Splitting bone marrow trephines into frozen and fixed fragments allows parallel histological and molecular detection of B cell malignant infiltrates.

abstract：:The sellar region is the site of a large number of pathological entities arising from the pituitary and adjacent anatomical structures, including brain, blood vessels, nerves and meninges. The surgical pathology of this area requires the accurate identification of neoplastic lesions, including pituitary adenoma and ca...

journal_title：Journal of clinical pathology

authors： Al-Brahim NY,Asa SL

更新日期：2006-12-01 00:00:00

abstract：:Tubulocystic carcinoma (TCC) is a very rare renal tumour with unique gross and microscopic features, alternatively considered as low-grade collecting duct carcinoma. Recent studies favoured distinction of TCC from collecting duct carcinoma, and some cases of TCC synchronously coexisting with other renal cell tumour su...

journal_title：Journal of clinical pathology

authors： Chen N,Nie L,Gong J,Chen X,Xu M,Chen M,Zhou Q

更新日期：2014-11-01 00:00:00

abstract：:Fluorigenic substrates prepared from 4-methylumbelliferone provide a simple, convenient method for detecting and assaying group-specific hydrolase activity in small quantities of whole mycobacteria. Physico-chemical properties of the enzymes such as pH dependence and heat stability may also be studied. A technique is ...

journal_title：Journal of clinical pathology

authors： Grange JM

更新日期：1978-04-01 00:00:00

abstract：:The Fisher Hem-Alyzer is a multitest sequential discrete analyser with automatic printout of digitized results on paper tape. The instrument is well designed, soundly constructed, and reliable in routine use. Cross contamination from the sampler probe or between the cuvettes is minimal. Accuracy and precision are both...

journal_title：Journal of clinical pathology

authors： Lappin TR,Lamont A,Nelson MG

更新日期：1970-02-01 00:00:00

abstract：:The rate of digestion of fibrin was measured in vitro by an isotopic technique in 140 blood samples of differing fibrinogen concentration; the assessment of fibrinolytic activity thus obtained was compared with a standard method of measurement, the dilute whole blood lysis time. The lysis time was related exponentiall...

journal_title：Journal of clinical pathology

authors： Hickman JA,Gordon-Smith IC,Whitfield PF,Godfrey SJ

更新日期：1973-03-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the risk factors for proximal resection margin involvement and its impact on survival outcome in patients with proximal gastric cancer. METHODS:A total of 488 patients who underwent potentially curative resection for proximal gastric cancer were retrospectively reviewed. Clini...

journal_title：Journal of clinical pathology

authors： Zhao B,Lu H,Bao S,Luo R,Mei D,Xu H,Huang B

更新日期：2020-08-01 00:00:00

abstract：AIMS:To determine prognostic significance of immunohistochemical markers and investigate possible germinal centre (GC) derivation in primary lymphoma of bone (PLB). METHODS:Immunohistochemical expression of BCL-6, CD10, BCL-2, p53, CD30, CD44 and MUM-1 was studied in 36 patients with PLB. All cases were clinically sta...

journal_title：Journal of clinical pathology

authors： Heyning FH,Hogendoorn PC,Kramer MH,Holland CT,Dreef E,Jansen PM

更新日期：2009-09-01 00:00:00

abstract：:A spectrophotometric assay of proteolytic enzyme activity is described in which the optical density obtained by a given enzyme preparation is related (2 alpha less than 0.01) to the serological activity of that preparation in a two stage technique. The assay appears to be of use for the standardisation of enzyme prepa...

journal_title：Journal of clinical pathology

authors： Phillips PK,Prior D,Dawes B

更新日期：1984-03-01 00:00:00

abstract：:Two patients are reported in whom initial misdiagnoses of medullary cancer or trabecular hyaline adenoma for papillary carcinoma were made. ...

journal_title：Journal of clinical pathology

authors： Andrew AC,Williamson JM

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Although Bulgaria has one of the highest rates of cervical cancer incidence and mortality in the EU, data on HPV type distribution are limited. AIM:To determine the prevalence of HPV types 16 and 18 in archival specimens from cervical cancer cases from Bulgaria. METHODS:A total of 145 formalin-fixed, paraf...

journal_title：Journal of clinical pathology

authors： Todorova I,Ganchev G,Shikova E

更新日期：2010-12-01 00:00:00

abstract：:Colonising Campylobacter pyloridis were identified histologically in gastric biopsy specimens from 89% of 83 patients with non-ulcer dyspepsia and chronic gastritis, but not in 58 dyspeptic patients with normal mucosa. The presence and population density of organisms was associated with the presence of intraepithelial...

