Abstract:
BACKGROUND:Gastric mucosa associated lymphoid tissue (MALT) lymphoma is a low grade B cell lymphoma histologically characterised by neoplastic B cells surrounding follicles in a marginal zone pattern and selectively infiltrating epithelium to form characteristic lymphoepithelial lesions. AIMS:To identify solitary epithelial cells in gastric MALT lymphoma and investigate their nature. METHODS:Anonymised endoscopic biopsies from eight B cell gastric MALT lymphomas and 10 control biopsies from chronic atrophic gastritis were selected. The numbers of solitary cytokeratin positive epithelial cells were assessed both semiquantitatively and quantitatively in immunostained sections. Chromogranin A expression was studied in sections consecutive to those stained for cytokeratin. RESULTS:Statistical analysis of the quantitative data confirmed that solitary epithelial cells were significantly more common in the lymphomas. The study of consecutive sections showed that the single cells express chromogranin A. CONCLUSIONS:The presence of solitary, cytokeratin positive epithelial cells within the neoplastic infiltrate is a characteristic feature of gastric B cell lymphoma. These solitary epithelial cells are of neuroendocrine origin.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Sutak J,Stoddard C,Smith MEdoi
10.1136/jcp.2004.023747keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
1226-8issue
11eissn
0021-9746issn
1472-4146pii
58/11/1226journal_volume
58pub_type
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:1971-04-01 00:00:00
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更新日期:2020-09-14 00:00:00
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journal_title:Journal of clinical pathology
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doi:10.1136/jcp.2009.064550
更新日期:2009-07-01 00:00:00
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journal_title:Journal of clinical pathology
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doi:10.1136/jcp.23.7.553
更新日期:1970-10-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:1974-05-01 00:00:00