Late relapse in IgD myeloma: value of immunohistochemistry in trephine biopsy specimens.

abstract：:Reticulin antibodies have been classified by immunofluorescence into five types reacting with distinct antigens of intra- and extracellular components in mesenchyme. Two types of fibrillar antigens can be distinguished on the basis of the staining patterns, anatomical distribution, and species specificity. A third ant...

journal_title：Journal of clinical pathology

authors： Rizzetto M,Doniach D

更新日期：1973-11-01 00:00:00

abstract：:Myelomatosis was diagnosed in a 64 year old man on the basis of a serum paraprotein band (type IgG lambda, 42 g/l), plasma cell infiltration of bone marrow, and multiple lytic lesions evident on skull x ray picture. Blood specimens taken into plain glass tubes showed bulky gelatinous clot formation with minimal clot r...

journal_title：Journal of clinical pathology

authors： O'Kane MJ,Wisdom GB,Desai ZR,Archbold GP

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:In experimental glomerulonephritis, inhibition of cyclooxygenase 2 (COX-2) enhances the renocortical expression of pathogenic alpha(v) integrins. AIMS:To study whether this effect is mediated by prostaglandin E(2) (PGE(2)) acting through its EP(3) receptor in cultured rat mesangial cells (MCs). METHODS:MCs...

journal_title：Journal of clinical pathology

authors： Waldner C,Schrör K,Heering P

更新日期：2004-05-01 00:00:00

abstract：:A case of bilateral gonadoblastoma/dysgerminoma in a 46 XY phenotypical female is presented. Increased circulating beta human chorionic gonadotropin (beta-HCG) and testosterone together with a decreased concentration of follicle stimulating hormone (FSH) reflected the activities of these tumours. The patient is alive ...

journal_title：Journal of clinical pathology

authors： Fisher RA,Salm R,Spencer RW

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Squamous differentiation/squamous metaplasia is often associated with endometrial adenocarcinoma and benign lesions, such as endometrial hyperplasia and chronic endometritis. Morules have distinct histological characteristics, and are referred to as squamous metaplasia or squamoid metaplasia. AIM:To focus o...

journal_title：Journal of clinical pathology

authors： Chinen K,Kamiyama K,Kinjo T,Arasaki A,Ihama Y,Hamada T,Iwamasa T

更新日期：2004-09-01 00:00:00

abstract：:Sperm-agglutinating antibodies were present in three (2-6%) of 117 fertile men and in 19 (33-9%) of 56 men who had been vasectomized. Twenty-four of the 56 vasectomized men had been studied before vasectomy; sperm-agglutinating antibodies were present in one (4-3%) compared with eight (33-3%) after vasectomy. No sperm...

journal_title：Journal of clinical pathology

authors： Hunter J,Logan H,Greer G

更新日期：1976-12-01 00:00:00

abstract：AIMS:Clot waveform analysis (CWA) has been reported to extend the interpretation of clotting time measurement. The parameters obtained from successive derivatives of the clotting reaction curves reflect the rates of activation of individual coagulation factors, theoretically dissecting the cascade pathway. This study a...

journal_title：Journal of clinical pathology

authors： Wakui M,Fujimori Y,Katagiri H,Nakamura S,Kondo Y,Kuroda Y,Nakagawa T,Shimizu N,Murata M

更新日期：2019-03-01 00:00:00

abstract：AIMS:The purpose of this study was to compare the DNA-methylation signature in classic chronic Philadelphia negative myeloproliferative neoplasms (MPN), polycythaemia vera (PV) and essential thrombocythaemia (ET), in order to obtain a global insight into DNA-methylation changes associated with these malignancies. METH...

journal_title：Journal of clinical pathology

authors： Barrio S,Gallardo M,Albizua E,Jimenez A,Rapado I,Ayala R,Gilsanz F,Martin-Subero JI,Martinez-Lopez J

更新日期：2011-11-01 00:00:00

abstract：AIMS:To evaluate an indirect immunofluorescence flow cytometry technique in a series of patients with large fetomaternal haemorrhage (FMH). METHODS:Patient samples identified by Kleihauer testing in local laboratories as having FMH > 4 ml were sent for flow cytometric analysis. In a proportion of cases the mothers rec...

journal_title：Journal of clinical pathology

authors： Johnson PR,Tait RC,Austin EB,Shwe KH,Lee D

更新日期：1995-11-01 00:00:00

abstract：:The presence of serum agglutinins and precipitins to Candida albicans in men and women who had impaired bladder function following spinal injury is compared with that in other patients in hospital and in apparently fit men and women. Antibody levels which have commonly been regarded as significant were found in 35 of ...