journal_title：Journal of clinical pathology

authors： Wyatt JI,Rathbone BJ,Heatley RV

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Nitric oxide synthase (NOS), particularly endothelial and inducible forms (e/i-NOS), are expressed in various cancers, including breast cancer. In mammary fibroepithelial lesions, NOS expression in stromal cells has been reported to be lower in fibroadenomas than in phyllodes tumours. AIMS:To investigate NO...

journal_title：Journal of clinical pathology

authors： Tse GM,Wong FC,Tsang AK,Lee CS,Lui PC,Lo AW,Law BK,Scolyer RA,Karim RZ,Putti TC

更新日期：2005-06-01 00:00:00

abstract：:In vitro morphological and functional studies were carried out on platelets which had been cryopreserved in the presence of 5% dimethyl sulphoxide (DMSO). Overall loss of platelets was around 50%. Those which survived freezing and reconstitution showed marked morphological deterioration, increase of procoagulant activ...

journal_title：Journal of clinical pathology

authors： Baythoon H,Tuddenham EG,Hutton RA

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Well differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS) have been shown to have supernumerary chromosomes with amplified sequences of the MDM2 and CDK4 genes. MDM2 and CDK4 protein overexpression have also been identified in these tumours. AIM:To investigate whether immunohistoche...

journal_title：Journal of clinical pathology

authors： Aleixo PB,Hartmann AA,Menezes IC,Meurer RT,Oliveira AM

更新日期：2009-12-01 00:00:00

abstract：AIMS:To establish the current sensitivity of two commercial kits for culture confirmation of Neisseria gonorrhoeae strains circulating in the UK. METHODS:A total of 544 strains were studied (199 gonococci from male patients attending hospitals in the county of Avon, 204 unselected N gonorrhoeae isolates from male pati...

journal_title：Journal of clinical pathology

authors： Turner A,Gough KR,Jephcott AE

更新日期：1995-10-01 00:00:00

abstract：:A patient with multiple injuries developed a severe coagulation defect due to a deficiency of vitamin K. None of the usual predisposing factors was present and the patient's diet was very poor. Dietary deficiency of vitamin K and the importance of antibiotic therapy in its production are discussed. ...

journal_title：Journal of clinical pathology

authors： Colvin BT,Lloyd MJ

更新日期：1977-12-01 00:00:00

abstract：:A radial immunodiffusion technique has been used to measure levels of four serum proteins in preeclampsia with or without proteinuria and in normal pregnant and non-pregnant controls. In preeclampsia unaccompanied by proteinuria, albumin and transferrin levels are similar to those found in the normal pregnant controls...

journal_title：Journal of clinical pathology

authors： Horne CH,Howie PW,Goudie RB

更新日期：1970-09-01 00:00:00

abstract：:The urinary excretion of the renal proximal tubular enzyme, gamma-glutamyltransferase (gamma-GT), has been studied in 41 patients receiving tobramycin, gentamicin or streptomycin for a variety of infections. All patients receiving tobramycin or gentamicin have shown increased excretion of gamma-GT in the urine. Only 4...

journal_title：Journal of clinical pathology

authors： Beck PR,Thomson RB,Chaudhuri AK

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Periostin is a secreted adhesion protein, normally expressed in mesenchime-derived cells. Aberrant expression of the periostin gene in epithelial tumours seems to play a role in angiogenesis and metastases. AIMS:To investigate periostin expression in a consecutive series of breast carcinomas and correlate i...

journal_title：Journal of clinical pathology

authors： Puglisi F,Puppin C,Pegolo E,Andreetta C,Pascoletti G,D'Aurizio F,Pandolfi M,Fasola G,Piga A,Damante G,Di Loreto C

更新日期：2008-04-01 00:00:00

abstract：AIMS:Accurate assessment of HER2 status is essential for selection of patients for HER2-targeted treatment such as trastuzumab. This study investigated the hypothesis that delayed fixation impairs HER2 assessment. METHODS:9 carcinomas were received fresh, and samples were fixed immediately or put in fixative at time i...

journal_title：Journal of clinical pathology

authors： Lee AH,Key HP,Bell JA,Kumah P,Hodi Z,Ellis IO

更新日期：2014-07-01 00:00:00

abstract：:Metabolic balance studies for iron have been carried out on 24 apparently healthy elderly people (11 men and 13 women) aged 69.7 to 85.5 years living in their own homes and eating self selected diets. Several biochemical and haematological indices of iron state were also measured. The mean daily iron intake was 176 mu...

