Hashimoto's thyroiditis associated with urticaria and angio-oedema: disappearance of cutaneous and mucosal manifestations after thyroidectomy.

Abstract:

:A 60 year old woman affected by Hashimoto's thyroiditis presented with a history of recurring episodes of urticaria and angio-oedema. Clinical and laboratory evaluation of the patient excluded allergy to external agents, hereditary angio-oedema, and occult infections. A pathogenic relation between Hashimoto's thyroiditis and chronic urticaria/angio-oedema was suspected. However, treatment with L-thyroxine had no influence on the frequency and severity of the cutaneous and mucosal manifestations, which occurred almost daily and required repeated administration of steroids. The patient therefore underwent total thyroidectomy. Cytometric analysis of intrathyroidal lymphocyte subsets showed unusual abnormalities. Urticaria and angio-oedema completely remitted after surgery; 18 months postoperatively the patient was still asymptomatic.

journal_name

J Clin Pathol

authors

Amoroso A,Garzia P,Pasquarelli C,Sportelli G,Afeltra A

doi

10.1136/jcp.50.3.254

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

254-6

issue

3

eissn

0021-9746

issn

1472-4146

journal_volume

50

pub_type

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