The value of a study of the mucosubstances in rectal biopsies from patients with carcinoma of the rectum and lower sigmoid in the diagnosis of premalignant mucosa.

abstract：BACKGROUND:The mitogenic kinin peptides formed by the serine protease, tissue kallikrein (TK1), stimulate the proliferation of tumour cells and, by increasing vascular permeability, enhance metastasis. Oesophageal mucosal epithelial cells are derived from the epithelial cell germ layer, which expresses the kallikrein-k...

journal_title：Journal of clinical pathology

authors： Dlamini Z,Bhoola KD

更新日期：2005-09-01 00:00:00

abstract：AIMS:In the time of COVID-19, predictive molecular pathology laboratories must still timely select oncological patients for targeted treatments. However, the need to respect social distancing measures may delay results generated by laboratory-developed tests based on sequential steps a long hands-on time. Laboratory wo...

journal_title：Journal of clinical pathology

authors： Malapelle U,De Luca C,Iaccarino A,Pepe F,Pisapia P,Russo M,Sgariglia R,Nacchio M,Vigliar E,Bellevicine C,Schmitt FC,Troncone G

更新日期：2020-05-19 00:00:00

abstract：:There is growing evidence of histopathological changes in autopsied individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, data on histopathological changes in autopsied patients with eradicated COVID-19 are limited. We performed an autopsy on a Caucasian female in her 80s, wh...

journal_title：Journal of clinical pathology

authors： Schwensen HF,Borreschmidt LK,Storgaard M,Redsted S,Christensen S,Madsen LB

更新日期：2020-07-28 00:00:00

abstract：:As part of a study to establish the prevalence of renal calculus disease, alkaline phosphatase activity was measured by the method recommended by the Scandinavian Society for Clinical Chemistry and Clinical Physiology in the plasma of 3823 adults from the Scottish new town of Cumbernauld. The enzyme activity differs i...

journal_title：Journal of clinical pathology

authors： Gardner MD,Scott R

更新日期：1978-12-01 00:00:00

abstract：:A case of combined squamous and intestinal metaplasia of the renal pelvis, associated with hydronephrosis, chronic pyelonephritis, and lithiasis, is reported. The changes are considered to be due primarily to mechanical irritation of the pelvic epithelium. ...

journal_title：Journal of clinical pathology

authors： Salm R

更新日期：1969-03-01 00:00:00

abstract：AIM:To establish whether infection with Epstein-Barr virus (EBV) contributed to the development of coronary artery lesions in a six year old child with an aneurysm and stenoses of the coronary arteries and suspected Kawasaki disease. METHODS:Postmortem paraffin wax sections of the coronary artery and myocardium were e...

journal_title：Journal of clinical pathology

authors： Culora GA,Moore IE

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Fibrinogen plays a crucial role in the pathophysiology of tumour cell growth, invasion and metastasis. The aim of this study was to evaluate the prognostic significance of pretreatment plasma fibrinogen levels in patients with diffuse large B cell lymphoma (DLBCL) METHODS: Data from 372 patients with DLBCL, ...

journal_title：Journal of clinical pathology

authors： Troppan KT,Melchardt T,Wenzl K,Schlick K,Deutsch A,Bullock MD,Reitz D,Beham-Schmid C,Weiss L,Neureiter D,Tränkenschuh W,Greil R,Neumeister P,Egle A,Pichler M

更新日期：2016-04-01 00:00:00

abstract：:The excretion of 2,3-dinor-6-keto prostaglandin F1 alpha, a major urinary metabolite of prostacyclin, and the formation of thromboxane B2, a stable metabolite of thromboxane A2, by platelets stimulated by adenosine diphosphate, were studied in alcoholics, who had been admitted for detoxification. Once prolonged heavy ...

journal_title：Journal of clinical pathology

authors： Neiman J,Hillbom M,Benthin G,Anggård EE

更新日期：1987-05-01 00:00:00

abstract：:Two patients are reported in whom initial misdiagnoses of medullary cancer or trabecular hyaline adenoma for papillary carcinoma were made. ...

journal_title：Journal of clinical pathology

authors： Andrew AC,Williamson JM

更新日期：1993-08-01 00:00:00

abstract：:Of 22 patients with Kaposi's sarcoma, 16 had the acquired immune deficiency syndrome (AIDS). The histological pattern in AIDS differs from the more familiar classical Kaposi's sarcoma. The features most useful in making the diagnosis are: dissection of collagen; lymphatic vessel like spaces; angiomatoid lesions; premo...

