An improved method for constructing tissue microarrays from prostate needle biopsy specimens.

abstract：AIMS:EGFR tyrosine kinase inhibitors (TKIs) are first-line molecularly targeted therapies in patients with advanced non-small cell lung cancer (NSCLC) who carry sensitising EGFR mutations, due to its superior survival outcomes compared with conventional chemotherapy regimens. In this study, we sought to identify clinic...

journal_title：Journal of clinical pathology

authors： Ng IK,Kumarakulasinghe NB,Syn NL,Soo RA

更新日期：2021-02-01 00:00:00

abstract：AIM:To develop a polymerase chain reaction (PCR) for the specific detection of the C protein gene in strains of group B Streptococcus. METHODS:A single primer pair derived from the nucleotide sequence of the IgA binding beta antigen of the C protein complex permitted the specific amplification of a 592 base pair DNA f...

journal_title：Journal of clinical pathology

authors： Mawn JA,Simpson AJ,Heard SR

更新日期：1993-07-01 00:00:00

abstract：AIMS:To describe the prostatic adenectomy specimens of six patients with symptomatic benign prostatic hyperplasia (BPH) who failed to respond to long term treatment with a 5-alpha-reductase inhibitor, finasteride. METHODS:Histological sections from six cases of BPH who had been treated with finasteride were investigat...

journal_title：Journal of clinical pathology

authors： Montironi R,Valli M,Fabris G

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Receptor activator of nuclear factor kappabeta ligand (RANKL) has an important role in bone remodelling, and tumour necrosis factor related, apoptosis inducing ligand (TRAIL) can induce apoptosis in cancer cells. Their functions are linked by their interactions with osteoprotegerin (OPG). OBJECTIVE:To inves...

journal_title：Journal of clinical pathology

authors： Cross SS,Harrison RF,Balasubramanian SP,Lippitt JM,Evans CA,Reed MW,Holen I

更新日期：2006-07-01 00:00:00

abstract：:Severe osteomalacia (confirmed by the examination of thin undecalcified bone biopsy sections) associated with hypophosphataemia developed in a 60 year old woman. A skeletal x-ray survey showed a lytic lesion in the right proximal femur, and this was curetted, showing a vascular tumour. The patient's symptoms improved ...

journal_title：Journal of clinical pathology

authors： McClure J,Smith PS

更新日期：1987-04-01 00:00:00

abstract：:This is an unusual case of total granulomatous infarction of testis due to Schistosoma haematobium, the first such case to be reported. This report reinforces the theory of extraportal maturation of worms in spermatic veins and capillaries as postulated earlier (Joshi, 1962). ...

journal_title：Journal of clinical pathology

authors： Joshi RA

更新日期：1967-05-01 00:00:00

abstract：:Candida spp are the fourth most common group of nosocomial pathogens isolated from patients on medical, surgical, and intensive care wards. Polymicrobial candidaemia has rarely been described. The diagnosis of candidaemia from peripheral blood smears has not been widely reported. This report describes the case of a yo...

journal_title：Journal of clinical pathology

authors： Yera H,Poulain D,Lefebvre A,Camus D,Sendid B

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND/AIMS:Mast cells, when activated, secrete a large number of fibrogenic factors and have been implicated in the development of fibrotic conditions of the liver, lung, and skin. There is evidence that renal fibrosis is closely linked with a chronic inflammatory cell infiltrate within the interstitium, but a pot...

journal_title：Journal of clinical pathology

authors： Roberts IS,Brenchley PE

更新日期：2000-11-01 00:00:00

abstract：:It was shown that, on average, the titres of the sera obtained by both the anti-complement immunofluorescence (ACIF) and indirect immunofluorescence for viral late antigens (IFA-LA) procedures were approximately eight times higher than those obtained by complement fixation. There was no significant difference between ...

journal_title：Journal of clinical pathology

authors： Griffiths PD,Buie KJ,Heath RB

更新日期：1978-09-01 00:00:00

abstract：:The results of measurement of gamma globulin in the cerebrospinal fluid by electrophoresis and by an immunological technique are compared. In some fluids marked discrepancies were found. Such discrepancies, when substantiated and better understood, may have diagnostic significance. ...

journal_title：Journal of clinical pathology

authors： COLOVER J,FEINBERG JG,TEMPLE A,TOOLEY M

更新日期：1963-07-01 00:00:00

abstract：BACKGROUND:Gastric mucosa associated lymphoid tissue (MALT) lymphoma is a low grade B cell lymphoma histologically characterised by neoplastic B cells surrounding follicles in a marginal zone pattern and selectively infiltrating epithelium to form characteristic lymphoepithelial lesions. AIMS:To identify solitary epit...

