A comparison of rapid methods including imprint cytodiagnosis for the diagnosis of breast tumours.

Abstract:

:Rapid diagnoses were made on 510 breast lumps by three methods in sequence and the results compared with those obtained by paraffin histology.Naked-eye examination of the excised lumps correctly distinguished between benign and malignant tumours in 95.1% of cases with 23 (4.5%) false negative and two (0.4%) false positive results.Rapid imprint cytodiagnosis was correct in 96.9% of the 391 lumps imprinted with 12 (3.1%) false negatives and no false positive results. Frozen sections gave the correct diagnosis in 99.4% of the 510 cases with three (0.6%) false negative and no false positive results. The use of cytology in the diagnosis of breast tumours is discussed.

journal_name

J Clin Pathol

authors

Tribe CR

doi

10.1136/jcp.26.4.273

subject

Has Abstract

pub_date

1973-04-01 00:00:00

pages

273-7

issue

4

eissn

0021-9746

issn

1472-4146

journal_volume

26

pub_type

杂志文章
  • Antithrombin activities in childhood malnutrition.

    abstract::Antithrombin activities in 30 severely malnourished children and 40 normal children were estimated in clotting tests by thrombin neutralisation as anti-Xa and by a heparin antithrombin assay; and by immunodiffusion as alpha 2-globulin and alpha 1-antitrypsin. The patients' mean alpha 2-globulin was severely depressed,...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.32.10.1025

    authors: Jiménez RA,Jiménez E,Ingram GI,Mora LA,Atmetlla F,Carrillo JM,Vargas W

    更新日期:1979-10-01 00:00:00

  • Oncogenic osteomalacia.

    abstract::Severe osteomalacia (confirmed by the examination of thin undecalcified bone biopsy sections) associated with hypophosphataemia developed in a 60 year old woman. A skeletal x-ray survey showed a lytic lesion in the right proximal femur, and this was curetted, showing a vascular tumour. The patient's symptoms improved ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.40.4.446

    authors: McClure J,Smith PS

    更新日期:1987-04-01 00:00:00

  • Mucosal argyrophil endocrine cells in pernicious anaemia and upper gastrointestinal carcinoid tumours.

    abstract::The number and density of argyrophil endocrine cells were morphometrically calculated in gastric fundal mucosal biopsy specimens taken from 64 patients with pernicious anaemia (five with gastric carcinoids, 15 with nodular argyrophil cell hyperplasia, 44 with diffuse argyrophil cell hyperplasia) and from 14 healthy co...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.42.4.371

    authors: Sjöblom SM,Sipponen P,Karonen SL,Järvinen HJ

    更新日期:1989-04-01 00:00:00

  • Rubella virus serology:detection of residual lipoprotein inhibitors of haemagglutination using sensitive indicator arboviruses.

    abstract::Immune and non-immune rubella sera were examined in the haemagglutination inhibition (HAI) test to evaluate the removal of lipoprotein non-specific inhibitors (NSI) of haemagglutination after kaolin and manganous chloride/heparin treatments. The sera were titrated fresh or after lipoprotein deterioration brought about...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.30.5.409

    authors: Shortridge KF

    更新日期:1977-05-01 00:00:00

  • Novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, ultrastructural and immunohistochemical findings.

    abstract::Gastroblastoma is a rare gastric epitheliomesenchymal biphasic tumour composed of spindle and epithelial cells, reported by Miettinen et al in a series of three cases in 2009. All those cases arose in stomachs of young adults. Neither the epithelial nor the mesenchymal component displayed sufficient atypia to diagnose...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2009.074104

    authors: Shin DH,Lee JH,Kang HJ,Choi KU,Kim JY,Park DY,Lee CH,Sol MY,Park JH,Kim HY,Montgomery E

    更新日期:2010-03-01 00:00:00

  • Detection of cytomegalovirus in upper gastrointestinal biopsies from heart transplant recipients: comparison of light microscopy, immunocytochemistry, in situ hybridisation, and nested PCR.

    abstract:AIM:To establish the diagnostic value of in situ hybridisation and the nested polymerase chain reaction (PCR) in detecting clinically relevant cytomegalovirus (CMV) infection in upper gastrointestinal biopsies from heart transplant patients. METHODS:Test sensitivity and specificity for detection of CMV early gene RNA ...

