Abstract：
:The incidence of jaundice and of abnormal liver function tests has been assessed in 91 multitransfused patients with severe haemophilia A and B. Tests of hepatocyte function were within the normal range in the majority of patients. On the contrary, tests of biliary cell function, liver cell damage, and bromsulphthalein retention gave high rates of abnormal values, which tended to increase with age. Hepatitis B surface antigen was present in 8% and the corresponding antibody in 66% of the cases; 18% had a history of jaundice. All patients were asymptomatic and only a minority showed clinical signs of liver involvement. These data suggest that in haemophilacs repeated and prolonged contact with the agent(s) responsible for post-transfusion hepatitis may cause chronic liver damage not associated with overt illness.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Mannucci PM,Capitanio A,Del Ninno E,Colombo M,Pareti F,Ruggeri ZMdoi
10.1136/jcp.28.8.620keywords:
subject
Has Abstractpub_date
1975-08-01 00:00:00pages
620-4issue
8eissn
0021-9746issn
1472-4146journal_volume
28pub_type
杂志文章abstract：AIM:To investigate the fate of Streptococcus pneumoniae C-polysaccharide antigen in serum in patients with S pneumoniae bacteraemia. METHOD:In vitro dissociation experiments were performed to demonstrate that C-polysaccharide was masked by ligands in normal and acute phase serum. Serum samples from 22 patients with S ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.48.9.803
更新日期：1995-09-01 00:00:00
abstract：:A 68 year old diabetic man developed septicaemia and multiple liver abscesses due to Streptococcus intermedius. Liver biopsy revealed streptococcal botryomycosis which showed the Splendore-Hoeppli phenomenon. Diabetes mellitus is an example of the immunosuppressed states that have been associated with botryomycosis. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.51.5.399
更新日期：1998-05-01 00:00:00
abstract：AIMS:To investigate treatment with glycerol/washing as a potential substitute for freeze-thawing in the production of leucocyte depleted red cell concentrates for patients with a history of non-haemolytic reactions following transfusion. METHODS:The standard procedure of treatment with glycerol/-80 degrees C freezing/...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.46.8.742
更新日期：1993-08-01 00:00:00
abstract：:Two diabetic patients with symptomatic urinary tract infection by Torulopsis glabrata were successfully treated with two-week courses of 5-fluorocytosine. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.27.1.50
更新日期：1974-01-01 00:00:00
abstract：:The test is an application of the method originally described by Boyden (1951) and adapted by Stavitsky and Arquilla (1958). Sera which contain anti-Panton-Valentine leucocidin agglutinate the prepared red cells, often to a very high dilution, and this has provided a useful serological test for the diagnosis of staphy...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.14.2.161
更新日期：1961-03-01 00:00:00
abstract：:Ten patients with severe megaloblastic anaemia were studied to investigate whether the causative metabolic defects might predispose them to lactic or other acidosis. One patient had compensated acidosis with hyperlactataemia before treatment but there were obvious causes other than anaemia. No other patient developed ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.35.9.984
更新日期：1982-09-01 00:00:00
abstract：AIMS:To determine the potential efficiency of molecular markers specific for neoplastic change--mutations of the K-ras oncogene and the p53 tumour suppressor gene--in diagnosing pancreatic carcinoma. METHODS:Archival cytology samples obtained from 17 patients with established pancreatic carcinoma were assayed for alte...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.48.3.218
更新日期：1995-03-01 00:00:00
abstract：AIM:To determine whether the pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence or absence of duodenal pathology. METHODS:50 cases (M:F, 26:24; median age 57 years) diagnosed as lymphocytic gastritis between 1986 and 1998 with concurrent duodenal (D2) biopsies were iden...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.52.11.815
更新日期：1999-11-01 00:00:00
abstract：AIM:To investigate the natural history of patients with non-alcoholic steatohepatitis by means of a prospective histological study. METHODS:One thousand five hundred and seventy one patients underwent liver biopsy at the Western Infirmary in Glasgow during the 10 year period 1985 to 1994. All biopsies were reported by...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.55.9.689
更新日期：2002-09-01 00:00:00
abstract：:A 65-year-old woman with a history of a left heminephrectomy for renal carcinoma developed hypercalcaemia 11 years after the operation. The same kidney was found to contain a recurrent renal carcinoma. After the radical nephrectomy of the left kidney, hypercalcaemia remitted but reappeared 11 months later. The right k...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.32.3.234
更新日期：1979-03-01 00:00:00
abstract：:Although the morphology of the pathognomonic Reed-Sternberg cells of Hodgkin lymphoma (HL) was described over a century ago, it was not until recently that their origin from B lymphocytes was recognised. The demonstration that a proportion of cases of HL harbour the Epstein-Barr virus (EBV) and that its genome is mono...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.2007.050146
更新日期：2007-12-01 00:00:00
abstract：AIM:The immunoproteasome is a specific proteasome isoform whose proteolytic activity enhances the generation of antigenic peptides to be presented by major histocompatibility complex class I molecules to CD8+ T cells. Physiologically, it is expressed abundantly in immune cells and is induced in somatic cells by cytokin...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2020-206618
更新日期：2020-09-17 00:00:00
abstract：:The peripheral lymphocytes of 50 cases of human immunodeficiency virus (HIV) infection (13 of acquired immune deficiency syndrome (AIDS), 17 of AIDS related complex (ARC), and 20 healthy carriers) were studied immunoultrastructurally. The prevalence of "tubuloreticular structures" and "tubular confronting cisternae" i...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.41.1.62
更新日期：1988-01-01 00:00:00
abstract：:Endogenous Cushing's syndrome is a rare endocrine disorder that incurs significant cardiovascular morbidity and mortality, due to glucocorticoid excess. It comprises adrenal (20%) and non-adrenal (80%) aetiologies. While the majority of cases are attributed to pituitary or ectopic corticotropin (ACTH) overproduction, ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jclinpath-2014-202612
