EGFR mutation detection by microfluidic technology: a validation study.

abstract：:The morphology of the labial salivary glands in subjects with and without cystic fibrosis has been studied by light and electron microscopy. The terms ;light' cell, ;dark' cell, ;clear' cell, and ;myoepithelial' cell are used to describe the four cell types distinguished at the level of the electron microscope. The da...

journal_title：Journal of clinical pathology

authors： Doggett RG,Bentinck B,Harrison GM

更新日期：1971-04-01 00:00:00

abstract：OBJECTIVE:Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy, most frequently affecting the head and neck. Treatment often requires surgery and can have significant functional morbidity. Research into disease pathogenesis and second line medical management of cSCC is limited. We assess geneti...

journal_title：Journal of clinical pathology

authors： Zilberg C,Lee MW,Kraitsek S,Ashford B,Ranson M,Shannon K,Iyer NG,Ch'ng S,Low TH,Palme C,Clark J,Gupta R,Yu B

更新日期：2020-01-01 00:00:00

abstract：:The technique devised by Moore (1960) for determining the sensitivity of staphylococci to mercuric chloride was investigated and the effect of variations in the medium determined. An alternative technique, in which paper discs impregnated with phenyl mercuric nitrate are used, was found to give identical results. Thre...

journal_title：Journal of clinical pathology

authors： GREEN SM

更新日期：1962-05-01 00:00:00

abstract：:Structural chromosomal aberrations, in the form of breaks, were found in a significantly higher proportion of bone marrow cells in patients with infective hepatitis than in controls. These anomalies were observed during the first and third weeks after the onset of jaundice but had subsided by the sixth week. Chromosom...

journal_title：Journal of clinical pathology

authors： Matsaniotis N,Kiossoglou K,Maounis F,Anagnostakis D

更新日期：1970-10-01 00:00:00

abstract：AIMS:To audit the cellular expression of the innate antibacterial enzyme lysozyme in colonic biopsies from a cohort of patients having microscopic colitis (MC-collagenous colitis (CC) or lymphocytic colitis (LC)). Results were compared with those recorded in patients with inflammatory bowel disease (IBD) of the colon (...

journal_title：Journal of clinical pathology

authors： Rubio CA

更新日期：2011-06-01 00:00:00

abstract：AIMS:Congenital neutropenia (CN) is a rare inherited disease that results in recurrent, life-threatening bacterial infections due to a deficiency of mature neutrophils. They are usually caused by heterozygous ELANE mutations although mutations in other genes like HAX-1, G6PC3 and GFI1 have also been reported. Identifyi...

journal_title：Journal of clinical pathology

authors： Arunachalam AK,Suresh H,Edison ES,Korula A,Aboobacker FN,George B,Shaji RV,Mathews V,Balasubramanian P

更新日期：2020-06-01 00:00:00

abstract：AIMS:To elucidate potential mechanisms of drug resistance, levels of topoisomerase II alpha mRNA, a target for cytostatic drugs, were measured in cryopreserved tumour tissue from 36 patients with non-Hodgkin's lymphoma. To evaluate the potential association between topoisomerase II alpha and cell proliferation, Ki-67 i...

journal_title：Journal of clinical pathology

authors： Lohri A,Reuter J,Gudat F,Herrmann R

更新日期：1997-01-01 00:00:00

abstract：:The plasma clearance of intravenously administered folic acid was abnormally rapid in all of five patients studied with untreated hyperthyroidism; in three, the basal serum L. casei folate level was subnormal. Four of these patients and another patient were studied at various intervals after partial or complete correc...

journal_title：Journal of clinical pathology

authors： Lindenbaum J,Klipstein FA

更新日期：1964-11-01 00:00:00

abstract：AIMS:Guaiac faecal occult blood tests are being replaced by faecal immunochemical tests (FIT). We investigated whether faecal haemoglobin concentration (f-Hb) was related to stage in progression of colorectal neoplasia, studying cancer and adenoma characteristics in an evaluation of quantitative FIT as a first-line scr...

journal_title：Journal of clinical pathology

authors： Digby J,Fraser CG,Carey FA,McDonald PJ,Strachan JA,Diament RH,Balsitis M,Steele RJ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Prostate cancer diagnosis is routinely made by the histopathological examination of formalin fixed needle biopsy specimens. Frequently this is the only cancer tissue available from the patient for the analysis of diagnostic and prognostic biomarkers. There is, therefore, an urgent need for methods that allow...

journal_title：Journal of clinical pathology

authors： McCarthy F,Fletcher A,Dennis N,Cummings C,O'Donnell H,Clark J,Flohr P,Vergis R,Jhavar S,Parker C,Cooper CS

