Abstract:
AIMS:To assess changes in volume and complexity of cellular pathology workload after clinical service reorganisation and alterations in pathology reporting practices, and to identify objective measures of change applicable to all cellular pathology departments. The ear, nose, and throat (ENT), head and neck (HN) specialty was chosen for assessment. METHODS:Cellular pathology workload from the ENT-HN surgical specialty was assessed numerically and the complexity in examination of cancer resection specimens was evaluated. Medical and technical time inputs in the reporting of ENT-HN cancer resections were measured prospectively, and the histological and cytological workload arising from the management of such cases was obtained. RESULTS:The 88.83% increase in ENT-HN specimens contrasted with a 13.53% increase in total surgical workload. Substantial increases in work complexity were found when measured as blocks/slides for each case and number of histochemical/immunohistochemical requests. On average, examination of one ENT-HN cancer case consumed 55% of one pathologist's work session and over one 10th of a technician's working week. On average, each cancer generated 3.3 histological and 1.06 cytological specimens. CONCLUSIONS:Evidence is provided of the increase in cellular pathology workload and in its complexity. This study lists objective measures of complexity applicable to all pathology subspecialties. Given the workforce crisis and expanding clinical needs, realistic workload calculations should include measurement of complexity and not just volumes.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Winter S,Cox GJ,Corbridge R,Chaplin AJ,Millard PR,Shah KAdoi
10.1136/jcp.57.1.22keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
22-6issue
1eissn
0021-9746issn
1472-4146journal_volume
57pub_type
杂志文章abstract::Serious infection caused by Lancefield group C streptococci is unusual in man. Two unrelated deaths associated with these organisms in a 55 year old woman who died after three days of diarrhoea and vomiting, and in a 65 old man who died after a week of non-specific symptoms, are presented. Post mortem examination show...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.10.965
更新日期:1993-10-01 00:00:00
abstract:AIMS:To determine the causes of death in patients with osteogenesis imperfecta, excluding infants with the perinatal lethal form (type II). METHODS:Seventy nine patients with known osteogenesis imperfecta were identified, 37 of whom had been seen clinically in life. Causes of death were identified from death certifica...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.8.627
更新日期:1996-08-01 00:00:00
abstract::The ability of erythrocytes to synthesize porphyrins from delta-aminolaevulic acid was compared in healthy people, patients with true iron-deficiency anaemia, and anaemic patients with rheumatoid arthritis. Porphyrin synthesis was found to be impaired in true iron deficiency but not in rheumatoid arthritis cases showi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.24.4.336
更新日期:1971-05-01 00:00:00
abstract:AIMS:To characterise further the proliferative compartment of the normal cervix and to document its alteration, if any, in the various grades of cervical intraepithelial neoplasia (CIN), particularly changes to the basal epithelial layer; to hypothesise as to the diagnostic and biological significance of any observed d...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.8.667
更新日期:1996-08-01 00:00:00
abstract::The role of active hepatitis B virus (HBV) infection in chronic HBsAg positive hepatitis with and without hepatitis delta virus (HDV) superinfection was analysed in percutaneous liver biopsy specimens from 50 patients. Each specimen was divided into two--one part for histological evaluation and for the detection of HB...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.7.689
更新日期:1989-07-01 00:00:00
abstract::Surface immunoglobulins (Ig) of normal and malignant lymphoid cells were detected on prefixed, smeared (method A) and live (method B) cell suspensions; the results were compared with regard to staining patterns, specificity and sensitivity. In both methods surface Ig were detected by a direct immunoperoxidase procedur...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.35.2.139
更新日期:1982-02-01 00:00:00
abstract::The incidence of placenta accreta, defined as the abnormal adherence of the placenta to the uterine wall, has been increasing alarmingly in the developed as well as the developing world. There is considerable maternal morbidity and mortality related to the condition. The pathophysiology focuses on the balance between ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2008.055202
