Staining clinical specimens for acid-fast bacilli by means of a mechanical conveyor system.

abstract：:The rate of digestion of fibrin was measured in vitro by an isotopic technique in 140 blood samples of differing fibrinogen concentration; the assessment of fibrinolytic activity thus obtained was compared with a standard method of measurement, the dilute whole blood lysis time. The lysis time was related exponentiall...

journal_title：Journal of clinical pathology

authors： Hickman JA,Gordon-Smith IC,Whitfield PF,Godfrey SJ

更新日期：1973-03-01 00:00:00

abstract：AIM:To determine the size of a cervical biopsy specimen with human papillomavirus (HPV) infection required to enable in situ hybridisation to be carried out with a guarantee of a reliable result. METHODS:In situ hybridisation was carried out in 142 cervical uterine biopsy specimens classified histologically as low gra...

journal_title：Journal of clinical pathology

authors： Gómez F,Corcuera MT,Muñoz E,Roldan M,Alonso MJ,Abad M,Paz JI,López-Bravo A

更新日期：1995-01-01 00:00:00

abstract：:Pathology review of gynaecological cancer specimens is often carried out as part of the working of gynaecological oncology multidisciplinary team meetings. This review describes the author's experience regarding the most common issues identified during this process. Ten subjects are covered; these range from histopath...

journal_title：Journal of clinical pathology

authors： McCluggage WG

更新日期：2012-04-01 00:00:00

abstract：:Two histochemical techniques, the PAT/KOH/PAS and the PBT/KOH/PAS, were used to investigate the side chain O-acyl substitution patterns of the sialic acids of the colonic epithelial mucins in cases of ulcerative colitis and Crohn's disease. In both diseases there was, as compared to normal, a reduction in the proporti...

journal_title：Journal of clinical pathology

authors： Culling CF,Reid PE,Dunn WL

更新日期：1979-12-01 00:00:00

abstract：:Five cases of malignant histiocytosis of the intestine and one case of true histiocytic lymphoma were studied using immunohistological techniques. In paraffin sections tumour cells in all cases were shown to contain alpha-1-antitrypsin and to express the leucocyte common antigen. Four of the five cases of malignant hi...

journal_title：Journal of clinical pathology

authors： Salter DM,Krajewski AS,Dewar AE

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Some uterine endometrioid adenocarcinomas exhibit a distinctive morphological phenotype characterised by the formation of microcystic, elongated and fragmented (MELF) glands. Immunohistochemical studies have suggested that MELF-type changes represent an epithelial-mesenchymal transition which has been associ...

journal_title：Journal of clinical pathology

authors： Stewart CJ,Amanuel B,Grieu F,Carrello A,Iacopetta B

更新日期：2010-07-01 00:00:00

abstract：:In vitro morphological and functional studies were carried out on platelets which had been cryopreserved in the presence of 5% dimethyl sulphoxide (DMSO). Overall loss of platelets was around 50%. Those which survived freezing and reconstitution showed marked morphological deterioration, increase of procoagulant activ...

journal_title：Journal of clinical pathology

authors： Baythoon H,Tuddenham EG,Hutton RA

更新日期：1982-08-01 00:00:00

abstract：:The plasma concentrations of biotin were measured for up to 49 days after injury in nine children with burns and scalds which involved from 12% to 50% of the surface area of the body. Biotin levels below the minimum of the control range were observed in eight of the nine injured children at some stage during the episo...

journal_title：Journal of clinical pathology

authors： Barlow GB,Dickerson JA,Wilkinson AW

更新日期：1976-01-01 00:00:00

abstract：:The principles which should govern the planning of benching and services for new laboratories are enumerated. These include the necessity for long-term planning, flexibility, and economy. The ;Cardiff benching system' where the benches are composed of units that consist of an independent movable table base, a removabl...

journal_title：Journal of clinical pathology

authors： LAURENCE KM

更新日期：1963-09-01 00:00:00

abstract：BACKGROUND:The "classical" antineutrophil cytoplasmic antibody (C-ANCA) pattern seen on indirect immunofluorescence (IIF) is characterised by granular cytoplasmic staining showing central or interlobular accentuation, and is strongly associated with antiproteinase-3 antibodies (PR3-ANCA) and Wegener's granulomatosis. H...

journal_title：Journal of clinical pathology

authors： Wong RC,Silvestrini RA,Savige JA,Fulcher DA,Benson EM

更新日期：1999-02-01 00:00:00

abstract：AIMS:To assess the relevance of genetic variants of hepatitis B virus (HBV) and to demonstrate the usefulness of the polymerase chain reaction (PCR) in cases of HBV diagnostic difficulty. METHODS:Five serum samples from patients that presented diagnostic difficulty in routine laboratories were sent to a research labor...

