Abstract：
AIM:To assess the topographical relation between gastric glands, using the minimum spanning tree (MST), to derive both a model of neighbourhood and quantitative representation of the tissue's architecture, to assess the characteristic features of gastric atrophy, and to assess the grades of gastric atrophy. METHODS:Haematoxylin and eosin stained sections from corporal and antral biopsy specimens (n = 139) from normal patients and from patients with nonatrophic gastritis and atrophic gastritis of grades 1, 2, and 3 (Sydney system) were assessed by image analysis system (Prodit 5.2) and 11 syntactic structure features were derived. These included both line and connectivity features. RESULTS:Syntactic structure analysis was correlated with the semiquantitative grading system of gastric atrophy. The study showed significant reductions in the number of points and the length of MST in both body and antrum. The standard deviation of the length of MST was significantly increased in all grades of atrophy. The connectivity to two glands was the highest and most affected by the increased grade of atrophy. The reciprocal values of the Wiener, Randic, and Balaban indices showed significant changes in the volume of gland, abnormality in the shape of glands, and changes in irregularity and branching of the glands in both types of gastric mucosa. There was a complete separation in the MST, connectivity, and index values between low grade and high grade gastric atrophy. CONCLUSIONS:(1) Gastric atrophy was characterised by loss of the gland, variation in the volume, reduction in the neighbourhood, irregularity in spacing, and abnormality in the shape of the glands. (2) Syntactic structure analysis significantly differentiated minor changes in gastric gland (low grade atrophy) from high grade atrophy of clinical significance. (3) Syntactic structure analysis is a simple, fast, and highly reproducible technique and appears a promising method for quantitative assessment of atrophy.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Zaitoun AM,al Mardini H,Record COdoi
10.1136/jcp.51.12.895keywords:
subject
Has Abstractpub_date
1998-12-01 00:00:00pages
895-900issue
12eissn
0021-9746issn
1472-4146journal_volume
51pub_type
杂志文章abstract：:The adhesion molecule E-cadherin is essential for maintaining epithelial intercellular adhesion. Loss or reduced expression of E-cadherin has been related to invasive behaviour in a wide range of carcinomas. Using immunoblotting techniques, the existence of multiple soluble forms of E-cadherin was demonstrated in urin...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.48.2.179
更新日期：1995-02-01 00:00:00
abstract：:Experiments are described with glass fibre filter paper and complete glass filters as fitted to high pre-vacuum autoclaves to determine whether organisms can grow or penetrate through the filters. A filter consisting of four layers of glass fibre paper fitted inside a sterilizer chamber for a year and used for 96 ster...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.16.3.259
更新日期：1963-05-01 00:00:00
abstract：:Pathology review of gynaecological cancer specimens is often carried out as part of the working of gynaecological oncology multidisciplinary team meetings. This review describes the author's experience regarding the most common issues identified during this process. Ten subjects are covered; these range from histopath...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2011-200352
更新日期：2012-04-01 00:00:00
abstract：:Microsatellite instability (MSI) testing is tricky in gynaecological cancers (GC). Thus, we aimed to describe the instability patterns to improve MSI test interpretation in sporadic and hereditary GCs. Ninety-five cases, including uterine and ovarian cancers, with known genetic and immunohistochemical (IHC) features, ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2017-204348
更新日期：2017-09-01 00:00:00
abstract：:The mucin and gland content of 26 rectal biopsy specimens--five normal specimens, 10 from patients with ulcerative colitis, and 11 from patients with Crohn's disease--were measured using a Quantimet image analyser. There was significantly less mucin in the groups with ulcerative colitis compared with either those with...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.43.2.143
更新日期：1990-02-01 00:00:00
abstract：AIMS:Evidence suggests that the presence of tumour necrosis is an adverse prognostic factor in renal cell carcinoma (RCC). However, it has also been shown that tumour regression, a microscopic feature associated with necrosis, may be a favourable short term prognostic factor in RCC. METHODS:Pathology reports of 253 RC...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2004.018846
更新日期：2005-01-01 00:00:00
abstract：:The clinical and pathological findings in 23 patients with ischaemic lesions of the alimentary tract (ischaemic enterocolitis) are described. These are compared with findings in 13 patients with occlusive thrombosis of the superior mesenteric artery. The pathological features distinguishing the two conditions are disc...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.25.2.99
更新日期：1972-02-01 00:00:00
abstract：:Sera can produce nuclear or perinuclear immunofluorescence staining in neutrophils which may be caused by antibodies with differing antigenic specificities. These include perinuclear antineutrophil cytoplasmic antibodies (P-ANCA), granulocyte specific antinuclear antibody (GS-ANA), and antinuclear antibody (ANA). Ther...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.52.6.475
