Abstract:
BACKGROUND:Fibrinogen plays a crucial role in the pathophysiology of tumour cell growth, invasion and metastasis. The aim of this study was to evaluate the prognostic significance of pretreatment plasma fibrinogen levels in patients with diffuse large B cell lymphoma (DLBCL) METHODS: Data from 372 patients with DLBCL, diagnosed and treated between 2004 and 2013 at two Austrian centres, were evaluated retrospectively. The prognostic influences of plasma fibrinogen levels and other factors, including age, tumour stage and the National Comprehensive Cancer Network-International Prognostic Index, on 5-year overall survival (OS) and 5-year disease-free survival (DFS) were studied using Kaplan-Meier curves as well as univariate and multivariate Cox regression models. RESULTS:Kaplan-Meier analysis revealed that a high fibrinogen plasma level is associated with decreased 5-year OS and 5-year DFS in patients with DLBCL (p<0.001, log-rank test). Furthermore, in multivariate analysis, elevated serum fibrinogen was found to be an independent marker of poor clinical outcome: 5-year OS (HR=1.69, 95% CI 1.06 to 2.72, p=0.029) and 5-year DFS (HR=1.68, 95% CI 1.08 to 2.61, p=0.021). CONCLUSIONS:In the current study, we demonstrate that high plasma fibrinogen levels at diagnosis predict poor outcome in patients with DLBCL. TRIAL REGISTRATION NUMBER:25-434 ex 12713 and 415-EP/73/127-2012.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Troppan KT,Melchardt T,Wenzl K,Schlick K,Deutsch A,Bullock MD,Reitz D,Beham-Schmid C,Weiss L,Neureiter D,Tränkenschuh W,Greil R,Neumeister P,Egle A,Pichler Mdoi
10.1136/jclinpath-2015-203356subject
Has Abstractpub_date
2016-04-01 00:00:00pages
326-30issue
4eissn
0021-9746issn
1472-4146pii
jclinpath-2015-203356journal_volume
69pub_type
杂志文章,多中心研究abstract::This memorandum proposes a standardized system of reporting the histology of human lymph nodes based on commonly used simple staining techniques. The purpose is to provide a uniform, internationally acceptable system by which the histological structure of lymph nodes can be correlated with other parameters of immunolo...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.26.5.317
更新日期:1973-05-01 00:00:00
abstract::A 57 year old woman presented complaining of increasing abdominal swelling of six months duration. A mixed solid cystic left ovarian tumour measuring 24 cm in diameter was excised. Histology showed numerous cysts lined by benign mucinous epithelium blending imperceptibly into borderline clear cell and mucinous areas t...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.53.12.938
更新日期:2000-12-01 00:00:00
abstract::The assessment of emphysema in human lungs has traditionally been based on observations made on whole lung slices. These methods are inappropriate for the study of early emphysema, because as much as 75% of the alveolar wall surface area may have been lost by the time airspaces are visible to the naked eye. A new, aut...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.12.1007
更新日期:1991-12-01 00:00:00
abstract:AIMS:This is a qualitative study of the perceived learning needs of trainees for graded responsibility in histopathological training in the UK. METHODS:A focus group with trainees and interviews with consultants was carried out. Participants were asked 'What do you perceive are the learning needs of histopathology tra...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2015-203090
更新日期:2016-01-01 00:00:00
abstract::The results have been compared of microbiological and radioisotope dilution (RID) assay of serum vitamin B12 by participants in national interlaboratory trials in Britain. There was wide variation between the individual participants, especially marked in the L. leichmannii microbiological assay and in the RID methods,...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.33.3.243
更新日期:1980-03-01 00:00:00
abstract::Hepatitis C virus (HCV) replication is reported in both tumour and non-tumour tissue in a case of hepatocellular carcinoma. Viral replication was established by showing the presence of minus strand HCV RNA by PCR amplification, after excluding residual reverse transcriptase activity of Taq polymerase. No minus strand ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.9.880
更新日期:1995-09-01 00:00:00
abstract:AIMS:To investigate how clinical microbiology laboratories should report and interpret mixed mould isolates including Aspergillus species from clinical samples and the criteria for susceptibility testing of the isolates. METHODS:Retrospectively collected data from our laboratory information system of moulds isolated b...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2010.084517
更新日期:2011-06-01 00:00:00