    journal_title:Journal of clinical pathology

    pub_type: 临床试验,杂志文章

    doi:10.1136/jcp.51.11.807

    authors: Muir SW,Murray J,Farquharson MA,Wheatley DJ,McPhaden AR

    更新日期:1998-11-01 00:00:00

  • Validation of whole slide imaging in the primary diagnosis of gynaecological pathology in a University Hospital.

    abstract:AIMS:Experience in the use of whole slide imaging (WSI) for primary diagnosis in pathology is very limited. We aimed to determine the accuracy of interpretation of WSI compared with conventional light microscopy (CLM) in the diagnosis of routine gynaecological biopsies. METHODS:All gynaecological specimens (n=452) rec...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2014-202524

    authors: Ordi J,Castillo P,Saco A,Del Pino M,Ordi O,Rodríguez-Carunchio L,Ramírez J

    更新日期:2015-01-01 00:00:00

  • Quantitative assessment of histological changes in chronic gastritis after eradication of Helicobacter pylori.

    abstract:AIMS:To evaluate the effect of 10 day triple treatment on H pylori eradication and associated gastritis. METHODS:Fifty patients with H pylori positive non-ulcer dyspepsia were treated for 10 days with amoxicillin, tinidazole, and bismuth salts. Histological examination of the antral mucosa was performed before (T0), s...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.45.9.796

    authors: Di Napoli A,Petrino R,Boero M,Bellis D,Chiandussi L

    更新日期:1992-09-01 00:00:00

  • Langerhans cells increase in the dermal lesions of adult T cell leukaemia in Japan.

    abstract::In cases of adult T cell leukaemia neoplastic T cell infiltration in the skin was accompanied by an increase in Langerhans cells. This is in keeping with the view that Langerhans cells may induce antigen-specific and allogenic T cell activation. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.36.3.307

    authors: Shamoto M

    更新日期:1983-03-01 00:00:00

  • Vitamin D deficiency and low osteocalcin concentrations in anorexia nervosa.

    abstract::The calcium, vitamin D, and osteocalcin concentrations were investigated in 17 patients with anorexia nervosa. Serum 25-hydroxyvitamin D (25 OHD) concentrations below normal were observed in 15 (88%); only two patients has serum 1,25 dihydroxycholecalciferol (1,25(OH)2D) concentrations below normal. Serum parathyroid ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.41.2.195

    authors: Fonseca VA,D'Souza V,Houlder S,Thomas M,Wakeling A,Dandona P

    更新日期:1988-02-01 00:00:00

  • Grading of breast cancer on needle core biopsy: does a reduction in mitotic count threshold improve agreement with grade on excised specimens?

    abstract:BACKGROUND:Accurate assessment of invasive breast cancer grade on needle core biopsy (NCB) is important as it guides treatment. AIM:To assess the agreement between grade of invasive cancer on NCB and excision and determine whether altering the mitotic count score threshold on NCB improves it. METHODS:Pathology slides...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2014-202294

    authors: Dhaliwal CA,Graham C,Loane J

    更新日期:2014-12-01 00:00:00

  • Use of the 'Analmatic clinical system' in the microbiological assay of vitamin B 12 and folic acid in serum.

    abstract::The routine estimation of large numbers of serum folic acid and vitamin B(12) levels using the Baird and Tatlock(1) Analmatic clinical system is described and the method evaluated.Precision, accuracy, and carryover are shown to be at acceptable levels, and the advantages and disadvantages of the use of the system are ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.24.1.18

    authors: Colvin G,Gibson GL,Neill DW

    更新日期:1971-02-01 00:00:00

  • Disorders of phosphate metabolism.

    abstract::Phosphate in both inorganic and organic form is essential for several functions in the body. Plasma phosphate level is maintained by a complex interaction between intestinal absorption, renal tubular reabsorption, and the transcellular movement of phosphate between intracellular fluid and bone storage pools. This home...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jclinpath-2018-205130

    authors: Leung J,Crook M

    更新日期:2019-11-01 00:00:00

  • Cultural characters of a newly recognized group of hospital staphylococci.

