Comparison of the expression of p53, p21, Bax and the induction of apoptosis between patients with basal cell carcinoma and normal controls in response to ultraviolet irradiation.

abstract：:Activation of the complement system, the main humoral mediator of inflammation, is restrained by the action of enzyme inhibitors including alpha 1-antitrypsin. Deficiency leads to chronic liver disease in about one in five children with this genetic defect. Complement activation was investigated in 34 children with al...

journal_title：Journal of clinical pathology

authors： Littleton ET,Bevis L,Hansen LJ,Peakman M,Mowat AP,Mieli-Vergani G,Vergani D

更新日期：1991-10-01 00:00:00

abstract：:A patient with multiple myeloma had antigenically related monoclonal Fc-gamma fragments and complete IgG-kappa molecules in the serum. The urine contained only Fc-gamma fragments in the absence of Bence-Jones protein. The two distinct M-components in the serum showed electrophoretic identity but could be separated by ...

journal_title：Journal of clinical pathology

authors： Bartoloni C,Flamini G,Gentiloni N,Russo MA,Barone C,Gambassi G,Terranova T

更新日期：1980-10-01 00:00:00

abstract：AIMS:To evaluate the influence of involvement of the peritoneal surface by carcinoma of the rectum on local recurrence and prognosis. METHODS:Prospective analysis of pathological prognostic factors in 209 resections for rectal carcinoma between 1988 and 1993 with meticulous pathological technique particularly to asses...

journal_title：Journal of clinical pathology

authors： Shepherd NA,Baxter KJ,Love SB

更新日期：1995-09-01 00:00:00

abstract：:Ten patients with severe megaloblastic anaemia were studied to investigate whether the causative metabolic defects might predispose them to lactic or other acidosis. One patient had compensated acidosis with hyperlactataemia before treatment but there were obvious causes other than anaemia. No other patient developed ...

journal_title：Journal of clinical pathology

authors： Franklin IM,Kernoff PB,Isherwood D,Leek J,Morgan DB

更新日期：1982-09-01 00:00:00

abstract：:There is currently much speculation over the precise nature of lobular carcinoma in-situ of the breast and its significance. Histochemical study shows that it is rich in sialomucin. This has a characteristic intracellular distribution which distinghishes lobular carcinoma in-situ from cancerization of lobules. The sam...

journal_title：Journal of clinical pathology

authors： Gad A,Azzopardi JG

更新日期：1975-09-01 00:00:00

abstract：:The histological appearances of the breast in a patient with mucoviscidosis are those of complete lobular agenesis. Ducts and ductules are well developed, and there is abundant fibrous tissue giving the breast a normal contour. The appearances are contrasted with those of gynaecomastia, and the aetiology is discussed....

journal_title：Journal of clinical pathology

authors： Ward AM

更新日期：1972-02-01 00:00:00

abstract：:Accurate histopathological assessment of biopsies is important for the diagnosis, subclassification, and management of chronic idiopathic inflammatory bowel disease (IBD). British Society of Gastroenterology (BSG) guidelines for the initial histopathological diagnosis of IBD were published in 1997. Changes since then ...

journal_title：Journal of clinical pathology

authors： Feakins RM,British Society of Gastroenterology.

更新日期：2013-12-01 00:00:00

abstract：AIMS:To audit the cellular expression of the innate antibacterial enzyme lysozyme in colonic biopsies from a cohort of patients having microscopic colitis (MC-collagenous colitis (CC) or lymphocytic colitis (LC)). Results were compared with those recorded in patients with inflammatory bowel disease (IBD) of the colon (...

journal_title：Journal of clinical pathology

authors： Rubio CA

更新日期：2011-06-01 00:00:00

abstract：:A rapid and reproducible electrophoretic method for the separation and quantitation of haemoglobins on cellulose acetate is described. The accuracy of the method and its possible sources of error are discussed. The normal range for haemoglobin A(2) by this method is 1% to 3% of the total haemoglobin concentration. Blo...

journal_title：Journal of clinical pathology

authors： Marengo-Rowe AJ

更新日期：1965-11-01 00:00:00

abstract：:Only four cases of tracheopathia osteoplastica have been reported in Britain in the past 110 years. Ten further cases are now reported; in two the diagnosis was made at bronchoscopy. It is suggested that the reputed rarity of the condition in Britain is not the whole picture. ...

