HER2 testing for breast carcinoma: recommendations for rapid diagnostic pathways in clinical practice.

Abstract:

:Human epidermal growth factor receptor 2 (HER2) testing is required for newly diagnosed breast cancer and advised for recurrent and metastatic breast cancer, to determine treatment planning using HER2-directed therapy in the neoadjuvant, adjuvant and advanced disease settings. Wide variation, nationally, in the turnaround time for HER2 testing may hinder equity of access for patients to both clinical trials and the timely implementation of HER2-directed therapy particularly in the neo-adjuvant setting. Process mapping from three recognised laboratories in the UK was applied to the logistics of HER2 testing in different geographic hub and spoke models. Consequently, recommendations for HER2 testing likely to facilitate access to clinical trials and timely patient care are presented.

journal_name

J Clin Pathol

authors

Shaaban AM,Purdie CA,Bartlett JM,Stein RC,Lane S,Francis A,Thompson AM,Pinder SE,Translational Subgroup of the NCRI Breast Clinical Studies Group.

doi

10.1136/jclinpath-2013-201819

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

161-7

issue

2

eissn

0021-9746

issn

1472-4146

pii

jclinpath-2013-201819

journal_volume

67

pub_type

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