更新日期:2008-12-01 00:00:00
abstract:AIMS:This is a qualitative study of the perceived learning needs of trainees for graded responsibility in histopathological training in the UK. METHODS:A focus group with trainees and interviews with consultants was carried out. Participants were asked 'What do you perceive are the learning needs of histopathology tra...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2015-203090
更新日期:2016-01-01 00:00:00
abstract::Phosphate in both inorganic and organic form is essential for several functions in the body. Plasma phosphate level is maintained by a complex interaction between intestinal absorption, renal tubular reabsorption, and the transcellular movement of phosphate between intracellular fluid and bone storage pools. This home...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jclinpath-2018-205130
更新日期:2019-11-01 00:00:00
abstract:AIM/BACKGROUND:Several studies have suggested that Helicobacter pylori which express CagA may be more virulent than those that do not, but limited populations have been studied to date. The aim of this study was to confirm and extend the association of CagA positive H pylori strains in a different geographical area and...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.10.829
更新日期:1996-10-01 00:00:00
abstract::TLE 1 is the human homologue belonging to a family of four genes and is located on chromosome 9q21. It consists of 19 exons. Although it does not bind directly to DNA, it acts as a repressor of several signalling pathways via transcription factors. TLE1 protein has several physiological roles in embryogenesis, haemato...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-207174
更新日期:2021-01-13 00:00:00
abstract::Painful lymphadenopathy developed in eight female patients after massive infusions of iron dextran for sideropaenic anaemia. Fever, arthralgias, and malaise were also features of the clinical picture. The histology of one lymph node is described and changes in it are discussed in relation to the pathogenesis of the sy...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.21.4.492
更新日期:1968-07-01 00:00:00
abstract:AIMS:To describe the prostatic adenectomy specimens of six patients with symptomatic benign prostatic hyperplasia (BPH) who failed to respond to long term treatment with a 5-alpha-reductase inhibitor, finasteride. METHODS:Histological sections from six cases of BPH who had been treated with finasteride were investigat...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.4.324
更新日期:1996-04-01 00:00:00
abstract:AIMS:To establish the number of histological levels necessary for the evaluation of breast needle core biopsy (NCB) specimens taken from areas of mammographic calcification in patients presenting via the UK National Health Service Breast Screening Programme. METHODS:Retrospective review of a series of breast NCB speci...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2006.038190
更新日期:2007-06-01 00:00:00
abstract::Platelet adhesiveness has been assessed on whole blood from a series of 34 diabetics and 50 control subjects using adenosine diphosphate (A.D.P.) and by adherence to glass microspherules (ballotini). Using both techniques it was possible to demonstrate a significant increase in platelet adhesiveness in the diabetic pa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.20.6.845
更新日期:1967-11-01 00:00:00
abstract::Clonality analysis of the immunoglobulin heavy chain (IgH) gene is helpful in identifying malignant B cell infiltrates in the bone marrow and is usually carried out on separate aspirates or on the same formalin-fixed decalcified bone marrow specimen. To determine whether the removal of the decalcification step would i...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2005.030379
更新日期:2006-10-01 00:00:00
abstract::A simple, standardised procedure was used for processing data from External Quality Assessment Schemes and for producing performance charts. A graphic presentation of cumulative performance is generated for each test, using an integrated software package to display results in a standardised format. This permits interp...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.1.17
更新日期:1991-01-01 00:00:00
abstract::A 35 year old man with a fatal Campylobacter jejuni infection is described. He had HbE/beta zero thalassaemia and had undergone splenectomy nine months previously for hypersplenism; he also had chronic hepatitis C infection. He presented with high grade fever but no gastrointestinal symptoms and rapidly progressed to ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.5.436
更新日期:1997-05-01 00:00:00