journal_title：Journal of clinical pathology

authors： Way SP

更新日期：1967-11-01 00:00:00

abstract：:A case of B-CLL which was complicated by chronic renal failure due to leukaemic infiltration of the kidney is reported. Treatment with chlorambucil, prednisolone, and renal bed irradiation resulted in a substantial improvement in renal function which persisted until the the patient's death from marrow failure some eig...

journal_title：Journal of clinical pathology

authors： Phillips JK,Bass PS,Majumdar G,Davies DR,Jones NF,Pearson TC

更新日期：1993-12-01 00:00:00

abstract：AIM:To investigate serum placental-type alkaline phosphatase (PLAP-type) activities in women with squamous and glandular malignancies of the reproductive tract using an immunoradiometric assay. METHODS:PLAP-type immunoreactivity was measured in 180 women with non-ovarian malignancies of the reproductive tract and the ...

journal_title：Journal of clinical pathology

authors： Ind TE,Iles RK,Carter PG,Lowe DG,Shepherd JH,Hudson CN,Chard T

更新日期：1994-11-01 00:00:00

abstract：:A new rapid automated method for the identification and classification of microorganisms is described. It is based on the incorporation of 35S-methionine into cellular proteins and subsequent separation of the radiolabelled proteins by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). The protein ...

journal_title：Journal of clinical pathology

authors： Tabaqchali S,Silman R,Holland D

更新日期：1987-09-01 00:00:00

abstract：:The biochemical assay for the oestrogen receptor has shown the clinical value of knowing the concentration of the receptor within tissue. The immunohistochemical assay is rapidly taking over from the biochemical assay. Therefore, it is vital to have an equivalent scoring system that will have the same predictive value...

journal_title：Journal of clinical pathology

authors： Leake R,Barnes D,Pinder S,Ellis I,Anderson L,Anderson T,Adamson R,Rhodes T,Miller K,Walker R

更新日期：2000-08-01 00:00:00

abstract：:Tumour associated antigens recognised by cellular or humoral effectors of the immune system are potential targets for antigen specific cancer immunotherapy. Different categories of cancer antigens have been identified that induce cytotoxic T lymphocyte (CTL) responses in vitro and in vivo, namely: (1) "cancer testis" ...

journal_title：Journal of clinical pathology

authors： Jäger D,Jäger E,Knuth A

更新日期：2001-09-01 00:00:00

abstract：AIM:To identify and review cases of false negative needle core biopsy (NCB) in the preoperative investigation of radial scar/complex sclerosing lesion (RS/CSL) lesions - that is, benign NCB from RS/CSL which contained malignancy on excision. METHODS AND RESULTS:A total of 11 false negative NCB in RS/CSL lesions from 2...

journal_title：Journal of clinical pathology

authors： Douglas-Jones AG,Denson JL,Cox AC,Harries IB,Stevens G

更新日期：2007-03-01 00:00:00

abstract：:A case of coexistent acute myeloid leukaemia and sarcoidosis is reported. This was complicated by recurrent pulmonary haemorrhage during reinduction and consolidation chemotherapy. A review of published papers on malignancy and sarcoidosis, in particular acute leukaemia is given. The outcome of most cases of acute leu...

journal_title：Journal of clinical pathology

authors： Williams B,Francis A,Durrant S

更新日期：1994-07-01 00:00:00

abstract：:This is an unusual case of total granulomatous infarction of testis due to Schistosoma haematobium, the first such case to be reported. This report reinforces the theory of extraportal maturation of worms in spermatic veins and capillaries as postulated earlier (Joshi, 1962). ...

journal_title：Journal of clinical pathology

authors： Joshi RA

更新日期：1967-05-01 00:00:00

abstract：:Most patients with gonadoblastoma have dysgenetic gonads. This rare tumour has been described in three pregnant women. A fourth case in a 26 year old pregnant woman who presented with gonadoblastoma and dysgerminoma, is reported. She had a normal term pregnancy, 46XX chromosomes, normal genitalia, no history of menstr...

journal_title：Journal of clinical pathology

authors： Erhan Y,Toprak AS,Ozdemir N,Tiras B

更新日期：1992-09-01 00:00:00

abstract：:Pathology review of gynaecological cancer specimens is often carried out as part of the working of gynaecological oncology multidisciplinary team meetings. This review describes the author's experience regarding the most common issues identified during this process. Ten subjects are covered; these range from histopath...

