Abstract:
BACKGROUND:Raised plasma ferritin concentrations occur unexpectedly during iron studies done by primary care physicians. Plasma ferritin concentration has been positively associated with alcohol use among men. AIM:To determine the post-test probability that men in the community with raised plasma ferritin concentrations are hazardous drinkers. METHODS:The subjects were 152 men, randomly selected from a city's electoral roll. Nineteen (12.5 (2.7)%, mean (SEM)) admitted to drinking hazardously. The pretest probability of a man being a hazardous drinker was 0.125. This was converted to pretest odds of 0.14. The likelihood ratio (the ratio of the probability of obtaining a raised plasma ferritin concentration in a hazardous drinker (sensitivity) to the probability of obtaining a raised plasma ferritin concentration in a non-hazardous drinker (1-specificity)) was calculated for different plasma ferritin cut off points. RESULTS:A plasma ferritin level of > 652 micrograms/l gave the largest likelihood ratio, 4.16. Post-test odds were obtained by multiplying the pretest odds (0.14) by the likelihood ratio (4.16). A plasma ferritin level of > 652 micrograms/l had a post-test odds for a man being a hazardous drinker of 0.58. This was converted to a post-test probability of 0.37. CONCLUSIONS:Inquiries could usefully be made into the alcohol consumption of men with a plasma ferritin concentration > 652 micrograms/l, as approximately one in three would admit to drinking hazardously.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Peach HG,Bath NEdoi
10.1136/jcp.52.11.853keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
853-5issue
11eissn
0021-9746issn
1472-4146journal_volume
52pub_type
杂志文章abstract:AIMS:To develop a strategy for neonatal screening of sickle cell disease (SCD) and effective enrollment of affected neonates in a comprehensive follow-up programme adapted to the socioeconomic conditions, health structures and cultural background of an African setting. METHODS:The strategy implemented at the two large...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jcp.2008.059113
更新日期:2009-01-01 00:00:00
abstract::The relationship between the intensity of the delayed hypersensitivity reaction and the dose of antigen used for its elicitation change with time after sensitization. At three weeks the reactions to 100 mug of egg albumen were little different from those to 1 mug but at 14 weeks 100 mug gave much stronger reactions. T...
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:2000-06-01 00:00:00
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更新日期:1971-03-01 00:00:00
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doi:10.1136/jcp.42.11.1166
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pub_type: 信件
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更新日期:2002-07-01 00:00:00
abstract::An enzyme immunoassay technique based on the direct detection of Chlamydia trachomatis antigen in urethral or cervical swabs was used for the rapid diagnosis of chlamydial genital infection. Urethral and cervical samples from 140 patients were tested in parallel by enzyme immunoassay and cell culture using iodine stai...
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pub_type: 杂志文章
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更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:Periostin is a secreted adhesion protein, normally expressed in mesenchime-derived cells. Aberrant expression of the periostin gene in epithelial tumours seems to play a role in angiogenesis and metastases. AIMS:To investigate periostin expression in a consecutive series of breast carcinomas and correlate i...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2007.052506
更新日期:2008-04-01 00:00:00
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doi:10.1136/jcp.55.12.926
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pub_type: 临床试验,杂志文章
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更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jcp.2005.029991
更新日期:2006-05-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.56.1.74
更新日期:2003-01-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.32.6.556
更新日期:1979-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1136/jcp.2005.033217
更新日期:2007-06-01 00:00:00
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更新日期:2003-11-01 00:00:00
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更新日期:1993-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1965-09-01 00:00:00