Abstract:
:In the course of the Paris study on risk factors of cardiovascular disease in a large professional group, 7710 active and apparently healthy men aged between 48 and 54 were examined. This study measured the relationship between clinical abnormalities suggesting alcoholic liver disease (ALD) and the following blood parameters: white (WBC) and red (RBC) blood cell counts, haematocrit (H), and mean corpuscular volume (MCV), the former computed as H/RBC ratio. A subsequent analysis was performed on a random sample of 485 subjects without ALD who were questioned on their daily average alcohol consumption. Each subject was classified as ;smoker' or ;non-smoker' according to his daily tobacco consumption for the last five years. Analysis of the data confirmed that smoking and alcohol were related to the blood parameters; but, according to smoking habit, different relationships between alcohol consumption (or ALD) and MCV, RBC, or WBC counts were found: for smokers, RBC count significantly decreased and MCV increased with alcohol consumption (or ALD); for non-smokers, WBC count significantly increased with alcohol consumption (or ALD). So, it would be of interest to consider the relation between alcohol and tobacco in interpreting possible changes in blood parameters and in formulating hypotheses on the mechanisms of their specific action.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Eschwege E,Papoz L,Lellouch J,Claude JR,Cubeau J,Pequignot G,Richard JL,Schwartz Ddoi
10.1136/jcp.31.7.654subject
Has Abstractpub_date
1978-07-01 00:00:00pages
654-8issue
7eissn
0021-9746issn
1472-4146journal_volume
31pub_type
杂志文章abstract::The development and evaluation of a new selective medium for Streptococcus pneumoniae is described. It is shown that the new medium (crystal violet-nalidixic acid-gentamicin agar:CVNG) is highly selective for Strep. pneumoniae in sputum specimens containing other organisms and is also sensitive, being only marginally ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.33.8.770
更新日期:1980-08-01 00:00:00
abstract::Three strains of Past. septica were isolated in Hong Kong. The clinical histories and the detailed bacteriological and serological studies are presented. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.17.2.107
更新日期:1964-03-01 00:00:00
abstract::The haematological features of 118 cases of primary myelodysplastic syndromes (PMDS) were reviewed to see how these could be related and classified according to the recent FAB proposals. A majority of the cases were elderly who presented with a macrocytic or normocytic anaemia and reticulocytopenia. Cases of acquired ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.10.1129
更新日期:1983-10-01 00:00:00
abstract::A case of chronic neutrophilic leukaemia (CNL) is reported. The diagnosis was based on leucocytosis with mature neutrophils, a raised leucocyte alkaline phosphatase score, negative Philadelphia chromosome, and extensive infiltration of neutrophils in various differentiation stages into the bone marrow. When viewed by ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.4.367
更新日期:1994-04-01 00:00:00
abstract::The isotopic estimation of the cortisol secretion rate in man is now an accepted and reliable method of assaying adrenal cortical function.Seven years' experience with its clinical use is reviewed and some practical aspects of technique are considered. The mean normal resting cortisol secretion rate is 16.2 +/- 5.7 mg...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.18.1.82
更新日期:1965-01-01 00:00:00
abstract:AIMS:To evaluate the influence of involvement of the peritoneal surface by carcinoma of the rectum on local recurrence and prognosis. METHODS:Prospective analysis of pathological prognostic factors in 209 resections for rectal carcinoma between 1988 and 1993 with meticulous pathological technique particularly to asses...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.9.849
更新日期:1995-09-01 00:00:00
abstract:AIMS:To investigate the histopathological features of the synovial lining of the knee following implantation of an artificial cruciate ligament. METHODS:Eighty two patients underwent anterior cruciate ligament reconstruction for chronic, symptomatic instability of the knee. The cruciate ligament was reconstructed with...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.6.556
更新日期:1995-06-01 00:00:00
abstract:AIMS:To evaluate a recently developed digital slide and virtual microscope system, and to compare this method with optical microscopy on routine gastrointestinal biopsy specimens in both local and remote access modes. METHODS:A fully computer controlled commercial microscope was used. The scanning program included obj...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.56.6.433
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:Intraduct papillary mucinous neoplasm (IPMN) is a pancreatic tumour that is often associated with chronic pancreatitis (CP) in the surrounding pancreas. Type 1 autoimmune pancreatitis (AIP) is a fibro-inflammatory condition with characteristic histological features and prominent IgG4+ plasma cells and is par...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2013-201516
更新日期:2013-08-01 00:00:00
abstract::Veno-occlusive disease of the liver with clinical and pathological features similar to those of the condition occurring in the Caribbean is described in a young woman resident in Britain. The diagnosis was made from liver biopsies and hepatic venography and was confirmed at necropsy. Small amounts of pyrroliziding alk...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.29.9.788
更新日期:1976-09-01 00:00:00
abstract::Thirty two fire victims with smoke inhalation, with or without burns, and 26 control subjects had bronchoalveolar lavage performed. Cell yields and differential cell counts were assessed. All patients and controls were cigarette smokers. Patients with smoke inhalation (SI) injury generally showed higher total bronchoa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.43.1.43
更新日期:1990-01-01 00:00:00
abstract::The plasma clearance of intravenously administered folic acid was abnormally rapid in all of five patients studied with untreated hyperthyroidism; in three, the basal serum L. casei folate level was subnormal. Four of these patients and another patient were studied at various intervals after partial or complete correc...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.17.6.666
更新日期:1964-11-01 00:00:00
abstract::Rapid diagnoses were made on 510 breast lumps by three methods in sequence and the results compared with those obtained by paraffin histology.Naked-eye examination of the excised lumps correctly distinguished between benign and malignant tumours in 95.1% of cases with 23 (4.5%) false negative and two (0.4%) false posi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.26.4.273
更新日期:1973-04-01 00:00:00