abstract::This study was undertaken to determine the interrelations between clinico-biochemical parameters and hepatic morphology in markedly obese patients. One hundred and sixty-six women and 52 men comprise this series. There was a statistically significant association of carbohydrate metabolism disturbance with increasing a...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.26.10.776
更新日期:1973-10-01 00:00:00
abstract::Rocket-line immunoelectrophoresis (R-LIE) with antigen containing intermediate gel, and co-agglutination utilising protein A-containing staphylococci coated with specific antibodies, were adapted for serotyping the prototypes of group B meningococci. Both were found to have the same specificity as agar gel double diff...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.32.2.136
更新日期:1979-02-01 00:00:00
abstract::An indirect immunoperoxidase technique has been used for visualisation of cellular immunoglobulins in chronic lymphocytic leukaemia. Baker's formol calcium was used as fixative. Monoclonal light and heavy chain patterns were demonstrated in 24 out of 27 cases. Only one case did not have any demonstrable immunoglobulin...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.12.1391
更新日期:1983-12-01 00:00:00
abstract::A new rapid automated method for the identification and classification of microorganisms is described. It is based on the incorporation of 35S-methionine into cellular proteins and subsequent separation of the radiolabelled proteins by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). The protein ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.40.9.1070
更新日期:1987-09-01 00:00:00
abstract::Urine specimens were collected from 26 normal subjects, 10 patients with proven primary hyperparathyroidism, and eight patients with hypercalcaemia due to other causes. After overnight urine concentration, an oral water load was given to induce a diuresis and provide urine specimens with a relatively wide range of cre...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.22.3.287
更新日期:1969-05-01 00:00:00
abstract::Specimens of muscle were obtained from non-suppurating lesions of nine patients with tropical myositis. When examined in an electron microscope, these revealed patchy myocytolysis with loss of band structure. Perimysial cells were also degenerate. Sections from two out of nine patients revealed intracellular vesicles,...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.29.12.1081
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:Cytokeratin immunohistochemistry (IHC) reveals a higher rate of occult lymph node metastases among lobular carcinomas than among ductal breast cancers. IHC is widely used but is seldom recommended for the evaluation of sentinel lymph nodes in breast cancer patients. OBJECTIVE:To assess the value of cytokera...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jcp.2005.029991
更新日期:2006-05-01 00:00:00
abstract::A case of acute myelomonocytic leukaemia (AMMOL) is reported in which skin infiltration with xanthomatous nodules was the presenting feature. The histological, including ultrastructural, appearances are described. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.35.11.1200
更新日期:1982-11-01 00:00:00
abstract:AIM:To examine tumour samples immunohistochemically for MUC1 (episialin), epidermal growth factor receptor (EGFR), and c-erbB-2, since the disruption of the cell-cell adhesion system by MUC1 and the c-erbB oncoprotein family is known to be important in the development of metastasis in human cancers. METHODS:93 tumour ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.51.9.667
更新日期:1998-09-01 00:00:00
abstract::Cervical biopsies from 97 women with malignant cells in cervical scrape smears have been studied. Forty-eight patients had invasive squamous carcinoma, and 49 had intraepithelial lesions. Of these, six had dedifferentiated carcinoma in situ, nine had the differentiated lesions generally known as ;severe dysplasia', an...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.20.1.7
更新日期:1967-01-01 00:00:00
abstract::Extracts of the seeds of Vicia cretica (NO Leguminosae) strongly agglutinate T- Th- but not Tk- or other polyagglutinable red cells. The V. cretica lectin is therefore a very useful laboratory reagent in the elucidation of erythrocyte polyagglutination due to T-like erythrocyte cryptantigens. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.1.69
更新日期:1981-01-01 00:00:00
abstract::By means of enzyme immunoassays based on two monoclonal antibodies with specificities for distinct forms of placental type alkaline phosphatase (Pl-ALP), together with L-leucine inhibition studies, it has been possible to distinguish the Nagao type carcinoplacental enzyme from other placental type alkaline phosphatase...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.7.826
更新日期:1984-07-01 00:00:00