Is the Idylla EGFR Mutation Assay feasible on archival stained cytological smears? A pilot study.

abstract：AIMS:To identify calcifying epithelial odontogenic tumour (CEOT) mutations in oncogenes and tumour suppressor genes. METHODS:A panel of 50 genes commonly mutated in cancer was sequenced in CEOT by next-generation sequencing. Sanger sequencing was used to cover the region of the frameshift deletion identified in one sa...

journal_title：Journal of clinical pathology

authors： de Sousa SF,Diniz MG,França JA,Fontes Pereira TDS,Moreira RG,Santos JND,Gomez RS,Gomes CC

更新日期：2018-03-01 00:00:00

abstract：:Superficial inflammatory dermatoses are very common and comprise a wide, complex variety of clinical conditions. Accurate histological diagnosis, although it can sometimes be difficult to establish, is essential for clinical management. Knowledge of the microanatomy of the skin is important to recognise the variable h...

journal_title：Journal of clinical pathology

authors： Alsaad KO,Ghazarian D

更新日期：2005-12-01 00:00:00

abstract：:Two patients are reported in whom initial misdiagnoses of medullary cancer or trabecular hyaline adenoma for papillary carcinoma were made. ...

journal_title：Journal of clinical pathology

authors： Andrew AC,Williamson JM

更新日期：1993-08-01 00:00:00

abstract：:A biochemical typing method is described for Klebsiella pneumoniae (sensu lato) and Enterobacter aerogenes. The technique depends on differences in metabolism of five carbon substrates--glycerol, inositol, lactose, glucose, and xylose--at two concentrations. Reproducibility is satisfactory and is monitored by the inco...

journal_title：Journal of clinical pathology

authors： Barr JG,Hogg GM

更新日期：1979-09-01 00:00:00

abstract：:A new sensitive nitrite test, the SRN test, was evaluated for its suitability as a reliable screening technique for the detection of bacteriuria. The SRN test was compared to a currently available nitrite test, the Microstix nitrite test, and the results obtained with both nitrite tests were assessed in comparison wit...

journal_title：Journal of clinical pathology

authors： Rabi T

更新日期：1981-07-01 00:00:00

abstract：:Staining with naphthol AS phosphate and Fast Blue BB salt has been used for the estimation of neutrophil alkaline phosphatase (NAP) scores in patients with chronic granulocytic leukaemia (CGL). The very low scores found at diagnosis rise when the disease is treated, and there is some inverse correlation between the NA...

journal_title：Journal of clinical pathology

authors： Spiers AS,Liew A,Baikie AG

更新日期：1975-07-01 00:00:00

abstract：:A case of Cryptococcus neoformans meningitis is described in an HIV negative patient with undiagnosed systemic sarcoidosis. The patient presented with signs of meningitis together with generalised lymphadenopathy and hepatosplenomegaly. Cryptococcal meningitis was diagnosed on lumbar puncture. She was treated with int...

journal_title：Journal of clinical pathology

authors： Botha RJ,Wessels E

更新日期：1999-12-01 00:00:00

abstract：AIM:To ascertain the views of Scottish hospital laboratory users on aspects of regional and supraregional biochemical services offered by the Institute of Biochemistry at Glasgow Royal Infirmary. METHODS:A questionnaire was circulated asking questions or inviting opinions under various headings, including current patt...

journal_title：Journal of clinical pathology

authors： Murphy MJ,Dryburgh FJ,Shepherd J

更新日期：1994-05-01 00:00:00

abstract：:A role has recently been assigned to cell-mediated immunity in chronic liver diseases in addition to the well-known alterations of humoral immunity. We now report the results of the rosette inhibition test for the evaluation of T-lymphocyte "sensitization" in patients with different chronic liver disorders. A cell-med...

journal_title：Journal of clinical pathology

authors： Salerno F,Fargion SR,Cappellini MD,Fiorelli G,Dioguardi N

更新日期：1976-09-01 00:00:00

abstract：:A patient with a 10 year history of monoclonal gammopathy of undetermined significance and Bence Jones proteinuria, and a 44 year history of ankylosing spondylitis, developed a nephrotic syndrome secondary to renal amyloidosis. Clinically the amyloidosis was ascribed to Bence Jones proteinuria rather than to the burnt...

journal_title：Journal of clinical pathology

authors： Quinton R,Siersema PD,Michiels JJ,ten Kate FJ

更新日期：1992-10-01 00:00:00

abstract：AIM:Definitive distinction between low-grade astrocytoma and astrogliosis is a long-standing difficulty due to their similar histopathological characteristics. To clarify differences in biological significance, this study focused on various components of the cell cycle machinery and proliferation as key parameters, com...