更新日期：2009-08-01 00:00:00

abstract：AIMS/BACKGROUND:A major medical role for postmortem examinations is the detection of clinically unexpected disease processes contributing to death. The aim of the present study was to determine whether simple clinical parameters can predict the presence of important unanticipated findings at necropsy. METHODS:Prospect...

journal_title：Journal of clinical pathology

authors： Robinson IA,Marley NJ

更新日期：1996-11-01 00:00:00

abstract：:Cutaneous melanoma causes most of the skin cancer deaths in the USA. Melanoma is the fifth most common cancer among men and the sixth most common cancer among women. The incidence of melanoma has risen sharply over the past three decades. In this review, which is informed by our extensive experience at a large cancer ...

journal_title：Journal of clinical pathology

authors： Trinidad CM,Torres-Cabala CA,Curry JL,Prieto VG,Aung PP

更新日期：2019-04-01 00:00:00

abstract：:Infection with Vibrio vulnificus is uncommon in Europe but is associated with necrotising wound infections and life-threatening septicaemia. This case is one of infection most likely to have been acquired from a thermal pool in Turkey without preceding exposure to seawater or shellfish. The report also describes how e...

journal_title：Journal of clinical pathology

authors： Partridge DG,Townsend R,Larkin S,Parsons HK

更新日期：2009-04-01 00:00:00

abstract：:In an era when immunohistochemistry (IHC) is increasingly depended on for histological subtyping, and IHC-determined biomarker informing rapid treatment choices is on the horizon; reproducible, quantifiable techniques are required. This study aimed to compare automated IHC scoring to quantify 6 DNA damage response pro...

journal_title：Journal of clinical pathology

authors： Gentles L,Howarth R,Lee WJ,Sharma-Saha S,Ralte A,Curtin N,Drew Y,O'Donnell RL

更新日期：2020-11-19 00:00:00

abstract：:Clinical trials have shown that many patients with breast cancer with limited sentinel lymph node (SLN) metastatic disease can safely avoid axillary lymph node dissection. Ultra-staging of initially negative SLNs may not confer additional clinical benefit. Despite this, protocols of 'enhanced pathological examination'...

journal_title：Journal of clinical pathology

authors： Murray C,Al Shehhi A,Ó'Riain C,Dunne B,Maguire A

更新日期：2020-10-22 00:00:00

abstract：:A case is described in which marked hepatic fibrosis probably resulted from the prolonged treatment of acute leukaemia with methotrexate. ...

journal_title：Journal of clinical pathology

authors： Talerman A,Thompson RB

更新日期：1966-01-01 00:00:00

abstract：AIMS:Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive non-Hodgkin's lymphoma that represents a heterogeneous group of disease that is differentially characterised by clinical, molecular and cytogenetic features. MYC, BCL2 and BCL6 gene rearrangements have been identified as prognostic factors...

journal_title：Journal of clinical pathology

authors： Tourneret A,Alame M,Rigau V,Bauchet L,Fabbro M,De Oliveira L,Cacheux V,Costes V,Lacheretz-Szablewski V

更新日期：2020-09-10 00:00:00

abstract：:A correlative clinical and Hemalog D study of 80 cases of chronic lymphocytic leukaemia (CLL) was performed and the results compared with those in other lymphoproliferative disorders affecting the blood (eight cases of hairy-cell leukaemia, HCL; three cases of prolymphocytic leukaemia, PLL: two cases of lymphoplasmacy...

journal_title：Journal of clinical pathology

authors： Patterson KG,Goldstone AH,Richards JD,Cawley JC

更新日期：1981-05-01 00:00:00

abstract：:Two cases of chronic coronary periarteritis associated with chronic periaortitis are described. In one, the chronic periaortitis took the form of perianeurysmal fibrosis around a thoracic atherosclerotic aneurysm; in the other it resembled idiopathic retroperitoneal fibrosis. The findings in the two subjects support t...

journal_title：Journal of clinical pathology

authors： Mitchinson MJ,Wight DG,Arno J,Milstein BB

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Squamous differentiation/squamous metaplasia is often associated with endometrial adenocarcinoma and benign lesions, such as endometrial hyperplasia and chronic endometritis. Morules have distinct histological characteristics, and are referred to as squamous metaplasia or squamoid metaplasia. AIM:To focus o...