journal_title：Journal of clinical pathology

authors： van Deursen FJ,Hino K,Wyatt D,Molyneaux P,Yates P,Wallace LA,Dow BC,Carman WF

更新日期：1998-02-01 00:00:00

abstract：:Investigations into the immunological functions of three patients with chronic mucocutaneous candidiasis were carried out. Phagocytosis of Candida albicans, nitroblue tetrazolium dye reduction, complement, and immunoglobulin levels were normal. Candidacidal assays using the neutrophils of the patients in autologous se...

journal_title：Journal of clinical pathology

authors： Walker SM,Urbaniak SJ

更新日期：1980-04-01 00:00:00

abstract：AIMS:The JAK2 V617F mutation is highly recurrent in many of the myeloproliferative neoplasms, a molecular variant that can be easily detected using sensitive and minimally invasive techniques. Given the ease of JAK2 V617F testing, this test may be improperly requested for the purposes of patient 'screening' and to opti...

journal_title：Journal of clinical pathology

authors： Mahe E,Pedersen KM,Çolak Y,Bojesen SE,Lynch T,Sinclair G,Khan F,Shabani-Rad MT

更新日期：2019-02-01 00:00:00

abstract：:Incomplete expression of human haemoglobin beta-chains at birth may lead to difficulty in the early demonstration of an inherited beta-chain variant. In this case, the rare unstable variant, Hb Tacoma beta30 (B12) arg leads to ser, although not present in cord blood in sufficient amounts to be easily detected by routi...

journal_title：Journal of clinical pathology

authors： Deacon-Smith RA,Lee-Potter JP

更新日期：1978-09-01 00:00:00

abstract：AIMS:To develop a specific radioimmunoassay for the routine determination of serum vitamin B12. METHODS:Antisera were raised in rabbits by immunisation with the monocarboxylic acid derivative of cyanocobalamin coupled to human serum albumin. Antibody titres and affinities were determined and the antiserum giving the h...

journal_title：Journal of clinical pathology

authors： O'Sullivan JJ,Leeming RJ,Lynch SS,Pollock A

更新日期：1992-04-01 00:00:00

abstract：:A method is described for the quantitative separation of radioactive bile acids and neutral sterols in human faeces on a potassium hydroxide-treated silicic acid column. Results obtained with faecal extracts containing metabolites derived from radioactive cholesterol, cholic acid, and chenodeoxycholic acid show that t...

journal_title：Journal of clinical pathology

authors： LEWIS B,MYANT NB

更新日期：1965-01-01 00:00:00

abstract：AIM:To assess the topographical relation between gastric glands, using the minimum spanning tree (MST), to derive both a model of neighbourhood and quantitative representation of the tissue's architecture, to assess the characteristic features of gastric atrophy, and to assess the grades of gastric atrophy. METHODS:Ha...

journal_title：Journal of clinical pathology

authors： Zaitoun AM,al Mardini H,Record CO

更新日期：1998-12-01 00:00:00

abstract：:A method of typing isolates of Proteus mirabilis and Proteus vulgaris is described based on the sensitivity of the organisms to bacteriocine. Twelve standard proteocine producing strains were selected from a large number of isolates tested, and from these liquid proteocine preparations were prepared. The sensitivities...

journal_title：Journal of clinical pathology

authors： Al-Jumaili IJ

更新日期：1975-10-01 00:00:00

abstract：:In the present investigation, the prevalence of focal lymphocytic adenitis in the submandibular salivary gland was observed in a series of 116 postmortem subjects after suitable exclusions had been made. Focal lymphocytic adenitis could not be demonstrated in the labial salivary glands. The degree of lymphocytic infil...

journal_title：Journal of clinical pathology

authors： Chisholm DM,Waterhouse JP,Mason DK

更新日期：1970-11-01 00:00:00

abstract：BACKGROUND:During the last decade, whole slide images (WSI) have been used in many areas of pathology such as teaching, research, digital archiving, teleconsultation and quality assurance testing. However, WSI have not regularly been used for routine diagnosis, because of the lack of validation studies. AIM:To test th...

journal_title：Journal of clinical pathology

authors： Al-Janabi S,Huisman A,Vink A,Leguit RJ,Offerhaus GJ,Ten Kate FJ,van Dijk MR,van Diest PJ

更新日期：2012-02-01 00:00:00

abstract：AIM:Ultraviolet light (UV) is known to cause DNA damage in the epidermis. The damaged DNA is repaired or deleted by apoptosis to prevent the generation of cancer. It has been suggested that a deficient apoptotic mechanism may predispose individuals to skin cancer. Therefore, the response of normal controls and patients...