journal_title：Journal of clinical pathology

authors： Sutak J,Stoddard C,Smith ME

更新日期：2005-11-01 00:00:00

abstract：AIMS:Experience in the use of whole slide imaging (WSI) for primary diagnosis in pathology is very limited. We aimed to determine the accuracy of interpretation of WSI compared with conventional light microscopy (CLM) in the diagnosis of routine gynaecological biopsies. METHODS:All gynaecological specimens (n=452) rec...

journal_title：Journal of clinical pathology

authors： Ordi J,Castillo P,Saco A,Del Pino M,Ordi O,Rodríguez-Carunchio L,Ramírez J

更新日期：2015-01-01 00:00:00

abstract：AIMS:To study the localisation of the endothelial nitric oxide synthase (eNOS) in the normal placenta, with special emphasis on the implantation site in the first trimester of pregnancy, and in the different subtypes of trophoblastic cells in gestational trophoblastic disease. METHODS:The immunoperoxidase technique wi...

journal_title：Journal of clinical pathology

authors： Ariel I,Hochberg A,Shochina M

更新日期：1998-06-01 00:00:00

abstract：AIM:To determine the frequency, pattern and distribution of stromal keratin expression in phyllodes tumours if any, which may impact diagnostic approaches. METHODS:The clinicopathological features of 109 phyllodes tumours comprising 70 (64.2%) benign, 30 (27.5%) borderline and nine (8.3%) malignant grades were evaluat...

journal_title：Journal of clinical pathology

authors： Chia Y,Thike AA,Cheok PY,Yong-Zheng Chong L,Man-Kit Tse G,Tan PH

更新日期：2012-04-01 00:00:00

abstract：:A rapid and simple enzyme linked immunosorbent assay (ELISA) for the detection of specific IgG against Toxoplasma gondii was compared with the dye test on 533 serum samples. In general, results were comparable but not with sera that contained high concentrations of toxoplasma specific IgM or that had been heated at 56...

journal_title：Journal of clinical pathology

authors： Francis JM,Payne RA,Joynson DH

更新日期：1988-07-01 00:00:00

abstract：:The cell volumes of mononuclear cells, T lymphocytes, B lymphocytes, and monocytes from the peripheral blood of 20 normal individuals were compared to neoplastic lymphoid cells from 14 patients with chronic lymphocytic leukaemia (CLL), 20 individuals with acute lymphocytic leukaemia (ALL), and 18 cases of non-Hodgkin'...

journal_title：Journal of clinical pathology

authors： Chapman EH,Kurec AS,Davey FR

更新日期：1981-10-01 00:00:00

abstract：AIMS:Epidermal growth factor receptor (EGFR) T790M mutations can be detected in the circulating tumour DNA from plasma of patients with non-small cell lung cancer (NSCLC) to triage patients for osimertinib eligibility and monitor patients longitudinally for development of T790M-mediated resistance. METHODS:Using dropl...

journal_title：Journal of clinical pathology

authors： Spence T,Perera S,Weiss J,Grenier S,Ranich L,Shepherd F,Stockley TL

更新日期：2021-02-01 00:00:00

abstract：AIMS:To develop a specific radioimmunoassay for the routine determination of serum vitamin B12. METHODS:Antisera were raised in rabbits by immunisation with the monocarboxylic acid derivative of cyanocobalamin coupled to human serum albumin. Antibody titres and affinities were determined and the antiserum giving the h...

journal_title：Journal of clinical pathology

authors： O'Sullivan JJ,Leeming RJ,Lynch SS,Pollock A

更新日期：1992-04-01 00:00:00

abstract：AIM:The prognostic significance of perineural invasion (PNI) in oesophageal adenocarcinoma (EAC) is unclear. We examined the association of PNI with clinical outcomes in patients treated with neoadjuvant chemoradiotherapy (nCRT) and surgery. METHODS:We performed a single institutional retrospective study. We evaluated...

journal_title：Journal of clinical pathology

authors： Patel AK,Pan X,Vila DM,Frankel WL,Chen W,Perry KA,Merritt RE,D'Souza DM,Wuthrick EJ,Williams TM

更新日期：2020-04-21 00:00:00

abstract：AIMS:Marked thrombocytosis is uncommon in chronic myelogenous leukaemia (CML) but may be associated with mutation of JAK2 V617F, calreticulin (CALR) and/or phospho-STAT5 (p-STAT5) activation in other myeloproliferative neoplasms (MPNs), particularly essential thrombocythaemia (ET). We investigated the JAK2 V617F, CALR ...