journal_title：Journal of clinical pathology

authors： Everall PH,Morris CA,Morris DF

更新日期：1974-09-01 00:00:00

abstract：BACKGROUND:The Glasgow Prognostic Score (GPS), an inflammation-based prognostic score formed from standard thresholds of C reactive protein (CRP) and albumin, has prognostic value in patients with advanced cancer. Little is known about the general biochemical disturbance associated with the systemic inflammatory respon...

journal_title：Journal of clinical pathology

authors： Brown DJ,Milroy R,Preston T,McMillan DC

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:To determine whether antibiotics are prescribed appropriately for acute tonsillitis in an emergency department (ED). METHODS:Cross-sectional observational study in large district general hospital in London. Patients diagnosed and coded with 'acute tonsillitis' in the ED over a 3-month period in 2015. Medica...

journal_title：Journal of clinical pathology

authors： Kanji K,Saatci D,Rao GG,Khanna P,Bassett P,Williams B,Khan M

更新日期：2016-09-01 00:00:00

abstract：AIMS:To assess the occurrence of diagnostic delay in primary antibody deficiency in the period 1989-2002, since a similar study in 1989, and to assess the impact of UK national guidelines communicated in 1995. METHODS:A retrospective case note review was performed of 89 consecutive patients with antibody deficiency re...

journal_title：Journal of clinical pathology

authors： Seymour B,Miles J,Haeney M

更新日期：2005-05-01 00:00:00

abstract：:The distribution of laminin, a basement membrane glycoprotein, was studied by an immunohistochemical technique in six samples of benign sclerosing lesions of extrahepatic bile ducts and in 11 sclerosing cholangiocarcinomas. The expression of laminin showed that benign glandular structures were surrounded by a mainly i...

journal_title：Journal of clinical pathology

authors： Haglund C,Roberts PJ,Nordling S

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVE:Few studies have modelled the economics of thyroid FNA. METHODS:A simple spreadsheet economic model for delivery of thyroid fine needle aspiration (FNA) cytology is described using the UK Royal College of Pathologists' Classification for thyroid FNA which is based on The Bethesda System for Reporting Thyroid...

journal_title：Journal of clinical pathology

authors： Poller DN,Kandaswamy P

更新日期：2013-07-01 00:00:00

abstract：AIMS:To describe the prostatic adenectomy specimens of six patients with symptomatic benign prostatic hyperplasia (BPH) who failed to respond to long term treatment with a 5-alpha-reductase inhibitor, finasteride. METHODS:Histological sections from six cases of BPH who had been treated with finasteride were investigat...

journal_title：Journal of clinical pathology

authors： Montironi R,Valli M,Fabris G

更新日期：1996-04-01 00:00:00

abstract：AIMS:To evaluate the influence of involvement of the peritoneal surface by carcinoma of the rectum on local recurrence and prognosis. METHODS:Prospective analysis of pathological prognostic factors in 209 resections for rectal carcinoma between 1988 and 1993 with meticulous pathological technique particularly to asses...

journal_title：Journal of clinical pathology

authors： Shepherd NA,Baxter KJ,Love SB

更新日期：1995-09-01 00:00:00

abstract：AIMS:Positive direct antiglobulin tests (DATs) are valuable in identifying the aetiology of autoimmune haemolysis and in guiding therapeutic intervention. However, in HIV-positive individuals with background polyclonal gammopathy, a positive DAT in the absence of haemolysis is common. In this setting, IgG quantificatio...

journal_title：Journal of clinical pathology

authors： Chetty T,Bouwer N,Wan YO,Mahlangu J

更新日期：2020-12-16 00:00:00

abstract：:The microwave tissue coagulator (MTC) is used in hepatectomy because it provides excellent haemostasis during the procedure. A 59 year old man underwent partial hepatic lobectomy with MTC, for metastasis from colon cancer. A tumorous necrotic nodule was discovered in the liver. The nodule measured 2.5 cm at its larges...

journal_title：Journal of clinical pathology

authors： Mikami Y,Shimizu M,Manabe T

更新日期：1997-08-01 00:00:00

abstract：:Patients with bacterial infection may show altered membrane permeability of the primary azurophilic lysosomes of blood neutrophils. A new enzyme cytochemical technique, sensitive to increased membrane permeability caused by contact of neutrophils with acetone, saponin, low pH, Streptolysin O, bacteria, and nylon wool,...

