Abstract:
AIMS:To describe characteristics of a series of people accidentally and deliberately killed by air powered weapons. METHODS:Five cases of fatal airgun injury were identified by forensic pathologists and histopathologists. The circumstances surrounding the case, radiological examination, and pathological findings are described. The weapon characteristics are also reported. RESULTS:Three of the victims were adult men, one was a 16 year old boy, and one an eight year old child. Four of the airguns were .22 air rifles, the other a .177 air rifle. Two committed suicide, one person shooting himself in the head, the other in the chest. In both cases the guns were fired at contact range. Three of the cases were classified as accidents: in two the pellet penetrated into the head and in one the chest. CONCLUSIONS:One person each year dies from an air powered weapon injury in the United Kingdom. In addition there is considerable morbidity from airgun injuries. Fatalities and injuries are most commonly accidents, but deliberately inflicted injuries occur. Airguns are dangerous weapons when inappropriately handled and should not be considered as toys. Children should not play with airguns unsupervised.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Milroy CM,Clark JC,Carter N,Rutty G,Rooney Ndoi
10.1136/jcp.51.7.525subject
Has Abstractpub_date
1998-07-01 00:00:00pages
525-9issue
7eissn
0021-9746issn
1472-4146journal_volume
51pub_type
杂志文章abstract::Serine esterases were detected in the granules of mucosal mast cells from rat, mouse, sheep, and man. Successful demonstration of enzyme activity required brief fixation (6 h) of tissues in 4% paraformaldehyde. Staining with naphthol AS-D chloroacetate produced an intense red reaction product in intraepithelial mucosa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.4.375
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:Currently, no specific immunohistochemical markers are available to differentiate primary mucinous epithelial ovarian cancer (MOC) from adenocarcinomas originating at other sites that have metastasised to the ovary, which may have an impact on patient management and prognosis. AIM:To investigate the express...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jcp.2005.034223
更新日期:2007-06-01 00:00:00
abstract::The nasal carrier status of 3,736 patients was determined throughout their stay in hospital. The carrier rate on admission, which was highest in patients under 20 years of age, did not appear to vary with season.The carriage of strains resistant to penicillin increased with the patients' stay in hospital from 13.% on ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.17.1.79
更新日期:1964-01-01 00:00:00
abstract:AIMS:Evidence suggests that the presence of tumour necrosis is an adverse prognostic factor in renal cell carcinoma (RCC). However, it has also been shown that tumour regression, a microscopic feature associated with necrosis, may be a favourable short term prognostic factor in RCC. METHODS:Pathology reports of 253 RC...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.018846
更新日期:2005-01-01 00:00:00
abstract:AIM:To evaluate a new enzyme immunoassay (EIA) method for detection of Clostridium difficile toxin by comparing it to cytotoxicity assay. To investigate the nature of false negative and false positive EIA results by evaluating clinical and therapeutic parameters. METHODS:737 consecutive diarrhoeal specimens collected ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.12.996
更新日期:1997-12-01 00:00:00
abstract::A commercial latex slide test (Oxoid DR 620) for the identification of Escherichia coli O157 was compared with a standard tube agglutination method using E coli O157 antiserum (Difco). Thirty isolates previously confirmed as E coli O157 were positive by both methods: 30 isolates of E coli of serogroups other than O157...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.10.1109
更新日期:1989-10-01 00:00:00
abstract::Apoptosis can be induced in response to hypoxia. The severity of hypoxia determines whether cells become apoptotic or adapt to hypoxia and survive. A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and cells become necrotic. Apoptosis regulatory proteins are delicately b...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2003.015032
更新日期:2004-10-01 00:00:00
abstract:AIMS:To assess changes in volume and complexity of cellular pathology workload after clinical service reorganisation and alterations in pathology reporting practices, and to identify objective measures of change applicable to all cellular pathology departments. The ear, nose, and throat (ENT), head and neck (HN) specia...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.57.1.22
更新日期:2004-01-01 00:00:00
abstract:AIM:To examine tumour samples immunohistochemically for MUC1 (episialin), epidermal growth factor receptor (EGFR), and c-erbB-2, since the disruption of the cell-cell adhesion system by MUC1 and the c-erbB oncoprotein family is known to be important in the development of metastasis in human cancers. METHODS:93 tumour ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.51.9.667
更新日期:1998-09-01 00:00:00
abstract::The necropsy findings in an elderly woman, who had been treated with methyldopa and who had died during treatment for accidental hypothermia, showed acute periductal inflammation of obviously similar duration in an entopic pancreas in the wall of the jejunum and in the ectopic pancreas. This supports the hypothesis th...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.4.430
更新日期:1988-04-01 00:00:00
abstract::Concentration of factor VIII from fresh plasma by cryoprecipitation remains the basis for preparation of products used to treat haemophilia A. This paper describes the preparation of a factor VIII concentrate from small plasma pools in transfusion centres with drying facilities. The dried concentrate from one litre of...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.10.1091
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:Receptor activator of nuclear factor kappabeta ligand (RANKL) has an important role in bone remodelling, and tumour necrosis factor related, apoptosis inducing ligand (TRAIL) can induce apoptosis in cancer cells. Their functions are linked by their interactions with osteoprotegerin (OPG). OBJECTIVE:To inves...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2005.030031
更新日期:2006-07-01 00:00:00
abstract::In a retrospective series of 40 appendiceal tumours occurring over a 10-year period, 30 were carcinoid tumours of classical histological pattern, five were adenocarcinomas, and two were tumours intermediate in pattern between carcinoid and carcinoma. The remaining three tumours were secondaries from primary colonic tu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.29.8.687
更新日期:1976-08-01 00:00:00
