Severe cutaneous reactions to captopril and enalapril; histological study and comparison with early mycosis fungoides.

abstract：:An antibody was raised against a protein isolated from the cytoplasm of mesothelioma cells. It was subsequently used in an immunoperoxidase procedure on formalin fixed, paraffin embedded tissue sections. A representative sample of benign and malignant tumours from all the systems of the human body was examined. All th...

journal_title：Journal of clinical pathology

authors： Donna A,Betta PG,Bellingeri D,Marchesini A

更新日期：1986-09-01 00:00:00

abstract：AIMS:Congenital neutropenia (CN) is a rare inherited disease that results in recurrent, life-threatening bacterial infections due to a deficiency of mature neutrophils. They are usually caused by heterozygous ELANE mutations although mutations in other genes like HAX-1, G6PC3 and GFI1 have also been reported. Identifyi...

journal_title：Journal of clinical pathology

authors： Arunachalam AK,Suresh H,Edison ES,Korula A,Aboobacker FN,George B,Shaji RV,Mathews V,Balasubramanian P

更新日期：2020-06-01 00:00:00

abstract：AIMS:To evaluate the effect of microwave irradiation on the staining quality of a range of commonly used primary antibodies in archival, formalin fixed, paraffin wax embedded material, with emphasis on antibodies that have previously worked successfully only on frozen tissue. METHODS:Immunocytochemistry (streptavidin-...

journal_title：Journal of clinical pathology

authors： Cuevas EC,Bateman AC,Wilkins BS,Johnson PA,Williams JH,Lee AH,Jones DB,Wright DH

更新日期：1994-05-01 00:00:00

abstract：:With lymph node enlargement, the possibility of a malignant process such as metastatic carcinoma or lymphoma needs to be excluded. This report describes a 47 year old woman with inguinal lymph node enlargement initially suspicious for lymphoma. Fine needle aspiration findings favoured reactive hyperplasia, but a malig...

journal_title：Journal of clinical pathology

authors： Péoc'h M,Duprez D,Grice G,Fabre-Bocquentin B,Gressin R,Pasquier B

更新日期：2000-07-01 00:00:00

abstract：:Hepatitis C virus (HCV) replication is reported in both tumour and non-tumour tissue in a case of hepatocellular carcinoma. Viral replication was established by showing the presence of minus strand HCV RNA by PCR amplification, after excluding residual reverse transcriptase activity of Taq polymerase. No minus strand ...

journal_title：Journal of clinical pathology

authors： Niu J,Kumar U,Monjardino J,Goldin R,Rosin D,Thomas HC

更新日期：1995-09-01 00:00:00

abstract：AIMS:The perforin mediated pathway is the major pathway of cytotoxicity induced by activated T cells and natural killer cells, and may be involved in the development of pulmonary fibrosis. METHODS:Perforin and granzyme B expression were examined in idiopathic pulmonary fibrosis by means of immunohistochemistry, and pe...

journal_title：Journal of clinical pathology

authors： Miyazaki H,Kuwano K,Yoshida K,Maeyama T,Yoshimi M,Fujita M,Hagimoto N,Yoshida R,Nakanishi Y

更新日期：2004-12-01 00:00:00

abstract：:Experience gained in the last four years concerning the capabilities and limitations of an 8K Elliott 903 (18-bit word) computer with magnetic tape backing store in the routine operation of a clinical chemistry laboratory is described. Designed as a total system, routine operation has latterly had to be confined to da...

journal_title：Journal of clinical pathology

authors： Whitby LG,Simpson D

更新日期：1973-07-01 00:00:00

abstract：:Plasma diamine oxidase levels were assayed in 66 patients who presented with pregnancy complicated by threatened abortion. Levels within the normal range were associated with continuing pregnancies, whereas levels below the normal range were associated with subsequent abortion. Among those patients in whom gestation w...

journal_title：Journal of clinical pathology

authors： Legge M,Duff GB

更新日期：1981-02-01 00:00:00

abstract：:Fifteen cases of large-cell lymphoma, diagnosed as centroblastic (5), B-immunoblastic (5) or true histiocytic (5). lymphoma and one case of malignant histiocytosis were studied with monoclonal antibodies. Each diagnosis was based on morphological as well as marker studies. A panel of monoclonal and heterologous antibo...

journal_title：Journal of clinical pathology

authors： van der Valk P,van den Besselaar-Dingjan G,Daha MR,Meijer CJ

更新日期：1983-01-01 00:00:00

abstract：AIMS:To investigate the role of needle core biopsy (NCB) in the preoperative assessment of impalpable breast lesions, mainly derived from the NHS Breast Screening Programme (NHSBSP) and to assess our own modifications to a suggested system for the classification of breast NCBs. METHODS:The NCB, fine needle aspiration ...