journal_title：Journal of clinical pathology

authors： Hara A,Saegusa M,Ichinoe M,Okayasu I

更新日期：2008-03-01 00:00:00

abstract：:Conventional prostate adenocarcinomas consist mainly of tumour cells of luminal immunophenotype with scattered neuroendocrine (NE) cells. NE cells are defined by chromogranin A (CGA) immunoreactivity. Unlike luminal cells, NE cells lack androgen receptor (AR) and prostate specific antigen (PSA) immunoreactivity. This ...

journal_title：Journal of clinical pathology

authors： Roudier MP,True LD,Vessella RL,Higano CS

更新日期：2004-03-01 00:00:00

abstract：:This report describes a case of myelofibrosis presenting as spinal cord compression on account of extramedullary haemopoietic tissue encroaching upon the spinal cord from a large pelvic mass. ...

journal_title：Journal of clinical pathology

authors： Horwood E,Dowson H,Gupta R,Kaczmarski R,Williamson M

更新日期：2003-02-01 00:00:00

abstract：AIMS:To analyse the expression of proteins involved in DNA double strand break detection and repair in the luminal and myoepithelial compartments of benign breast lesions and malignant breast tumours with myoepithelial differentiation. METHODS:Expression of the ataxia telangiectasia (ATM) and p53 proteins was immunohi...

journal_title：Journal of clinical pathology

authors： Angèle S,Jones C,Reis Filho JS,Fulford LG,Treilleux I,Lakhani SR,Hall J

更新日期：2004-11-01 00:00:00

abstract：:Four assays for the detection of alphafetoprotein (AFP) in the diagnosis of primary hepatocellular carcinoma (HCC) were evaluated. The frequency of AFP detection was compared in 89 HCC patients and in 71 patients with chronic active hepatitis/cirrhosis. Of the four assays, immunodiffusion, counterimmunoelectrophoresis...

journal_title：Journal of clinical pathology

authors： Chan SH,Heng SH,Yo SL,Oon CJ

更新日期：1980-08-01 00:00:00

abstract：:Non-Hodgkin's lymphoma is not commonly a familial condition. This is believed to be the first two cases of primary pancreatic lymphoma within a single family. The two cases, a brother and sister, both presented in their 60s and were diagnosed histologically as having high grade B cell lymphoma affecting the pancreas, ...

journal_title：Journal of clinical pathology

authors： James JA,Milligan DW,Morgan GJ,Crocker J

更新日期：1998-01-01 00:00:00

abstract：AIMS:To identify the amyloid protein in a patient with amyloidosis localised to the urinary bladder, and to see whether subtyping of the protein by sequence analysis increases the understanding of the selection of the urinary bladder as the site of amyloid deposition. METHODS:A patient with gross haematuria and a cong...

journal_title：Journal of clinical pathology

authors： Livneh A,Shtrasburg S,Martin BM,Baniel J,Gal R,Pras M

更新日期：2001-12-01 00:00:00

abstract：:In-vivo studies of fibrinogen metabolism were carried out using an I-120 labelled preparation of fibrinogen supplied commercially by the Radiochemical Centre, Amerhsham for use in the diagnosis of deep venous thrombosis. These studies show that the material is suitable for obtaining the main metabolic parameters of c...

journal_title：Journal of clinical pathology

authors： Bradley J,Hickman JA

更新日期：1975-06-01 00:00:00

abstract：:A technique, using indirect immunoperoxidase antibody (IPA), was developed for the detection of IgG antibody to Chlamydia trachomatis. The IPA technique employs glass slides with air-dried and acetone-fixed C trachomatis infected cells, which can be stored at -70 degrees C and used for several months. Antibody titres ...

journal_title：Journal of clinical pathology

authors： Cevenini R,Rumpianesi F,Donati M,Sarov I

更新日期：1983-03-01 00:00:00

abstract：AIMS:To establish a mechanism to examine the components of turnaround time in a representative cross-section of laboratory users; and to identify potential areas for improvement. METHODS:Information was collected manually from result reports received by eight laboratory users: three wards in the main hospital, four GP...

journal_title：Journal of clinical pathology

authors： Smellie WS,Johnston J,Galloway PJ

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy, most frequently affecting the head and neck. Treatment often requires surgery and can have significant functional morbidity. Research into disease pathogenesis and second line medical management of cSCC is limited. We assess geneti...