journal_title：Journal of clinical pathology

authors： Francis ND,Parkin JM,Weber J,Boylston AW

更新日期：1986-05-01 00:00:00

abstract：AIMS:To investigate whether increasing the daily baseline of gut calcium can cause a gradual downregulation of the active intestinal transport of calcium via reduced parathyroid hormone (PTH) mediated activation of vitamin D, and to discuss why such a mechanism might prevent calcium oxalate rich stones. To demonstrate ...

journal_title：Journal of clinical pathology

authors： Williams CP,Child DF,Hudson PR,Davies GK,Davies MG,John R,Anandaram PS,De Bolla AR

更新日期：2001-01-01 00:00:00

abstract：:Although Neisseria species other than N gonorrhoeae and N meningitidis normally comprise part of the commensal bacterial flora of the oropharynx, they may occasionally act as opportunistic pathogens. Infections in which these organisms have been implicated include cases of endocarditis, meningitis, septicaemia, otitis...

journal_title：Journal of clinical pathology

authors： Johnson AP

更新日期：1983-02-01 00:00:00

abstract：AIMS:Next Generation Sequencing (NGS)-based BRCA tumour tissue testing poses several challenges. As a first step of its implementation within a regional health service network, an in-house validation study was compared with published recommendations. METHODS:Epithelial ovarian cancer (EOC) formalin-fixed paraffin-embe...

journal_title：Journal of clinical pathology

authors： Rivera D,Paudice M,Gismondi V,Anselmi G,Vellone VG,Varesco L,Ligurian BRCA Working Group.

更新日期：2020-09-07 00:00:00

abstract：:The results of a histological study of normal osteoid tissue in man, the monkey, the dog, and the rat, using thin microtome sections of plastic-embedded undecalcified bone, are described. Osteoid tissue covers the entire bone surface, except for areas of active resorption, although the thickness of the layer of osteoi...

journal_title：Journal of clinical pathology

authors： Raina V

更新日期：1972-03-01 00:00:00

abstract：AIMS:It has been suggested that adenocarcinomas of the lower oesophagus and gastric cardia should be reclassified as oesophagogastric junction (OGJ) cancers. This study aimed to define the frequency of OGJ cancers in a geographically defined population of 4.3 million people. METHODS:All cases of oesophageal and gastri...

journal_title：Journal of clinical pathology

authors： Byrne JP,Mathers JM,Parry JM,Attwood SE,Bancewicz J,Woodman CB

更新日期：2002-03-01 00:00:00

abstract：:A quantitative histological analysis of the major salivary glands was carried out at necropsy in 28 alcoholics and in a series of age and sex matched controls. The findings were related to the different types of histologically diagnosed liver disease present. Significant quantitative changes of salivary gland structur...

journal_title：Journal of clinical pathology

authors： Scott J,Burns J,Flower EA

更新日期：1988-08-01 00:00:00

abstract：:A Cyto-Tek staining machine designed for Papanicolau staining of cervical smears has been adapted for auramine staining of smears of sputum and other clinical specimens for acid-fast bacilli. The results compared favourably with those obtained by a manual method of staining. Contamination of negative smears by acid-fa...

journal_title：Journal of clinical pathology

authors： Heimer GV,Joseph N,Taylor CE

更新日期：1978-02-01 00:00:00

abstract：:The cytological features of testicular germ cell tumours were established in smears from 15 freshly resected tumours. These features were applied to the fine needle aspiration cytology diagnosis of metastases in 27 patients referred for chemotherapy. There were 16 positive reports in 32 aspirates of which 13 were take...

journal_title：Journal of clinical pathology

authors： Highman WJ,Oliver RT

更新日期：1987-11-01 00:00:00

abstract：:The possible use of sodium hypochlorite solution buffered to pH 7.6 and containing 100 ppm available chlorine (avCl) for disinfecting fibrescopes was investigated. A flexible fibrescope experimentally contaminated with Pseudomonas putida, Mycobacterium fortuitum, or Bacillus subtilis spores was effectively disinfected...

journal_title：Journal of clinical pathology

authors： Coates D,Death JE

更新日期：1982-03-01 00:00:00

abstract：:Sera obtained from 34 men with Chlamydia trachomatis positive non-gonococcal urethritis, 34 men with C trachomatis negative non-gonococcal urethritis, 42 women with acute salpingitis, 38 healthy women, and 34 healthy men were studied for the presence of specific serum C trachomatis IgA and IgG antibodies. Serological ...

