An assessment of techniques suitable for the diagnosis of sickle-cell disease and haemoglobin C disease in cord blood samples.

abstract：AIMS:Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive non-Hodgkin's lymphoma that represents a heterogeneous group of disease that is differentially characterised by clinical, molecular and cytogenetic features. MYC, BCL2 and BCL6 gene rearrangements have been identified as prognostic factors...

journal_title：Journal of clinical pathology

authors： Tourneret A,Alame M,Rigau V,Bauchet L,Fabbro M,De Oliveira L,Cacheux V,Costes V,Lacheretz-Szablewski V

更新日期：2020-09-10 00:00:00

abstract：:A 19 year old man presented with unilateral testicular swelling and pain. An initial diagnosis of epididymo-orchitis was modified to a presumed testicular neoplasm following ultrasonography. The final diagnosis of isolated testicular vasculitis was established following histological examination of the orchidectomy spe...

journal_title：Journal of clinical pathology

authors： Warfield AT,Lee SJ,Phillips SM,Pall AA

更新日期：1994-12-01 00:00:00

abstract：:A small epidemic of gastroenteritis in a children's hospital is described, and also the biochemical characteristics of the causative organism. Stress is laid on the fact that failure to recognize that epidemic strains of Escherichia coli may be late lactose fermentors can lead to errors or delay in diagnosis. ...

journal_title：Journal of clinical pathology

authors： SHEDDEN WI,POTTER CW,DUBOWITZ V,WOOD M

更新日期：1962-09-01 00:00:00

abstract：:Platelet concentrates were prepared for in vitro storage in either Fenwal PL-732 or Cutter CLX platelet packs. The units were stored at 22 degrees C for seven days with either horizontal or tumbler agitation. Measurement of pH, hypotonic shock response and serotonin uptake indicated in vitro viability was well maintai...

journal_title：Journal of clinical pathology

authors： Taylor MA,Tandy NP,Fraser ID

更新日期：1983-12-01 00:00:00

abstract：:Antibodies against alpha smooth muscle actin (ASMA) and S100 protein were applied to paraffin wax embedded sections from 40 salivary gland tumours and seven normal salivary glands. The results indicate that ASMA is useful in the diagnosis of epithelial-myoepithelial carcinoma, but is otherwise only of limited use in d...

journal_title：Journal of clinical pathology

authors： Jones H,Moshtael F,Simpson RH

更新日期：1992-10-01 00:00:00

abstract：:Platelet adhesiveness was measured in patients undergoing operation. With the rotating bulb technique adhesiveness increased steadily to the sixth and ninth days following surgery. The glass bead filter technique demonstrated a marked increase in platelet adhesiveness on the day following operation. ...

journal_title：Journal of clinical pathology

authors： Bennett PN

更新日期：1967-09-01 00:00:00

abstract：:Haemoglobin (Hb) Bonn is a newly described benign Hb variant that causes falsely depressed oxygen saturation as measured by pulse oximetry. It was found to be associated with mild haemolysis. Since its first report in a German family, no further cases have been documented in the literature. We report the first Chinese...

journal_title：Journal of clinical pathology

authors： So CC,Chan AY,Chow EY,Lin SY,Yip SF,Szeto SC,Chan LC

更新日期：2010-10-01 00:00:00

abstract：:In decalcified (5% nitric acid) and undecalcified (glycol-methacrylate or resin embedded) routinely processed bone specimens osteoclasts against resorbing surfaces were identified with monoclonal antibodies directed against leucocyte common antigen (LCA) (PD7/26, 2B11), CD68 (KP1), and gpIIIa (Y2/51) but not against H...

journal_title：Journal of clinical pathology

authors： Athanasou NA,Puddle B,Quinn J,Woods CG

更新日期：1991-08-01 00:00:00

abstract：:A spectrophotometric assay of proteolytic enzyme activity is described in which the optical density obtained by a given enzyme preparation is related (2 alpha less than 0.01) to the serological activity of that preparation in a two stage technique. The assay appears to be of use for the standardisation of enzyme prepa...

journal_title：Journal of clinical pathology

authors： Phillips PK,Prior D,Dawes B

更新日期：1984-03-01 00:00:00

abstract：AIMS:To develop a strategy for neonatal screening of sickle cell disease (SCD) and effective enrollment of affected neonates in a comprehensive follow-up programme adapted to the socioeconomic conditions, health structures and cultural background of an African setting. METHODS:The strategy implemented at the two large...

journal_title：Journal of clinical pathology

authors： Rahimy MC,Gangbo A,Ahouignan G,Alihonou E

更新日期：2009-01-01 00:00:00

abstract：:MUCs are glycoproteins with various roles in homeostasis and carcinogenesis. Among other actions, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. In contrast, MUC2 is normally found only in goblet cells, where it contributes to the prote...