abstract:AIMS:Because sentinel lymph node (SLN) biopsy for breast cancer has become well established, one of the challenges now is to determine which patients require a completion axillary dissection following a positive SLN biopsy. METHODS:A prospective database of patients who underwent SLN biopsy for invasive breast cancer ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.57.1.73
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterised by the presence of various laboratory abnormalities but the precise role of laboratory staff in initiating clinical referral and subsequent biopsy is not clear. OBJECTIVE:To examine the impact of laboratory abnormalities in the inv...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2005.028936
更新日期:2006-04-01 00:00:00
abstract::A case of pigmented basal cell carcinoma developing in a smallpox revaccination site is presented. Any progressive change within a smallpox vaccination scar should be thoroughly evaluated and treated appropriately after tissue diagnosis. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.33.2.134
更新日期:1980-02-01 00:00:00
abstract:INTRODUCTION:Cellular blue naevi (CBN) measure 1-2 cm in diameter and affect the dermis, occasionally extending into the subcutaneous fat. The case of a 14-year-old boy with a giant CBN (GCBN) involving the right half of the face, the jugal mucosa and the lower eyelid with a tumour that had infiltrated the bone and the...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2005.029488
更新日期:2007-01-01 00:00:00
abstract:CLINICAL QUESTION:A 45-year-old woman presented with painless vaginal bleeding for 2 months. A biopsy was taken from the uterine cervix, and poorly differentiated adenocarcinoma was suspected. After three cycles of neoadjuvant chemotherapy treatment, the patient underwent radical hysterectomy with bilateral salpingo-oo...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2018-205081
更新日期:2018-11-01 00:00:00
abstract:AIMS/BACKGROUND:Telomerase, an enzyme associated with cellular immortality, is expressed by most malignant tumours, but is inactive in normal somatic cells except for male germ cells and proliferating stem cells. Thus, the measurement of telomerase activity in tissue samples may provide useful diagnostic and prognostic...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.2.110
更新日期:1997-02-01 00:00:00
abstract::Rabbit antiserum, elicited by the intravenous injection of a strain of Campylobacter jejuni heated to 100 degrees C, cross reacted strongly with all other thermophilic campylobacters tested as well as with "C pyloridis" and could be detected by indirect fluorescence with labelled anti-rabbit serum. Antisera to formali...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.9.1007
更新日期:1984-09-01 00:00:00
abstract:AIMS:To establish the current sensitivity of two commercial kits for culture confirmation of Neisseria gonorrhoeae strains circulating in the UK. METHODS:A total of 544 strains were studied (199 gonococci from male patients attending hospitals in the county of Avon, 204 unselected N gonorrhoeae isolates from male pati...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.10.919
更新日期:1995-10-01 00:00:00
abstract:AIMS:To describe the prostatic adenectomy specimens of six patients with symptomatic benign prostatic hyperplasia (BPH) who failed to respond to long term treatment with a 5-alpha-reductase inhibitor, finasteride. METHODS:Histological sections from six cases of BPH who had been treated with finasteride were investigat...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.4.324
更新日期:1996-04-01 00:00:00
abstract::Fluorescence in situ hybridisation (FISH) analysis is now widely employed in the diagnosis and risk stratification of a wide range of malignant diseases. While this technique is used successfully with formalin-fixed paraffin-embedded (FFPE) sections from numerous tissue types, FISH analysis of FFPE tissue sections fro...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2012-201131
更新日期:2013-01-01 00:00:00
abstract::A method is described for the quantitative separation of radioactive bile acids and neutral sterols in human faeces on a potassium hydroxide-treated silicic acid column. Results obtained with faecal extracts containing metabolites derived from radioactive cholesterol, cholic acid, and chenodeoxycholic acid show that t...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.18.1.105
更新日期:1965-01-01 00:00:00
abstract::Cancer lineage/tissue-of-origin assignment in cancers of unknown primary remains a challenge even when aided by massively parallel sequencing. The stakes are high for patients as many contemporary therapeutic strategies are disease-specific, and the biological differences can influence the patients' responses. Herein,...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-206895
更新日期:2020-08-27 00:00:00
abstract::A case of Cryptococcus neoformans meningitis is described in an HIV negative patient with undiagnosed systemic sarcoidosis. The patient presented with signs of meningitis together with generalised lymphadenopathy and hepatosplenomegaly. Cryptococcal meningitis was diagnosed on lumbar puncture. She was treated with int...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.52.12.928
更新日期:1999-12-01 00:00:00
abstract::A pseudolymphomatous reaction involving subcutaneous tissue and underlying skeletal muscle is described in a woman who was receiving phenytoin sodium and phenobarbitone. The histological appearance was of nodular, densely cellular tissue composed of histiocytes, plasma cells, lymphocytes, fibroblasts, and occasional p...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.31.8.761
更新日期:1978-08-01 00:00:00
abstract:AIMS:To determine the possible histogenesis of the intracranial variant of olfactory neuroblastoma. METHODS:Four specimens from three cases of intracranial olfactory neuroblastoma were studied by light microscopy and immuno-histochemistry, and electron microscopy in two cases. RESULTS:Light microscopical examination ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.4.299
更新日期:1992-04-01 00:00:00
abstract::A method utilizing a general dehydrogenase reaction has been used to demonstrate early gross myocardial infarctions. The procedure takes advantage of substrate and enzyme loss from the damaged myocardium. In the viable muscle, where endogenous substrates, coenzymes, and dehydrogenases are present, reduction of Nitro-B...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.19.5.479
更新日期:1966-09-01 00:00:00
abstract::A recently developed procedure, that has been shown to be suitable for detailed immunohistological analysis, has been used to prepare cryostat sections of bone marrow to investigate whether enzyme-histochemical techniques are also feasible on such material. A selected group of enzymes, some of which are inhibited or d...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.35.11.1220
更新日期:1982-11-01 00:00:00