journal_title：Journal of clinical pathology

authors： Ibrahim AE,Bateman AC,Theaker JM,Low JL,Addis B,Tidbury P,Rubin C,Briley M,Royle GT

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Venous invasion (VI) is an important prognosis predictor after colorectal carcinoma (CRC) resection, enabling more accurate staging and influencing postoperative management. AIMS:To assess/compare various tissue block types (perpendicular, tangential, across mesentery (AM), from major vessels or lymph nodes...

journal_title：Journal of clinical pathology

authors： Sternberg A,Mizrahi A,Amar M,Groisman G

更新日期：2006-02-01 00:00:00

abstract：:A method for identifying Helicobacter pylori using a non-isotopic in situ hybridisation technique is described. A probe generated by polymerase chain reaction (PCR) with primers directed against parts of the Helicobacter pylori 16SrRNA sequence was used. Paraffin wax embedded gastric biopsy specimens from patients wit...

journal_title：Journal of clinical pathology

authors： Bashir MS,Lewis FA,Quirke P,Lee A,Dixon MF

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND/AIMS:In the natural history of gastric cancer, non-invasive neoplasia (NiN) precedes invasive carcinoma. A histological classification of gastric NiN has recently been proposed by a World Health Organisation international panel of experts. Genetic instability is known to be among the molecular pathways invol...

journal_title：Journal of clinical pathology

authors： Rugge M,Bersani G,Bertorelle R,Pennelli G,Russo VM,Farinati F,Bartolini D,Cassaro M,Alvisi V

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Many patients with advanced cancer are malnourished. Anorexia is common, as is the use of chemotherapy, which may cause nausea and poor appetite. Ten per cent of these patients experience haemorrhagic events. AIM:Since vitamin K deficiency (VKD) causes bleeding, to establish the prevalence of VKD in patient...

journal_title：Journal of clinical pathology

authors： Harrington DJ,Western H,Seton-Jones C,Rangarajan S,Beynon T,Shearer MJ

更新日期：2008-04-01 00:00:00

abstract：:Cervical smears were reviewed from 62 women who developed squamous carcinoma of the cervix up to 18 years later. The findings indicate that the prevention of cervical cancer by screening depends very largely on the detection of severe dyskaryosis. In this series there was no evidence that mild dyskaryosis was a foreru...

journal_title：Journal of clinical pathology

authors： Robertson JH,Woodend B,Elliott H

更新日期：1994-03-01 00:00:00

abstract：:To determine the functional importance of the low B12 and red cell folate concentrations repeatedly observed in the elderly 200 consecutive patients admitted to a geriatric unit were studied. Forty six of the patients had low serum concentrations of B12 (15), red cell folate (26), or both (five). Serum B12 and red cel...

journal_title：Journal of clinical pathology

authors： Blundell EL,Matthews JH,Allen SM,Middleton AM,Morris JE,Wickramasinghe SN

更新日期：1985-10-01 00:00:00

abstract：:Eight strains of Pseudomonas putrefaciens have been received from among 466 strains of Pseudomonas submitted to the Computer Trials Laboratory for identification over the last eight years. Two of the strains of P. putrefaciens from patients with otitis media and otitis externa respectively appear to have played a path...

journal_title：Journal of clinical pathology

authors： Holmes B,Lapage SP,Malnick H

更新日期：1975-02-01 00:00:00

abstract：:Sodium-alpha-naphthylamine-4-sulphonate (Naphthionin) appears to shorten the bleeding time in normal subjects and to be of value in the management of the bleeding defect in patients with thrombocytopenia when given by intravenous or intramuscular injection. A good response was achieved in three patients suffering from...

journal_title：Journal of clinical pathology

authors： POLLER L,MORE JR

更新日期：1964-11-01 00:00:00

abstract：:An enzyme linked immunosorbent assay (ELISA) to measure free serum IgG antibodies to Pseudomonas aeruginosa in patients with cystic fibrosis was developed. Seven strains of P aeruginosa cells, treated with glutaraldehyde and representing the most commonly isolated serotypes in our cystic fibrosis unit, were used. The ...

journal_title：Journal of clinical pathology

authors： Brett MM,Ghoneim AT,Littlewood JM,Losowsky MS

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Recent studies have shown that minichromosome maintenance (MCM) proteins (Mcm2-7) may be useful proliferation markers in dysplasia and cancer in various tissues. AIMS:To investigate the use of Mcm7 as a proliferation marker in 79 lymph node negative prostate cancers and compare it with Ki-67, a commonly use...