journal_title：Journal of clinical pathology

authors： Zilberg C,Lee MW,Kraitsek S,Ashford B,Ranson M,Shannon K,Iyer NG,Ch'ng S,Low TH,Palme C,Clark J,Gupta R,Yu B

更新日期：2020-01-01 00:00:00

abstract：AIMS:To describe the prostatic adenectomy specimens of six patients with symptomatic benign prostatic hyperplasia (BPH) who failed to respond to long term treatment with a 5-alpha-reductase inhibitor, finasteride. METHODS:Histological sections from six cases of BPH who had been treated with finasteride were investigat...

journal_title：Journal of clinical pathology

authors： Montironi R,Valli M,Fabris G

更新日期：1996-04-01 00:00:00

abstract：:Using a short series of biochemical tests already in use in many routine laboratories, it is possible to identify strains of the genus Klebsiella and to differentiate K. aerogenes from other types. Marked production of slime is not peculiar to the group and colonial appearance alone is not a satisfactory basis for ide...

journal_title：Journal of clinical pathology

authors： DARRELL JH,HURDLE AD

更新日期：1964-11-01 00:00:00

abstract：AIMS:To investigate proliferative activity in leukaemic and lymphomatous bone marrow infiltrates and to assess the feasibility of transport of specimens among institutions. METHODS:Proliferative activity in bone marrow trephine cryosections from 99 patients with non-Hodgkin's lymphoma (NHL), 23 patients with acute mye...

journal_title：Journal of clinical pathology

authors： White DM,Smith AG,Smith JL

更新日期：1994-03-01 00:00:00

abstract：AIMS:Apoptosis in prostate cancer was evaluated after three months of combined endocrine therapy to investigate the association with tumour grade, tumour stage, and the immunohistochemical detection of p53 and bcl-2 in tumour cells before and after therapy. METHODS:Twenty six formalin fixed, paraffin wax embedded core...

journal_title：Journal of clinical pathology

authors： Colecchia M,Frigo B,Del Boca C,Guardamagna A,Zucchi A,Colloi D,Leopardi O

更新日期：1997-05-01 00:00:00

abstract：:A histological diagnosis of pT4 stage is used as the basis for offering adjuvant therapy to patients with colorectal cancer. Histological features diagnostic of pT4 stage in colorectal cancer include: (1) presence of tumour perforation, (2) invasion of an adjacent organ, (3) direct or discontinuous tumour extending to...

journal_title：Journal of clinical pathology

authors： Swamy R

更新日期：2010-02-01 00:00:00

abstract：:A radioimmunoassay for human growth hormone using activated charcoal is described and its precision, accuracy, and sensitivity are defined. Results are presented for growth hormone measurements in plasma obtained during hypoglycaemia induced with insulin in patients of short stature and during glucose tolerance tests ...

journal_title：Journal of clinical pathology

authors： Thomas FJ,Lloyd HM,Thomas MJ

更新日期：1972-09-01 00:00:00

abstract：:Eight isolates of C. albicans were used to determine the frequency with which germ tube formation occurred: on rice extract -Tween 80 agar, on its components, and on 1% bactopeptone agar after three hr at 37 degrees C; in 0.5% aqueous solution of various carbohydrates; in various concentrations of glucose; on 0.5 and ...

journal_title：Journal of clinical pathology

authors： Joshi KR,Bremner DA,Parr DN,Gavin JB

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND/AIMS:The programmed cell death receptor 1 (PD-1) checkpoint inhibitor, nivolumab, has been approved for the treatment of metastatic renal cell carcinoma (RCC). However, the understanding of the expression and distribution of PD ligand 1 (PD-L1) in the tumour immune microenvironment and its prognostic role in...

journal_title：Journal of clinical pathology

authors： Yeong J,Zhao Z,Lim JCT,Li H,Thike AA,Koh VCY,Teh BT,Kanesvaran R,Toh CK,Tan PH,Khor LY

更新日期：2020-08-01 00:00:00

abstract：AIM:To assess the clinical value of malignancy grading systems compared with nuclear DNA content, protein p53, and angiogenesis for predicting recurrence of stage I (UICC, 1987) tongue carcinomas. METHODS:Histopathological malignancy grading according to Jakobsson and tumour front grading according to Bryne et al were...

journal_title：Journal of clinical pathology

authors： Högmo A,Kuylenstierna R,Lindholm J,Munck-Wikland E

更新日期：1999-01-01 00:00:00