abstract:AIM:The prognostic significance of perineural invasion (PNI) in oesophageal adenocarcinoma (EAC) is unclear. We examined the association of PNI with clinical outcomes in patients treated with neoadjuvant chemoradiotherapy (nCRT) and surgery. METHODS:We performed a single institutional retrospective study. We evaluated...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-206424
更新日期:2020-04-21 00:00:00
abstract::A patient with multiple myeloma had antigenically related monoclonal Fc-gamma fragments and complete IgG-kappa molecules in the serum. The urine contained only Fc-gamma fragments in the absence of Bence-Jones protein. The two distinct M-components in the serum showed electrophoretic identity but could be separated by ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.33.10.936
更新日期:1980-10-01 00:00:00
abstract::Results of blood culture examination using the radiometric (Bactec-460) system for one year showed no overall improvement compared with those of the previous three years when a manual system with early blind subculture was used. The isolates from the manual system were available more often on solid media, 24 hours ear...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.10.1146
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:A small subset (10-15%) of gastrointestinal stromal tumours (GISTs) lack mutations in KIT and PDGFRA (wild-type GIST). Recently, a novel BRAF exon 15 mutation (V600E) was detected in imatinib-naive wild-type high-risk intestinal GISTs (4%). However, the frequency and distribution of BRAF mutations within the...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2009.064550
更新日期:2009-07-01 00:00:00
abstract:AIM:To examine peripheral blood and skeletal muscle from patients with chronic fatigue syndrome for exogenous retrovirus. METHODS:Blood samples from 30 patients and muscle biopsy specimens of 15 patients were examined for retroviral sequences by DNA extraction, polymerase chain reaction (PCR), and Southern blotting hy...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.12.1058
更新日期:1992-12-01 00:00:00
abstract::Urines from patients with symptoms of urinary tract infection yielded mixed growths of different colony types of Escherichia coli. The different colony types were found to be variants of single infecting strains caused by mutation or by phase action. It is suggested that care should be exercised in the interpretation ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.28.9.728
更新日期:1975-09-01 00:00:00
abstract::Five cases of inflammatory pseudotumour of the liver are reported and compared with seven individual previously published case reports. Clinical presentation was variable but often comprised low grade intermittent fever, vague abdominal symptoms, and a history of weight loss. Leucocytosis, raised erythrocyte sedimenta...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.39.7.761
更新日期:1986-07-01 00:00:00
abstract::Organising pneumonia (otherwise referred to as bronchiolitis obliterans organising pneumonia) is characterised histologically by plugs of granulation tissue, which are present predominantly within small airways, alveolar ducts and peri-bronchiolar alveoli. This pattern is not specific for any disorder or cause, but is...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jclinpath-2012-201342
更新日期:2013-10-01 00:00:00
abstract::Three cases of islet cell necrosis in neonates are reported. The association of this rare condition with antepartum haemorrhage, anoxia, shock and intravascular coagulation are discussed. The clinical and morphological appearances were compared with previous descriptions of this condition and an association with neona...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.40.10.1206
更新日期:1987-10-01 00:00:00
abstract::The morphological classification and diagnosis of bladder neoplasms is summarised, with specific focus on histological typing, grading and staging. Four diagnostic categories are described on the basis of the pattern of growth of the urothelial lesions and tumours (flat, exophytic or papillary, endophytic, and invasiv...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2007.049312
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Raised plasma ferritin concentrations occur unexpectedly during iron studies done by primary care physicians. Plasma ferritin concentration has been positively associated with alcohol use among men. AIM:To determine the post-test probability that men in the community with raised plasma ferritin concentratio...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.52.11.853
更新日期:1999-11-01 00:00:00
abstract::A spectrophotometric assay of proteolytic enzyme activity is described in which the optical density obtained by a given enzyme preparation is related (2 alpha less than 0.01) to the serological activity of that preparation in a two stage technique. The assay appears to be of use for the standardisation of enzyme prepa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.3.329
更新日期:1984-03-01 00:00:00
abstract::Zygomycosis is not often diagnosed in the United Kingdom, and so the possible importance of the findings in a patient with disseminated zygomycosis who had been treated with chemotherapy for erythroleukaemia was not appreciated until histological examination of specimens obtained at necropsy provided a presumptive dia...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.9.1039
更新日期:1985-09-01 00:00:00
abstract::A latex enzyme immunoassay (LEIA) for detecting IgG class antibody to rubella virus was compared with the latex agglutination test (LA) and a haemagglutination inhibition assay (HI). Of 243 sera tested, four discrepant results were observed among all three techniques, corresponding to borderline values. Except for one...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.43.9.766
更新日期:1990-09-01 00:00:00
abstract::Extracts of the seeds of Vicia cretica (NO Leguminosae) strongly agglutinate T- Th- but not Tk- or other polyagglutinable red cells. The V. cretica lectin is therefore a very useful laboratory reagent in the elucidation of erythrocyte polyagglutination due to T-like erythrocyte cryptantigens. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.1.69
更新日期:1981-01-01 00:00:00
abstract::A questionnaire was circulated to clinical biochemistry laboratories in the North West Thames region of the United Kingdom requesting information on extralaboratory equipment. Data on the types and numbers of instruments in use, their relationship with the laboratory, and quality assurance procedures were obtained. La...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.9.925
更新日期:1988-09-01 00:00:00
abstract::The mucin and gland content of 26 rectal biopsy specimens--five normal specimens, 10 from patients with ulcerative colitis, and 11 from patients with Crohn's disease--were measured using a Quantimet image analyser. There was significantly less mucin in the groups with ulcerative colitis compared with either those with...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.43.2.143
更新日期:1990-02-01 00:00:00