journal_title：Journal of clinical pathology

authors： Cevenini R,Sarov I,Rumpianesi F,Donati M,Melega C,Varotti C,La Placa M

更新日期：1984-06-01 00:00:00

abstract：:It was shown that, on average, the titres of the sera obtained by both the anti-complement immunofluorescence (ACIF) and indirect immunofluorescence for viral late antigens (IFA-LA) procedures were approximately eight times higher than those obtained by complement fixation. There was no significant difference between ...

journal_title：Journal of clinical pathology

authors： Griffiths PD,Buie KJ,Heath RB

更新日期：1978-09-01 00:00:00

abstract：AIM:To assess the reliability of local international normalised ratios (INR) using a set of three international reference preparation (IRP) certified freeze dried plasmas. METHODS:55 centres in the United Kingdom and the Republic of Ireland participated; 36 centres employed coagulometers and 19 a manual prothrombin ti...

journal_title：Journal of clinical pathology

authors： Poller L

更新日期：1998-05-01 00:00:00

abstract：:Ten patients with severe megaloblastic anaemia were studied to investigate whether the causative metabolic defects might predispose them to lactic or other acidosis. One patient had compensated acidosis with hyperlactataemia before treatment but there were obvious causes other than anaemia. No other patient developed ...

journal_title：Journal of clinical pathology

authors： Franklin IM,Kernoff PB,Isherwood D,Leek J,Morgan DB

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is an important diagnosis. New criteria have been defined for impaired glucose metabolism and, accordingly, there is a need for precise and accurate glucose analysis for the correct classification of patients. However, neither the World Health Organisation nor the National Service Framework...

journal_title：Journal of clinical pathology

authors： Twomey PJ

更新日期：2004-07-01 00:00:00

abstract：:Sink drains in a medical-surgical intensive care unit (ICU) were cultured during six consecutive weeks as part of a seven month prospective study of acquisition of Pseudomonas aeruginosa by ICU patients. Isolates were typed serologically and by aminoglycoside and chlorhexidine susceptibility patterns. All 11 sinks con...

journal_title：Journal of clinical pathology

authors： Levin MH,Olson B,Nathan C,Kabins SA,Weinstein RA

更新日期：1984-04-01 00:00:00

abstract：:An ultrastructural cytochemical study of lysosomal acid phosphatase was performed on leukemic cells in a case of chronic lymphocytic leukaemia of T cell origin (T-CLL). The cells showed inclusion bodies known as parallel tubular arrays, which often lay within acid phosphatase-positive, membrane-bound spaces. This sugg...

journal_title：Journal of clinical pathology

authors： Capron F,PErrot JY,Boucheix C,Reynes M,Tricottet V,Bernadou A,Diebold J

更新日期：1982-02-01 00:00:00

abstract：:The laboratory findings in seven cases of endocarditis caused by coagulase-negative staphylococci are presented. The usefulness of biochemical characterization of the strains in diagnosis and the selection of antibiotics for prophylaxis and treatment are discussed. ...

journal_title：Journal of clinical pathology

authors： Speller DC,Mitchell RG

更新日期：1973-07-01 00:00:00

abstract：:Several diseases of the small intestine, including gluten-sensitivity, present with malabsorption and a "flat" mucosa. Determination of the mitotic index of epithelial lymphocytes provides a simple, objective method of assessing, and thus of predicting, whether a flat mucosa is due to gluten-sensitivity (index greater...

journal_title：Journal of clinical pathology

authors： Marsh MN,Haeney MR

更新日期：1983-02-01 00:00:00

abstract：:Visceral candidiasis in 56 patients, 39 of whom were thought to be immune deficient, was investigated using three serological detection methods--whole cell agglutination, haemagglutination, and counterimmunoelectrophoresis for antibodies; two determinations of circulating antigens--haemagglutination inhibition and lat...

journal_title：Journal of clinical pathology

authors： Platenkamp GJ,Van Duin AM,Porsius JC,Schouten HJ,Zondervan PE,Michel MF

更新日期：1987-10-01 00:00:00

abstract：:A quantitative method of estimating heparin co-factor in terms of percentage activity is presented. The activity in sera from 75 normal subjects varied little from 100%. Low results were obtained in sera from 50 cases of varying types of malignancy. ...

journal_title：Journal of clinical pathology

authors： TEMPERLEY IJ

更新日期：1963-03-01 00:00:00