Chlorhexidine resistance in Proteus mirabilis.

Abstract:

:A total of 104 clinical isolates of Pr. mirabilis from three hospitals were screened for their sensitivity to chlorhexidine. The minimum inhibitory concentrations of the antiseptic for these strains ranged from 10 to 800 mug/ml. Two strains sensitive to 20 mug of chlorhexidine/ml were adapted to resistance by growth in subinhibitory concentrations of the antiseptic, their MIC values increasing to 200 and 800 mug/ml. These derived strains exhibited slightly reduced sensitivity to cetrimide and benzalkonium chloride. The chlorhexidine-resistant clinical isolates also exhibited this partially decreased sensitivity to the quaternary ammonium compounds. Both the chlorhexidine-sensitive and -resistant strains were uniformly sensitive to chloroxylenol (Dettol), glutaraldehyde, and 2-phenoxyethanol.

journal_name

J Clin Pathol

authors

Stickler DJ

doi

10.1136/jcp.27.4.284

subject

Has Abstract

pub_date

1974-04-01 00:00:00

pages

284-7

issue

4

eissn

0021-9746

issn

1472-4146

journal_volume

27

pub_type

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