更新日期：1999-06-01 00:00:00
abstract：AIMS:To use the polymerase chain reaction to detect monoclonality at the immunoglobulin heavy chain gene locus in cells derived from lymph node aspirates. METHODS:A nested two-stage polymerase chain reaction (PCR) for the VDJ region of the immunoglobulin heavy chain gene was used to detect monoclonality. The total num...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.45.5.420
更新日期：1992-05-01 00:00:00
abstract：AIMS:It has been suggested that adenocarcinomas of the lower oesophagus and gastric cardia should be reclassified as oesophagogastric junction (OGJ) cancers. This study aimed to define the frequency of OGJ cancers in a geographically defined population of 4.3 million people. METHODS:All cases of oesophageal and gastri...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.55.3.191
更新日期：2002-03-01 00:00:00
abstract：:A miniaturised method for the identification of anaerobic bacteria is described which employs microtitre fermentation tests, a spot indole test and a nitrate reduction disc test. The results obtained are directly comparable with those produced by a standard conventional method in use at present. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.37.1.70
更新日期：1984-01-01 00:00:00
abstract：:Agar gel, cellulose acetate, and starch gel electrophoresis are all capable of diagnosing sickle-cell anaemia, sickle-cell haemoglobin C disease, and haemoglobin C disease in cord blood samples. Of these three electrophoretic techniques, agar gel is the easiest to interpret.Paper electrophoresis can reliably and rapid...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.23.6.533
更新日期：1970-09-01 00:00:00
abstract：BACKGROUND:Cardiac remodelling after acute myocardial infarction (AMI) is characterised by molecular and cellular mechanisms involving both left and right ventricles, and biventricular failure identifies patients with an extremely unfavourable prognosis. AIMS:To assess whether a link exists between increased myocardia...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.56.9.672
更新日期：2003-09-01 00:00:00
abstract：:The results of an investigation show that there is no statistically significant excess of blood group A in cases of carcinoma of the oesophagus or in cases of benign prostatic hyperplasia. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.17.1.42
更新日期：1964-01-01 00:00:00
abstract：:Enteroviruses are rare causes of acute focal encephalitis. A fatal case of echovirus type 9 infection is reported in a 9 month old boy who presented with a fever and a macular rash followed by two focal seizures. Echovirus type 9 was isolated from lung tissue after seven days. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.46.9.865
更新日期：1993-09-01 00:00:00
abstract：:A case of combined squamous and intestinal metaplasia of the renal pelvis, associated with hydronephrosis, chronic pyelonephritis, and lithiasis, is reported. The changes are considered to be due primarily to mechanical irritation of the pelvic epithelium. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.22.2.187
更新日期：1969-03-01 00:00:00
abstract：:The PAS and acid phosphatase reactions showed a different pattern of positivity in the cells of lymphoproliferative disorders according to their B or T cell nature. In B-cell leukaemias (chronic lymphocytic and prolymphocytic) a low proportion of lymphocytes gave a positive result with the acid phosphatase reaction, w...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.27.10.767
更新日期：1974-10-01 00:00:00
abstract：:Neutropenia is a rare complication of Diamond-Blackfan syndrome (congenital hypoplastic anaemia). Three patients are reported: all had neutropenia as well as anaemia, and to investigate the cause of the neutropenia culture of bone marrow for granulocyte-macrophage colony forming cells (GMCFCs) was performed. Two cases...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.44.9.742
更新日期：1991-09-01 00:00:00
abstract：:A study has been made by clinical methods and by bio-assay of the effectiveness of a régime for prophylaxis against tetanus. The two principal objects of the method were to ensure that active immunization was offered to all patients who had received antitoxin and to measure the effect of the combined administration of...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.18.1.23
更新日期：1965-01-01 00:00:00
abstract：:This review surveys the staging systems used for the classification of colorectal carcinomas, including the TNM system, and focuses on the assessment of the nodal stage of the disease. It reviews the quantitative requirements for a regional metastatic work up, and some qualitative features of lymph nodes that may help...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.56.5.327
更新日期：2003-05-01 00:00:00
abstract：:Temporal changes in gastric antibody response were investigated in 113 (51 men, 62 women) patients with confirmed pernicious anaemia. Their ages ranged from 31-92 years (mean (SD 13.2) 66). At diagnosis, parietal cell antibody and intrinsic factor antibody were detected in 90.9% and 39.1% of all patients, respectively...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.42.10.1092
更新日期：1989-10-01 00:00:00
abstract：AIMS:Acute traumatic coagulopathy is characterised by fibrinolysis and low fibrinogen. It is unclear how much fibrinogenolysis contributes to reduce fibrinogen levels. The study aim was to: investigate in vitro the effects of tissue-plasminogen activator (t-PA) and tranexamic acid (TXA) on coagulation and fibrinolysis....