更新日期：2015-03-01 00:00:00
abstract：:Foveolar dysplasia is an uncommon form of dysplasia that is encountered in the stomach and oesophagus in the context of Barrett’s oesophagus. Glands displaying foveolar dysplasia also show architectural abnormalities that are similar to those encountered in adenomatous dysplasia. However, from a cytological point of v...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jclinpath-2014-202600
更新日期：2014-10-01 00:00:00
abstract：AIMS:It has been suggested that adenocarcinomas of the lower oesophagus and gastric cardia should be reclassified as oesophagogastric junction (OGJ) cancers. This study aimed to define the frequency of OGJ cancers in a geographically defined population of 4.3 million people. METHODS:All cases of oesophageal and gastri...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.55.3.191
更新日期：2002-03-01 00:00:00
abstract：:Incomplete expression of human haemoglobin beta-chains at birth may lead to difficulty in the early demonstration of an inherited beta-chain variant. In this case, the rare unstable variant, Hb Tacoma beta30 (B12) arg leads to ser, although not present in cord blood in sufficient amounts to be easily detected by routi...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.31.9.883
更新日期：1978-09-01 00:00:00
abstract：:Of the first 166 heart and 15 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 162 were investigated for cytomegalovirus (CMV) infection by serological methods. Altogether, 73 (45%) developed CMV infection after transplantation: 30 (18.5%...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.41.6.660
更新日期：1988-06-01 00:00:00
abstract：:Forty six lymph nodes were examined with the indirect immunoperoxidase technique for the distribution of fibronectin and laminin. Fibronectin was present in the framework of the tissue and the basal lamina of blood vessels, giving a clear outline of nodal architecture. Intracellular fibronectin was observed in cases o...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.38.8.849
更新日期：1985-08-01 00:00:00
abstract：:The results of an investigation show that there is no statistically significant excess of blood group A in cases of carcinoma of the oesophagus or in cases of benign prostatic hyperplasia. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.17.1.42
更新日期：1964-01-01 00:00:00
abstract：:The cytological features of testicular germ cell tumours were established in smears from 15 freshly resected tumours. These features were applied to the fine needle aspiration cytology diagnosis of metastases in 27 patients referred for chemotherapy. There were 16 positive reports in 32 aspirates of which 13 were take...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.40.11.1324
更新日期：1987-11-01 00:00:00
abstract：BACKGROUND:Venous invasion (VI) is an important prognosis predictor after colorectal carcinoma (CRC) resection, enabling more accurate staging and influencing postoperative management. AIMS:To assess/compare various tissue block types (perpendicular, tangential, across mesentery (AM), from major vessels or lymph nodes...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2004.023333
更新日期：2006-02-01 00:00:00
abstract：:It is found that serum antifibrinolytic activity is inhibitory both to the spontaneous fibrinolytic activity and to the activity of streptokinase-activated plasminogen. The titres of serum antiplasmin activity during gestation, labour, and the puerperium are all of the same order and do not differ from those in non-pr...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.13.3.220
更新日期：1960-05-01 00:00:00
abstract：:In a post-mortem analysis of 1,500 patients, aged 70 years or more, heart disease and malignancy were the two major causes of death. Coronary disease was exceedingly prevalent, almost one in five being subject to this form of heart disease, and 13% dying from its effects. The levelling of the sex ratio in coronary dis...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.16.6.532
更新日期：1963-11-01 00:00:00
abstract：AIMS:To investigate the problems involved in undertaking immunohistochemistry (IHC) and nuclear morphometry using Bouin's fixed prostate biopsies. METHODS:Archival Bouin's fixed and formalin fixed, paraffin wax embedded prostatic biopsies were immunostained for three nuclear biomarkers (minichromosome maintenance prot...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2004.019299
更新日期：2005-03-01 00:00:00
abstract：AIM:To identify and review cases of false negative needle core biopsy (NCB) in the preoperative investigation of radial scar/complex sclerosing lesion (RS/CSL) lesions - that is, benign NCB from RS/CSL which contained malignancy on excision. METHODS AND RESULTS:A total of 11 false negative NCB in RS/CSL lesions from 2...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2006.037069
更新日期：2007-03-01 00:00:00
abstract：:Two aspects of handwashing in hospital were considered. A study was carried out to examine the contamination of bar soap and containers, and the use of antiseptic soaps in reducing the resident flora of the skin. Swabs were collected from soap dishes on six wards and from a bacteriology laboratory on four consecutive ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.32.7.732
更新日期：1979-07-01 00:00:00
abstract：:A case is reported of a patient with plasmacytoma which assumed different clinicopathological features over seven years. The tumour first presented as a subcutaneous mass which was misdiagnosed as anaplastic carcinoma. Complete response to radiotherapy ensued but recurrence took the form of an intracerebral tumour. Fu...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.10.951
更新日期：1994-10-01 00:00:00
abstract：:An immunochemical procedure for routine laboratory diagnosis of pregnancy utilizing adsorption of human chorionic gonadotrophin onto kaolin and the Ortho pregnancy test reagents is described. The method is suitable for quantitative assay of urinary human chorionic gonadotrophin and can be adapted for use with serum. I...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.17.5.548
更新日期：1964-09-01 00:00:00
abstract：:Organising pneumonia (otherwise referred to as bronchiolitis obliterans organising pneumonia) is characterised histologically by plugs of granulation tissue, which are present predominantly within small airways, alveolar ducts and peri-bronchiolar alveoli. This pattern is not specific for any disorder or cause, but is...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jclinpath-2012-201342
更新日期：2013-10-01 00:00:00
