Abstract:
:The Fisher Hem-Alyzer is a multitest sequential discrete analyser with automatic printout of digitized results on paper tape. The instrument is well designed, soundly constructed, and reliable in routine use. Cross contamination from the sampler probe or between the cuvettes is minimal. Accuracy and precision are both highly satisfactory. Although the standard rate of throughput is 32 specimens per hour the instrument can be used at irregular intervals to analyse smaller batches or even individual specimens. In a routine daily service the Hem-Alyzer was capable of handling a workload of 200 specimens per day, requiring three hours of laboratory technician time. The Hem-Alyzer produces only three parameters. By not determining the packed cell volume it is not possible to incorporate the derived indices (MCV and MCHC) into the system and this, in the long term, is bound to be a disadvantage.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Lappin TR,Lamont A,Nelson MGdoi
10.1136/jcp.23.1.60subject
Has Abstractpub_date
1970-02-01 00:00:00pages
60-4issue
1eissn
0021-9746issn
1472-4146journal_volume
23pub_type
杂志文章abstract::Twenty five specimens of branchial cyst from the same number of patients have been examined. On staining with haematoxylin and eosin a consistent finding was that the mural lymphoid follicles were always aligned with their mantle zones towards the luminal epithelium. With conventional staining lymphatic sinuses were n...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.7.784
更新日期:1985-07-01 00:00:00
abstract::The cellularity of 104 primary breast carcinomata was determined by semiautomated image analysis to allow the relation between cellularity and oestrogen receptor content values to be assessed. The oestrogen receptor content of tumours detected by a steroid binding assay showed no correlation with cellularity, although...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.11.1166
更新日期:1989-11-01 00:00:00
abstract::The number and density of argyrophil endocrine cells were morphometrically calculated in gastric fundal mucosal biopsy specimens taken from 64 patients with pernicious anaemia (five with gastric carcinoids, 15 with nodular argyrophil cell hyperplasia, 44 with diffuse argyrophil cell hyperplasia) and from 14 healthy co...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.4.371
更新日期:1989-04-01 00:00:00
abstract:AIMS:To investigate how clinical microbiology laboratories should report and interpret mixed mould isolates including Aspergillus species from clinical samples and the criteria for susceptibility testing of the isolates. METHODS:Retrospectively collected data from our laboratory information system of moulds isolated b...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2010.084517
更新日期:2011-06-01 00:00:00
abstract:AIMS:To determine whether myelodysplastic syndromes (MDS) are associated with sea blue histiocytosis in the bone marrow. METHODS:A retrospective review of bone marrow aspirates from 35 patients presenting consecutively with MDS and from 20 patients with each of the following: normal marrow appearance (routine staging ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.11.1030
更新日期:1993-11-01 00:00:00
abstract:AIM:To analyse whether the mean nuclear area of the 10 largest nuclei (MNA-10), the mitotic activity index (MAI), and Ki-67 immunoquantitative features have additional value to discriminate different grades of T(A,1) transitional cell carcinoma (TCC) of the urinary bladder. MATERIALS/METHODS:One hundred and fifty of 2...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.54.11.854
更新日期:2001-11-01 00:00:00
abstract::Although Neisseria species other than N gonorrhoeae and N meningitidis normally comprise part of the commensal bacterial flora of the oropharynx, they may occasionally act as opportunistic pathogens. Infections in which these organisms have been implicated include cases of endocarditis, meningitis, septicaemia, otitis...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.36.2.213
更新日期:1983-02-01 00:00:00
abstract::One hundred and two bone marrow samples were analysed by histological and immunohistochemical methods for neurone specific enolase (NSE). The biopsies were performed to determine the extent of bone marrow disease in 84 neuroblastomas, nine embryonal rhabdomyosarcomas, five Ewing's sarcomas, two cases of Hodgkin's dise...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.4.309
更新日期:1991-04-01 00:00:00
abstract:AIMS:To examine the correlation between bromodeoxyuridine (BrdU) labelling indices (LI) and tubular damage in renal biopsy specimens; to evaluate the diagnostic and prognostic potential of measuring cell proliferation in a variety of renal lesions. METHODS:In vitro BrdU labelling of renal biopsy specimens was undertak...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.12.1085
更新日期:1994-12-01 00:00:00
abstract:AIMS:Although the autopsy is still the gold standard for quality assessment of clinical diagnoses, autopsy rates have been declining over the last decades to <10%. The aim of this study was to investigate the value of autopsies in the high-tech medicine era by determining the frequency of discrepancies between clinical...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2013-202122
更新日期:2014-06-01 00:00:00
abstract:AIM:To determine whether sampling the anterior and posterior cervical lips in hysterectomy specimens provides the best opportunity for detecting unsuspected cervical intraepithelial neoplasia (CIN). METHODS:The frequency with which CIN was identified at a range of positions on the anterior and posterior lips and left ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.4.323
更新日期:1995-04-01 00:00:00
abstract::Although the UK National Institute for Health and Care Excellence guidelines recommend that in patients with biopsy-proven invasive lobular carcinoma (ILC), preoperative MRI scan is considered, the accuracy of diagnosis of ILC in core biopsy of the breast has not been previously investigated. Eleven pathology laborato...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jclinpath-2016-203886
更新日期:2016-12-01 00:00:00
abstract::Expression profiling has been extensively applied to the study of breast cancer and undoubtedly is changing the way breast cancer is perceived. Over the past few years, several groups have described prognostic "signatures" (gene lists) that are purported to be more accurate prognostic factors than well established cli...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2005.028324
更新日期:2006-03-01 00:00:00
abstract::Rhombencephalitis is not a rare presentation of listerial central nervous system infections in healthy adults. This report describes a case with several management difficulties linked to antibiotic related adverse events, pointing to alternative solutions to aminopenicillins. In addition, the role of dexamethasone in ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2003.014738