journal_title：Journal of clinical pathology

authors： Chinen K,Kamiyama K,Kinjo T,Arasaki A,Ihama Y,Hamada T,Iwamasa T

更新日期：2004-09-01 00:00:00

abstract：AIM:The rapid and fully automated Idylla EGFR Mutation Assay has been specifically designed to process formalin-fixed, paraffin-embedded sections without requiring preliminary DNA extraction. This study evaluates whether this approach can also process archival smears from patients with non-small cell lung cancer (NSCLC...

journal_title：Journal of clinical pathology

authors： De Luca C,Conticelli F,Leone A,Gragnano G,Salatiello M,Galasso P,Pisapia P,Grillo LR,Iaccarino A,Vigliar E,Bellevicine C,Malapelle U,Troncone G

更新日期：2019-09-01 00:00:00

abstract：:Fluorescence in situ hybridisation (FISH) analysis is now widely employed in the diagnosis and risk stratification of a wide range of malignant diseases. While this technique is used successfully with formalin-fixed paraffin-embedded (FFPE) sections from numerous tissue types, FISH analysis of FFPE tissue sections fro...

journal_title：Journal of clinical pathology

authors： Neat MJ,Moonim MT,Dunn RG,Geoghegan H,Foot NJ

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:The role of single mutations has been extensively studied myelodysplastic syndromes (MDS), but the impact of genetic aberrations in the context of other mutations is less well understood. BCOR is an epigenetic transcriptional corepressor. In MDS, BCOR mutations are rare and certain mutations are associated...

journal_title：Journal of clinical pathology

authors： Badaat I,Mirza S,Padron E,Sallman D,Komrokji R,Song J,Hussaini MO

更新日期：2020-04-01 00:00:00

abstract：AIMS:To investigate staining patterns for mannan binding protein (MBP) by immunocytochemistry in liver biopsy specimens from patients with various hepatic disorders; to measure the serum MBP concentration in the patients at the time of biopsy; and to compare these to define further the role of MBP in disease. METHODS:...

journal_title：Journal of clinical pathology

authors： Ryley NG,Heryet AR,Lu J,Reid KB,Fleming KA

更新日期：1993-03-01 00:00:00

abstract：AIM:Heart failure (HF) affects millions of older individuals in both developed and low/middle-income countries. Serum galectin-3 levels have been shown to have prognostic value. However, its use as a diagnostic biomarker has not been explored. The aim was to establish a saliva galectin-3 reference range and to demonstr...

journal_title：Journal of clinical pathology

authors： Zhang X,Wan Y,Chata R,Brazzale A,Atherton JJ,Kostner K,Dimeski G,Punyadeera C

更新日期：2016-12-01 00:00:00

abstract：:A method of typing isolates of Proteus mirabilis and Proteus vulgaris is described based on the sensitivity of the organisms to bacteriocine. Twelve standard proteocine producing strains were selected from a large number of isolates tested, and from these liquid proteocine preparations were prepared. The sensitivities...

journal_title：Journal of clinical pathology

authors： Al-Jumaili IJ

更新日期：1975-10-01 00:00:00

abstract：:The isotopic estimation of the cortisol secretion rate in man is now an accepted and reliable method of assaying adrenal cortical function.Seven years' experience with its clinical use is reviewed and some practical aspects of technique are considered. The mean normal resting cortisol secretion rate is 16.2 +/- 5.7 mg...

journal_title：Journal of clinical pathology

authors： COPE CL,PEARSON J

更新日期：1965-01-01 00:00:00

abstract：:Although Neisseria species other than N gonorrhoeae and N meningitidis normally comprise part of the commensal bacterial flora of the oropharynx, they may occasionally act as opportunistic pathogens. Infections in which these organisms have been implicated include cases of endocarditis, meningitis, septicaemia, otitis...

journal_title：Journal of clinical pathology

authors： Johnson AP

更新日期：1983-02-01 00:00:00

abstract：AIMS:To determine the causes of ovarian granulomatous inflammation and to discuss the differential diagnoses. METHODS:The pathological features of all ovarian granulomas identified by pathology SNOMED coding in Northern Ireland over a 13 year period were reviewed. Case notes of patients were also reviewed. RESULTS:Th...

journal_title：Journal of clinical pathology

authors： McCluggage WG,Allen DC

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Laboratories traditionally culture toxoplasma tachyzoites in animals for testing and experimental use. This article considers why available cell culture methods are not used more often. AIM:To compare HeLa cell culture and animal culture for production of toxoplasma tachyzoites. METHODS:In 2000 HeLa cultur...

journal_title：Journal of clinical pathology

authors： Chatterton JM,McDonagh S,Ho-Yen DO

更新日期：2010-05-01 00:00:00