journal_title：Journal of clinical pathology

authors： McCluggage WG

更新日期：2012-04-01 00:00:00

abstract：:In-vivo studies of fibrinogen metabolism were carried out using an I-120 labelled preparation of fibrinogen supplied commercially by the Radiochemical Centre, Amerhsham for use in the diagnosis of deep venous thrombosis. These studies show that the material is suitable for obtaining the main metabolic parameters of c...

journal_title：Journal of clinical pathology

authors： Bradley J,Hickman JA

更新日期：1975-06-01 00:00:00

abstract：:Sections of tissue embedded in paraffin wax from 18 selected odontogenic cysts were studied both histologically and immunohistochemically with antibodies to cytokeratins using the indirect peroxidase technique. The cysts were divided on a clinical and histological basis into two equal groups comprising dentigerous cys...

journal_title：Journal of clinical pathology

authors： MacDonald AW,Fletcher A

更新日期：1989-07-01 00:00:00

abstract：:A latex agglutination test for the detection of Pseudomonas pseudomallei antigen in urine was evaluated for the rapid diagnosis of melioidosis. With unconcentrated urine, antigen was detected in only 18% of patients with melioidosis overall. However, when urine was concentrated 100-fold, antigen was detected in 47% ov...

journal_title：Journal of clinical pathology

authors： Smith MD,Wuthiekanun V,Walsh AL,Teerawattanasook N,Desakorn V,Suputtamongkol Y,Pitt TL,White NJ

更新日期：1995-02-01 00:00:00

abstract：:The production of antitoxin after Clostridium difficile-induced diarrhoea has not been reported previously. The stool of a patient with prolonged antibiotic-associated diarrhoea contained C. difficile toxin, and the serum neutralised the cytopathic effect of C. difficile toxin in tissue culture. ...

journal_title：Journal of clinical pathology

authors： Lishman AH,Al-Jumaili IJ,Record CO

更新日期：1981-04-01 00:00:00

abstract：:Factor VIII-containing materials were administered to four severely affected haemophiliacs twice weekly in doses calculated to raise the factor VIII level to either 15% or 30% of average normal. The pooled results from those patients with statistically similar baseline bleeding frequencies showed a significant reducti...

journal_title：Journal of clinical pathology

authors： Aronstam A,Kirk PJ,McHardy J,Culver-James JW,McLellan DS,Turk P,Rainsford SG,Slattery M

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Triple-negative breast cancers (TNBCs) are defined by their lack of oestrogen receptor, progesterone receptor and epidermal growth factor receptor 2. Although heterogeneous, the majority are aggressive and treatment options are limited. Caveolin acts as tumour suppressor or promoter depending on the cancer t...

journal_title：Journal of clinical pathology

authors： Yeong J,Thike AA,Ikeda M,Lim JCT,Lee B,Nakamura S,Iqbal J,Tan PH

更新日期：2018-02-01 00:00:00

abstract：:The titre of antibodies to Toxoplasma gondii was compared in 1985 sera by use of an indirect haemagglutination test (ToxHA test--Wellcome Reagents Ltd) and the dye test. Sera from 42 patients with clinical or serological indications of recent toxoplasmosis were also examined to determine if the ToxHA test would be of ...

journal_title：Journal of clinical pathology

authors： Balfour AH,Bridges JB,Harford JP

更新日期：1980-07-01 00:00:00

abstract：:Blood cultures drawn from a patient with clinically diagnosed invasive meningococcal disease, who had been previously administered benzylpenicillin, had beta-lactamases added to increase the probability of recovery of the causative organism. The blood cultures subsequently yielded Neisseria meningitidis but direct sus...

journal_title：Journal of clinical pathology

authors： Weightman NC

更新日期：2001-11-01 00:00:00

abstract：:Urine specimens were collected from 26 normal subjects, 10 patients with proven primary hyperparathyroidism, and eight patients with hypercalcaemia due to other causes. After overnight urine concentration, an oral water load was given to induce a diuresis and provide urine specimens with a relatively wide range of cre...

journal_title：Journal of clinical pathology

authors： Wills MR

更新日期：1969-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) replication is reported in both tumour and non-tumour tissue in a case of hepatocellular carcinoma. Viral replication was established by showing the presence of minus strand HCV RNA by PCR amplification, after excluding residual reverse transcriptase activity of Taq polymerase. No minus strand ...

journal_title：Journal of clinical pathology

authors： Niu J,Kumar U,Monjardino J,Goldin R,Rosin D,Thomas HC

更新日期：1995-09-01 00:00:00