journal_title：Journal of clinical pathology

authors： Levi E,Klimstra DS,Andea A,Basturk O,Adsay NV

更新日期：2004-05-01 00:00:00

abstract：AIMS:To evaluate two detailed step sectioning protocols for sentinel lymph nodes (SLNs). METHODS:After vital dye or combined dye and radiocolloid guided biopsy, SLNs were fixed in formalin and embedded in paraffin wax. In protocol A, SLNs from 123 patients were sectioned in steps of 50-100 micro m, whereas in protocol...

journal_title：Journal of clinical pathology

authors： Cserni G

更新日期：2002-12-01 00:00:00

abstract：:Fifty-three breast carcinomas were examined by an indirect immunoperoxidase technique for the presence of the alpha-subunit of human chorionic gonadotrophin. Positive staining occurred in 12 (22.6%). There was no correlation between alpha-subunit production and specific histological features, but production was relate...

journal_title：Journal of clinical pathology

authors： Walker RA

更新日期：1978-03-01 00:00:00

abstract：:By means of enzyme immunoassays based on two monoclonal antibodies with specificities for distinct forms of placental type alkaline phosphatase (Pl-ALP), together with L-leucine inhibition studies, it has been possible to distinguish the Nagao type carcinoplacental enzyme from other placental type alkaline phosphatase...

journal_title：Journal of clinical pathology

authors： McLaughlin PJ,Twist AM,Evans CC,Johnson PM

更新日期：1984-07-01 00:00:00

abstract：AIM:We aimed to assess the one step nucleic acid amplification (OSNA) assay as an intraoperative method in comparison with frozen sections (FS) for detection of metastasis in sentinel lymph nodes (SLNs) of breast cancer. METHOD:100 SLNs from patients with breast carcinoma were enrolled within a 3-month period. Alterna...

journal_title：Journal of clinical pathology

authors： Jara-Lazaro AR,Hussain IH,Thike AA,Wong CY,Ho GH,Yong WS,Ong KW,Madhukumar P,Tan BK,Oey CL,Hwang JS,Tan PH

更新日期：2014-12-01 00:00:00

abstract：:A patient with a 10 year history of monoclonal gammopathy of undetermined significance and Bence Jones proteinuria, and a 44 year history of ankylosing spondylitis, developed a nephrotic syndrome secondary to renal amyloidosis. Clinically the amyloidosis was ascribed to Bence Jones proteinuria rather than to the burnt...

journal_title：Journal of clinical pathology

authors： Quinton R,Siersema PD,Michiels JJ,ten Kate FJ

更新日期：1992-10-01 00:00:00

abstract：AIM:To examine tumour samples immunohistochemically for MUC1 (episialin), epidermal growth factor receptor (EGFR), and c-erbB-2, since the disruption of the cell-cell adhesion system by MUC1 and the c-erbB oncoprotein family is known to be important in the development of metastasis in human cancers. METHODS:93 tumour ...

journal_title：Journal of clinical pathology

authors： Guddo F,Giatromanolaki A,Koukourakis MI,Reina C,Vignola AM,Chlouverakis G,Hilkens J,Gatter KC,Harris AL,Bonsignore G

更新日期：1998-09-01 00:00:00

abstract：:Serial plasmaphereses were performed on a 23-year-old haemophiliac, with antibodies to factor VIII (FVIII), in order to reduce the antibody level before multiple dental extractions. Eight phereses were carried out in which approximately 1.5 litres plasma was exchanged with isotonic saline. By the ninth exchange, which...

journal_title：Journal of clinical pathology

authors： Cobcroft R,Tamagnini G,Dormandy KM

更新日期：1977-08-01 00:00:00

abstract：:Synovium was collected from 15 patients who were undergoing joint surgery. Two groups were defined by clinical diagnosis: patients with primary osteoarthritis (n = 4); and those with rheumatoid arthritis (n = 11). The synovium was studied using histological and morphometric techniques. In agreement with previous studi...

journal_title：Journal of clinical pathology

authors： Kennedy TD,Plater-Zyberk C,Partridge TA,Woodrow DF,Maini RN

更新日期：1988-08-01 00:00:00

abstract：AIMS:Caucasian patients with disorders of sex development (DSD) are at a high risk of developing germ cell cancer (GCC). GCC is prominent in young adults in Western countries, while the incidence is significantly lower in Asia. So far, the risk of GCC in Asian DSD patients is unknown. METHODS AND RESULTS:A detailed st...

journal_title：Journal of clinical pathology

authors： Juniarto AZ,Setyawati BA,Miranti IP,Santosa A,Hersmus R,Stoop H,Cools M,Oosterhuis JW,Drop SL,Faradz SM,Looijenga LH

