Abstract:
OBJECTIVES:Intraduct papillary mucinous neoplasm (IPMN) is a pancreatic tumour that is often associated with chronic pancreatitis (CP) in the surrounding pancreas. Type 1 autoimmune pancreatitis (AIP) is a fibro-inflammatory condition with characteristic histological features and prominent IgG4+ plasma cells and is part of the spectrum of IgG4-related disease (IgG4-RD). The aim of this study was to determine whether CP associated with pancreatic IPMN commonly represents AIP. METHODS:We identified two consecutive 'index' cases of pancreatic IPMN during routine reporting in which the adjacent pancreas showed morphological features suggestive of AIP. These cases were investigated using the Boston criteria for the histopathological diagnosis of IgG4-RD and the HISORt criteria for the clinical and histopathological diagnosis of AIP. Using the same criteria, we proceeded to a clinical review of 12 extra cases of IPMN in which the tumour or the surrounding pancreas showed significant lymphoplasmacytic inflammation and/or fibrosis. RESULTS:Both of the 'index' cases fulfilled the HISORt criteria for AIP and both had morphological features characteristic of IgG4-RD using the Boston criteria, although only one possessed features 'highly suggestive of IgG4-RD' after immunohistochemistry. Additionally, both 'index' cases had radiological features that could represent extrapancreatic manifestations. Review of the 12 additional cases of IPMN revealed no further examples showing co-existent AIP. CONCLUSION:While pancreatic IPMN and AIP may co-exist, most CP associated with IPMN does not represent AIP.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Bateman AC,Culver EL,Sommerlad M,Chetty Rdoi
10.1136/jclinpath-2013-201516subject
Has Abstractpub_date
2013-08-01 00:00:00pages
671-5issue
8eissn
0021-9746issn
1472-4146pii
jclinpath-2013-201516journal_volume
66pub_type
杂志文章abstract::Neisseria gonorrhoeae is one of the most important causes of sexually transmitted disease. We do not fully understand the pathogenesis of infection with this organism, although recent improvements in immunological and molecular techniques have brought us closer to an answer. These techniques are now also being used to...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.40.9.1088
更新日期:1987-09-01 00:00:00
abstract::Partial myoepithelial differentiation is common in simple epithelial hyperplasia (epitheliosis) of the breast but functional myoepithelial differentiation with basement membrane production is exceedingly rare. A peculiar change of hyaline globules within benign epithelial hyperplasia has been recognised before as "col...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.43.11.905
更新日期:1990-11-01 00:00:00
abstract::Review of published work and analysis of clinical data and pathology of four biopsy specimens from two patients with laryngeal contact granuloma showed that its peptic origin was derived from a gastro-oesophago-laryngeal reflux. It is proposed that the term "peptic granuloma" should be given to this phenomenon. This t...
journal_title:Journal of clinical pathology
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doi:10.1136/jcp.42.8.800
更新日期:1989-08-01 00:00:00
abstract::Lung tissue from 13 cases of unexplained non-immunological hydrops fetalis was examined by in situ hybridisation to detect parvovirus. Four specimens contained parvovirus DNA in cells in the blood vessel lumina and alveoli. Twenty six control cases were negative for parvovirus DNA. As there was no known epidemic of pa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.4.381
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:The Sysmex XN haematology instrument performs automatic reflex testing, depending on sample results. A nucleated red blood cell (NRBC) count is provided on all samples. The instrument has a smaller footprint (34%) than previous Sysmex XE analysers. METHODS:An evaluation comparing all results to the Sysmex X...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2012-200930
更新日期:2012-11-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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journal_title:Journal of clinical pathology
pub_type: 临床试验,杂志文章
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更新日期:1998-11-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.6.551
更新日期:1993-06-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.31.3.268
更新日期:1978-03-01 00:00:00
abstract::Antithrombin activities in 30 severely malnourished children and 40 normal children were estimated in clotting tests by thrombin neutralisation as anti-Xa and by a heparin antithrombin assay; and by immunodiffusion as alpha 2-globulin and alpha 1-antitrypsin. The patients' mean alpha 2-globulin was severely depressed,...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.32.10.1025
更新日期:1979-10-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.31.4.378
更新日期:1978-04-01 00:00:00
abstract:AIMS:The assessment of lymphatic vessel density (LVD) has been suggested as a tool to determine the metastatic risk of neoplasias. On this premise, the authors aimed to verify whether progression risk of stage I colorectal cancer may be related to LVD. The authors also evaluated and correlated vascular endothelial grow...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2010.083550
更新日期:2011-01-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.7.585
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Serum prostate specific antigen (PSA) increases after radical prostatectomy are thought to indicate recurrent disease, although some suggest they result from benign prostatic epithelial tissue left at surgical margins. AIMS:To investigate whether presence, location, and extent of benign prostatic tissue at ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.024182
更新日期:2005-07-01 00:00:00
abstract::Isolates of Bacillus cereus from 118 cases, and two maternity unit outbreaks, of non-gastrointestinal infection were grouped on the basis of their estimated probable involvement in the infections from which they were isolated: (i) high probability--48 strains; (ii) intermediate--16 strains; (iii) low--7 strains; (iv) ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.10.1091
更新日期:1983-10-01 00:00:00
abstract::Results of serological investigations on patients with joint pain, arthralgia or polyarthritis were analysed and this information was used to develop a diagnostic algorithm to ensure optimal utilisation of laboratory resources. Accordingly, all cases are now examined for parvovirus IgM, mycoplasma IgM and streptococca...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.8.777
更新日期:1995-08-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2006.038240
更新日期:2006-12-01 00:00:00
abstract:AIMS:To determine whether the presence of disseminated bone marrow tumour cells at diagnosis is a prognostic factor for breast cancer patients at high risk of recurrence or bone metastasis, and to assess their presence as a criterion for evaluation of the potential benefits of adjuvant chemotherapy. METHODS:Multiple b...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.3.206
更新日期:1997-03-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.11.1176
更新日期:1988-11-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.24.3.270
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.21.1.14
更新日期:1968-01-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1977-04-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.51.7.525
更新日期:1998-07-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1980-07-01 00:00:00
abstract::In four persons of one family the existence of an enzymatic defect, presumably consisting of a deficiency of glutaminase in the cells of the renal tubules, is postulated, and is implied by a reduced elimination of ammonia in the urine, by a relatively low urinary pH, and by its increased titratable acidity. The most c...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.18.2.219
更新日期:1965-03-01 00:00:00
abstract:AIMS:Heightened B-cell receptor (BCR) activity in diffuse large B-cell lymphoma (DLBCL) is well established, and a subset of patients with relapsed DLBCL can benefit from BCR-targeted therapies. Universal outreach of such emerging therapies mandates forming a global landscape of BCR molecular signalling in DLBCL, inclu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
abstract:AIMS:In the gastric antrum and body, foveolar hyperplasia is a feature of reactive gastritis resulting from--for example, duodenogastric bile reflux and the use of non-steroidal anti-inflammatory drugs (NSAIDs). The aim of this study was to examine the occurrence and clinical relevance of gastric cardiac foveolar hyper...
journal_title:Journal of clinical pathology
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更新日期:2002-05-01 00:00:00
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journal_title:Journal of clinical pathology
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更新日期:1994-02-01 00:00:00
abstract:AIMS:To document the features of the so-called aplastic presentation of childhood acute lymphoblastic leukaemia (ALL) and to determine whether this prodrome can be distinguished from aplasia. METHODS:The peripheral blood and bone marrow appearances of all cases of childhood ALL presenting in one health region of Engla...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.8.697
更新日期:1992-08-01 00:00:00