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2016-203854
更新日期：2017-02-01 00:00:00
abstract：AIMS:To evaluate an indirect immunofluorescence flow cytometry technique in a series of patients with large fetomaternal haemorrhage (FMH). METHODS:Patient samples identified by Kleihauer testing in local laboratories as having FMH > 4 ml were sent for flow cytometric analysis. In a proportion of cases the mothers rec...
journal_title：Journal of clinical pathology
pub_type： 临床试验,杂志文章
doi：10.1136/jcp.48.11.1005
更新日期：1995-11-01 00:00:00
abstract：AIMS:To determine whether myelodysplastic syndromes (MDS) are associated with sea blue histiocytosis in the bone marrow. METHODS:A retrospective review of bone marrow aspirates from 35 patients presenting consecutively with MDS and from 20 patients with each of the following: normal marrow appearance (routine staging ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.46.11.1030
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:The prognosis of adenoid cystic carcinoma (ACC), a malignant salivary gland tumour, depends on clinicopathological parameters. To decipher the biological behaviour of ACC, and to identify patients at risk of developing metastases, additional markers are needed. METHODS:Expression of the cell cycle proteins ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2007.054262
更新日期：2008-06-01 00:00:00
abstract：:Plasma diamine oxidase levels were assayed in 66 patients who presented with pregnancy complicated by threatened abortion. Levels within the normal range were associated with continuing pregnancies, whereas levels below the normal range were associated with subsequent abortion. Among those patients in whom gestation w...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.34.2.187
更新日期：1981-02-01 00:00:00
abstract：:This report describes a case of myelofibrosis presenting as spinal cord compression on account of extramedullary haemopoietic tissue encroaching upon the spinal cord from a large pelvic mass. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.56.2.154
更新日期：2003-02-01 00:00:00
abstract：:A Cyto-Tek staining machine designed for Papanicolau staining of cervical smears has been adapted for auramine staining of smears of sputum and other clinical specimens for acid-fast bacilli. The results compared favourably with those obtained by a manual method of staining. Contamination of negative smears by acid-fa...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.31.2.185
更新日期：1978-02-01 00:00:00
abstract：:In order to detect the heat labile toxin of Escherichia coli human embryo lung fibroblast cells were seeded with whole cell lysate preparations of the organism to be tested. Positive results consisted of growth inhibition and cytopathic change which were easily seen. Heat-labile toxin was produced by strains belonging...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.32.12.1216
更新日期：1979-12-01 00:00:00
abstract：:In October 1859, 'The Queen of Hearts' was published by Wilkie Collins. This book is a collection of 10 short stories written by the protagonists (three retired brothers), in order to keep their niece (aka the queen of hearts) entertained, until the arrival of her fiancé-to-be. The second story of the book, titled 'Br...
journal_title：Journal of clinical pathology
pub_type： 历史文章,杂志文章
doi：10.1136/jcp.2010.085571
更新日期：2011-02-01 00:00:00