abstract:AIM:To better understand the spectrum of primary lymphomas in the upper aerodigestive tract, a common site of extranodal lymphoma. MATERIALS AND METHODS:Lymphoma cases diagnosed at an institution in southern Taiwan from 1992 to 2007 were retrospectively studied with pathology and history review, immunohistochemistry, ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2010.081927
更新日期:2010-10-01 00:00:00
abstract::Serum alanine aminotransferase (ALT) and gamma-glutamyltransferase (gamma-GT) activities were measured in over 2000 north London blood donors. The results were compared with those from the United States. The percentage of the total donor population with ALT activities above 40 IU/l in 1986 was greater than that found ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.40.11.1340
更新日期:1987-11-01 00:00:00
abstract::Plasma antithrombin levels were measured by clotting, immunological, and amidolytic methods on two groups of subjects: 20 normal individuals and nine patients studied serially post-operatively (hip replacement). The postoperative patients were observed for the emergence of deep-vein thrombosis using 125I-fibrinogen up...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.33.5.438
更新日期:1980-05-01 00:00:00
abstract::Urine specimens were collected from 26 normal subjects, 10 patients with proven primary hyperparathyroidism, and eight patients with hypercalcaemia due to other causes. After overnight urine concentration, an oral water load was given to induce a diuresis and provide urine specimens with a relatively wide range of cre...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.22.3.287
更新日期:1969-05-01 00:00:00
abstract::It is found that serum antifibrinolytic activity is inhibitory both to the spontaneous fibrinolytic activity and to the activity of streptokinase-activated plasminogen. The titres of serum antiplasmin activity during gestation, labour, and the puerperium are all of the same order and do not differ from those in non-pr...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.13.3.220
更新日期:1960-05-01 00:00:00
abstract::The thyroids of primary thyrotoxicosis patients prepared for partial thyroidectomy with propranolol contained much more lymphoid infiltrate than those prepared with carbimazole. No relation was found between the extent of lymphoid infiltrate in the thyroid and the development of postoperative hypothyroidism either bet...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.29.5.398
更新日期:1976-05-01 00:00:00
abstract::Cancer lineage/tissue-of-origin assignment in cancers of unknown primary remains a challenge even when aided by massively parallel sequencing. The stakes are high for patients as many contemporary therapeutic strategies are disease-specific, and the biological differences can influence the patients' responses. Herein,...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-206895
更新日期:2020-08-27 00:00:00
abstract::Review of published work and analysis of clinical data and pathology of four biopsy specimens from two patients with laryngeal contact granuloma showed that its peptic origin was derived from a gastro-oesophago-laryngeal reflux. It is proposed that the term "peptic granuloma" should be given to this phenomenon. This t...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.8.800
更新日期:1989-08-01 00:00:00
abstract:AIMS:To determine the causes of ovarian granulomatous inflammation and to discuss the differential diagnoses. METHODS:The pathological features of all ovarian granulomas identified by pathology SNOMED coding in Northern Ireland over a 13 year period were reviewed. Case notes of patients were also reviewed. RESULTS:Th...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.4.324
更新日期:1997-04-01 00:00:00
abstract::Streptex was compared to routine laboratory identification methods available. The results from Streptex sometimes required several attempts before final identification could be achieved. In the main, group D streptococci other than Strep. faecalis failed to group with the Streptex antisera, and this method cannot ther...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.32.12.1234
更新日期:1979-12-01 00:00:00
abstract:AIMS:Iron overload is a major factor contributing to the overall pathology of thalassaemia, which is primarily mediated by ineffective erythropoiesis and shorter mature red blood cell (RBC) survival. Iron accumulation in RBCs generates reactive oxygen species (ROS) that cause cellular damage such as lipid peroxidation ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2019-205775
更新日期:2019-08-01 00:00:00