更新日期:2004-06-01 00:00:00
abstract::A family with hypobetalipoproteinaemia was studied to examine the Lp(a) lipoprotein, lipoprotein cholesterol, and triglyceride composition of the serum lipids. Lp(a) lipoprotein was measured by immunoassay. Serum lipoproteins were separated by ultracentrifugation. Cholesterol and triglycerides were measured using stan...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.6.587
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Breast cancer is increasing in Indonesia and other developing countries. Germline mutations in the BRCA1/2 genes are most strongly associated with a high risk for breast cancer development. There have been no reports on BRCA1/2 gene mutations in the Indonesian population. Genetic research yielding insight in...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.020388
更新日期:2005-05-01 00:00:00
abstract:AIMS:To characterise further the proliferative compartment of the normal cervix and to document its alteration, if any, in the various grades of cervical intraepithelial neoplasia (CIN), particularly changes to the basal epithelial layer; to hypothesise as to the diagnostic and biological significance of any observed d...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.8.667
更新日期:1996-08-01 00:00:00
abstract::A total of 104 clinical isolates of Pr. mirabilis from three hospitals were screened for their sensitivity to chlorhexidine. The minimum inhibitory concentrations of the antiseptic for these strains ranged from 10 to 800 mug/ml. Two strains sensitive to 20 mug of chlorhexidine/ml were adapted to resistance by growth i...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.27.4.284
更新日期:1974-04-01 00:00:00
abstract::A sensitive gas chromatography-mass spectrometric method was used to measure the generation in whole blood of leukotriene B4 (LTB4), a potent stimulator of neutrophil chemotaxis, in eight patients with chronic granulocytic leukaemia (CGL) and 12 healthy controls. LTB4 was detectable in unstimulated samples from all th...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.11.1163
更新日期:1988-11-01 00:00:00
abstract:AIMS:Sentinel lymph node (SLN) biopsy is the preferred surgical technique for staging the axilla in clinically node-negative breast cancer. Accurate intraoperative staging allows for the immediate performance of an axillary clearance in node-positive patients. We assessed the Metasin assay for the intraoperative analys...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2016-203728
更新日期:2017-02-01 00:00:00
abstract:AIMS:The assessment of lymphatic vessel density (LVD) has been suggested as a tool to determine the metastatic risk of neoplasias. On this premise, the authors aimed to verify whether progression risk of stage I colorectal cancer may be related to LVD. The authors also evaluated and correlated vascular endothelial grow...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2010.083550
更新日期:2011-01-01 00:00:00
abstract:AIM:To examine tumour samples immunohistochemically for MUC1 (episialin), epidermal growth factor receptor (EGFR), and c-erbB-2, since the disruption of the cell-cell adhesion system by MUC1 and the c-erbB oncoprotein family is known to be important in the development of metastasis in human cancers. METHODS:93 tumour ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.51.9.667
更新日期:1998-09-01 00:00:00
abstract::A 45-year-old man is described in whom there is currently ERCP and histological evidence of primary sclerosing cholangitis (PSC). A liver biopsy obtained 29 years ago shows similar histological features confirming that he had PSC at that time. This case indicates that PSC may follow a relatively benign course. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.11.1298
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Accurate assessment of invasive breast cancer grade on needle core biopsy (NCB) is important as it guides treatment. AIM:To assess the agreement between grade of invasive cancer on NCB and excision and determine whether altering the mitotic count score threshold on NCB improves it. METHODS:Pathology slides...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2014-202294
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Peutz-Jeghers syndrome (PJS) is an autosomal dominant hamartomatous polyposis syndrome of the gastrointestinal tract, caused by a germline STK11/LKB1 mutation. Nasal polyposis was described in the original report by Peutz. Recently, a molecular-genetic association between nasal polyposis and PJS has been rep...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2005.036418
更新日期:2007-04-01 00:00:00
abstract::Of the first 250 heart and 35 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 217 heart and 33 heart and lung patients were investigated serologically for evidence of Toxoplasma gondii infection. Six patients acquired primary T gondii in...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.2.194
更新日期:1989-02-01 00:00:00
abstract::It is found that serum antifibrinolytic activity is inhibitory both to the spontaneous fibrinolytic activity and to the activity of streptokinase-activated plasminogen. The titres of serum antiplasmin activity during gestation, labour, and the puerperium are all of the same order and do not differ from those in non-pr...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.13.3.220
更新日期:1960-05-01 00:00:00
abstract::Visceral candidiasis in 56 patients, 39 of whom were thought to be immune deficient, was investigated using three serological detection methods--whole cell agglutination, haemagglutination, and counterimmunoelectrophoresis for antibodies; two determinations of circulating antigens--haemagglutination inhibition and lat...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.40.10.1162
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND:Microscopic examination of scalp hair can provide important diagnostic information in a range of paediatric conditions. It is a non-invasive and cost effective investigation, which is not widely performed. AIMS:To examine retrospectively the value of hair examination by light microscopy, including polarisin...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2005.027581
更新日期:2005-12-01 00:00:00
abstract::There is currently much speculation over the precise nature of lobular carcinoma in-situ of the breast and its significance. Histochemical study shows that it is rich in sialomucin. This has a characteristic intracellular distribution which distinghishes lobular carcinoma in-situ from cancerization of lobules. The sam...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.28.9.711
更新日期:1975-09-01 00:00:00