Disorders of phosphate metabolism.

Abstract:

:Phosphate in both inorganic and organic form is essential for several functions in the body. Plasma phosphate level is maintained by a complex interaction between intestinal absorption, renal tubular reabsorption, and the transcellular movement of phosphate between intracellular fluid and bone storage pools. This homeostasis is regulated by several hormones, principally the parathyroid hormone, 1,25-dihydroxyvitamin D and fibroblast growth factor 23. Abnormalities in phosphate regulation can lead to serious and fatal complications. In this review phosphate homeostasis and the aetiology, pathophysiology, clinical features, investigation and management of hypophosphataemia and hyperphosphataemia will be discussed.

journal_name

J Clin Pathol

authors

Leung J,Crook M

doi

10.1136/jclinpath-2018-205130

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

741-747

issue

11

eissn

0021-9746

issn

1472-4146

pii

jclinpath-2018-205130

journal_volume

72

pub_type

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