    abstract::Members of a newly recognized group of hospital staphylococci, which are believed to have arisen from 83A staphylococci by lysogenization, differ from them in several cultural characters. Some but not all of these characters appear to be determined by the carriage of phage. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.19.4.305

    authors: Jevons MP,John M,Parker MT

    更新日期:1966-07-01 00:00:00

  • Lymphocytic gastritis-like T cell lymphoma: molecular evidence of an unusual recurrence.

    abstract::This report describes a patient with a gastric biopsy specimen showing histomorphological and immunohistochemical appearances indistinguishable from those usually present in lymphocytic gastritis, a rare condition of unknown aetiology with a distinctive phenotype. The patient had a history of a biopsy confirmed T cell...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2004.017350

    authors: Nga ME,Tan SH,Teh M,Koay ES,Chong SM,Putti TC,Salto-Tellez M

    更新日期:2004-11-01 00:00:00

  • A solitary benign lymphoid polyp of the rectum in a 51 year old woman.

    abstract::A 51 year old woman presented with rectal bleeding from a mass lying just above the dentate line. Multiple biopsies were taken before the diagnosis of a benign lymphoid polyp was made. This is a rare condition that more commonly presents in children and poses a diagnostic challenge. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.50.12.1034

    authors: Lloyd J,Darzi A,Teare J,Goldin RD

    更新日期:1997-12-01 00:00:00

  • Rapid fixation of brains: a viable alternative?

    abstract:AIM:Recent events surrounding postmortem practices have necessitated several changes in the way necropsies are conducted both within the medicolegal and hospital settings. These changes have resulted in a striking reduction in the frequency of brain retention for neuropathological examination. Aberdeen Royal Infirmary,...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2005.028274

    authors: Sharma M,Grieve JH

    更新日期:2006-04-01 00:00:00

  • Development of a quantitative assay for SARS coronavirus and correlation of GAPDH mRNA with SARS coronavirus in clinical specimens.

    abstract:AIMS:To develop a quantitative reverse transcriptase polymerase chain reaction (Q-RT-PCR) for severe acute respiratory syndrome coronavirus (SARS-CoV) detection and explore the potential of using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA as an internal control to exclude false negative results. METHODS:SAR...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2004.016592

    authors: Wong SC,Chan JK,Lee KC,Lo ES,Tsang DN

    更新日期:2005-03-01 00:00:00

  • A modified rapid slide test for anti-streptolysin O.

    abstract::This paper describes the modification of a commercially available rapid slide screening test(1) for anti-streptolysin O to give quantitative results. The modified technique is compared with the long-established haemolytic technique of Rantz and Randall (1945). The quantitative results for both techniques are shown to ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.25.6.543

    authors: Ingram GB,Hughes JE

    更新日期:1972-06-01 00:00:00

  • Deletion and methylation of the tumour suppressor gene p16/CDKN2 in primary head and neck squamous cell carcinoma.

    abstract:AIMS:To study the homozygous deletion and methylation status of the 5' CpG island of the p16 and p15 genes (9p21) in a set of primary advanced head and neck squamous cell carcinomas (SCC) and to test whether inactivation of these genes by these mechanisms contributes to head and neck SCC development. METHODS:DNA was e...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.50.6.509

    authors: González MV,Pello MF,López-Larrea C,Suárez C,Menéndez MJ,Coto E

    更新日期:1997-06-01 00:00:00

  • Lipoprotein (a) and stroke.

    abstract::Strokes are one of the most common causes of mortality and long term severe disability. There is evidence that lipoprotein (a) (Lp(a)) is a predictor of many forms of vascular disease, including premature coronary artery disease. Several studies have also evaluated the association between Lp(a) and ischaemic (thrombot...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.53.7.487

    authors: Milionis HJ,Winder AF,Mikhailidis DP

    更新日期:2000-07-01 00:00:00

  • Tropical myositis: ultrastructural studies.

    abstract::Specimens of muscle were obtained from non-suppurating lesions of nine patients with tropical myositis. When examined in an electron microscope, these revealed patchy myocytolysis with loss of band structure. Perimysial cells were also degenerate. Sections from two out of nine patients revealed intracellular vesicles,...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.29.12.1081

    authors: Taylor JF,Fluck D,Fluck D

    更新日期:1976-12-01 00:00:00

  • Endocardial fibroelastosis in infants with hydrops fetalis.

