Vitamin D deficiency and low osteocalcin concentrations in anorexia nervosa.

abstract：:Severe osteomalacia (confirmed by the examination of thin undecalcified bone biopsy sections) associated with hypophosphataemia developed in a 60 year old woman. A skeletal x-ray survey showed a lytic lesion in the right proximal femur, and this was curetted, showing a vascular tumour. The patient's symptoms improved ...

journal_title：Journal of clinical pathology

authors： McClure J,Smith PS

更新日期：1987-04-01 00:00:00

abstract：AIMS:Evidence suggests that the presence of tumour necrosis is an adverse prognostic factor in renal cell carcinoma (RCC). However, it has also been shown that tumour regression, a microscopic feature associated with necrosis, may be a favourable short term prognostic factor in RCC. METHODS:Pathology reports of 253 RC...

journal_title：Journal of clinical pathology

authors： Foria V,Surendra T,Poller DN

更新日期：2005-01-01 00:00:00

abstract：AIM:To investigate the fate of Streptococcus pneumoniae C-polysaccharide antigen in serum in patients with S pneumoniae bacteraemia. METHOD:In vitro dissociation experiments were performed to demonstrate that C-polysaccharide was masked by ligands in normal and acute phase serum. Serum samples from 22 patients with S ...

journal_title：Journal of clinical pathology

authors： Gillespie SH,Smith MD,Dickens A,Raynes JG,McAdam KP

更新日期：1995-09-01 00:00:00

abstract：:Two histochemical techniques, the PAT/KOH/PAS and the PBT/KOH/PAS, were used to investigate the side chain O-acyl substitution patterns of the sialic acids of the colonic epithelial mucins in cases of ulcerative colitis and Crohn's disease. In both diseases there was, as compared to normal, a reduction in the proporti...

journal_title：Journal of clinical pathology

authors： Culling CF,Reid PE,Dunn WL

更新日期：1979-12-01 00:00:00

abstract：:In order to detect the heat labile toxin of Escherichia coli human embryo lung fibroblast cells were seeded with whole cell lysate preparations of the organism to be tested. Positive results consisted of growth inhibition and cytopathic change which were easily seen. Heat-labile toxin was produced by strains belonging...

journal_title：Journal of clinical pathology

authors： Holzel H

更新日期：1979-12-01 00:00:00

abstract：:This report describes a case of aleukaemic myeloid sarcoma of the small intestine in a 50-year-old woman presenting with small bowel obstruction. Fluorescence in situ hybridisation analysis of interphase nuclei revealed a split CBFbeta signal, consistent with an underlying inversion of chromosome 16, inv(16)(p13q22). ...

journal_title：Journal of clinical pathology

authors： McKenna M,Arnold C,Catherwood MA,Humphreys MW,Cuthbert RJ,Bueso-Ramos C,McManus DT

更新日期：2009-08-01 00:00:00

abstract：:Fifteen cases of large-cell lymphoma, diagnosed as centroblastic (5), B-immunoblastic (5) or true histiocytic (5). lymphoma and one case of malignant histiocytosis were studied with monoclonal antibodies. Each diagnosis was based on morphological as well as marker studies. A panel of monoclonal and heterologous antibo...

journal_title：Journal of clinical pathology

authors： van der Valk P,van den Besselaar-Dingjan G,Daha MR,Meijer CJ

更新日期：1983-01-01 00:00:00

abstract：:Methods are described for the estimation of plasma and urine alpha-amino nitrogen by the colorimetric ninhydrin reaction; in the method for urine, both ammonia and urea are separated by a rapid ion-exchange resin procedure. Two methods of estimation are given; one has the advantage of great simplicity, but involves th...

journal_title：Journal of clinical pathology

authors： MATTHEWS DM,MUIR GG,BARON DN

更新日期：1964-03-01 00:00:00

abstract：AIMS:To develop a quantitative reverse transcriptase polymerase chain reaction (Q-RT-PCR) for severe acute respiratory syndrome coronavirus (SARS-CoV) detection and explore the potential of using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA as an internal control to exclude false negative results. METHODS:SAR...

journal_title：Journal of clinical pathology

authors： Wong SC,Chan JK,Lee KC,Lo ES,Tsang DN

更新日期：2005-03-01 00:00:00

abstract：:The placenta is the fetal organ providing the interchange between mother and fetus. This organ needs to provide its function such as transport and secretion even during its development and thus all developmental changes need to be in accordance with its function. This review describes development of the placenta durin...