journal_title：Journal of clinical pathology

authors： Padmanabhan V,Callas P,Philips G,Trainer TD,Beatty BG

更新日期：2004-10-01 00:00:00

abstract：AIMS:To evaluate and compare the long term prognostic value of the WHO classification and the computerised multivariate morphometrical D score in endometrial hyperplasia. To test the reproducibility of the D score in two different centres. METHODS:Histopathological WHO classification and computerised morphometrical an...

journal_title：Journal of clinical pathology

authors： Orbo A,Baak JP,Kleivan I,Lysne S,Prytz PS,Broeckaert MA,Slappendel A,Tichelaar HJ

更新日期：2000-09-01 00:00:00

abstract：:Accurate diagnosis of Clostridium difficile infection (CDI) is essential for optimal treatment, prevention and control. There are two reference assays for CDI diagnosis: the cell cytotoxicity assay (CCTA) and toxigenic culture (TC). Importantly, these tests actually detect different targets: CCTA detects the presence ...

journal_title：Journal of clinical pathology

authors： Planche T,Wilcox M

更新日期：2011-01-01 00:00:00

abstract：AIMS:Myospherulosis is a rare condition characterised by sac-like structures containing spheroid bodies in cysts or cystic spaces in the tissue. This condition has not previously been reported in the liver. The association with previous portal vein embolisation using a mixture of butyl 2-cyanoacrylate and ethiodised oi...

journal_title：Journal of clinical pathology

authors： Lui PC,Luk IS,Lee CK,Lui YH,Leung CY,Choi CH

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Fungal infection is increasingly recognised as an important cause of morbidity and mortality, especially in immunocompromised patients. Little information exists on laboratory services available and the methods used by general microbiology laboratories to diagnose these important infections. AIM:To investig...

journal_title：Journal of clinical pathology

authors： Hassan IA,Critten P,Isalska B,Denning DW

更新日期：2006-07-01 00:00:00

abstract：:Taking a kidney biopsy is not a trivial procedure. The sample is almost invariably smaller than the pathologist would like. Investigation usually requires division into even smaller samples to permit the application of specialist techniques. In some cases the biopsy is taken not for diagnosis, but to assess the extent...

journal_title：Journal of clinical pathology

authors： Furness PN

更新日期：2000-06-01 00:00:00

abstract：:Cervical smears from 327 women were examined using the polymerase chain reaction (PCR) targeted to a sequence in the Bam H1 W region of the Epstein-Barr virus (EBV) to determine the prevalence of the virus in the cervix. EBV was detected in 131 (40%) of the 327 women. Of the 235 women with normal cytology, 98 (42%) we...

journal_title：Journal of clinical pathology

authors： Taylor Y,Melvin WT,Sewell HF,Flannelly G,Walker F

更新日期：1994-01-01 00:00:00

abstract：AIMS:Dysfunctional prothrombin residue Arg596 associated mutation has been found to precipitate venous thromboembolism (VTE). In the current study we investigated the prevalence of Arg596 associated mutations in Chinese patients with VTE and explored the functional impact of Arg596Gln mutation on coagulation function i...

journal_title：Journal of clinical pathology

authors： Wu X,Li L,Ding Q,Wang X,Wu F,Wu W

更新日期：2018-07-01 00:00:00

abstract：:Specimens from 95 patients attending a venereal diseases clinic were examined for gonococci by three methods--a conventional culture technique using modified Thayer-Martin medium, microscopy of a Gram-stained direct smear, and the Microcult system. For 56% of the specimens the results by all three methods agreed. Assu...

journal_title：Journal of clinical pathology

authors： Williams RJ,Ratnatunga CS,Hamilton-Miller JM,Brumfitt W

更新日期：1978-03-01 00:00:00

abstract：AIM:We examined the genetic alterations in a mother and son with multiple eosinophilic chromophobe renal cell carcinomas (chRCCs) showing no other features. METHODS:Germline DNA and bilateral renal cell carcinoma DNA were genetically analysed by whole-exome sequencing. Candidate gene alterations in the first patient's...

journal_title：Journal of clinical pathology

authors： Sakamoto H,Yamasaki T,Sumiyoshi T,Utsunomiya N,Takeda M,Kamba T,Nakamura E,Ogawa O

更新日期：2018-10-01 00:00:00

abstract：AIM:To assess the topographical relation between gastric glands, using the minimum spanning tree (MST), to derive both a model of neighbourhood and quantitative representation of the tissue's architecture, to assess the characteristic features of gastric atrophy, and to assess the grades of gastric atrophy. METHODS:Ha...

journal_title：Journal of clinical pathology

authors： Zaitoun AM,al Mardini H,Record CO

更新日期：1998-12-01 00:00:00