fetoprotein.

    abstract:AIMS:To investigate a potential diagnostic use of alpha fetoprotein (alpha FP) isoform analysis by lectin affinity electrophoresis to distinguish between endodermal sinus tumours arising in the vagina in infants from those at other sites. METHODS:alpha FP in the serum of a patient with a vaginal endodermal sinus tumou...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.50.10.856

    authors: Yamamoto R,Taketa K,Ebina Y,Cho Y,Hareyama H,Sakuragi N,Makinoda S,Kobayashi K,Nishi S,Fujimoto S

    更新日期:1997-10-01 00:00:00

  • Simultaneous in situ hybridisation of native mRNA and immunoglobulin detection by conventional immunofluorescence in paraffin wax embedded sections.

    abstract:AIMS:The development of a technique for simultaneous in situ hybridisation for native mRNA and conventional immunofluorescence for cytoplasmic antigens in routine pathology specimens. METHODS:Cocktails of synthetic deoxyoligonucleotides coding for immunoglobulin J chain and kappa light chain were 3' end labelled enzym...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.45.2.114

    authors: Harper SJ,Pringle JH,Gillies A,Allen AC,Layward L,Feehally J,Lauder I

    更新日期:1992-02-01 00:00:00

  • Severe cutaneous reactions to captopril and enalapril; histological study and comparison with early mycosis fungoides.

    abstract::A severe non-dose related skin eruption attributable to treatment with captopril was recently reported: this is distinct from the dose related rashes that have been widely described. Ultrastructural and immunohistochemical studies were carried out to determine in detail the histological features of this eruption: the ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.39.8.902

    authors: Furness PN,Goodfield MJ,MacLennan KA,Stevens A,Millard LG

    更新日期:1986-08-01 00:00:00

  • Microsatellite instability and gastric non-invasive neoplasia in a high risk population in Cesena, Italy.

    abstract:BACKGROUND/AIMS:In the natural history of gastric cancer, non-invasive neoplasia (NiN) precedes invasive carcinoma. A histological classification of gastric NiN has recently been proposed by a World Health Organisation international panel of experts. Genetic instability is known to be among the molecular pathways invol...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.2004.025676

    authors: Rugge M,Bersani G,Bertorelle R,Pennelli G,Russo VM,Farinati F,Bartolini D,Cassaro M,Alvisi V

    更新日期:2005-08-01 00:00:00

  • Serum CagA antibodies in asymptomatic subjects and patients with peptic ulcer: lack of correlation of IgG antibody in patients with peptic ulcer or asymptomatic Helicobacter pylori gastritis.

    abstract:AIM/BACKGROUND:Several studies have suggested that Helicobacter pylori which express CagA may be more virulent than those that do not, but limited populations have been studied to date. The aim of this study was to confirm and extend the association of CagA positive H pylori strains in a different geographical area and...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.49.10.829

    authors: Graham DY,Genta RM,Graham DP,Crabtree JE

    更新日期:1996-10-01 00:00:00

  • Diagnosis of human toxocariasis by antigen capture enzyme linked immunosorbent assay.

    abstract:AIMS:To evaluate an antigen capture enzyme linked immunosorbent assay (ELISA) which detects a carbohydrate epitope on the excretory-secretory (ES) antigens of Toxocara canis in clinical practice. METHODS:Serum specimens from healthy adults, patients with acute visceral larva migrans, ocular and inactive toxocariasis, ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.46.6.551

    authors: Gillespie SH,Bidwell D,Voller A,Robertson BD,Maizels RM

    更新日期:1993-06-01 00:00:00

  • Haematological features of primary myelodysplastic syndromes (PMDS) at initial presentation: a study of 118 cases.

    abstract::The haematological features of 118 cases of primary myelodysplastic syndromes (PMDS) were reviewed to see how these could be related and classified according to the recent FAB proposals. A majority of the cases were elderly who presented with a macrocytic or normocytic anaemia and reticulocytopenia. Cases of acquired ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.36.10.1129

    authors: Juneja SK,Imbert M,Jouault H,Scoazec JY,Sigaux F,Sultan C

    更新日期:1983-10-01 00:00:00

  • Epigenomic profiling in polycythaemia vera and essential thrombocythaemia shows low levels of aberrant DNA methylation.

    abstract:AIMS:The purpose of this study was to compare the DNA-methylation signature in classic chronic Philadelphia negative myeloproliferative neoplasms (MPN), polycythaemia vera (PV) and essential thrombocythaemia (ET), in order to obtain a global insight into DNA-methylation changes associated with these malignancies. METH...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2011-200175

    authors: Barrio S,Gallardo M,Albizua E,Jimenez A,Rapado I,Ayala R,Gilsanz F,Martin-Subero JI,Martinez-Lopez J

    更新日期:2011-11-01 00:00:00

  • The problem of the demonstration of hepatitis B antigen in faeces and bile.

    abstract::Attempts to detect hepatitis B antigen in faeces and bile should take into account the degradation and disappearance of the surface antigens in an environment containing proteolytic enzymes in the presence of bile salts as in the intestinal lumen. The cores of the Dane particles are much more stable than the surface a...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.27.9.693

    authors: Moodie JW,Stannard LM,Kipps A

    更新日期:1974-09-01 00:00:00

  • An immunohistochemical study of branchial cysts.

    abstract::Twenty five specimens of branchial cyst from the same number of patients have been examined. On staining with haematoxylin and eosin a consistent finding was that the mural lymphoid follicles were always aligned with their mantle zones towards the luminal epithelium. With conventional staining lymphatic sinuses were n...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.38.7.784

    authors: Crocker J,Jenkins R

    更新日期:1985-07-01 00:00:00

  • Expression of laminin in benign and malignant sclerosing lesions of extrahepatic bile ducts.

    abstract::The distribution of laminin, a basement membrane glycoprotein, was studied by an immunohistochemical technique in six samples of benign sclerosing lesions of extrahepatic bile ducts and in 11 sclerosing cholangiocarcinomas. The expression of laminin showed that benign glandular structures were surrounded by a mainly i...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.42.9.927

    authors: Haglund C,Roberts PJ,Nordling S

    更新日期:1989-09-01 00:00:00

  • Diagnosis of invasive candidiasis in patients with and without signs of immune deficiency: a comparison of six detection methods in human serum.

    abstract::Visceral candidiasis in 56 patients, 39 of whom were thought to be immune deficient, was investigated using three serological detection methods--whole cell agglutination, haemagglutination, and counterimmunoelectrophoresis for antibodies; two determinations of circulating antigens--haemagglutination inhibition and lat...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.40.10.1162

    authors: Platenkamp GJ,Van Duin AM,Porsius JC,Schouten HJ,Zondervan PE,Michel MF

    更新日期:1987-10-01 00:00:00

  • Erythrocyte radiolabelling: in vitro comparison of chromium, technetium, and indium in undamaged and heat damaged cells.

    abstract::The stability of the commonly used red cell radio labels chromium-51, indium-(111 or 113m), and technetium-99m, within intact red cells and stroma and their distribution within the cell were compared in undamaged and heat damaged red cells in relation to the clinical use of heat damaged cells in the assessment of sple...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.39.7.717

    authors: Peters AM,Osman S,Reavy HJ,Chambers B,Deenmamode M,Lewis SM

    更新日期:1986-07-01 00:00:00