journal_title：Journal of clinical pathology

authors： Turakhia SK,Murugesan G,Cotta CV,Theil KS

更新日期：2016-08-01 00:00:00

abstract：:Serum total calcium was measured in 1693 patients during a four-month period. We examined the effects of adjustment for albumin concentration on the interpretation of single measurements of serum total calcium and on the variation of series of measurements in individual patients. Markedly abnormal total calcium concen...

journal_title：Journal of clinical pathology

authors： Payne RB,Carver ME,Morgan DB

更新日期：1979-01-01 00:00:00

abstract：AIMS:To test whether a hypoacidic environment may potentially "stress" Helicobacter pylori DNA, encouraging the emergence of strain variation. METHODS:This hypothesis was tested by inducing prolonged hypoacidity with omeprazole, a potent antisecretory drug. The genomic DNA of H pylori was studied by electrophoretic se...

journal_title：Journal of clinical pathology

authors： Fraser AG,Bickley J,Owen RJ,Pounder RE

更新日期：1992-12-01 00:00:00

abstract：:Pathology review of gynaecological cancer specimens is often carried out as part of the working of gynaecological oncology multidisciplinary team meetings. This review describes the author's experience regarding the most common issues identified during this process. Ten subjects are covered; these range from histopath...

journal_title：Journal of clinical pathology

authors： McCluggage WG

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Although Hashimoto thyroiditis (HT) is a predisposing factor for B-lineage thyroid lymphoma, clonal B-cell populations in HT are rare. AIM:To investigate whether there is a clonal relationship between HT and primary thyroid lymphoma. METHODS:Clonalilty and sequence similarity was determined by PCR followed...

journal_title：Journal of clinical pathology

authors： Moshynska OV,Saxena A

更新日期：2008-04-01 00:00:00

abstract：:In patients with chronic renal failure, blood samples for laboratory analysis are often taken via dialysis catheters. This report describes a case of gross spurious hypernatraemia in a blood sample collected from a patient undergoing haemodialysis. After centrifugation of the blood sample in question, the separator ge...

journal_title：Journal of clinical pathology

authors： Srivastava R,Murphy MJ,Card J,Severn A,Fraser CG

更新日期：2004-12-01 00:00:00

abstract：AIMS:The IHC4+C score combines assessment of oestrogen receptor (ER), progesterone receptor (PgR), HER2 and Ki67 with clinicopathological parameters to identify the risk of distant disease recurrence in patients with breast cancer, so, aiding treatment decision-making on adjuvant chemotherapy. Despite low cost and wide...

journal_title：Journal of clinical pathology

authors： Dodson A,Zabaglo L,Yeo B,Miller K,Smith I,Dowsett M

更新日期：2016-02-01 00:00:00

abstract：:Liver diseases are associated with complex haemostasis defects, in which platelets, coagulation, and fibrinolysis may all be affected. The low plasma concentrations of clotting factors often found can be the result of many changes such as impaired synthesis, increased catabolism due to intravascular coagulation, or al...

journal_title：Journal of clinical pathology

authors： Knot E,Ten Cate JW,Drijfhout HR,Kahlé LH,Tytgat GN

更新日期：1984-05-01 00:00:00

abstract：:Sera from 20 cases of toxoplasmic lymphadenopathy were examined by an enzyme linked immunosorbent assay toxoplasma IgG avidity (ELISA) at two laboratories. The results obtained were largely in agreement and showed that sera from patients with acute infection had low avidity IgG (30% or less), whereas sera from patient...

journal_title：Journal of clinical pathology

authors： Joynson DH,Payne RA,Rawal BK

更新日期：1990-12-01 00:00:00

abstract：:The isotopic estimation of the cortisol secretion rate in man is now an accepted and reliable method of assaying adrenal cortical function.Seven years' experience with its clinical use is reviewed and some practical aspects of technique are considered. The mean normal resting cortisol secretion rate is 16.2 +/- 5.7 mg...

journal_title：Journal of clinical pathology

authors： COPE CL,PEARSON J

更新日期：1965-01-01 00:00:00

abstract：:This report describes a patient with a gastric biopsy specimen showing histomorphological and immunohistochemical appearances indistinguishable from those usually present in lymphocytic gastritis, a rare condition of unknown aetiology with a distinctive phenotype. The patient had a history of a biopsy confirmed T cell...

journal_title：Journal of clinical pathology

authors： Nga ME,Tan SH,Teh M,Koay ES,Chong SM,Putti TC,Salto-Tellez M

更新日期：2004-11-01 00:00:00