    abstract::Endocardial fibroelastosis, defined as an endocardium in excess of 30 microns thick, was found in 10 out of 34 cases of hydrops fetalis in a review of 1589 perinatal necropsies carried out between 1976 and 1989. The infants comprised 16 cases of rhesus haemolytic disease, of whom three had endocardial fibroelastosis, ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.44.7.576

    authors: Newbould MJ,Armstrong GR,Barson AJ

    更新日期:1991-07-01 00:00:00

  • Late relapse in IgD myeloma: value of immunohistochemistry in trephine biopsy specimens.

    abstract::IgD myeloma is a rare disorder with a very poor prognosis. An unusual case is reported where prolonged remission was obtained. Immunohistochemical staining of the bone marrow trephine biopsy specimen proved invaluable in documenting early relapse. It is suggested that immunohistochemistry should be adopted more widely...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.47.8.773

    authors: Kettle P,Morris TC

    更新日期:1994-08-01 00:00:00

  • Clinicopathological significance of HER2/neu genetic heterogeneity in HER2/neu non-amplified invasive breast carcinomas and its concurrent axillary metastasis.

    abstract:BACKGROUND:HER2/neu (HER2) is a significant prognostic marker for breast carcinomas. Recently, new guidelines defining HER2 genetic heterogeneity (GH) were published by the College of American Pathologists. AIMS:To determine the prevalence of HER2 GH as defined in primary invasive breast carcinoma, to determine its re...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2012-201403

    authors: Shafi H,Astvatsaturyan K,Chung F,Mirocha J,Schmidt M,Bose S

    更新日期:2013-08-01 00:00:00

  • Fibrinolysis in leukaemia.

    abstract::Components of the blood fibrinolytic system were measured in 43 patients with leukaemia. Increased fibrinolytic activity, indicated by a reduced plasma plasminogen level, was found in 14 patients. The combination of severe thrombocytopenia and increased fibrinolysis appeared to be a determinant in the production of a ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.21.2.136

    authors: Ogston D,McAndrew GM,Ogston CM

    更新日期:1968-03-01 00:00:00

  • Primary cutaneous Ewing sarcoma/primitive neuroectodermal tumour: a clinicopathological analysis of seven cases highlighting diagnostic pitfalls and the role of FISH testing in diagnosis.

    abstract:AIMS:To perform a clinicopathological analysis of a series of primary cutaneous Ewing sarcomas/primitive neuroectodermal tumours (ES/PNET) to highlight the pathological features, discuss the differential diagnosis, emphasise the role of molecular testing (particularly fluorescence in situ hybridisation, FISH) in diagno...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2008.064014

    authors: Shingde MV,Buckland M,Busam KJ,McCarthy SW,Wilmott J,Thompson JF,Scolyer RA

    更新日期:2009-10-01 00:00:00

  • How morphometric analysis of metastatic load predicts the (un)usefulness of PET scanning: the case of lymph node staging in melanoma.

    abstract:BACKGROUND:In primary cutaneous melanoma, the sentinel node (SN) biopsy is an accurate method for the staging of the lymph nodes. Positron emission tomography (PET) has been suggested as a useful alternative. However, the sensitivity of PET may be too low to detect SN metastases, which are often small. AIM:To predict ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.56.4.283

    authors: Mijnhout GS,Hoekstra OS,van Lingen A,van Diest PJ,Adèr HJ,Lammertsma AA,Pijpers R,Meijer S,Teule GJ

    更新日期:2003-04-01 00:00:00

  • The pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence of duodenal pathology.

    abstract:AIM:To determine whether the pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence or absence of duodenal pathology. METHODS:50 cases (M:F, 26:24; median age 57 years) diagnosed as lymphocytic gastritis between 1986 and 1998 with concurrent duodenal (D2) biopsies were iden...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.52.11.815

    authors: Hayat M,Arora DS,Wyatt JI,O'Mahony S,Dixon MF

    更新日期:1999-11-01 00:00:00

  • Histological study of two cases of Coxsackie B virus pneumonia in children.

    abstract::Two cases of interstitial pneumonia are described. They were characterized by mononuclear cell infiltration of the alveolar walls and protein-rich exudate into the alveolar cavities, with localized hyaline membrane formation. Coxsackie B5 virus was isolated from the lungs of both patients at necropsy. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.18.6.743

    authors: Flewett TH

    更新日期:1965-11-01 00:00:00