journal_title：Journal of clinical pathology

authors： Murphy M,Mabruk MJ,Lenane P,Liew A,McCann P,Buckley A,O Flatharta C,Hevey D,Billet P,Robertson W,Javed S,Leader M,Kay E,Murphy GM

更新日期：2002-11-01 00:00:00

abstract：:Primary low grade marginal zone B cell lymphoma (MZL) of the breast and localised mammary amyloidosis are exceedingly rare entities. This report describes the case of a woman with long standing Sjögren's syndrome presenting with asymptomatic MZL of the breast showing plasmacytic differentiation, associated with local ...

journal_title：Journal of clinical pathology

authors： Kambouchner M,Godmer P,Guillevin L,Raphaël M,Droz D,Martin A

更新日期：2003-01-01 00:00:00

abstract：:A 60 year old woman affected by Hashimoto's thyroiditis presented with a history of recurring episodes of urticaria and angio-oedema. Clinical and laboratory evaluation of the patient excluded allergy to external agents, hereditary angio-oedema, and occult infections. A pathogenic relation between Hashimoto's thyroidi...

journal_title：Journal of clinical pathology

authors： Amoroso A,Garzia P,Pasquarelli C,Sportelli G,Afeltra A

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:RCAS1 (receptor binding cancer antigen expressed on SiSo cells) is a tumour associated antigen. It is involved in immune evasion by tumour cells, by binding to receptors on cells involved in the immune response, such as T cells and natural killer cells, and inducing apoptosis. High expression of RCAS1 has be...

journal_title：Journal of clinical pathology

authors： Leelawat K,Watanabe T,Nakajima M,Tujinda S,Suthipintawong C,Leardkamolkarn V

更新日期：2003-10-01 00:00:00

abstract：AIMS:To determine the possible histogenesis of the intracranial variant of olfactory neuroblastoma. METHODS:Four specimens from three cases of intracranial olfactory neuroblastoma were studied by light microscopy and immuno-histochemistry, and electron microscopy in two cases. RESULTS:Light microscopical examination ...

journal_title：Journal of clinical pathology

authors： Banerjee AK,Sharma BS,Vashista RK,Kak VK

更新日期：1992-04-01 00:00:00

abstract：AIM:To investigate morphological changes in the tumour vessel adventitia, particularly the distribution of vascular adventitial fibroblastic cells (VAFCs)--namely, CD34 positive fibroblastic cells just outside the vascular media--in diffuse-type gastric carcinomas. METHOD:In total, 18 surgically resected advanced typi...

journal_title：Journal of clinical pathology

authors： Nakayama H,Enzan H,Miyazaki E,Kuroda N,Toi M,Hiroi M,Yasui W

更新日期：2004-09-01 00:00:00

abstract：:Recent evidence shows that chronic liver disease induced by hepatitis delta virus is closely associated with production of autoantibodies. To verify this sera from patients with hepatitis delta virus and from those with hepatitis B virus mediated chronic liver disease were tested for a panel of autoantibodies. Althoug...

journal_title：Journal of clinical pathology

authors： Zauli D,Crespi C,Bianchi FB,Craxi A,Pisi E

更新日期：1986-08-01 00:00:00

abstract：:Two patients are reported in whom initial misdiagnoses of medullary cancer or trabecular hyaline adenoma for papillary carcinoma were made. ...

journal_title：Journal of clinical pathology

authors： Andrew AC,Williamson JM

更新日期：1993-08-01 00:00:00

abstract：:The arrangement of the T cell receptor and immunoglobulin genes was analysed in lymphoid tissue biopsy specimens from 25 cases of angioimmunoblastic lymphadenopathy. Nineteen cases showed a rearrangement of the gene coding for the beta chain of the T cell receptor, and in one case a clonal rearrangement of immunoglobu...

journal_title：Journal of clinical pathology

authors： O'Connor NT,Crick JA,Wainscoat JS,Gatter KC,Stein H,Falini B,Mason DY

更新日期：1986-11-01 00:00:00

abstract：AIMS:The incidence of RAS/RAF/PI3KA and TP53 gene mutations in colorectal cancer (CRC) is well established. Less information, however, is available on other components of the CRC genomic landscape, which are potential CRC prognostic/predictive markers. METHODS:Following a previous validation study, ion-semiconductor n...

journal_title：Journal of clinical pathology

authors： Malapelle U,Pisapia P,Sgariglia R,Vigliar E,Biglietto M,Carlomagno C,Giuffrè G,Bellevicine C,Troncone G

更新日期：2016-09-01 00:00:00