abstract::The incidence of jaundice and of abnormal liver function tests has been assessed in 91 multitransfused patients with severe haemophilia A and B. Tests of hepatocyte function were within the normal range in the majority of patients. On the contrary, tests of biliary cell function, liver cell damage, and bromsulphthalei...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.28.8.620
更新日期:1975-08-01 00:00:00
abstract::In decalcified (5% nitric acid) and undecalcified (glycol-methacrylate or resin embedded) routinely processed bone specimens osteoclasts against resorbing surfaces were identified with monoclonal antibodies directed against leucocyte common antigen (LCA) (PD7/26, 2B11), CD68 (KP1), and gpIIIa (Y2/51) but not against H...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.8.664
更新日期:1991-08-01 00:00:00
abstract::Of the first 166 heart and 15 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 162 were investigated for cytomegalovirus (CMV) infection by serological methods. Altogether, 73 (45%) developed CMV infection after transplantation: 30 (18.5%...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.6.660
更新日期:1988-06-01 00:00:00
abstract:AIMS:Low-grade myofibroblastic sarcoma (LGMS) represents a rare soft tissue neoplasm with a predilection for the head and neck. Intra-abdominal LGMS are rare with only four unequivocal examples reported so far. Two further cases in females in their 60s and 70s are analysed here. METHODS:Immunohistochemical stains were...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2007.048561
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND/AIMS:In the natural history of gastric cancer, non-invasive neoplasia (NiN) precedes invasive carcinoma. A histological classification of gastric NiN has recently been proposed by a World Health Organisation international panel of experts. Genetic instability is known to be among the molecular pathways invol...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2004.025676
更新日期:2005-08-01 00:00:00
abstract::An immunohistochemical study of the tissue CEA content of 82 epithelial neoplasms of the ovary has shown that mucinous tumours contain more of this substance than do their serous counterparts; otherwise a knowledge of tissue CEA content appears to be of little value in the differential histological diagnosis of this g...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.32.9.918
更新日期:1979-09-01 00:00:00
abstract:AIM:To determine whether the pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence or absence of duodenal pathology. METHODS:50 cases (M:F, 26:24; median age 57 years) diagnosed as lymphocytic gastritis between 1986 and 1998 with concurrent duodenal (D2) biopsies were iden...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.52.11.815
更新日期:1999-11-01 00:00:00
abstract::The interference of IgM-class rheumatoid factor (RF) in the solid-phase radioimmunoassay (RIA) of rubella virus IgM antibodies was studied. Acute rubella infections did not significantly activate RF. False-positive rubella antibody results were obtained, however, when patients with raised RF levels were tested. If a l...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.31.5.483
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:HER2/neu (HER2) is a significant prognostic marker for breast carcinomas. Recently, new guidelines defining HER2 genetic heterogeneity (GH) were published by the College of American Pathologists. AIMS:To determine the prevalence of HER2 GH as defined in primary invasive breast carcinoma, to determine its re...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2012-201403
更新日期:2013-08-01 00:00:00
abstract:AIM:To examine tumour samples immunohistochemically for MUC1 (episialin), epidermal growth factor receptor (EGFR), and c-erbB-2, since the disruption of the cell-cell adhesion system by MUC1 and the c-erbB oncoprotein family is known to be important in the development of metastasis in human cancers. METHODS:93 tumour ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.51.9.667
更新日期:1998-09-01 00:00:00
abstract::This report describes a case of aleukaemic myeloid sarcoma of the small intestine in a 50-year-old woman presenting with small bowel obstruction. Fluorescence in situ hybridisation analysis of interphase nuclei revealed a split CBFbeta signal, consistent with an underlying inversion of chromosome 16, inv(16)(p13q22). ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2008.063669
更新日期:2009-08-01 00:00:00
abstract::As part of a quality assurance programme at the Aga Khan University Medical Centre, Karachi, Pakistan, all hysterectomy specimens were reviewed from January 1986 to December 1989. Adenomyosis was found in 237 of the 419 (56.5%) specimens studied. Of these 237 patients, 232 (97.9%) were parous and 196 (82.8%) were in t...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.43.10.817
更新日期:1990-10-01 00:00:00