journal_title：Journal of clinical pathology

authors： Huppertz B

更新日期：2008-12-01 00:00:00

abstract：AIMS:To elucidate potential mechanisms of drug resistance, levels of topoisomerase II alpha mRNA, a target for cytostatic drugs, were measured in cryopreserved tumour tissue from 36 patients with non-Hodgkin's lymphoma. To evaluate the potential association between topoisomerase II alpha and cell proliferation, Ki-67 i...

journal_title：Journal of clinical pathology

authors： Lohri A,Reuter J,Gudat F,Herrmann R

更新日期：1997-01-01 00:00:00

abstract：:This review deals with difficulties of diagnosis in cutaneous malignant melanoma encountered by histopathologists of variable seniority and is based on referred material at The Royal Marsden Hospital over a 20-year period and on the experience of more than two-and-a-half thousand cases referred to The World Health Org...

journal_title：Journal of clinical pathology

authors： Levene A

更新日期：1980-02-01 00:00:00

abstract：:Serum total calcium was measured in 1693 patients during a four-month period. We examined the effects of adjustment for albumin concentration on the interpretation of single measurements of serum total calcium and on the variation of series of measurements in individual patients. Markedly abnormal total calcium concen...

journal_title：Journal of clinical pathology

authors： Payne RB,Carver ME,Morgan DB

更新日期：1979-01-01 00:00:00

abstract：AIMS:To detect cells bearing BRAF mutations in colorectal tumour samples and peritoneal washings, using a mismatch ligation assay (MLA). METHODS:DNA from 46 colorectal tumours was studied. Part of exon 15 of the BRAF gene was amplified using the polymerase chain reaction, and T-->A mutations at codon 600 were detected...

journal_title：Journal of clinical pathology

authors： Busby K,Morris A

更新日期：2005-04-01 00:00:00

abstract：AIM:To assess the topographical relation between gastric glands, using the minimum spanning tree (MST), to derive both a model of neighbourhood and quantitative representation of the tissue's architecture, to assess the characteristic features of gastric atrophy, and to assess the grades of gastric atrophy. METHODS:Ha...

journal_title：Journal of clinical pathology

authors： Zaitoun AM,al Mardini H,Record CO

更新日期：1998-12-01 00:00:00

abstract：:Investigations into the immunological functions of three patients with chronic mucocutaneous candidiasis were carried out. Phagocytosis of Candida albicans, nitroblue tetrazolium dye reduction, complement, and immunoglobulin levels were normal. Candidacidal assays using the neutrophils of the patients in autologous se...

journal_title：Journal of clinical pathology

authors： Walker SM,Urbaniak SJ

更新日期：1980-04-01 00:00:00

abstract：AIM:To investigate the association between the quantity of gastric chemokine mRNA expression, severity of gastritis, and cagA positivity in Helicobacter pylori associated gastritis. METHODS:In 83 dyspeptic patients, antral and corpus biopsies were taken for semiquantitative reverse transcription polymerase chain react...

journal_title：Journal of clinical pathology

authors： Shimoyama T,Everett SM,Dixon MF,Axon AT,Crabtree JE

更新日期：1998-10-01 00:00:00

abstract：:This is a retrospective study of the results of 4,642 blood cultures taken from 2,190 patients from 1960 to 1967 in one London hospital. The results suggested that an increased incidence of bacteraemias at this particular hospital was mainly due to the increase in the number of patients having blood cultures. Some of ...

journal_title：Journal of clinical pathology

authors： Crowley N

更新日期：1970-03-01 00:00:00

abstract：:Recent evidence shows that chronic liver disease induced by hepatitis delta virus is closely associated with production of autoantibodies. To verify this sera from patients with hepatitis delta virus and from those with hepatitis B virus mediated chronic liver disease were tested for a panel of autoantibodies. Althoug...

journal_title：Journal of clinical pathology

authors： Zauli D,Crespi C,Bianchi FB,Craxi A,Pisi E

更新日期：1986-08-01 00:00:00

abstract：AIMS:To determine the effect of pregnancy on C4d concentrations and to assess whether C4d remains a useful disease activity marker in the management of connective tissue diseases during pregnancy. METHODS:Plasma C3, C4, and C4d concentrations were measured in 83 women at various stages of normal pregnancy and compared...