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Optimal management of patients with lung cancer requires accurate cell typing of tumours and staging at the time of diagnosis. Endobronchial ultrasound-guided lymph node aspiration as a method of diagnosing and staging lung cancer is a relatively new technique. AIM:To report the use of liquid-based-thin-lay...

journal_title：Journal of clinical pathology

authors： Wallace WA,Monaghan HM,Salter DM,Gibbons MA,Skwarski KM

更新日期：2007-04-01 00:00:00

abstract：:A monoclonal antibody, produced by peptide immunisation was used to detect the distribution of p62c/myc by immunohistology in normal and coeliac small intestinal mucosa. The effect of gluten in four treated coeliac patients was investigated by taking serial jejunal biopsy specimens for six hours after a 10 g oral glut...

journal_title：Journal of clinical pathology

authors： Ciclitira PJ,Stewart J,Evan G,Wight DG,Sikora K

更新日期：1987-03-01 00:00:00

abstract：:A manual system of microbiology reporting with a National Cash Register (NCR) form with printed names of bacteria and antiboitics required less time to compose reports than a previous manual system that involved rubber stamps and handwriting on plain report sheets. The NCR report cost 10-28 pence and, compared with a ...

journal_title：Journal of clinical pathology

authors： Goodwin CS

更新日期：1976-06-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) testing is required for newly diagnosed breast cancer and advised for recurrent and metastatic breast cancer, to determine treatment planning using HER2-directed therapy in the neoadjuvant, adjuvant and advanced disease settings. Wide variation, nationally, in the turnar...

journal_title：Journal of clinical pathology

authors： Shaaban AM,Purdie CA,Bartlett JM,Stein RC,Lane S,Francis A,Thompson AM,Pinder SE,Translational Subgroup of the NCRI Breast Clinical Studies Group.

更新日期：2014-02-01 00:00:00

abstract：:Surface immunoglobulins (Ig) of normal and malignant lymphoid cells were detected on prefixed, smeared (method A) and live (method B) cell suspensions; the results were compared with regard to staining patterns, specificity and sensitivity. In both methods surface Ig were detected by a direct immunoperoxidase procedur...

journal_title：Journal of clinical pathology

authors： Laurent G,Gourdin MF,Reyes F

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND:The Wnt pathway is important in cell signalling transduction and is involved in the pathogenesis of multiple tumour types. A comprehensive analysis of the expression of Wnt signalling pathway proteins in mammary phyllodes tumours (PTs) has not been previously performed. AIMS:To evaluate the immunohistochemi...

journal_title：Journal of clinical pathology

authors： Karim RZ,Gerega SK,Yang YH,Horvath L,Spillane A,Carmalt H,Scolyer RA,Lee CS

更新日期：2009-11-01 00:00:00

abstract：AIM:To investigate the association between the quantity of gastric chemokine mRNA expression, severity of gastritis, and cagA positivity in Helicobacter pylori associated gastritis. METHODS:In 83 dyspeptic patients, antral and corpus biopsies were taken for semiquantitative reverse transcription polymerase chain react...

journal_title：Journal of clinical pathology

authors： Shimoyama T,Everett SM,Dixon MF,Axon AT,Crabtree JE

更新日期：1998-10-01 00:00:00

abstract：:The usefulness of placental alkaline phosphatase (PLAP) as a diagnostic marker of malignancy was assessed in pleural fluid from 60 patients with effusions. Pleural fluid PLAP activities were measured by an enzyme linked immunoassay (ELISA) using the two monoclonal antibodies H17E2 and H317. Similar values were found i...

journal_title：Journal of clinical pathology

authors： Fergusson RJ,Fisken J,McIntyre MA,Roulston JE,Leonard RC

更新日期：1992-12-01 00:00:00

abstract：:Care in the preparation and preservation of reagents, together with certain modifications in apparatus and technique, have eliminated the difficulties from plasma ammonia analysis. Ammonia contamination from the laboratory atmosphere has not proved an especial hazard, and no major setback has been encountered in the a...

journal_title：Journal of clinical pathology

authors： Fenton JC,Williams AH

更新日期：1968-01-01 00:00:00

abstract：BACKGROUND:The Sysmex XN haematology instrument performs automatic reflex testing, depending on sample results. A nucleated red blood cell (NRBC) count is provided on all samples. The instrument has a smaller footprint (34%) than previous Sysmex XE analysers. METHODS:An evaluation comparing all results to the Sysmex X...

journal_title：Journal of clinical pathology

authors： Briggs C,Longair I,Kumar P,Singh D,Machin SJ

更新日期：2012-11-01 00:00:00