journal_title：Journal of clinical pathology

authors： Wozniak JT,Orchard TL,Mackie PH,Mistry DK,Stuart J

更新日期：1978-07-01 00:00:00

abstract：AIM:To investigate the natural history of patients with non-alcoholic steatohepatitis by means of a prospective histological study. METHODS:One thousand five hundred and seventy one patients underwent liver biopsy at the Western Infirmary in Glasgow during the 10 year period 1985 to 1994. All biopsies were reported by...

journal_title：Journal of clinical pathology

authors： Evans CD,Oien KA,MacSween RN,Mills PR

更新日期：2002-09-01 00:00:00

abstract：:Routine endometrial cytology was used instead of curettage as the first step in a morphological investigation of the endometrium in patients with postmenopausal bleeding. Premenopausal women with symptoms or signs indicative of premalignant or malignant disease were also studied using this method. Patients with alarmi...

journal_title：Journal of clinical pathology

authors： Skaarland E

更新日期：1986-01-01 00:00:00

abstract：:Pre-mRNA splicing is an essential process in eukaryotic cells where the transcribed intronic sequences are removed, prior to translation into protein. PRPF31 is a ubiquitously expressed splicing factor, which aids in the assembly of the macromolecular spliceosome. Mutations in PRPF31 cause autosomal dominant retinitis...

journal_title：Journal of clinical pathology

authors： Rose AM,Luo R,Radia UK,Bhattacharya SS

更新日期：2017-09-01 00:00:00

abstract：AIMS:In everyday practice, epidermal growth factor receptor (EGFR) testing is centralised in referral laboratories that receive paucicellular cytological specimens. Ideally, EGFR testing should be carried out in the centre where the patient is diagnosed such that the most cellular slide can be selected from in-house co...

journal_title：Journal of clinical pathology

authors： De Luca C,Gragnano G,Pisapia P,Vigliar E,Malapelle U,Bellevicine C,Troncone G

更新日期：2017-04-01 00:00:00

abstract：:Fluorescence in situ hybridisation (FISH) analysis is now widely employed in the diagnosis and risk stratification of a wide range of malignant diseases. While this technique is used successfully with formalin-fixed paraffin-embedded (FFPE) sections from numerous tissue types, FISH analysis of FFPE tissue sections fro...

journal_title：Journal of clinical pathology

authors： Neat MJ,Moonim MT,Dunn RG,Geoghegan H,Foot NJ

更新日期：2013-01-01 00:00:00

abstract：:Bilateral adrenalectomy produces a reduction in the alkaline phosphatase concentration in rat intestine, which is not prevented by the administration of saline, but is prevented by the administration of cortisone. The administration of A.C.T.H. to normal rats leads to a rise in intestinal alkaline phosphatase levels a...

journal_title：Journal of clinical pathology

authors： Watson WC,Murray ES,Gardner MD

更新日期：1967-03-01 00:00:00

abstract：:Experience after 18 months' work with the SMA-4 system of multiple analysis for routine haematology is described, as well as the modifications to the machine which have been made for smoother operation. ...

journal_title：Journal of clinical pathology

authors： Green AE,Middleton VL,Prentis KG,Signy AG

更新日期：1969-01-01 00:00:00

abstract：AIMS:To demonstrate expression of immunoglobulin light chain mRNA in diagnostic fine needle aspiration (FNA) cytology specimens using an in situ hybridisation (ISH) technique; and to evaluate ISH in a series of reactive lymphoid proliferations and malignant lymphomas. METHODS:Forty diagnostic FNA specimens showing a l...

journal_title：Journal of clinical pathology

authors： Stewart CJ,Farquharson MA,Kerr T,McCorriston J

更新日期：1996-09-01 00:00:00

abstract：:The case records and pathology of all children with kidney tumours treated in the West Midlands Health Authority Region (WMHAR) from 1957 to 1986 were reviewed. The histology was reviewed by a panel of three paediatric pathologists. Thirteen (6%) out of 211 cases were considered to have congenital mesoblastic nephroma...

journal_title：Journal of clinical pathology

authors： Barrantes JC,Toyn C,Muir KR,Parkes SE,Raafat F,Cameron AH,Marsden HB,Mann JR

更新日期：1991-04-01 00:00:00

abstract：AIMS:To develop a rapid, sensitive, and safe method for the analysis of von Willebrand factor (vWf) multimers in plasma or platelet lysates. METHOD:Analysis of vWf multimers was carried out by sodium dodecyl sulphate-agarose discontinuous gel electrophoresis followed by protein transfer to nitrocellulose membranes by ...

journal_title：Journal of clinical pathology

authors： Cumming AM,Wensley RT

更新日期：1993-05-01 00:00:00