Rosette inhibition test in chronic liver disease.

Abstract:

:A role has recently been assigned to cell-mediated immunity in chronic liver diseases in addition to the well-known alterations of humoral immunity. We now report the results of the rosette inhibition test for the evaluation of T-lymphocyte "sensitization" in patients with different chronic liver disorders. A cell-mediated immune reaction was found in 81% of patients with chronic active hepatitis and in 71% with primary biliary cirrhosis, whereas patients with chronic persistent hepatitis showed no reaction. The correlation with the incidence of hepatitis B antigen showed that T-lymphocyte sensitization was more frequent in the group of HB-positive patients. Finally, improvement of the test was observed in four out of nine patients given immunosuppressive treatment.

journal_name

J Clin Pathol

authors

Salerno F,Fargion SR,Cappellini MD,Fiorelli G,Dioguardi N

doi

10.1136/jcp.29.9.778

keywords:

subject

Has Abstract

pub_date

1976-09-01 00:00:00

pages

778-81

issue

9

eissn

0021-9746

issn

1472-4146

journal_volume

29

pub_type

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