journal_title：Journal of clinical pathology

authors： Hopkinson ND,Powell RJ

更新日期：1992-01-01 00:00:00

abstract：:A latex enzyme immunoassay (LEIA) for detecting IgG class antibody to rubella virus was compared with the latex agglutination test (LA) and a haemagglutination inhibition assay (HI). Of 243 sera tested, four discrepant results were observed among all three techniques, corresponding to borderline values. Except for one...

journal_title：Journal of clinical pathology

authors： Duverlie G,Roussel C,Driencourt M,Orfila J

更新日期：1990-09-01 00:00:00

abstract：AIMS:To establish a mechanism to examine the components of turnaround time in a representative cross-section of laboratory users; and to identify potential areas for improvement. METHODS:Information was collected manually from result reports received by eight laboratory users: three wards in the main hospital, four GP...

journal_title：Journal of clinical pathology

authors： Smellie WS,Johnston J,Galloway PJ

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:An increase in intraepithelial lymphocytes (IELs) is mandatory for the histological diagnosis of coeliac disease (CD). Currently, duodenal biopsies are used almost exclusively to establish the diagnosis, yet published work continues to cite an upper limit of 40 lymphocytes/100 epithelial cells, a figure deri...

journal_title：Journal of clinical pathology

authors： Hayat M,Cairns A,Dixon MF,O'Mahony S

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterised by the presence of various laboratory abnormalities but the precise role of laboratory staff in initiating clinical referral and subsequent biopsy is not clear. OBJECTIVE:To examine the impact of laboratory abnormalities in the inv...

journal_title：Journal of clinical pathology

authors： Sinclair D,Spedding A,Young R

更新日期：2006-04-01 00:00:00

abstract：:A technique is described for obtaining samples of bladder epithelium using soluble swabs. Changes indicating neoplasia were seen in a large proportion of patients with bladder carcinoma. These changes were absent in the non-neoplastic control cases. The method provided tissue similar to that obtained by biopsy and sur...

journal_title：Journal of clinical pathology

authors： Trott PA,Williams G,Attridge PW

更新日期：1969-11-01 00:00:00

abstract：:The 24-hour urinary excretion of cyclic 3',5'-adenosine monophosphate (cAMP) was measured by a protein-binding assay in 55 healthy volunteers (aged 20-35 yr) and in 30 hospitalized elderly subjects (aged 70-93 yr). In the older subjects the mean 24-hour cAMP excretion was significantly lower; the correlation between c...

journal_title：Journal of clinical pathology

authors： Gennari C,Galli M,Montagnani M

更新日期：1976-01-01 00:00:00

abstract：:The results of a histological study of normal osteoid tissue in man, the monkey, the dog, and the rat, using thin microtome sections of plastic-embedded undecalcified bone, are described. Osteoid tissue covers the entire bone surface, except for areas of active resorption, although the thickness of the layer of osteoi...

journal_title：Journal of clinical pathology

authors： Raina V

更新日期：1972-03-01 00:00:00

abstract：AIMS:To assess the occurrence of diagnostic delay in primary antibody deficiency in the period 1989-2002, since a similar study in 1989, and to assess the impact of UK national guidelines communicated in 1995. METHODS:A retrospective case note review was performed of 89 consecutive patients with antibody deficiency re...

journal_title：Journal of clinical pathology

authors： Seymour B,Miles J,Haeney M

更新日期：2005-05-01 00:00:00

abstract：:Immunological methods of pregnancy diagnosis using both tanned red cell and latex particles are compared in a series of women (up to the fourteenth week of gestation) and also in negative controls. The tanned red cell test showed slightly more accurate and sensitive results throughout the trial. In 31 samples also sub...

journal_title：Journal of clinical pathology

authors： WORT AJ,VARDE KN,FAIRWEATHER DV,GREEN CA

更新日期：1963-11-01 00:00:00

abstract：AIMS:We aimed to study epidermal growth factor receptor (EGFR) expression in surgically resected pancreatic ductal adenocarcinomas (PDACs) by immunohistochemistry and their relationship to clinicopathological features, cell proliferation and cell adhesion protein expression. METHODS:A total of 99 PDACs were analysed o...

journal_title：Journal of clinical pathology

authors： Handra-Luca A,Hammel P,Sauvanet A,Lesty C,Ruszniewski P,Couvelard A

更新日期：2014-04-01 00:00:00