journal_title：Journal of clinical pathology

authors： Bunker VW,Lawson MS,Clayton BE

更新日期：1984-12-01 00:00:00

abstract：:Serum and tissue hepatitis B virus (HBV) markers were compared in 35 alcoholic and 23 non-alcoholic subjects affected by chronic liver disease. Seventeen point one per cent of alcoholic and 21.7% of non-alcoholic subjects had HBV tissue markers, but not serum markers, for this virus. It is therefore concluded that sho...

journal_title：Journal of clinical pathology

authors： Cuccurullo L,Rambaldi M,Iaquinto G,Ferraraccio F,Ambrosone L,Giardullo N,De Vita A

更新日期：1987-02-01 00:00:00

abstract：:One hundred and two bone marrow samples were analysed by histological and immunohistochemical methods for neurone specific enolase (NSE). The biopsies were performed to determine the extent of bone marrow disease in 84 neuroblastomas, nine embryonal rhabdomyosarcomas, five Ewing's sarcomas, two cases of Hodgkin's dise...

journal_title：Journal of clinical pathology

authors： Caillaud JM,Martinez-Madrigal F,Hartmann O,Carlu C

更新日期：1991-04-01 00:00:00

abstract：:Three patients with aplastic anaemia had a history of substantial previous exposure to organochlorine pesticides. The temporal association between chemical exposure and the onset of first symptoms of anaemia was strongly supportive. Organochlorines have the property of lipid affinity and accumulation in adipose tissue...

journal_title：Journal of clinical pathology

authors： Rugman FP,Cosstick R

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND/AIMS:The programmed cell death receptor 1 (PD-1) checkpoint inhibitor, nivolumab, has been approved for the treatment of metastatic renal cell carcinoma (RCC). However, the understanding of the expression and distribution of PD ligand 1 (PD-L1) in the tumour immune microenvironment and its prognostic role in...

journal_title：Journal of clinical pathology

authors： Yeong J,Zhao Z,Lim JCT,Li H,Thike AA,Koh VCY,Teh BT,Kanesvaran R,Toh CK,Tan PH,Khor LY

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:The study sought to determine whether mast cell counts in endobronchial biopsies of large airways are related to mast cell counts in the small airways. METHODS:Lungs, obtained postmortem from 10 subjects who had died of non-respiratory causes, were fixed in inflation. Mast cell densities (cells/mm(3)), de...

journal_title：Journal of clinical pathology

authors： Carroll ML,Carroll NG,Gundersen HJ,James AL

更新日期：2011-05-01 00:00:00

abstract：AIMS:To assess the effect of cellulosic dialysis membranes on the production of complement degradation products to determine to the role of the classical pathway. METHOD:Complement activation was studied in 33 patients during a single haemodialysis session using cellulosic membranes. Pre- and post-dialysis plasma EDTA...

journal_title：Journal of clinical pathology

authors： Innes A,Farrell AM,Burden RP,Morgan AG,Powell RJ

更新日期：1994-02-01 00:00:00

abstract：:Angiogenesis plays a crucial role in melanoma metastasis and progression. In recent years, numerous studies have investigated the prognostic and clinical significance of this phenomenon, and the development of molecular techniques has enabled us to achieve a better understanding of angiogenesis in melanoma. Herein, we...

journal_title：Journal of clinical pathology

authors： Jour G,Ivan D,Aung PP

更新日期：2016-06-01 00:00:00

abstract：:A young woman presented with bilateral ovarian tumours. Multiple sections of each tumour were shown to many pathologists for consultation; some considered the tumours to be borderline, whereas others thought that one or both of them was malignant. Morphometry showed that the numerical classification probabilities for ...

journal_title：Journal of clinical pathology

authors： Baak JP,Van der Ley G

更新日期：1984-10-01 00:00:00

abstract：:The principal neuropathological and general pathological findings in a group of 24 patients with renal transplants who died in a nine-year period at the Western Infirmary, Glasgow, are described. Opportunistic infections--bacterial, protozoal, and fungal--were the commonest causes of death. Other causes included cardi...

journal_title：Journal of clinical pathology

authors： Morton R,Graham DI,Briggs JD,Hamilton DN

更新日期：1982-01-01 00:00:00